An efficient decomposition approach for surgical planning

This talk presents an efficient decomposition approach to surgical planning. Given a set of surgical waiting lists (one for each discipline) and an operating theater, the problem is to decide the room-to-discipline assignment for the next planning period (Master Surgical Schedule), and the surgical cases to be performed (Surgical Case Assignment), with the objective of optimizing a score related to priority and current waiting time of the cases. While in general MSS and SCA may be concurrently found by solving a complex integer programming problem, we propose an effective decomposition algorithm which does not require expensive or sophisticated computational resources, and is therefore suitable for implementation in any real-life setting. Our decomposition approach consists in first producing a number of subsets of surgical cases for each discipline (potential OR sessions), and select a subset of them. The surgical cases in the selected potential sessions are then discarded, and only the structure of the MSS is retained. A detailed surgical case assignment is then devised filling the MSS obtained with cases from the waiting lists, via an exact optimization model. The quality of the plan obtained is assessed by comparing it with the plan obtained by solving the exact integrated formulation for MSS and SCA. Nine different scenarios are considered, for various operating theater sizes and management policies. The results on instances concerning a medium-size hospital show that the decomposition method produces comparable solutions with the exact method in much smaller computation time

Enabling Railway AM Optimization Using a Rationale KPIs Framework

Often the top management, in the phase of asset controls, finds itself overwhelmed by the availability of a huge amount of Key Performance Indicators (KPIs). Most managers are struggling to understand and identify the vital few management metrics and instead collect and report a vast amount of everything that is easy to measure. As a consequence they end up drowning in data while thirsting for information. This condition does not allow a good management of the systems. The research aim’s is to help the Asset Management System (AMS) of a railway infrastructure manager using Business Intelligence (BI) to have a KPIs management system in line with the principles of AM presented by the normative ISO 55000 - 55001 - 55002 and UIC (International Union of Railways) guideline, for the specific case of a railway infrastructure. This work starts from the study of these regulations, continues with the exploration, definition and use of KPIs. Subsequently KPIs of a generic infrastructure are identified and analyzed , especially for the specific case of a railway infrastructure manager. These KPIs are fitted in the internal elements of the AM frameworks (ISO-UIC) for systematization. Moreover an analysis of the KPIs now used in the company is made, compared with the KPIs that an infrastructure manager should have. Starting from here a Gap Analysis is made for the optimization of AMS

3DHOP una piattaforma flessibile per la pubblicazione e visualizzazione su Web dei risultati di digitalizzazioni 3D

3DHOP (3D Heritage Online Presenter) is an innovative technological solution for the advanced presentation of high-resolution 3D content on the Web. The design of this tool has been focused towards the Cultural Heritage (CH) field, even though its versatility makes it a general-purpose instrument. 3DHOP is particularly suitable for the online presentation of CH artifacts due to its main features: the capability to efficiently stream high-resolution 3D models (as the ones coming from 3D scanning which are usually employed in CH); the possibility to build integrated presentations schemes by interconnecting the viewer to the rest of web pages elements; and, finally, the ready-to-use templates and examples of configuration focused towards CH applications. In its design and development, we put particular attention on three factors: easiness of use, smooth learning curve and performances. 3DHOP is written in JavaScript and it uses the WebGL subset of HTML5 for efficient rendering. Thanks to its modular nature, and a declarative-like setup, it is easy to learn and may be configured and customized at different levels, making it accessible for people without skilled knowledge in Computer Graphics (CG) programming. In this paper we present capabilities and characteristics of the third release of this tool, using some examples based on real-world projects

The mechanical and EM simulations of the CryoAC for the ATHENA X-IFU

The design phase of the CryoAC DM for the ATHENA X-IFU has concerned numerical simulations to exploit different fabrication possibilities. The mechanical simulations have accounted for the peculiar detector structure: 4 silicon chips asymmetrically suspended by means of 4 microbridges each. A preliminary study was performed to analyze the response to acceleration spectra in the frequency domain, shocks and time domain random displacement, prior to a real vibration test campaign. EM simulations to spot unwanted magnetic fields have been conducted as well. In this work we will show the latest advance in the design of the new detectors, showing the main results coming from various simulations

Distinct core and halo stellar populations and the formation history of the bright Coma cluster early-type galaxy NGC 4889

We study the stellar population far into the halo of one of the two brightest galaxies in the Coma cluster, NGC 4889, based on deep medium resolution spectroscopy with FOCAS at the Subaru 8.2m telescope. We fit single stellar population models to the measured line-strength (Lick) indices (Hbeta, Mgb, [MgFe]' and ). Combining with literature data, we construct radial profiles of metallicity, [alpha/Fe] element abundance ratio and age for NGC 4889, from the center out to ~60 kpc (~4Re). We find evidence for different chemical and star formation histories for stars inside and outside 1.2Re = 18 kpc radius. The inner regions are characterized by a steep [Z/H] gradient and high [alpha/Fe] at ~2.5 times solar value. In the halo, between 18 and 60 kpc, the [Z/H] is near-solar with a shallow gradient, while [alpha/Fe] shows a strong negative gradient, reaching solar values at ~60 kpc. We interpret these data in terms of different formation histories for both components. The data for the inner galaxy are consistent with a rapid, quasi-monolithic, dissipative merger origin at early redshifts, followed by one or at most a few dry mergers. Those for the halo argue for later accretion of stars from old systems with more extended star formation histories. The half-light radius of the inner component alone is estimated as ~6 kpc, suggesting a significantly smaller size of this galaxy in the past. This may be the local stellar population signature of the size evolution found for early-type galaxies from high-redshift observations.Comment: 5 pages, 2 figures, accepted for publication in MNRAS letter

