2,059 research outputs found
Rudiments of Holography
An elementary introduction to Maldacena's AdS/CFT correspondence is given,
with some emphasis in the Fefferman-Graham construction. This is based on
lectures given by one of us (E.A.) at the Universidad Autonoma de Madrid.Comment: 60 pages, additional misprints corrected, references adde
Adipokines and inflammation: is it a question of weight?
Obesity has reached epidemic proportions in the Western society and is increasing in the developing world. It is considered as one of the major contributors to the global burden of disability and chronic diseases, including autoimmune, inflammatory and degenerative diseases. Research conducted on obesity and its complications over the last two decades has transformed the outdated concept of white adipose tissue (WAT) merely serving as an energy depot. WAT is now recognized as an active and inflammatory organ capable of producing a wide variety of factors known as adipokines. These molecules participate through endocrine, paracrine, autocrine, or juxtacrine cross-talk mechanisms in a great variety of physiological or pathophysiological processes, regulating food intake, insulin sensitivity, immunity, and inflammation.
Although initially restricted to metabolic activities (regulation of glucose and lipid metabolism), adipokines currently represent a new family of proteins that can be considered key players in the complex network of soluble mediators involved in the pathophysiology of immune/inflammatory diseases. However, the complexity of the adipokine network in the pathogenesis and progression of inflammatory diseases has posed, since the beginning, the important question of whether it may be possible to target the mechanism(s) by which adipokines contribute to disease selectively without suppressing their physiological functions.
Here we explore in depth the most recent findings concerning the involvement of adipokines in inflammation and immune responses, in particular in rheumatic, inflammatory and degenerative diseases. We also highlight several possible strategies for therapeutic development and propose that adipokines and their signalling pathways may represent innovative therapeutic strategies for inflammatory disorders.ACKNOWLEDGMENTS: OG and FL are Staff Personnel of Xunta de Galicia (Servizo Galego de Saude, SERGAS) through a research-staff stabilization contract (ISCIII/SERGAS). VF is a “Sara Borrell” Researcher funded by ISCIII and FEDER. RG is a “Miguel Servet” Researcher funded by Instituto de Salud Carlos III (ISCIII) and FEDER. OG, MAGG and RG are members of RETICS Programme, RD16/0012/0014 (RIER: Red de Investigación en Inflamación y Enfermedades Reumáticas) via Instituto de Salud Carlos III (ISCIII) and FEDER. FL is a member of CIBERCV (Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares). The work of OG (PIE13/00024 and PI14/00016, PI17/00409), FL (PI15/00681 and CB16/11/00226) and RG (PI16/01870 and CP15/00007) was funded by Instituto de Salud Carlos III and FEDER. OG is a beneficiary of a project funded by Research Executive Agency of the European Union in the framework of MSCA-RISE Action of the H2020 Programme (Project number 734899). AM has received funding from the European Commission Framework 7 programme (EU FP7; HEALTH.2012.2.4.5-2, project number 305815; Novel Diagnostics and Biomarkers for Early Identification of Chronic Inflammatory Joint Diseases) plus generous support from the Innovative Medicines Initiative Joint Undertaking under grant agreement No. 115770, resources of which are composed of financial contribution from the European Union’s Seventh Framework programme (FP7/2007-2013) and EFPIA companies’ in kind contribution. The funders had no role in study design, data collection, and analysis, decision to publish, or preparation of the manuscript
Galaxy Clusters as Reservoirs of Heavy Dark Matter and High-Energy Cosmic Rays: Constraints from Neutrino Observations
Galaxy Clusters (GCs) are the largest reservoirs of both dark matter and
cosmic rays (CRs). Dark matter self-annihilation can lead to a high luminosity
in gamma rays and neutrinos, enhanced by a strong degree of clustering in dark
matter substructures. Hadronic CR interactions can also lead to a high
luminosity in gamma rays and neutrinos, enhanced by the confinement of CRs from
cluster accretion/merger shocks and active galactic nuclei. We show that
IceCube/KM3Net observations of high-energy neutrinos can probe the nature of
GCs and the separate dark matter and CR emission processes, taking into account
how the results depend on the still-substantial uncertainties. Neutrino
observations are relevant at high energies, especially at >10 TeV. Our results
should be useful for improving experimental searches for high-energy neutrino
emission. Neutrino telescopes are sensitive to extended sources formed by dark
matter substructures and CRs distributed over large scales. Recent observations
by Fermi and imaging atmospheric Cherenkov telescopes have placed interesting
constraints on the gamma-ray emission from GCs. We also provide calculations of
the gamma-ray fluxes, taking into account electromagnetic cascades inside GCs,
which can be important for injections at sufficiently high energies. This also
allows us to extend previous gamma-ray constraints to very high dark matter
masses and significant CR injections at very high energies. Using both
neutrinos and gamma rays, which can lead to comparable constraints, will allow
more complete understandings of GCs. Neutrinos are essential for some dark
matter annihilation channels, and for hadronic instead of electronic CRs. Our
results suggest that the multi-messenger observations of GCs will be able to
give useful constraints on specific models of dark matter and CRs. [Abstract
abridged.]Comment: 31 pages, 20 figures, 1 table, accepted for publication in JCAP,
references and discussions adde
Could the Fermi-LAT detect gamma-rays from dark matter annihilation in the dwarf galaxies of the Local Group?
