Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.

Over the past decade, the Nomenclature Committee on Cell Death (NCCD) has formulated guidelines for the definition and interpretation of cell death from morphological, biochemical, and functional perspectives. Since the field continues to expand and novel mechanisms that orchestrate multiple cell death pathways are unveiled, we propose an updated classification of cell death subroutines focusing on mechanistic and essential (as opposed to correlative and dispensable) aspects of the process. As we provide molecularly oriented definitions of terms including intrinsic apoptosis, extrinsic apoptosis, mitochondrial permeability transition (MPT)-driven necrosis, necroptosis, ferroptosis, pyroptosis, parthanatos, entotic cell death, NETotic cell death, lysosome-dependent cell death, autophagy-dependent cell death, immunogenic cell death, cellular senescence, and mitotic catastrophe, we discuss the utility of neologisms that refer to highly specialized instances of these processes. The mission of the NCCD is to provide a widely accepted nomenclature on cell death in support of the continued development of the field

Autophagy-dependent cell death

Autophagy-dependent cell death can be defined as cell demise that has a strict requirement of autophagy. Although autophagy often accompanies cell death following many toxic insults, the requirement of autophagic machinery for cell death execution, as established through specific genetic or chemical inhibition of the process, is highly contextual. During animal development, perhaps the best validated model of autophagy-dependent cell death is the degradation of the larval midgut during larval-pupal metamorphosis, where a number of key autophagy genes are required for the removal of the tissues. Surprisingly though, even in the midgut, not all of the 'canonical' autophagic machinery appears to be required. In other organisms and cancer cells many variations of autophagy-dependent cell death are apparent, pointing to the lack of a unifying cell death pathway. It is thus possible that components of the autophagy machinery are selectively utilised or repurposed for this type of cell death. In this review, we discuss examples of cell death that utilise autophagy machinery (or part thereof), the current knowledge of the complexity of autophagy-dependent cellular demise and the potential mechanisms and regulatory pathways involved in such cell death.Donna Denton and Sharad Kuma

Autophagy as a decisive process for cell death

Cell death: cell component recycling in health and disease A natural cellular recycling process could be harnessed or targeted for the treatment of multiple diseases including cancer and psychological disorders. Autophagy is a process that occurs within cells, whereby damaged, toxic, or obsolete cellular components are degraded and recycled to release energy and maintain balance. However, scientists now recognize that autophagy can trigger cell death under certain conditions. Seong-Woon Yu and co-workers at the Daegu Gyeongbuk Institute of Science and Technology, South Korea, reviewed recent research into the mechanisms and role of autophagy in health and disease. Autophagic cell death is implicated in the suppression of tumor development; for example, inducing autophagy led to the death of precancerous cells in mice. Autophagy may also regulate immune cell populations, and play a role in the death of brain cells during chronic stress-related disorders