LauncherOne Now in Orbit: Dedicated Air-Launch Brings Proven, Responsive Space Access with Historic NASA VCLS Demonstration Mission

The Launcher One air-launched rocket system, under commercial development by Virgin Orbit since 2015, is now fully flight-qualified. This small, dedicated launch vehicle first reached orbit on January 17th, 2021 as part of the NASA Venture Class Launch Services (VCLS) ELaNa 20 mission, injecting ten small satellites into orbit. This historic mission saw the world’s first liquid-propulsion, orbital class air-launched vehicle succeed with incredible performance and accuracy. Founded upon the capabilities of the Boeing 747-400 carrier aircraft, LauncherOne maintains safe operations using flight controls and an Autonomous Flight Safety System (AFSS) that have been fully internally-developed and certified by the Federal Aviation Administration (FAA) of the United States. T his uniquely mobile launch system is designed to bring tailored small satellite launch services to any corner of the globe. This paper details the inaugural NASA VCLS LauncherOne mission. Review of the mission and customer outcome will reveal how some of the most challenging aspects of air-launch have now been achieved by the LauncherOne design. In successfully overcoming the design challenges of a cryogenic air-launch vehicle, the substantial accompanying rewards can now be realized. We have shown how such a modular launch system can be replicated and disaggregated across many sites, offering flexibility and extreme orbital access for small satellites without a fixed infrastructure or permanent footprint. Accordingly, we have continued to grow our spaceport network to support domestic and international mission planners that benefit from such a capability. The status of these activities and facilities will be discussed. Following extensive qualification testing, the NASA VCLS mission success, and all of the associated cryogenic loading and vehicle preparation operations successfully completed from an austere runway apron, LauncherOne’s air-launch approach is now proven to be foundationally responsive. Virgin Orbit and the dedicated, flight-proven LauncherOne system are now uniquely positioned to both serve and grow the global small satellite market from spaceports around the world

A fully coupled hydro-mechanical model for the modeling of coalbed methane recovery

Most coal seams hold important quantities of methane which is recognized as a valuable energy resource. Coal reservoir is considered not conventional because methane is held adsorbed on the coal surface. Coal is naturally fractured, it is a dual-porosity system made of matrix blocks and cleats (i.e fractures). In general, cleats are initially water saturated with the hydrostatic pressure maintaining the gas adsorbed in the coal matrix. Production of coalbed methane (CBM) first requires the mobilization of water in the cleats to reduce the reservoir pressure. Changes of coal properties during methane production are a critical issue in coalbed methane recovery. Indeed, any change of the cleat network will likely translate into modifications of the reservoir permeability. This work consists in the formulation of a consistent hydro-mechanical model for the CBM production modeling. Due to the particular structure of coal, the model is based on a dual-continuum approach to enrich the macroscale with microscale considerations. Shape factors are employed to take into account the geometry of the matrix blocks in the mass exchange between matrix and fractures. The hydro-mechanical model is fully coupled. For example, it captures the sorption-induced volumetric strain or the dependence of permeability on fracture aperture, which evolves with the stress state. The model is implemented in the finite element code Lagamine and is used for the modeling of one production well. A synthetic reservoir and then a real production case are considered. To date, attention has focused on a series of parametric analyses that can highlight the influence of the production scenario or key parameters related to the reservoir

Hydromechanical modelling of shaft sealing for CO2 storage

The geological sequestration of CO2 in abandoned coal mines is a promising option to mitigate climate changes while providing sustainable use of the underground cavities. In order to certify the efficiency of the storage, it is essential to understand the behaviour of the shaft sealing system. The paper presents a numerical analysis of CO2 transfer mechanisms through a mine shaft and its sealing system. Different mechanisms for CO2 leakage are considered, namely multiphase flow through the different materials and flow along the interfaces between the lining and the host rock. The study focuses on the abandoned coal mine of Anderlues, Belgium, which was used for seasonal storage of natural gas. A two-dimensional hydromechanical modelling of the storage site is performed and CO2 injection into the coal mine is simulated. Model predictions for a period of 500 years are presented and discussed with attention. The role and influence of the interface between the host rock and the concrete lining are examined. In addition the impact of some uncertain model parameters on the overall performance of the sealing system is analysed through a sensitivity analysis

Long-Baseline Neutrino Facility (LBNF) and Deep Underground Neutrino Experiment (DUNE) Conceptual Design Report Volume 2: The Physics Program for DUNE at LBNF