Bright light exposure reduces TH-positive dopamine neurons: Implications of light pollution in Parkinson\u27s disease epidemiology

This study explores the effect of continuous exposure to bright light on neuromelanin formation and dopamine neuron survival in the substantia nigra. Twenty-one days after birth, Sprague–Dawley albino rats were divided into groups and raised under different conditions of light exposure. At the end of the irradiation period, rats were sacrificed and assayed for neuromelanin formation and number of tyrosine hydroxylase (TH)-positive neurons in the substantia nigra. The rats exposed to bright light for 20 days or 90 days showed a relatively greater number of neuromelanin-positive neurons. Surprisingly, TH-positive neurons decreased progressively in the substantia nigra reaching a significant 29% reduction after 90 days of continuous bright light exposure. This decrease was paralleled by a diminution of dopamine and its metabolite in the striatum. Remarkably, in preliminary analysis that accounted for population density, the age and race adjusted Parkinson's disease prevalence significantly correlated with average satellite-observed sky light pollution

Prodromal angina and risk of 2-year cardiac mortality in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous intervention

We sought to investigate the prognostic significance of prodromal angina (PA) in unselected patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PPCI) and its additive predictive value to the GRACE score.We prospectively enrolled 3015 consecutive STEMI patients undergoing PPCI. Patients were divided in 2 groups according to the presence or absence of PA. Multivariable Cox regression was used to establish the relation to 2-year cardiac mortality of PA.The mean age of the study population was 68 (±14) years; 2178 patients (72%) were male. During follow-up, 395 (13%) patients died with 278 of these (9.2%) suffering from cardiac mortality. Kaplan-Meier estimates showed a survival rate of 95% and 87% for patients with PA and no PA, respectively (log rank test < 0.001). After multivariable analysis, patients with PA had still a lower risk of 2 years' cardiac mortality compared with patients without PA (adjusted hazard ratio = 0.50; 95% confidence interval [CI] 1.06-1.81, P = .001). Evaluation of net reclassification improvement showed that reclassification improved by 0.16% in case patients, whereas classification worsened in control patients by 1.08% leading to a net reclassification improvement of -0.93% (95% CI: -0.98, -0.88).In patients with STEMI undergoing PPCI the presence of PA is independently associated with a lower risk of 2-year cardiac mortality. However, the incorporation of this variable to the GRACE score slightly worsened the classification of risk. Accordingly, it seems unlikely that the evaluation of PA may be useful in clinical practice

Bright light exposure reduces TH-positive dopamine neurons: implications of light pollution in Parkinson's disease epidemiology.

This study explores the effect of continuous exposure to bright light on neuromelanin formation and dopamine neuron survival in the substantia nigra. Twenty-one days after birth, Sprague-Dawley albino rats were divided into groups and raised under different conditions of light exposure. At the end of the irradiation period, rats were sacrificed and assayed for neuromelanin formation and number of tyrosine hydroxylase (TH)-positive neurons in the substantia nigra. The rats exposed to bright light for 20 days or 90 days showed a relatively greater number of neuromelanin-positive neurons. Surprisingly, TH-positive neurons decreased progressively in the substantia nigra reaching a significant 29% reduction after 90 days of continuous bright light exposure. This decrease was paralleled by a diminution of dopamine and its metabolite in the striatum. Remarkably, in preliminary analysis that accounted for population density, the age and race adjusted Parkinson's disease prevalence significantly correlated with average satellite-observed sky light pollution

Fossil Groups Origins: I. RX J105453.3+552102 a very massive and relaxed system at z~0.5

The most accepted scenario for the origin of fossil groups (FGs) is that they are galaxy associations in which the merging rate was fast and efficient. These systems have assembled half of their mass at early epoch of the Universe, subsequently growing by minor mergers. They could contain a fossil record of the galaxy structure formation. We have started a project in order to characterize a large sample of FGs. In this paper we present the analysis of the fossil system RX J105453.3+552102. Optical deep images were used for studying the properties of the brightest group galaxy and for computing the photometric luminosity function of the group. We have also performed a detail dynamical analysis of the system based on redshift data for 116 galaxies. This galaxy system is located at z=0.47, and shows a quite large line-of-sight velocity dispersion \sigma_{v}~1000 km/s. Assuming the dynamical equilibrium, we estimated a virial mass of M ~ 10^{15} h_{70} M_{\odot}. No evidence of substructure was found within 1.4 Mpc radius. We found a statistically significant departure from Gaussianity of the group members velocities in the most external regions of the group. This could indicate the presence of galaxies in radial orbits in the external region of the group. We also found that the photometrical luminosity function is bimodal, showing a lack of M_{r} ~ -19.5 galaxies. The brightest group galaxy shows low Sersic parameter (n~2) and a small peculiar velocity. Indeed, our accurate photometry shows that the difference between the brightest and the second brightest galaxies is 1.9 mag in the r-band, while the classical definition of FGs is based on a magnitude gap of 2. We conclude that this fossil system does not follow the empirical definition of FGs. Nevertheless, it is a massive, old and undisturbed galaxy system with little infall of L^{*} galaxies since its initial collapse.Comment: 17 pages, 14 figures, accepted for publication at A&

The reduction techniques of the particle background for the ATHENA X-IFU instrument at L2 orbit: Geant4 and the CryoAC

We present the particles background reduction techniques aimed at increasing the X-IFU sensitivity which is reduced by primary protons of both solar and Cosmic Rays origin, and secondary electrons. The adopted solutions involve Monte Carlo simulation by both Geant4 toolkit related to the "expected" background at L2 orbit through the payload mass model and the ray tracing technique to evaluate the soft protons components focussed by the optics to the main detector, and the development of an active Cryogenic AntiCoincidence detector and a passive electron shielding to meet the scientific requirements. <P /