Parentalidade socioafetiva - um direito da criança e do adolescente

Trabalho de Conclusão de Curso (Graduação)O presente trabalho se faz no intuito de reconhecer a parentalidade socioafetiva como um direito da criança e do adolescente, tendo como base principalmente os princípios do melhor interesse da criança e do adolescente e o princípio da afetividade. Sabe-se que com as constantes modificações que a família vem tendo na sociedade, deve-se atentar principalmente para os indivíduos que ainda estão em desenvolvimento, sendo necessário sempre buscar o melhor interesse da criança e do adolescente

Literacy in Portugal: country report: children and adolescents

This report on the state of literacy in Portugal is one of a series produced in 2015 and 2016 by ELINET, the European Literacy Policy Network. ELINET was founded in February 2014 and has 78 partner organisations in 28 European countries1. ELINET aims to improve literacy policies in its member countries in order to reduce the number of children, young people and adults with low literacy skills. One major tool to achieve this aim is to produce a set of reliable, up-to-date and comprehensive reports on the state of literacy in each country where ELINET has one or more partners, and to provide guidance towards improving literacy policies in those countries. The reports are based (wherever possible) on available, internationally comparable performance data, as well as reliable national data provided (and translated) by our partners.ELINET - EAC/S05/201

Literacy in Italy: country report: children and adolescents

This report on the state of literacy in Italy is one of a series produced in 2015 and 2016 by ELINET, the European Literacy Policy Network. ELINET was founded in February 2014 and has 78 partner organisations in 28 European countries. ELINET aims to improve literacy policies in its member countries in order to reduce the number of children, young people and adults with low literacy skills. One major tool to achieve this aim is to produce a set of reliable, up-to-date and comprehensive reports on the state of literacy in each country where ELINET has one or more partners, and to provide guidance towards improving literacy policies in those countries. The reports are based (wherever possible) on available, internationally comparable performance data, as well as reliable national data provided (and translated) by our partners.ELINET - EAC/S05/201

COVID-19 Fears and Preventive Behaviors among Prison Staff.

This study focused on COVID-19 preventive behaviors and fears among prison staff members after the first wave of the pandemic. Cross-sectional data from 171 participants were collected in Switzerland. The level of fears (58.5%) and protective behaviors (100%) were high. Correctional officers adhered less to preventive measures than other staff members (p = .001). Fears were related to a reduction of social contacts (p = .006) and worries about physical health was related to preventive behaviors in general (p = .006). There is a need to raise prison staff awareness regarding their vulnerability to the SARS-CoV-2 in order to improve the effectiveness of health campaigns in prison settings. Special attention should be given to correctional officers

Androgen-dependent apoptosis in male germ cells is regulated through the proto-oncoprotein Cbl

The proto-oncoprotein Cbl is known to control several signaling processes. It is highly expressed in the testis, and because spermatogenesis is androgen dependent, we investigated the androgen dependency expression of Cbl through its testicular sublocalization and its expression levels in rats that were exposed to the antiandrogen flutamide or were hypophysectomized. We report the androgen dependency of Cbl as it localizes in pachytene spermatocytes during androgen-dependent stages, is down-regulated upon flutamide exposure, and is up-regulated with testosterone in hypophysectomized rats. Coculture experiments showed the key control exerted by the Sertoli cell on Cbl activity. As flutamide induces germ cell apoptosis, we investigate members of the Bcl-2 family upon flutamide exposure. We show that the proapoptotic Bcl-2 family member Bim mirrored Cbl expression through a posttranscriptional process. We also show that in Cbl knockout mouse testes, the imbalance between the high expression of Bim and Smac/Diablo and antiapoptotic factors such as cellular inhibitor of apoptosis 2 favors a survival process, which makes these mice unresponsive to androgen withdrawal and could explain their hypofertility