The detection of gamma-rays from dark matter (DM) annihilation is among the
scientific goals of the Fermi Large Area Telescope (formerly known as GLAST)
and Cherenkov telescopes. In this paper we investigate the existence of
realistic chances of such a discovery selecting some nearby dwarf spheroidal
galaxies (dSph) as a target. We study the detectability with the Fermi-LAT of
the gamma-ray flux from DM annihilation in Draco, Ursa Minor, Carina, and
Sextans, for which the state-of-art DM density profiles were available. We
assume the DM is made of Weakly Interacting Massive Particles such as the
Lightest Supersymmetric Particle (LSP) and compute the expected gamma-ray flux
for optimistic choices of the unknown underlying particle physics parameters.
We then compute the boost factors due to the presence of DM clumps and of a
central supermassive black hole. Finally, we compare our predictions with the
Fermi-LAT sensitivity maps. We find that the dSph galaxies shine above the
Galactic smooth halo: e.g., the Galactic halo is brighter than the Draco dSph
only for angles smaller than 2.3 degrees above the Galactic Center. We also
find that the presence of a cusp or a constant density core in the DM mass
density profile does not produce any relevant effect in the gamma-ray flux due
to the fortunate combination of the geometrical acceptance of the Fermi-LAT
detector and the distance of the galaxies and that no significant enhancement
is given by the presence of a central black hole or a population of
sub-subhalos. We conclude that, even for the most optimistic scenario of
particle physics, the gamma-ray flux from DM annihilation in the dSph galaxies
of the LG would be too low to be detected with the Fermi-LAT.Comment: 11 pages, 11 figures, accepted for publication in A&
International estimated fetal weight standards of the INTERGROWTH-21(st) Project.
OBJECTIVE: Estimated fetal weight (EFW) and fetal biometry are complementary measures used to screen for fetal growth disturbances. Our aim was to provide international EFW standards to complement the INTERGROWTH-21(st) Fetal Growth Standards that are available for use worldwide. METHODS: Women with an accurate gestational-age assessment, who were enrolled in the prospective, international, multicenter, population-based Fetal Growth Longitudinal Study (FGLS) and INTERBIO-21(st) Fetal Study (FS), two components of the INTERGROWTH-21(st) Project, had ultrasound scans every 5 weeks from 9-14 weeks' until 40 weeks' gestation. At each visit, measurements of fetal head circumference (HC), biparietal diameter, occipitofrontal diameter, abdominal circumference (AC) and femur length (FL) were obtained blindly by dedicated research sonographers using standardized methods and identical ultrasound machines. Birth weight was measured within 12 h of delivery by dedicated research anthropometrists using standardized methods and identical electronic scales. Live babies without any congenital abnormality, who were born within 14 days of the last ultrasound scan, were selected for inclusion. As most births occurred at around 40 weeks' gestation, we constructed a bootstrap model selection and estimation procedure based on resampling of the complete dataset under an approximately uniform distribution of birth weight, thus enriching the sample size at extremes of fetal sizes, to achieve consistent estimates across the full range of fetal weight. We constructed reference centiles using second-degree fractional polynomial models. RESULTS: Of the overall population, 2404 babies were born within 14 days of the last ultrasound scan. Mean time between the last scan and birth was 7.7 (range, 0-14) days and was uniformly distributed. Birth weight was best estimated as a function of AC and HC (without FL) as log(EFW) = 5.084820 - 54.06633 × (AC/100)(3) - 95.80076 × (AC/100)(3) × log(AC/100) + 3.136370 × (HC/100), where EFW is in g and AC and HC are in cm. All other measures, gestational age, symphysis-fundus height, amniotic fluid indices and interactions between biometric measures and gestational age, were not retained in the selection process because they did not improve the prediction of EFW. Applying the formula to FGLS biometric data (n = 4231) enabled gestational age-specific EFW tables to be constructed. At term, the EFW centiles matched those of the INTERGROWTH-21(st) Newborn Size Standards but, at < 37 weeks' gestation, the EFW centiles were, as expected, higher than those of babies born preterm. Comparing EFW cross-sectional values with the INTERGROWTH-21(st) Preterm Postnatal Growth Standards confirmed that preterm postnatal growth is a different biological process from intrauterine growth. CONCLUSIONS: We provide an assessment of EFW, as an adjunct to routine ultrasound biometry, from 22 to 40 weeks' gestation. However, we strongly encourage clinicians to evaluate fetal growth using separate biometric measures such as HC and AC, as well as EFW, to avoid the minimalist approach of focusing on a single value
Dualising the baryonic branch: Dynamic SU(2) and confining backgrounds in IIA
In this paper we construct and examine new supersymmetric solutions of massive IIA supergravity that are obtained using non-Abelian T-duality applied to the Baryonic Branch of the Klebanov-Strassler background. The geometries display SU(2) structure which we show flows from static in the UV to dynamical in the IR. Confinement and symmetry breaking are given a geometrical interpretation by this change of structure. Various field theory observables are studied, suggesting possible ways to break conformality and flow in N=1 TN and related field theories
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