Marco teórico y Propuesta de Unidad Didáctica para la Educación Intercultural desde el Área de Educación Plástica y Visual

Sin resume

Análisis de la crítica especializada de cine y videojuegos desde la sociología cultural

This communication aims to show, based on a comparative analysis since cultural sociology, the projective effect of the consumption of video game and film products based on the evaluation given in specialized magazines. It also delves into an analysis of both cultural industries from the 20 products with the highest revenue in 2016, comparing elements such as recommended age codes for both products or specific genres. Among the main results we can observe how there is a greater evaluation by the critics specialized in the most sold videogames with respect to the films with the highest box-office takings, and how there is significant differences about age rating in both cultural industries. In the film industry, only four Spanish films have made it into the top 20, unfortunately there isn´t any Spanish videogame. It is also important to highlight the large number of films with a category suitable for children in this classification, reaching two out of three films suitable for children under 12 years of age, thus offering a panorama of more family cinema, videogames are more diverse in this subject.Este artículo pretende mostrar, a partir de un análisis comparativo desde la sociología cultural del efecto proyectivo tanto en el consumo de videojuegos como en el de cine a partir de la valoración de la crítica realizada en revistas especializadas de ambos sectores ya sea en papel u online. Para ello se profundiza en el análisis cuantitativo de los veinte productos con mayores ingresos de estas dos industrias culturales durante el pasado 2016, comparando elementos como los códigos de edad recomendados para ambos productos o géneros específicos. Entre los principales resultados podemos observar cómo hay una mayor o mejor valoración por parte de la crítica especializada acerca los videojuegos más vendidos, respecto a las películas con mayor recaudación de taquilla, y cómo hay diferencias significativas en las recomendaciones de edad para estos productos. En la industria cinematográfica solo cuatro películas españolas se han situado entre las veinte primeras, mientras que ningún videojuego español ha conseguido situarse entre los más vendidos. También es importante destacar el gran número de películas con una categoría apta para niños en esta clasificación, alcanzando dos de cada tres películas aptas para personas menores de doce años, ofreciendo así un panorama de más cine familiar frente a los videojuegos, más diversos respecto a este factor

Encuesta: El método comparado en derecho constitucional

En esta encuesta un grupo de Catedráticos de Derecho Constitucional contestan un conjunto de preguntas sobre el uso del método comparado en el derecho constitucional español, y sobre la influencia de modelos o referentes extranjeros durante el proceso constituyente, en la actividad legislativa y en la del Tribunal Constitucional, así como también algunas preguntas sobre los estudios de derecho constitucional comparado.In this academic survey a group of Constitutional Law Professors answer some questions about the role of the comparative method in the Spanish constitutional law, and the influence of foreign models in the constitutional process, the legislator and the Constitutional Court, as well as about the present situation of comparative constitutional law studies

Energy efficiency in Edge TPU vs. embedded GPU for computer-aided medical imaging segmentation and classification

Manuscrito enviado para su revisión por la revista "Engineering Applications of Artificial Intelligence" (Elsevier) el 25 de noviembre de 2022. Se envió la versión revisada el 26 de julio de 2023. El manuscrito fue aceptado el 11 de octubre de 2023, y desde el 28 de octubre aparece el artículo publicado en el portal ScienceDirect (https://doi.org/10.1016/j.engappai.2023.107298).In this work, we evaluate the energy usage of fully embedded medical diagnosis aids based on both segmentation and classification of medical images implemented on Edge TPU and embedded GPU processors. We use glaucoma diagnosis based on color fundus images as an example to show the possibility of performing segmentation and classification in real time on embedded boards and to highlight the different energy requirements of the studied implementations. Several other works develop the use of segmentation and feature extraction techniques to detect glaucoma, among many other pathologies, with deep neural networks. Memory limitations and low processing capabilities of embedded accelerated systems (EAS) limit their use for deep network-based system training. However, including specific acceleration hardware, such as NVIDIA’s Maxwell GPU or Google’s Edge TPU, enables them to perform inferences using complex pre-trained networks in very reasonable times. In this study, we evaluate the timing and energy performance of two EAS equipped with Machine Learning (ML) accelerators executing an example diagnostic tool developed in a previous work. For optic disc (OD) and cup (OC) segmentation, the obtained prediction times per image are under 29 and 43 ms using Edge TPUs and Maxwell GPUs respectively. Prediction times for the classification subsystem are lower than 10 and 14 ms for Edge TPUs and Maxwell GPUs respectively. Regarding energy usage, in approximate terms, for OD segmentation Edge TPUs and Maxwell GPUs use 38 and 190 mJ per image respectively. For fundus classification, Edge TPUs and Maxwell GPUs use 45 and 70 mJ respectively.Manuscrito de 33 páginas

Non-small cell lung cancer diagnosis aid with histopathological images using Explainable Deep Learning techniques

