The Effectiveness of Attachment Injury Resolution Protocol (AIRP) in Reducing Marital Distress and Improving Marital Satisfaction in the Areas of Communication, Commitment, and Trust in High-Conflict Couples Affected by Infidelity

A quasi-experimental pilot study of fourteen heterosexual couples, twenty-eight participants, was conducted to assess whether Attachment Injury Resolution Protocol (AIRP) was effective in reducing marital distress and improving marital satisfaction in the areas of communication, commitment, and trust post infidelity for high-conflict couples. This study was important due to the fact that roughly thirty percent of couples engaged in marital infidelity (Norona et al., 2018). Fourteen heterosexual couples volunteered and were chosen from the clinician’s private mental-health practice to participate in a quasi-experimental pilot study. Four self-report assessments were implemented, including the Kansas Marital Conflict Scale (KMCS), Interpersonal Communication Skills Inventory, Commitment-Investment Model Scale, and Trust in Close Relationship Scale. All assessments were administered pre- and post-intervention; four dependent variables included marital distress, marital communication, marital commitment, and trust. An independent t-test was conducted for each variable. Results for this pilot study concluded that Attachment Injury Resolution Protocol (AIRP) is an effective form of treatment, but further research is needed. Also, Attachment Injury Resolution Protocol (AIRP) does not effectively improve marital communication for high-conflict couples than Phase II of EFT without AIRP. Recommendations for future research would include a study on a larger population, more diverse ethnicities, and additional domains for testing, including sexual satisfaction and forgiveness

Entre collègues, face à la caméra: Saisir les relations entre science et société dans les paroles et postures de chercheurs

International audienceEn 2006, nous menons une enquête par entretiens filmés auprès de chercheurs sur le thème des relations entre science et société. La logique de réalisation et d’exploitation de ces entretiens est d’emblée double, scientifique d’une part (procéder à l’analyse de la thématisation des relations entre sciences et société), médiatique d’autre part (à la demande du CNRS, produire un film présentant les points de vue de chercheurs sur ces relations).Il s'agit ici d'examiner conjointement le dispositif de recueil de données, situation indécise mais non brouillée, et ses implications dans la production de parole.Les relations entre sciences et société n’émergent pas secondairement du traitement de la parole des enquêtés traités après coup, mais elles s’expriment directement dans l’attention très fine portée par les chercheurs à la situation d’enquête elle-même, au statut de leurs propos, à la gamme des possibilités d’expression qu’elle leur offre, et qui fait de cette situation une épreuve de la dimension communicationnelle statut de chercheur tout autant qu’une situation sociale de communication à propos des sciences

Observer les usages des sciences humaines dans l'exposition d'art contemporain

What can we "see" from the social sciences? After discussing the difficulties of identifying them in other speeches and other practices, those of the contemporary displayed art, the paper presents and defends, by the description, the analysis and the comparison of two exhibitions, a sociodiscursive approach considering a set of articulated and contextualized elements. This approach allows reconstructing in their complexity the differentiated modalities of social sciences' uses, depending on the characteristics of the artist and the exhibition place.Que peut-on " voir " des sciences humaines ? Après avoir discuté les difficultés de les identifier dans d'autres discours et d'autres pratiques, ceux de l'art contemporain exposé, l'article présente et défend, par la description, l'analyse et la comparaison de deux expositions, une approche sociodiscursive prenant en considération un ensemble d'éléments articulés et contextualisés. Cette démarche permet de restituer dans leur complexité les modalités différenciées d'usage des sciences humaines selon les caractéristiques de l'artiste et du lieu d'exposition

Fait-divers global et redéfinition du mythe. Approche fait-diversière du 11 septembre 2001

