La estructura de la Serie Oriental en la zona del río Maule, Constitución (Chile)

Congreso Geológico Chileno "Geociencias hacia la comunidad" (15th, 2018, Concepción, Chile

The polygenic basis of relapse after a first episode of schizophrenia

Little is known about genetic predisposition to relapse. Previous studies have linked cognitive and psychopathological (mainly schizophrenia and bipolar disorder) polygenic risk scores (PRS) with clinical manifestations of the disease. This study aims to explore the potential role of PRS from major mental disorders and cognition on schizophrenia relapse. 114 patients recruited in the 2EPs Project were included (56 patients who had not experienced relapse after 3 years of enrollment and 58 patients who relapsed during the 3-year follow-up). PRS for schizophrenia (PRS-SZ), bipolar disorder (PRS-BD), education attainment (PRS-EA) and cognitive performance (PRS-CP) were used to assess the genetic risk of schizophrenia relapse.Patients with higher PRS-EA, showed both a lower risk (OR=0.29, 95% CI [0.11–0.73]) and a later onset of relapse (30.96± 1.74 vs. 23.12± 1.14 months, p=0.007. Our study provides evidence that the genetic burden of neurocognitive function is a potentially predictors of relapse that could be incorporated into future risk prediction models. Moreover, appropriate treatments for cognitive symptoms appear to be important for improving the long-term clinical outcome of relapse

Late Neoproterozoic-Paleozoic geodynamic evolution of the Argentine-Chilean Andes and the Antarctic Peninsula

Fil: Heredia, Nemesio. Instituto Geológico y Minero de España; España.Fil: García Sansegundo, Joaquín. Universidad de Oviedo; España.Fil: Gallastegui, Gloria. Instituto Geológico y Minero de España; España.Fil: Farias, Pedro. Universidad de Oviedo; España.Fil: Giacosa, Raul Eduardo. Secretaría de Industria y Minería. Servicio Geológico Minero Argentino; Argentina.Fil: Alonso, Juan. Universidad de Oviedo; España.Fil: Busquets, Pere. Universidad de Barcelona; España.Fil: Charrier, Reynaldo. Universidad de Chile; Chile. Universidad Andrés Bello; Chile.Fil: Clariana, Pilar. Instituto Geológico y Minero de España; España.Fil: Colombo, Ferran. Universidad de Barcelona; España.Fil: Cuesta, Andrés. Universidad de Oviedo; España.Fil: Gallastegui, Jorge. Universidad de Oviedo; España.Fil: Giambiagi, Laura Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto Argentino de Nivología, Glaciología y Ciencias Ambientales. Provincia de Mendoza. Instituto Argentino de Nivología, Glaciología y Ciencias Ambientales. Universidad Nacional de Cuyo. Instituto Argentino de Nivología, Glaciología y Ciencias Ambientales; Argentina.Fil: González Menéndez, Luis. Instituto Geológico y Minero de España; España.Fil: Limarino, Carlos Oscar. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Estudios Andinos "Don Pablo Groeber". Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Estudios Andinos "Don Pablo Groeber"; Argentina.Fil: Martín González, Fidel. Universidad Rey Juan Carlos; EspañaFil: Méndez Bedia, Isabel. Universidad de Oviedo; España.Fil: Pedreira, David. Universidad de Oviedo; España.Fil: Quintana, Luis. Universidad de Oviedo; España. Instituto Geológico y Minero de España; España.Fil: Rodríguez Fernández, Luis. Universidad de Oviedo; España.Fil: Rubio Ordóñez, Álvaro. Universidad de Oviedo; España.Fil: Seggiaro, Raul Eudocio. Universidad Nacional de Salta; Argentina. Secretaría de Industria y Minería. Servicio Geológico Minero Argentino; Argentina.Fil: Serra Varela, Samanta. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte. Instituto de Investigación en Paleobiología y Geología; Argentina.Fil: Spalletti, Luis Antonio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigaciones Geológicas. Universidad Nacional de La Plata. Facultad de Ciencias Naturales y Museo. Centro de Investigaciones Geológicas; Argentina.Fil: Cardo, Andrea Romina. Universidad Nacional de San Juan; Argentina. Secretaría de Industria y Minería. Servicio Geológico Minero Argentino; Argentina.Fil: Ramos, Victor Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Estudios Andinos "Don Pablo Groeber". Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Estudios Andinos "Don Pablo Groeber"; ArgentinaFil: Giacosa, Raul Eduardo. Universidad Nacional de Río Negro. Instituto de Investigaciones en Paleobiología y Geología. Río Negro, Argentina.During the late Neoproterozoic and Paleozoic times, the Argentine-Chilean Andes -and since the late Paleozoic the Antarctic Peninsula- formed part of the southwestern margin of Gondwana. During this period of time, a set of continental fragments of variable extension and allochtonie was successively accreted to that margin, resulted in six Paleozoic orogenies of different temporal and spatial extension: Pampean (Ediacaran-early Cambrian), Famatinian (Middle Ordovician-Silurian), Chanic (Middle Devonian-early Carboniferous), Ocloyic (Middle Ordovician-Devonian), Gondwanan (Middle Devonian-middle Permian) and Tabarin (late Permian-Triassic). All these orogenies had a collisional character, with the exception of the Tabarin and the Gondwanan south of 38º SDurante el Neoproterozoico tardío y el Paleozoico, el actual segmento argentino-chileno de la Cordillera de los Andes y, desde finales del Paleozoico, la Península Antártica, formaron parte del margen suroccidental de Gondwana. Durante este periodo de tiempo, a dicho margen se fue acrecionando un conjunto de fragmentos continentales de tamaño y aloctonía variable, dando lugar en el Paleozoico a seis orogenias de diferente extensión temporal y espacial: Pampeana (Ediacárico-Cámbrico temprano), Famatiniana (Ordovícico Medio-Silúrico), Chánica (Devónico Medio-Carbonífero temprano), Oclóyica (Ordovícico Medio-Devónico), Gondwánica (Devónico Medio-Pérmico medio) y Tabarin (Pérmico tardío-Triásico). Todas estas orogenias son colisionales, salvo la Tabarin y la Gondwánica al sur de los 38º S