Background: Lung cancer has the highest mortality rate in the world, twice as high as the second highest. On the other hand, pathologists are overworked and this is detrimental to the time spent on each patient, diagnostic turnaround time, and their success rate. Objective: In this work, we design, implement, and evaluate a diagnostic aid system for non-small cell lung cancer detection, using Deep Learning techniques. Methods: The classifier developed is based on Artificial Intelligence techniques, obtaining an automatic classification result between healthy, adenocarcinoma and squamous cell carcinoma, given an histopathological image from lung tissue. Moreover, a report module based on Explainable Deep Learning techniques is included and gives the pathologist information about the image’s areas used to classify the sample and the confidence of belonging to each class. Results: The results show a system accuracy between 97.11 and 99.69%, depending on the number of classes classified, and a value of the area under ROC curve between 99.77 and 99.94%. Conclusions: The classification results obtain a substantial improvement according to previous works. Thanks to the given report, the time spent by the pathologist and the diagnostic turnaround time can be reduced.Andalusian Regional I+D+i FEDER Project DAFNE US-138161

Análisis comparativo de la participación por género en la olimpiada estatal de química Chihuahua, México

The disciplines in science, technology, engineering and mathematics (STEM), present a direct contribution in the fulfillment of the 17 objectives presented by the 2030 Agenda adopted by the General Assembly of the United Nations (UN) in September 2015, for which It is essential to promote the scientific vocation among girls, boys and young people. In addition, the Sustainable Development Goals (SDG) 4 and 5 are aimed at quality in education and gender equality. Taking into account the aforementioned, the main purpose of this research is to carry out a comparative analysis to determine the degree of participation by gender of the students in the State Chemistry Olympiad Chihuahua Mexico, as well as the trend that exists in the same indicator by gender. campus and by city, in addition to the influence of the event in promoting scientific and/or technological vocationsLas disciplinas en ciencias, tecnología, ingeniería y matemáticas, STEM acrónimo de Science, Technology, Engineering and Mathematics presentan una contribución directamente en el cumplimiento a los 17 objetivos presentados por la Agenda 2030 adoptada por la Asamblea General de las Naciones Unidas (ONU) en septiembre de 2015, por lo que es imprescindible fomentar la vocación científica entre niñas, niños y jóvenes. Además, los Objetivos de Desarrollo Sostenible (ODS) 4 y 5 están orientados a la calidad en la educación e igualdad de género. Teniendo en cuenta lo antes mencionado, la finalidad principal de la presente investigación es realizar un análisis comparativo para determinar el grado de participación por género de los estudiantes en la Olimpiada Estatal de Química Chihuahua México, así como la tendencia que existe en el mismo indicador por plantel y por ciudad, además de la influencia del certamen en fomentar las vocaciones científicas y/o tecnológicas

Anti-Inflammatory Activity and Changes in Antioxidant Properties of Leaf and Stem Extracts from Vitex mollis

Vitex mollis is used in traditional Mexican medicine for the treatment of some ailments. However, there are no studies on what happens to the anti-inflammatory activity or antioxidant properties and total phenolic content of leaves and stem extracts of Vitex mollis during the digestion process; hence, this is the aim of this work. Methanolic, acetonic, and hexanic extracts were obtained from both parts of the plant. Extract yields and anti-inflammatory activity (elastase inhibition) were measured. Additionally, changes in antioxidant activity (DPPH and ABTS) and total phenols content of plant extracts before and after in vitro digestion were determined. The highest elastase inhibition to prevent inflammation was presented by hexanic extracts (leaf = 94.63% and stem = 98.30%). On the other hand, the major extract yield (16.14%), antioxidant properties (ABTS = 98.51% and DPPH = 94.47% of inhibition), and total phenols (33.70 mg GAE/g of dried sample) were showed by leaf methanolic extract. Finally, leaf and stem methanolic extracts presented an antioxidant activity increase of 35.25% and 27.22%, respectively, in comparison to their initial values after in vitro digestion process. All samples showed a decrease in total phenols at the end of the digestion. These results could be the basis to search for new therapeutic agents from Vitex mollis

Axicabtagene ciloleucel compared to tisagenlecleucel for the treatment of aggressive B-cell lymphoma