The journalistic treatment of fait divers consists in the stage of mythical characters in accord to a cultural universe. This communication explores the discourse's properties of media coverage of an important event: Terrorists attacks committed on September the 11th 2001. This coverage shows in the surface, especially in fictional productions, some new discursive characters that could invest classical categories as the goodness and the evil, the hero and the victim or the fear and the courage.Le fait-divers comme genre journalistique met en scène des figures mythiques rattachées à des univers culturels de référence. Cette communication s'interroge sur les caractéristiques discursives du traitement médiatique d'un événement majeur : les attentats commis le 11 septembre 2001. Ce traitement fait affleurer, notamment dans les productions fictionnelles, un certain nombre de figures discursives nouvelles susceptibles d'investir les catégories classiques du bien et du mal, du héros et de la victime ou de la peur et du courage

L'édition des centres d'art, de l'archive à l'énonciation éditoriale

Cet article porte sur les enjeux de l'édition au sein des centres d'art, lieux de production d'expositions d'art contemporain. Au-delà d'un accompagnement des expositions, d'une publication " événementielle " et ponctuelle, l'édition des centres d'art s'inscrit dans la durée, comme mémoire des expositions qui, elles-mêmes, constituent l'art. Une approche de l'histoire collective de ces publications et des régularités de leur objet (les artistes auxquels sont consacrées des monographies) permet de repérer des éléments d'identification de l'art, des artistes et des centres d'art à destination interne et externe au champ artistique. Ces éléments sont envisagés à l'aide du concept d'archive et du concept d'énonciation éditoriale afin de saisir, par-delà les dimensions collectives, l'espace des positions énonciatives où s'inscrit et s'affirme la hiérarchie des légitimités des centres d'art, des artistes et des auteurs des textes insérés dans les publications

Rôles différenciés des sigles dans la transmission orale et les processus mémoriels

In a corpus of memory chronicles on urban policies relating to citizens, professionals and/or elected members of a particular area, a great deal of initials have been used by those interviewed in the survey. According to their characteristics as well as the communication situation the use of such initials is more or less naturalized or introspective. Consequently they allow to notice how the people interviewed run positions and also allow to analyse construction within the interaction of the various features of " the legitimate witness ".Dans un corpus de récits mémoriels d'habitants, professionnels et/ou élus d'un territoire relevant de la Politique de la ville, de nombreux sigles sont utilisés par les enquêtés. Selon les propriétés de ces derniers et la situation de communication, leur usage est plus ou moins naturalisé ou réflexif. Ils permettent ainsi d'observer l'économie des positions des enquêtés et d'analyser la construction, dans l'interaction, des différentes postures de " témoin légitime "

Tackling challenges in care of Alzheimer's disease and other dementias amid the COVID-19 pandemic, now and in the future

We have provided an overview on the profound impact of COVID-19 upon older people with Alzheimer's disease and other dementias and the challenges encountered in our management of dementia in different health-care settings, including hospital, outpatient, care homes, and the community during the COVID-19 pandemic. We have also proposed a conceptual framework and practical suggestions for health-care providers in tackling these challenges, which can also apply to the care of older people in general, with or without other neurological diseases, such as stroke or parkinsonism. We believe this review will provide strategic directions and set standards for health-care leaders in dementia, including governmental bodies around the world in coordinating emergency response plans for protecting and caring for older people with dementia amid the COIVD-19 outbreak, which is likely to continue at varying severity in different regions around the world in the medium term

Platelet transfusion versus standard care after acute stroke due to spontaneous cerebral haemorrhage associated with antiplatelet therapy (PATCH): a randomised, open-label, phase 3 trial