The Physics Program for the Deep Underground Neutrino Experiment (DUNE) at the Fermilab Long-Baseline Neutrino Facility (LBNF) is described

In vivo real-time imaging of TGF-Β-induced transcriptional activation of the RANK ligand gene promoter in intraosseous prostate cancer

BACKGROUND Current animal models of prostate cancer (CaP) bone metastasis do not allow measurement of either tumor growth in bone over time or activation of gene promoters in intraosseous tumors. To develop these methods, we used bioluminescent imaging (BLI) to determine if expression of receptor activator of NF-ΚB ligand (RANKL), a pro-osteoclastogenic factor that promotes CaP bone metastases, is modulated by the bone matrix protein transforming growth factor-Β (TGF-Β) in vivo. METHODS C4-2B human CaP cells were treated with TGF-Β in vitro and RANKL mRNA and protein production were measured by polymerase chain reaction (PCR) and ELISA, respectively. Then C4-2B cells stably transfected with the RANKL promoter driving luciferase (lux) were injected intra-tibially into severe combined immundeficient (SCID) mice. Tumors were subjected to BLI every 2 weeks for 6 weeks and serum prostate specific antigen (PSA) was measured using ELISA. Vehicle (V), 1,25 dihydroxyvitamin D (VitD), or TGF-Β was administered to mice with established tumors and BLI to measure RANKL promoter activity was performed. Tumors were then subjected to immunohistochemistry for lux and assayed for RANKL mRNA levels. RESULTS TGF-Β induced RANKL protein and mRNA expression and activated the RANKL promoter activity in a dose-dependent manner in vitro. BLI demonstrated an increase in intraosseous tumor size over time, which correlated with serum PSA levels. Administration of TGF-Β and VitD to mice with established intraosseous tumors increased lux activity compared to V. Intratibial tumor RANKL mRNA expression paralleled the increased promoter activity. Immunohistochemistry confirmed the presence of lux in the intraosseous tumors. CONCLUSIONS These results demonstrate the ability to measure intraosseous tumor growth over time and gene promoter activation in an established intraosseous tumor in vivo and also demonstrate that TGF-Β induces activates the RANKL promoter. These results provide a novel method to explore the biology of CaP bone metastases. © 2004 Wiley-Liss, Inc.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/34765/1/20019_ftp.pd

The DUNE Far Detector Interim Design Report, Volume 3: Dual-Phase Module

The DUNE IDR describes the proposed physics program and technical designs of the DUNE far detector modules in preparation for the full TDR to be published in 2019. It is intended as an intermediate milestone on the path to a full TDR, justifying the technical choices that flow down from the high-level physics goals through requirements at all levels of the Project. These design choices will enable the DUNE experiment to make the ground-breaking discoveries that will help to answer fundamental physics questions. Volume 3 describes the dual-phase module's subsystems, the technical coordination required for its design, construction, installation, and integration, and its organizational structure

Long-Baseline Neutrino Facility (LBNF) and Deep Underground Neutrino Experiment (DUNE) Conceptual Design Report Volume 1: The LBNF and DUNE Projects

This document presents the Conceptual Design Report (CDR) put forward by an international neutrino community to pursue the Deep Underground Neutrino Experiment at the Long-Baseline Neutrino Facility (LBNF/DUNE), a groundbreaking science experiment for long-baseline neutrino oscillation studies and for neutrino astrophysics and nucleon decay searches. The DUNE far detector will be a very large modular liquid argon time-projection chamber (LArTPC) located deep underground, coupled to the LBNF multi-megawatt wide-band neutrino beam. DUNE will also have a high-resolution and high-precision near detector

Long-Baseline Neutrino Facility (LBNF) and Deep Underground Neutrino Experiment (DUNE) Conceptual Design Report Volume 2: The Physics Program for DUNE at LBNF

The Physics Program for the Deep Underground Neutrino Experiment (DUNE) at the Fermilab Long-Baseline Neutrino Facility (LBNF) is described

The Single-Phase ProtoDUNE Technical Design Report

ProtoDUNE-SP is the single-phase DUNE Far Detector prototype that is under construction and will be operated at the CERN Neutrino Platform (NP) starting in 2018. ProtoDUNE-SP, a crucial part of the DUNE effort towards the construction of the first DUNE 10-kt fiducial mass far detector module (17 kt total LAr mass), is a significant experiment in its own right. With a total liquid argon (LAr) mass of 0.77 kt, it represents the largest monolithic single-phase LArTPC detector to be built to date. It's technical design is given in this report