Application of Flow-Injection Spectrophotometry to Pharmaceutical and Biomedical Analyses

The discovery of new drugs, especially when many samples have to be analyzed in the minimum of time, demand the improvement or development of new analytical methods. Various techniques may be employed for this purpose. In this context, this chapter gathers the collection of paper and represents the review of past work on spectrophotometric technique coupled to a continuous flow system to determine low concentrations of several chemical species in different kinds of pharmaceutical and biological samples. A short historical background of the flow-injection analysis technique and a brief discussion of the basic principles and potential are presented. Part of this chapter is devoted to describing the sample preparation techniques, principles, and figures of merit of analytical methods. Representative applications of flow-injection spectrophotometry to pharmaceutical and biomedical analysis are also described

Static analysis of a lamppost according to Eurocode EN-40

When people move around a town, at some point in their journey they need to cross the road using a dedicated crosswalk. However, crossing is not always done safely due to weather conditions, lack of visibility or distraction. The VALLPASS project, aims to install two lampposts in opposite positions to the direction of crossing, with various functionalities and technological innovations, creating a luminous tunnel for the safe passage of pedestrians. To verify the mechanical resistance of the lighting poles, numerical simulations were performed using the finite element method, where the boundary conditions considered the criteria defined by the European standard EN-40 "Lighting Columns". This standard specifies the loads acting on the column, namely the horizontal forces due to the action of wind according to standard NP EN 1991-1-4:2010 and the vertical forces due to the self-weight of the entire structure. Considering a lighting pole with a square lower section and a cylindrical upper section, with a total height of 7 meters and with a support structure for photovoltaic panels, according to the static analysis performed, a maximum combination of axial and bending stresses of 138.74MPa, was obtained in the connection zone between the square section and the pole shaft. The maximum displacement of 6.9cm, was obtained at the free ends of the photovoltaic panel support structure and a minimum factor of safety of 1.64 in the zone where the combination of axial and bending stresses is more severe.The authors would like to thank the NORTE-01-0247-FEDER-113439 project for the financial support for this work. Part of financial support was also provided by Portugal’s national funding FCT/MCTES (PIDDAC) to Centro de Investigação de Montanha (CIMO) (UIDB/00690/2020 and UIDP/00690/2020) and SusTEC (LA/P/0007/2020).info:eu-repo/semantics/publishedVersio

Thermal analysis for testing underground battery location

The energy storage batteries, employed in solar systems installed on lampposts, are usually placed in devices such as switchboards fixed at an elevation near the top of the column. However, this storage solution becomes inefficient, because it is not possible to guarantee the control of the working temperature of the batteries, due to the low thermal insulation capacity of these storage devices. In this sense, an underground compartment made of concrete, steel plate and rock wool were created, embedded in the foundation of the lamppost, with the purpose of using geothermal energy to maintain an adequate temperature inside the compartment. To verify the temperature inside the battery storage compartment, a thermal analysis was performed, where heat transfer by conduction, convection and radiation was considered. Analyses were performed in steady state, and later, transient state, considering the initial temperatures of the thermal study in the previous steady state. With a storage volume of 1m3 and the base of the compartment at a depth of 2m, it was verified that it is possible to use geothermal energy to cool or heat, depending on the season, a system through geothermal energy. Considering a typical day in July, with room temperature of 35oC, a reduction of approximately 8oC was obtained inside the storage compartment, compared to the ambient temperature.The authors would like to thank the NORTE-01-0247-FEDER-113439 project for the financial support for this work. Part of financial support was also provided by Portugal's national funding FCT/MCTES (PIDDAC) to Centro de Investigação de Montanha (CIMO) (UIDB/00690/2020 and UIDP/00690/2020) andSusTEC (LA/P/0007/2020).info:eu-repo/semantics/publishedVersio

Green manure in coffee systems in the region of Zona da Mata, Minas Gerais: characteristics and kinetics of carbon and nitrogen mineralization.

The use of green manure may contribute to reduce soil erosion and increase the soil organic matter content and N availability in coffee plantations in the Zona da Mata, State of Minas Gerais, in Southeastern Brazil. The potential of four legumes (A. pintoi, C. mucunoides, S. aterrimum and S. guianensis)to produce above-ground biomass, accumulate nutrients and mineralize N was studied in two coffee plantations of subsistence farmers under different climate conditions. The biomass production of C. mucunoides was influenced by the shade of the coffee plantation.C. mucunoides tended to mineralize more N than the other legumes due to the low polyphenol content and polyphenol/N ratio. In the first year, the crop establishment of A. pintoi in the area took longer than of the other legumes, resulting in lower biomass production and N2 fixation. In the long term, cellulose was the main factor controlling N mineralization. The biochemical characteristics, nutrient accumulation and biomass production of the legumes were greatly influenced by the altitude and position of the area relative to the sun

Agreement between dual x-ray absorptiometers using pencil beam and fan beam: indicators of bone health and whole-body plus appendicular tissue composition in adult athletes

OBJECTIVE: The current study was aimed to examine intra-individual variation on indicators of bone health in addition to whole-body plus appendicular tissue measurements using two concurrent assessments based on pencil beam and fan beam dual energy X-ray absorptiometry (DXA) systems in adult athletes from several sports. METHOD: Thirty-two male participants (27.6±10.1 years) were measured on anthropometry including multifrequency bioelectric impedance and air-displacement plethysmography. Bone mineral content (BMC), bone area, fat and lean soft tissue were derived using pencil beam (Lunar DPX-MD+) and fan beam (Lunar iDXA) absorptiometry. Bone mineral density (BMD) was obtained for the femoral neck, trochanter and triangle of ward. Finally, the right thigh was defined as a region of interest (ROI). Analyses comprised intra-class correlation (ICC), Effect size (d) from mean differences of repeated measurements, coefficient of variation (CV) RESULTS: ICC were >0.900 for all measurements. Intra-individual differences were large for BMC (d=1,312; CV=2,7%), bone area (d=1,761; CV=2,7%), fat tissue (d=1,612; CV=11%) and all indicators of appendicular lean soft tissue (d=1,237-1687; CV=2,0-4,1%). A very large difference (d=4,014; CV=8.4%) was diagnosed for lean soft tissue of the ROI. CONCLUSION: Although differences among concurrent instruments for BMC and bone area, the effect size of mean differences was negligible for BMD. Fat and lean soft tissue derived from DXA should be interpreted as reference values (not criterion) due to equipment-related variation, more apparently in the ROI values.info:eu-repo/semantics/publishedVersio

Rules, Standards, and the Internal Point of View

Large scale structure and cosmolog

Numerical convergence of the block-maxima approach to the Generalized Extreme Value distribution

In this paper we perform an analytical and numerical study of Extreme Value distributions in discrete dynamical systems. In this setting, recent works have shown how to get a statistics of extremes in agreement with the classical Extreme Value Theory. We pursue these investigations by giving analytical expressions of Extreme Value distribution parameters for maps that have an absolutely continuous invariant measure. We compare these analytical results with numerical experiments in which we study the convergence to limiting distributions using the so called block-maxima approach, pointing out in which cases we obtain robust estimation of parameters. In regular maps for which mixing properties do not hold, we show that the fitting procedure to the classical Extreme Value Distribution fails, as expected. However, we obtain an empirical distribution that can be explained starting from a different observable function for which Nicolis et al. [2006] have found analytical results.Comment: 34 pages, 7 figures; Journal of Statistical Physics 201

Similaridade genética em casais, variáveis culturais e personalidade

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