Item does not contain fulltextBACKGROUND: Platelet transfusion after acute spontaneous primary intracerebral haemorrhage in people taking antiplatelet therapy might reduce death or dependence by reducing the extent of the haemorrhage. We aimed to investigate whether platelet transfusion with standard care, compared with standard care alone, reduced death or dependence after intracerebral haemorrhage associated with antiplatelet therapy use. METHODS: We did this multicentre, open-label, masked-endpoint, randomised trial at 60 hospitals in the Netherlands, UK, and France. We enrolled adults within 6 h of supratentorial intracerebral haemorrhage symptom onset if they had used antiplatelet therapy for at least 7 days beforehand and had a Glasgow Coma Scale score of at least 8. With use of a secure web-based system that concealed allocation and used biased coin randomisation, study collaborators randomly assigned participants (1:1; stratified by hospital and type of antiplatelet therapy) to receive either standard care or standard care with platelet transfusion within 90 min of diagnostic brain imaging. Participants and local investigators giving interventions were not masked to treatment allocation, but allocation was concealed from outcome assessors and investigators analysing data. The primary outcome was shift towards death or dependence rated on the modified Rankin Scale (mRS) at 3 months, and analysed by ordinal logistic regression, adjusted for stratification variables and the Intracerebral Haemorrhage Score. The primary analysis was done in the intention-to-treat population and safety analyses were done in the intention-to-treat and as-treated populations. This trial is registered with the Netherlands Trial Register, number NTR1303, and is now closed. FINDINGS: Between Feb 4, 2009, and Oct 8, 2015, 41 sites enrolled 190 participants. 97 participants were randomly assigned to platelet transfusion and 93 to standard care. The odds of death or dependence at 3 months were higher in the platelet transfusion group than in the standard care group (adjusted common odds ratio 2.05, 95% CI 1.18-3.56; p=0.0114). 40 (42%) participants who received platelet transfusion had a serious adverse event during their hospital stay, as did 28 (29%) who received standard care. 23 (24%) participants assigned to platelet transfusion and 16 (17%) assigned to standard care died during hospital stay. INTERPRETATION: Platelet transfusion seems inferior to standard care for people taking antiplatelet therapy before intracerebral haemorrhage. Platelet transfusion cannot be recommended for this indication in clinical practice. FUNDING: The Netherlands Organisation for Health Research and Development, Sanquin Blood Supply, Chest Heart and Stroke Scotland, French Ministry of Health

An aberrant NOTCH2-BCR signaling axis in B cells from patients with chronic GVHD

B-cell receptor (BCR)-activated B cells contribute to pathogenesis in chronic graft-versus-host disease (cGVHD), a condition manifested by both B-cell autoreactivity and immune deficiency. We hypothesized that constitutive BCR activation precluded functional B-cell maturation in cGVHD. To address this, we examined BCR-NOTCH2 synergy because NOTCH has been shown to increase BCR responsiveness in normal mouse B cells. We conducted ex vivo activation and signaling assays of 30 primary samples from hematopoietic stem cell transplantation patients with and without cGVHD. Consistent with a molecular link between pathways, we found that BCR-NOTCH activation significantly increased the proximal BCR adapter protein BLNK. BCR-NOTCH activation also enabled persistent NOTCH2 surface expression, suggesting a positive feedback loop. Specific NOTCH2 blockade eliminated NOTCH-BCR activation and significantly altered NOTCH downstream targets and B-cell maturation/effector molecules. Examination of the molecular underpinnings of this “NOTCH2-BCR axis” in cGVHD revealed imbalanced expression of the transcription factors IRF4 and IRF8, each critical to B-cell differentiation and fate. All-trans retinoic acid (ATRA) increased IRF4 expression, restored the IRF4-to-IRF8 ratio, abrogated BCR-NOTCH hyperactivation, and reduced NOTCH2 expression in cGVHD B cells without compromising viability. ATRA-treated cGVHD B cells had elevated TLR9 and PAX5, but not BLIMP1 (a gene-expression pattern associated with mature follicular B cells) and also attained increased cytosine guanine dinucleotide responsiveness. Together, we reveal a mechanistic link between NOTCH2 activation and robust BCR responses to otherwise suboptimal amounts of surrogate antigen. Our findings suggest that peripheral B cells in cGVHD patients can be pharmacologically directed from hyperactivation toward maturity