Effectiveness of an intervention for improving drug prescription in primary care patients with multimorbidity and polypharmacy:Study protocol of a cluster randomized clinical trial (Multi-PAP project)

This study was funded by the Fondo de Investigaciones Sanitarias ISCIII (Grant Numbers PI15/00276, PI15/00572, PI15/00996), REDISSEC (Project Numbers RD12/0001/0012, RD16/0001/0005), and the European Regional Development Fund ("A way to build Europe").Background: Multimorbidity is associated with negative effects both on people's health and on healthcare systems. A key problem linked to multimorbidity is polypharmacy, which in turn is associated with increased risk of partly preventable adverse effects, including mortality. The Ariadne principles describe a model of care based on a thorough assessment of diseases, treatments (and potential interactions), clinical status, context and preferences of patients with multimorbidity, with the aim of prioritizing and sharing realistic treatment goals that guide an individualized management. The aim of this study is to evaluate the effectiveness of a complex intervention that implements the Ariadne principles in a population of young-old patients with multimorbidity and polypharmacy. The intervention seeks to improve the appropriateness of prescribing in primary care (PC), as measured by the medication appropriateness index (MAI) score at 6 and 12months, as compared with usual care. Methods/Design: Design:pragmatic cluster randomized clinical trial. Unit of randomization: family physician (FP). Unit of analysis: patient. Scope: PC health centres in three autonomous communities: Aragon, Madrid, and Andalusia (Spain). Population: patients aged 65-74years with multimorbidity (≥3 chronic diseases) and polypharmacy (≥5 drugs prescribed in ≥3months). Sample size: n=400 (200 per study arm). Intervention: complex intervention based on the implementation of the Ariadne principles with two components: (1) FP training and (2) FP-patient interview. Outcomes: MAI score, health services use, quality of life (Euroqol 5D-5L), pharmacotherapy and adherence to treatment (Morisky-Green, Haynes-Sackett), and clinical and socio-demographic variables. Statistical analysis: primary outcome is the difference in MAI score between T0 and T1 and corresponding 95% confidence interval. Adjustment for confounding factors will be performed by multilevel analysis. All analyses will be carried out in accordance with the intention-to-treat principle. Discussion: It is essential to provide evidence concerning interventions on PC patients with polypharmacy and multimorbidity, conducted in the context of routine clinical practice, and involving young-old patients with significant potential for preventing negative health outcomes. Trial registration: Clinicaltrials.gov, NCT02866799Publisher PDFPeer reviewe

Geographical and temporal distribution of SARS-CoV-2 clades in the WHO European Region, January to June 2020

We show the distribution of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) genetic clades over time and between countries and outline potential genomic surveillance objectives. We applied three genomic nomenclature systems to all sequence data from the World Health Organization European Region available until 10 July 2020. We highlight the importance of real-time sequencing and data dissemination in a pandemic situation, compare the nomenclatures and lay a foundation for future European genomic surveillance of SARS-CoV-2

Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality

Relación entre consumo de tabaco y alcohol, número de horas de sueño y ejercicio físico en jóvenes en Madrid

Incluye un póster con gráficos sobre el mismo temaCurso 2010-2011Vicerrectorado de Investigación UF

Estudio descriptivo de hábitos en estudiantes madrileños respecto a su IMC, ejercicio físico, horas de sueño y consumo de alcohol.

Curso 2010-2011Vicerrectorado de Investigación UF

The importance of our environment: a qualitative study of water and soil in Iznalloz (Granada, Spain)

Proceedings of the I Congress PIIISA celebrado en la Estación Experimental del Zaidín (Granada), en mayo de 2013.-- Winning article of the II EEZ Science AwardUnderstanding and preserving our environment and spreading the information found about the richness of our cultural and natural background in Iznalloz (Granada, Spain) is essential for the development of our students. Therefore, by applying the scientific method and focusing our research on the surrounding fields through a water and soil quality analysis, we have obtained knowledge of how farming activities or even uncontrolled dumping of waste prove to be substantial in the modification of the quality of our environment. Thus, the presence of polluting elements in water like nitrates, phosphates or ammonia, can be attributed to a number of factors such as some farming routines. Olive trees, for instance, are located in fields with high cationic exchange capacity. High levels of microorganisms have been found to cause the high rate of fertility of these soils. On the other hand, the tests done on the wastelands which are too often used as uncontrolled dumping areas rather than farming fields show significant reductions in the amount of beneficiary parameters mentioned above. The whole educational community can benefit from the results and learning processes of this research in terms of a higher environmental awareness.Peer reviewe