Performance of an ablator for Space Shuttle inorbit repair in an arc-plasma airstream

An ablator patch material performed well in an arc plasma environment simulating nominal Earth entry conditions for the Space Shuttle. Ablation tests using vacuum molded cones provided data to optimize the formulation of a two part polymer system for application under space conditions. The blunt cones were made using a Teflon mold and a state of the art caulking gun. Char stability of formulations with various amounts of catalyst and diluent were investigated. The char was found to be unstable in formulations with low amounts of catalyst and high amounts of diluent. The best polymer system determined by these tests was evaluated using a half tile patch in a multiple High Temperature Reusable surface Insulation tile model. It was demonstrated that this ablator could be applied in a space environment using a state of the art caulking gun, would maintain the outer mold line of the thermal protection system during entry, and would keep the bond line temperature at the aluminum tile interface below the design limit

Informality, Gender Employment Gap, and COVID-19 in Mexico: Identifying Persistence and Dynamic Structural Effects

The objective is to analyze the impact of the COVID-19 pandemic on the dynamics of the Mexican labor market (formal-informal employment) by gender. It is built consistent micro-founded time-series from 1987:Q1 to 2019:Q4 using the Mexican urban employment surveys and estimate a VAR model linking aggregate production and each market segment. Our results suggest significant adverse effects on formal employment resulting from the COVID-19 pandemic, with lengthy job recovery for females and males. The informal sector in both genders presents a lower forecasted response to the initial production shock but substantial observed employment losses, potentially linked to structural changes in the market. In the COVID-19 crisis, the informal sector is not a substitute for formal employment losses. The complexity of this crisis suggests crafting policies to improve the easiness of the market to enhance formal job recovery while promoting gender equality. Our main contribution is to estimate the diverse employment losses by segments and a critical structural change in the labor market dynamics resulting from the COVID-19 pandemic focusing on urban employment.Informalidad, brecha de género en el empleo y COVID-19 en México: identificando la persistencia y los efectos estructurales dinámicosEl objetivo es analizar el impacto de la pandemia del COVID-19 en la dinámica del mercado laboral mexicano (empleo formal-informal) por género. Se construyen series de tiempo microfundamentales consistentes desde 1987:Q1 hasta 2019:Q4 utilizando las encuestas de empleo urbanas mexicanas, y se estima un modelo VAR que vincula la producción agregada y cada segmento del mercado. Nuestros resultados sugieren que hay efectos adversos significativos en el empleo formal como resultado de la pandemia del COVID-19, con una larga recuperación del empleo para las mujeres y los hombres. El sector informal, en ambos sexos, presenta una respuesta pronosticada menor al choque de producción inicial, pero pérdidas sustanciales de empleo observadas, potencialmente vinculadas a cambios estructurales en el mercado. En la crisis de COVID-19, el sector informal no es un sustituto de las pérdidas de empleo formal. La complejidad de esta crisis sugiere la elaboración de políticas que mejoren la facilidad del mercado para potenciar la recuperación del empleo formal al tiempo que se promueve la igualdad de género. Nuestra principal contribución es estimar las diversas pérdidas de empleo por segmentos y un cambio estructural crítico en la dinámica del mercado laboral resultante de la pandemia de COVID-19, centrando el análisis en el empleo urbano

Variations to the cryptographics algorithms AES and TWOFISH

The cryptographic algorithms AES and Twofish guarantee a high diffusion by the use of fixed 4x4 MDS matrices. In this article variations to the algorithms AES and Twofish are made. They allow that the process of cipher - decipher come true with MDS matrices selected randomly from the set of all MDS matrices with the use of proposed algorithm. A new key schedule with a high diffusion is designed for the algorithm AES. Besides proposed algorithm generate new S - box that depends of the key

Novel genetic loci associated with hippocampal volume

The hippocampal formation is a brain structure integrally involved in episodic memory, spatial navigation, cognition and stress responsiveness. Structural abnormalities in hippocampal volume and shape are found in several common neuropsychiatric disorders. To identify the genetic underpinnings of hippocampal structure here we perform a genome-wide association study (GWAS) of 33,536 individuals and discover six independent loci significantly associated with hippocampal volume, four of them novel. Of the novel loci, three lie within genes (ASTN2, DPP4 and MAST4) and one is found 200 kb upstream of SHH. A hippocampal subfield analysis shows that a locus within the MSRB3 gene shows evidence of a localized effect along the dentate gyrus, subiculum, CA1 and fissure. Further, we show that genetic variants associated with decreased hippocampal volume are also associated with increased risk for Alzheimer's disease (rg =-0.155). Our findings suggest novel biological pathways through which human genetic variation influences hippocampal volume and risk for neuropsychiatric illness

Análisis de la carga de trabajo en la empresa Servi Hervel de la costa S.A.S

Document describes how the workload analysis was performed in the company Server of the Coast S.A.S using the NASA TLX evaluation too l, created by Sandra Hart, for the measurement, analysis and finding of the variables most associated with the high degree of workload and the identification of the unemployed in wich it is present, Providing the company with information to help it level the workload of its employees by eficiently managing all tasks.En este documento describe como fue realizado el análisis de carga laboral en la empresa SERVI HERVEL DE LA COSTA S.A.S utilizando la herramienta de evaluación NASA TLX, creada por Sandra Hart, para la medición análisis y hallazgo de las variables mas asociadas al alto grado de carga laboral, y a la identificación de empleados en que se presenta, brindándole a la empresa información que le ayude a nivelar la carga laboral de sus colaboradores administrando de manera eficiente todas las tareas

A922 Sequential measurement of 1 hour creatinine clearance (1-CRCL) in critically ill patients at risk of acute kidney injury (AKI)

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The disruption of proteostasis in neurodegenerative diseases

Cells count on surveillance systems to monitor and protect the cellular proteome which, besides being highly heterogeneous, is constantly being challenged by intrinsic and environmental factors. In this context, the proteostasis network (PN) is essential to achieve a stable and functional proteome. Disruption of the PN is associated with aging and can lead to and/or potentiate the occurrence of many neurodegenerative diseases (ND). This not only emphasizes the importance of the PN in health span and aging but also how its modulation can be a potential target for intervention and treatment of human diseases.info:eu-repo/semantics/publishedVersio

Cross-ancestry genome-wide association analysis of corneal thickness strengthens link between complex and Mendelian eye diseases

Central corneal thickness (CCT) is a highly heritable trait associated with complex eye diseases such as keratoconus and glaucoma. We perform a genome-wide association meta-analysis of CCT and identify 19 novel regions. In addition to adding support for known connective tissue-related pathways, pathway analyses uncover previously unreported gene sets. Remarkably, >20% of the CCT-loci are near or within Mendelian disorder genes. These included FBN1, ADAMTS2 and TGFB2 which associate with connective tissue disorders (Marfan, Ehlers-Danlos and Loeys-Dietz syndromes), and the LUM-DCN-KERA gene complex involved in myopia, corneal dystrophies and cornea plana. Using index CCT-increasing variants, we find a significant inverse correlation in effect sizes between CCT and keratoconus (r =-0.62, P = 5.30 × 10-5) but not between CCT and primary open-angle glaucoma (r =-0.17, P = 0.2). Our findings provide evidence for shared genetic influences between CCT and keratoconus, and implicate candidate genes acting in collagen and extracellular matrix regulation