Axicabtagene ciloleucel (axi-cel) and tisagenlecleucel (tisa-cel) are CD19-targeted chimeric antigen receptor (CAR) T cells approved for relapsed/refractory (R/R) large B-cell lymphoma (LBCL). We performed a retrospective study to evaluate safety and efficacy of axi-cel and tisa-cel outside the setting of a clinical trial. Data from consecutive patients with R/R LBCL who underwent apheresis for axi-cel or tisa-cel were retrospectively collected from 12 Spanish centers. A total of 307 patients underwent apheresis for axi-cel (n=152) and tisa-cel (n=155) from November 2018 to August 2021, of which 261 (85%) received a CAR T infusion (88% and 82%, respectively). Median time from apheresis to infusion was 41 days for axi-cel and 52 days for tisa-cel (P=0.006). None of the baseline characteristics were significantly different between both cohorts. Both cytokine release syndrome and neurologic events (NE) were more frequent in the axi-cel group (88% vs. 73%, P=0.003, and 42% vs. 16%, P= 2 and progressive disease before lympho-depletion. Safety and efficacy results in our real-world experience were comparable with those reported in the pivotal trials. Patients treated with axi-cel experienced more toxicity but similar non-relapse mortality compared with those re-ceiving tisa-cel. Efficacy was not significantly different between both products

Axicabtagene ciloleucel compared to tisagenlecleucel for the treatment of aggressive B-cell lymphoma

Axicabtagene ciloleucel (axi-cel) and tisagenlecleucel (tisa-cel) are CD19-targeted chimeric antigen receptor (CAR) T cells approved for relapsed/refractory (R/R) large B-cell lymphoma (LBCL). We performed a retrospective study to evaluate safety and efficacy of axi-cel and tisa-cel outside the setting of a clinical trial. Data from consecutive patients with R/R LBCL who underwent apheresis for axi-cel or tisa-cel were retrospectively collected from 12 Spanish centers. A total of 307 patients underwent apheresis for axi-cel (n=152) and tisa-cel (n=155) from November 2018 to August 2021, of which 261 (85%) received a CAR T infusion (88% and 82%, respectively). Median time from apheresis to infusion was 41 days for axi-cel and 52 days for tisa-cel (P =0.006). None of the baseline characteristics were significantly different between both cohorts. Both cytokine release syndrome and neurologic events (NE) were more frequent in the axi-cel group (88% vs. 73%, P =0.003, and 42% vs. 16%, P <0.001, respectively). Infections in the first 6 months post-infusion were also more common in patients treated with axi-cel (38% vs. 25%, P =0.033). Non-relapse mortality was not significantly different between the axi-cel and tisa-cel groups (7% and 4%, respectively, P =0.298). With a median follow-up of 9.2 months, median PFS and OS were 5.9 and 3 months, and 13.9 and 11.2 months for axi-cel and tisa-cel, respectively. The 12-month PFS and OS for axi-cel and tisa-cel were 41% and 33% (P =0.195), 51% and 47% (P =0.191), respectively. Factors associated with lower OS in the multivariate analysis were increased lactate dehydrogenase, ECOG ≥2 and progressive disease before lympho-depletion. Safety and efficacy results in our real-world experience were comparable with those reported in the pivotal trials. Patients treated with axi-cel experienced more toxicity but similar non-relapse mortality compared with those receiving tisa-cel. Efficacy was not significantly different between both products

Role of age and comorbidities in mortality of patients with infective endocarditis

[Purpose]: The aim of this study was to analyse the characteristics of patients with IE in three groups of age and to assess the ability of age and the Charlson Comorbidity Index (CCI) to predict mortality. [Methods]: Prospective cohort study of all patients with IE included in the GAMES Spanish database between 2008 and 2015.Patients were stratified into three age groups:<65 years,65 to 80 years,and ≥ 80 years.The area under the receiver-operating characteristic (AUROC) curve was calculated to quantify the diagnostic accuracy of the CCI to predict mortality risk. [Results]: A total of 3120 patients with IE (1327 < 65 years;1291 65-80 years;502 ≥ 80 years) were enrolled.Fever and heart failure were the most common presentations of IE, with no differences among age groups.Patients ≥80 years who underwent surgery were significantly lower compared with other age groups (14.3%,65 years; 20.5%,65-79 years; 31.3%,≥80 years). In-hospital mortality was lower in the <65-year group (20.3%,<65 years;30.1%,65-79 years;34.7%,≥80 years;p < 0.001) as well as 1-year mortality (3.2%, <65 years; 5.5%, 65-80 years;7.6%,≥80 years; p = 0.003).Independent predictors of mortality were age ≥ 80 years (hazard ratio [HR]:2.78;95% confidence interval [CI]:2.32–3.34), CCI ≥ 3 (HR:1.62; 95% CI:1.39–1.88),and non-performed surgery (HR:1.64;95% CI:11.16–1.58).When the three age groups were compared,the AUROC curve for CCI was significantly larger for patients aged <65 years(p < 0.001) for both in-hospital and 1-year mortality. [Conclusion]: There were no differences in the clinical presentation of IE between the groups. Age ≥ 80 years, high comorbidity (measured by CCI),and non-performance of surgery were independent predictors of mortality in patients with IE.CCI could help to identify those patients with IE and surgical indication who present a lower risk of in-hospital and 1-year mortality after surgery, especially in the <65-year group