241 research outputs found

    TNFÁ impairs mitochondrial metabolism in 3T3-L1 adipocytes

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    Magnetopause Surface Reconstruction from Tangent Vector Observations

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    Entire fields of science, most notably in astrophysics, rely on line-of-sight observations. In planetary science and heliophysics, the techniques of soft X-ray and energetic neutral atom (ENA) imaging also produce line-of-sight measurements. An important question is whether the geometry of the surface, for example the magnetopause, can be reconstructed using only line-of-sight observations from a single spacecraft. Under a broad range of conditions, the peak emission corresponds to the tangent to the boundary surface, such as the planetary surface or magnetopause, the so-called "limb brightening" phenomenon. Thus, line-of-sight observations frequently provide information concerning the tangent to the surfaces being observed. We present an algorithm to reconstruct the cross-section of the magnetopause using line-of-sight soft X-ray observations (and, in principle, ENA observations). The algorithm successfully reconstructs the cross section of the magnetopause in the orbit plane. The threedimensional magnetopause structure can be recovered from observations by a spacecraft whose orbit precesses around the magnetosphere

    Distributed local energy: Assessing the determinants of domestic-scale solar photovoltaic uptake at the local level across England and Wales

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    This is the final version. Available from Elsevier via the DOI in this record. Data availability: Data will be made available on request.The withdrawal of the Feed-in Tariff (FiT) by the UK Government at the end of March 2019, which rewarded low carbon electricity generators with subsidy payments, has led to doubts over the future of small-scale generation in the country's energy system. This study contributes to navigating this post-subsidy uncertainty by identifying the factors associated with the uptake of a domestic-scale technology, solar photovoltaics (PV), in England and Wales, and exploring its spatial distribution. It uses FiT installation data from Ofgem, available at a fine-grained spatial resolution for the period April 2010–September 2019, to test the effect of social, housing, political, energy and environmental factors. It is shown that population demographics, housing density, size, type and tenure, and energy consumption practices are important factors influencing the uptake of domestic PV at the local level. The South West and East of England are identified as regions of unexpectedly high uptake, controlling for the other factors. This is, at the time of writing, the first attempt to model PV uptake at a fine-grained spatial level across England and Wales.Economic and Social Research Counci

    Soft X‐ray and ENA Imaging of the Earth’s Dayside Magnetosphere

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    The LEXI and SMILE missions will provide soft X‐ray images of the Earth's magnetosheath and cusps after their anticipated launch in 2023 and 2024, respectively. The IBEX mission showed the potential of an Energetic Neutral Atom (ENA) instrument to image dayside magnetosheath and cusps, albeit over the long hours required to raster an image with a single pixel imager. Thus, it is timely to discuss the two imaging techniques and relevant science topics. We simulate soft X‐ray and low‐ENA images that might be observed by a virtual spacecraft during two interesting solar wind scenarios: a southward turning of the interplanetary magnetic field and a sudden enhancement of the solar wind dynamic pressure. We employ the OpenGGCM global magnetohydrodynamics model and a simple exospheric neutral density model for these calculations. Both the magnetosheath and the cusps generate strong soft X‐rays and ENA signals that can be used to extract the locations and motions of the bow shock and magnetopause. Magnetopause erosion corresponds closely to the enhancement of dayside reconnection rate obtained from the OpenGGCM model, indicating that images can be used to understand global‐scale magnetopause reconnection. When dayside imagers are installed with high‐ENA inner‐magnetosphere and FUV/UV aurora imagers, we can trace the solar wind energy flow from the bow shock to the magnetosphere and then to the ionosphere in a self‐standing manner without relying upon other observatories. Soft X‐ray and/or ENA imagers can also unveil the dayside exosphere density structure and its response to space weather