INTERCORRÊNCIAS PERIODONTAIS DEVIDO A FALHAS EM FACETAS DENTÁRIAS: REVISÃO DE LITERATURA

As facetas odontológicas são opções estéticas para tratamento de anomalias dentárias, alteração de cor e posicionamento dentário, fraturas amplas, dentes conóides e hipoplásicos, fechamento de diastemas, entre outros. Entretanto, falhas durante a execução deste procedimento podem ocasionar intercorrências periodontais, causando desconforto e comprometendo a saúde bucal. Este artigo busca, por meio de uma revisão de literatura, analisar os principais fatores que contribuem para o insucesso na execução de facetas e as consequências periodontais resultantes. Além disso, reitera-se a importância de um plano de tratamento adequado, ensaio restaurador, materiais de qualidade e técnicas precisas para garantir um resultado satisfatório e duradouro. A metodologia utilizada foi baseada em artigos científicos publicados nas bases de dados online: Google Acadêmico, PubMed e Lilacs. Grande parte das falhas de facetas são provenientes de uma execução inadequada por parte do cirurgião-dentista responsável. Portanto, é fundamental que os profissionais estejam em constante aprendizado e conduzam cada caso de acordo com as necessidades dos pacientes

SEGURANÇA DO PACIENTE EM ANESTESIA E ESTRATÉGIA PARA PREVENÇÃO DE EVENTOS ADVERSOS

Patient safety during anesthetic procedures is a fundamental pillar in medical practice, aiming to mitigate risks and prevent adverse events. In this context, the implementation of effective strategies plays a crucial role in ensuring patient well-being. Objectives: Implement effective strategies in anesthesia to prevent adverse events, ensuring patient safety during surgical procedures. Methodology: The articles found were read, upon reading the articles were subjected to inclusion and exclusion criteria, within the inclusion criteria original articles were considered, which addressed the topic researched and allowed full access to the content of the study, published in the period of 2015 to 2023, in Portuguese and English, totaling 22 articles for the present study. The research was carried out through online access to the National Library of Medicine (PubMed MEDLINE), Scientific Electronic Library Online (SCIELO), Latin American and Caribbean Literature in Health Sciences (LILACS) databases in March 2024. Results and Discussions:  Consistent application of safety protocols significantly reduced the incidence of adverse events in anesthesia. The effectiveness of these strategies such as the checklist before the procedure, during and after the procedure is highlighted, emphasizing the continuous importance of monitoring and improving practices carried out in the surgical environment during the anesthesia process, further improving patient safety. Conclusion: In summary, the implementation of preventive strategies proves to be crucial in reducing adverse events in anesthesia, strengthening patient safety. The constant evaluation and improvement of these approaches are essential to ensure increasingly safe and effective anesthetic practices.A segurança do paciente durante procedimentos anestésicos é um pilar fundamental na prática médica, visando mitigar riscos e prevenir eventos adversos. Nesse contexto, a implementação de estratégias eficazes desempenha um papel crucial na garantia do bem-estar do paciente. Objetivos: Implementar estratégias eficazes na anestesia para prevenir eventos adversos, garantindo a segurança do paciente durante procedimentos cirúrgicos. Metodologia: Foi realizada a leitura doas artigos encontrados, mediante a leitura os artigos foram submetidos a critérios de inclusão e de exclusão, dentro os de inclusão foram considerados artigos originais, que abordassem o tema pesquisado e permitissem acesso integral ao conteúdo do estudo, publicados no período de 2015 a 2023, em português e em inglês, totalizando 22 artigos para o presente estudo. A pesquisa foi realizada através do acesso online nas bases de dados National Library of Medicine (PubMed MEDLINE), Scientific Electronic Library Online (SCIELO), Literatura Latino-Americana e do Caribe em Ciências da Saúde (LILACS) no mês de março de 2024. Resultados e Discussões: A aplicação consistente de protocolos de segurança reduziu significativamente a incidência de eventos adversos em anestesia. Destaca-se a eficácia dessas estratégias como o checklist antes do procedimento, durante e a pós, enfatizando a importância contínua da vigilância e aprimoramento das práticas realizadas no ambiente cirúrgico mediante ao processo de anestesia melhorando ainda mais a segurança do paciente. Conclusão: Em síntese, a implementação de estratégias preventivas demonstra ser crucial na redução de eventos adversos em anestesia, fortalecendo a segurança do paciente. A constante avaliação e aprimoramento dessas abordagens são essenciais para garantir práticas anestésicas cada vez mais seguras e eficazes

Literacy in Lithuania. Country Report - Children and Adolescents

European Literacy policy network (ELINET

The Fourteenth Data Release of the Sloan Digital Sky Survey: First Spectroscopic Data from the extended Baryon Oscillation Spectroscopic Survey and from the second phase of the Apache Point Observatory Galactic Evolution Experiment

