HIGH PURITY SINGLE PHOTONS ENTANGLED WITH BARIUM IONS FOR QUANTUM NETWORKING

Increasing the number of qubits that can be controlled in a quantum system represents an essential challenge to the field of quantum computing. Quantum networks consisting of nodes for local information processing and photonic channels to distribute entanglement between different nodes represent a promising modular approach to achieve this scaling. Trapped atomic ions are an ideal candidate for quantum network nodes, with long-lived identical qubit memories that can be locally entangled through their Coulomb interaction and remotely entangled through photonic channels. In this work I will first discuss our established toolkit for using 171Yb+ and 138Ba+ ions individually or together within a quantum node. Next I will show how the 138Ba+ toolkit has been extended to allow for quantum operations in the 52D3/2 manifold. I will then demonstrate how we can generate ion-photon entanglement as a resource to connect separate nodes with a focus on some important improvements which will allow us to implement it as part of a larger network. These improvements include first the use of separate memory (171Yb+ ) and photon generating (138Ba+ ) ions. Additionally, the use of separate atomic lines within 138Ba+ for excitation and collection allows us to preserve integrity of this photonic interface by ensuring the purity of the single photons that are produced. To this end I demonstrate a single-photon source for quantum networking based on a trapped 138Ba+ ion with a single photon purity of g2(0) = (8.1 ± 2.3) × 10−5 without background subtraction. Trade-offs between the photonic generation rate and the memory-photon entanglement fidelity for the case of polarization photonic qubits are also examined and optimized by tailoring the spatial mode of the collected light. These techniques should be useful in constructing larger ion-photon networks

Galectin-9 binds IgM-BCR to regulate B cell signaling

The galectin family of secreted lectins are important regulators of immune cell function; however, their role in B cell responses is poorly understood. Here, the authors identify IgM-BCR as a ligand for galectin-9. In resting naive cells, they show that galectin-9 mediates a close association between IgM and CD22

Single molecule imaging and FLIM show different structures for high and low-affinity EGFRs in A431 cells

Epidermal growth factor (EGF) receptor (EGFR) modulates mitosis and apoptosis through signaling by its high-affinity (HA) and low-affinity (LA) EGF-binding states. The prevailing model of EGFR activation—derived from x-ray crystallography—involves the transition from tethered ectodomain monomers to extended back-to-back dimers and cannot explain these EGFR affinities or their different functions. Here, we use single-molecule Förster resonant energy transfer analysis in combination with ensemble fluorescence lifetime imaging microscopy to investigate the three-dimensional architecture of HA and LA EGFR-EGF complexes in cells by measuring the inter-EGF distances within discrete EGF pairs and the vertical distance from EGF to the plasma membrane. Our results show that EGFR ectodomains form interfaces resulting in two inter-EGF distances (∼8 nm and < 5.5 nm), different from the back-to-back EGFR ectodomain interface (∼11 nm). Distance measurements from EGF to the plasma membrane show that HA EGFR ectodomains are oriented flat on the membrane, whereas LA ectodomains stand proud from it. Their flat orientation confers on HA EGFR ectodomains the exclusive ability to interact via asymmetric interfaces, head-to-head with respect to the EGF-binding site, whereas LA EGFRs must interact only side-by-side. Our results support a structural model in which asymmetric EGFR head-to-head interfaces may be relevant for HA EGFR oligomerization