    Gender differences in the correlates of reactive aggression

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    The main aim of the present study was to examine the relationships between four psychopathy dimensions (Interpersonal Manipulation, Callous Affect, Erratic Lifestyle, and Antisocial Behaviour) as well as childhood exposure to violence and reactive aggression in men and women. Participants were a sample of working adults (N = 319) recruited from the University of Security in Poznan. Results indicated that reactive aggression among males formed significant associations with Erratic Lifestyle, Interpersonal Manipulation, and childhood exposure to violence. Only one variable, Erratic Lifestyle, was a significant correlate of reactive aggression in females. These findings are discussed in light of theory and previous research findings. © 2015 Polish Academy of Sciences, Committee for Psychological Sciences

    Estimating the subsolar magnetopause position from soft X-ray images using a low-pass image filter

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    The Lunar Environment heliospheric X-ray Imager (LEXI) and Solar wind Magnetosphere Ionosphere Link Explorer (SMILE) missions will image the Earth’s dayside magnetopause and cusps in soft X-rays after their respective launches in the near future, to specify global magnetic reconnection modes for varying solar wind conditions. To support the success of these scientific missions, it is critical to develop techniques that extract the magnetopause locations from the observed soft X-ray images. In this research, we introduce a new geometric equation that calculates the subsolar magnetopause position (\begin{document}Rs {R}_{\mathrm{s}} \end{document}) from a satellite position, the look direction of the instrument, and the angle at which the X-ray emission is maximized. Two assumptions are used in this method: (1) The look direction where soft X-ray emissions are maximized lies tangent to the magnetopause, and (2) the magnetopause surface near the subsolar point is almost spherical and thus \begin{document}Rs {R}_{\mathrm{s}} \end{document} is nearly equal to the radius of the magnetopause curvature. We create synthetic soft X-ray images by using the Open Geospace General Circulation Model (OpenGGCM) global magnetohydrodynamic model, the galactic background, the instrument point spread function, and Poisson noise. We then apply the fast Fourier transform and Gaussian low-pass filters to the synthetic images to remove noise and obtain accurate look angles for the soft X-ray peaks. From the filtered images, we calculate \begin{document}Rs {R}_{\mathrm{s}} \end{document} and its accuracy for different LEXI locations, look directions, and solar wind densities by using the OpenGGCM subsolar magnetopause location as ground truth. Our method estimates \begin{document}Rs {R}_{\mathrm{s}} \end{document} with an accuracy of \begin{document}10  cm−3 {10\;\mathrm{c}\mathrm{m}}^{-3} \end{document}. The accuracy improves for greater solar wind densities and during southward interplanetary magnetic fields. The method captures the magnetopause motion during southward interplanetary magnetic field turnings. Consequently, the technique will enable quantitative analysis of the magnetopause motion and help reveal the dayside reconnection modes for dynamic solar wind conditions. This technique will support the LEXI and SMILE missions in achieving their scientific objectives

    Cycloaddition Strategies for the Synthesis of Diverse Heterocyclic Spirocycles for Fragment-Based Drug Discovery.

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    In recent years the pharmaceutical industry has benefited from the advances made in fragment-based drug discovery (FBDD) with more than 30 fragment-derived drugs currently marketed or progressing through clinical trials. The success of fragment-based drug discovery is entirely dependent upon the composition of the fragment screening libraries used. Heterocycles are prevalent within marketed drugs due to the role they play in providing binding interactions; consequently, heterocyclic fragments are important components of FBDD libraries. Current screening libraries are dominated by flat, sp2-rich compounds, primarily owing to their synthetic tractability, despite the superior physicochemical properties displayed by more three-dimensional scaffolds. Herein, we report step-efficient routes to a number of biologically relevant, fragment-like heterocyclic spirocycles. The use of both electron-deficient and electron-rich 2-atom donors was explored in complexity-generating [3+2]-cycloadditions to furnish products in 3 steps from commercially available starting materials. The resulting compounds were primed for further fragment elaboration through the inclusion of synthetic handles from the outset of the syntheses
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