The fourth generation of the Sloan Digital Sky Survey (SDSS-IV) has been in operation since July 2014. This paper describes the second data release from this phase, and the fourteenth from SDSS overall (making this, Data Release Fourteen or DR14). This release makes public data taken by SDSS-IV in its first two years of operation (July 2014-2016). Like all previous SDSS releases, DR14 is cumulative, including the most recent reductions and calibrations of all data taken by SDSS since the first phase began operations in 2000. New in DR14 is the first public release of data from the extended Baryon Oscillation Spectroscopic Survey (eBOSS); the first data from the second phase of the Apache Point Observatory (APO) Galactic Evolution Experiment (APOGEE-2), including stellar parameter estimates from an innovative data driven machine learning algorithm known as "The Cannon"; and almost twice as many data cubes from the Mapping Nearby Galaxies at APO (MaNGA) survey as were in the previous release (N = 2812 in total). This paper describes the location and format of the publicly available data from SDSS-IV surveys. We provide references to the important technical papers describing how these data have been taken (both targeting and observation details) and processed for scientific use. The SDSS website (www.sdss.org) has been updated for this release, and provides links to data downloads, as well as tutorials and examples of data use. SDSS-IV is planning to continue to collect astronomical data until 2020, and will be followed by SDSS-V.Comment: SDSS-IV collaboration alphabetical author data release paper. DR14 happened on 31st July 2017. 19 pages, 5 figures. Accepted by ApJS on 28th Nov 2017 (this is the "post-print" and "post-proofs" version; minor corrections only from v1, and most of errors found in proofs corrected

Preclinical Evidence Supporting Early Initiation of Citalopram Treatment in Machado-Joseph Disease

Spinocerebellar ataxias are dominantly inherited neurodegenerative disorders with no disease-modifying treatment. We previously identified the selective serotonin reuptake inhibitor citalopram as a safe and effective drug to be repurposed for Machado-Joseph disease. Pre-symptomatic treatment of transgenic (CMVMJD135) mice strikingly ameliorated mutant ataxin-3 (ATXN3) pathogenesis. Here, we asked whether citalopram treatment initiated at a post-symptomatic age would still show efficacy. We used a cohort of CMVMJD135 mice that shows increased phenotypic severity and faster disease progression (CMVMJD135hi) compared to the mice used in the first trial. Groups of hemizygous CMVMJD135hi mice were orally treated with citalopram. Behavior, protein analysis, and pathology assessment were performed blindly to treatment. Our results show that even when initiated after symptom onset, treatment of CMVMJD135hi mice with citalopram ameliorated motor coordination and balance, attenuating disease progression, albeit to a lesser extent than that seen with pre-symptomatic treatment initiation. There was no impact on ATXN3 aggregation, which contrasts with the robust reduction in ATXN3-positive inclusions observed in CMVMJD135 mice, when treated pre-symptomatically. Post-symptomatic treatment of CMVMJD135hi mice revealed, however, a limited neuroprotective effect by showing a tendency to repair cerebellar calbindin staining, and to increase the number of motor neurons and of NeuN-positive cells in certain brain regions. While supporting that early initiation of treatment with citalopram leads to a marked increase in efficacy, these results strengthen our previous observation that modulation of serotonergic signaling by citalopram is a promising therapeutic approach for Machado-Joseph disease even after symptom onset.European Regional Development Funds (FEDER), through the Competitiveness Factors Operational Programme (COMPETE), and by National funds, through the Foundation for Science and Technology (FCT), under the scope of the project POCI-01-0145-FEDER-007038. This article has been developed under the scope of the project NORTE-01-0145-FEDER-000013, supported by the Northern Portugal Regional Operational Programme (NORTE 2020), under the Portugal 2020 Partnership Agreement, through the FEDER. This work was also supported by FCT and COMPETE through the projects [PTDC/SAU-GMG/112617/2009] (to PM) and [EXPL/BIM-MEC/0239/2012] (to AT-C), by FCT through the project [POCI-01-0145-FEDER-016818 (PTDC/NEU-NMC/3648/2014)] (to PM), by National Ataxia foundation (to PM and to AT-C), and by Ataxia UK (to PM). SE, SD-S, SO, and AT-C were supported by the FCT individual fellowships, SFRH/BD/78554/2011, SFRH/BD/78388/2011, PD/BD/127818/2016, and SFRH/BPD/102317/2014, respectively. FCT fellowships are co-financed by POPH, QREN, Governo da República Portuguesa, and EU/FSEinfo:eu-repo/semantics/publishedVersio