The Light of Knowledge

Cowinner of the Society for Linguistic Anthropology’s Edward Sapir Book Prize Since the early 1990s hundreds of thousands of Tamil villagers in southern India have participated in literacy lessons and other events designed to transform them into active citizens with access to state power. These efforts are part of a movement known as the Arivoli Iyakkam (the Enlightenment Movement), one of the most successful mass literacy movements in recent history. This rich ethnographic account of highlights the paradoxes inherent in such movements that seek to emancipate people through literacy. “A work of linguistic anthropology that makes crucial contributions to the study of literacy and language ideologies. It is also a broadly ranging work of social theory that will be of interest to students and scholars of the postcolonial state and neoliberal governmentality in South Asia and beyond, and of activism and social movements more generally.”—Anthropological Quarterl

MAPK/ERK Signaling in Osteosarcomas, Ewing Sarcomas and Chondrosarcomas: Therapeutic Implications and Future Directions

The introduction of cytotoxic chemotherapeutic drugs in the 1970's improved the survival rate of patients with bone sarcomas and allowed limb salvage surgeries. However, since the turn of the century, survival data has plateaued for a subset of metastatic, nonresponding osteo, and/or Ewing sarcomas. In addition, most high-grade chondrosarcoma does not respond to current chemotherapy. With an increased understanding of molecular pathways governing oncogenesis, modern targeted therapy regimens may enhance the efficacy of current therapeutic modalities. Mitogen-Activated Protein Kinases (MAPK)/Extracellular-Signal-Regulated Kinases (ERK) are key regulators of oncogenic phenotypes such as proliferation, invasion, angiogenesis, and inflammatory responses; which are the hallmarks of cancer. Consequently, MAPK/ERK inhibitors have emerged as promising therapeutic targets for certain types of cancers, but there have been sparse reports in bone sarcomas. Scattered papers suggest that MAPK targeting inhibits proliferation, local invasiveness, metastasis, and drug resistance in bone sarcomas. A recent clinical trial showed some clinical benefits in patients with unresectable or metastatic osteosarcomas following MAPK/ERK targeting therapy. Despite in vitro proof of therapeutic concept, there are no sufficient in vivo or clinical data available for Ewing sarcomas or chondrosarcomas. Further experimental and clinical trials are awaited in order to bring MAPK targeting into a clinical arena

Long-term Declines in the Size of Northern Fulmar (Fulmarus glacialis) Colonies on Eastern Baffin Island, Canada

We censused three colonies of Northern Fulmars (Fulmarus glacialis) along eastern Baffin Island, Canada, that were estimated to support 155 000 breeding pairs in 1973, but had not been adequately counted since then. The colonies were surveyed in July and August 2018 using photographs taken from a helicopter or a drone. The combined estimated colony sizes were 36 500 pairs, much smaller than historical estimates. Although the 1973 estimates were coarse, this difference represents an apparent 3+% annual decline in numbers at each colony over approximately four decades or more than 87% over three generations (66 years). Several factors may be contributing to these declines, including changes in winter food supplies and the susceptibility of fulmars to fisheries bycatch. We recommend efforts to survey the remaining major fulmar colonies in Arctic Canada to assess the overall population size and trends, and allow for further analyses of potential population drivers.Nous avons recensé trois colonies de fulmars boréaux (Fulmarus glacialis) sur la côte est de l’île de Baffin, au Canada. Selon des estimations réalisées en 1973, 155 000 couples reproducteurs y nichaient, mais aucun dénombrement adéquat n’avait été effectué depuis. Les colonies ont été recensées en juillet et en août 2018 au moyen de photographies prises à partir d’un hélicoptère ou d’un drone. La taille combinée des colonies a été estimée à 36500 couples, soit un nombre beaucoup moins élevé que les estimations précédentes. Bien que les estimations de 1973 étaient des estimations grossières, cette différence représente une baisse annuelle apparente de plus de 3 % à chacune des colonies sur environ quatre décennies, soit plus de 87 % sur trois générations (66 ans). Ces diminutions peuvent être attribuables à plusieurs facteurs, dont les changements caractérisant les approvisionnements en nourriture pendant l’hiver et la susceptibilité des fulmars à faire l’objet de captures accessoires. Nous recommandons que des efforts soient faits pour recenser les grandes colonies de fulmars qui restent dans l’Arctique canadien afin d’évaluer la taille globale de la population et les tendances la caractérisant, ainsi que pour pousser plus loin l’analyse des facteurs susceptibles d’avoir un effet sur leurs populations

Molecular Characterization of Host-Specific Biofilm Formation in a Vertebrate Gut Symbiont

Although vertebrates harbor bacterial communities in their gastrointestinal tract whose composition is host-specific, little is known about the mechanisms by which bacterial lineages become selected. The goal of this study was to characterize the ecological processes that mediate host-specificity of the vertebrate gut symbiont Lactobacillus reuteri, and to systematically identify the bacterial factors that are involved. Experiments with monoassociated mice revealed that the ability of L. reuteri to form epithelial biofilms in the mouse forestomach is strictly dependent on the strain’s host origin. To unravel the molecular basis for this host-specific biofilm formation, we applied a combination of transcriptome analysis and comparative genomics and identified eleven genes of L. reuteri 100-23 that were predicted to play a role. We then determined expression and importance of these genes during in vivo biofilm formation in monoassociated mice. This analysis revealed that six of the genes were upregulated in vivo, and that genes encoding for proteins involved in epithelial adherence, specialized protein transport, cell aggregation, environmental sensing, and cell lysis contributed to biofilm formation. Inactivation of a serine-rich surface adhesin with a devoted transport system (the SecA2-SecY2 pathway) completely abrogated biofilm formation, indicating that initial adhesion represented the most significant step in biofilm formation, likely conferring host specificity. In summary, this study established that the epithelial selection of bacterial symbionts in the vertebrate gut can be both specific and highly efficient, resulting in biofilms that are exclusively formed by the coevolved strains, and it allowed insight into the bacterial effectors of this process

Conservative interventions for urinary incontinence in women: an overview of Cochrane systematic reviews

This is the protocol for a review and there is no abstract. The objectives are as follows:  To synthesise Cochrane reviews of conservative interventions, as described above, for the prevention or treatment of female urinary incontinence.Output Type: Protoco

Prospectus, October 12, 1976

STUDENTS WANT \u27PINS\u27; \u27You can help your child to read\u27: Oct. 19; PC news in brief: Bridge Club, Tickets on sale till noon, Blazing saddles, Vet Tech bake sale, Fly away, Hunting symposium, Baha\u27i Club, Scott Shearer speaks; Stu-Go: Get to know us: Free food, drink, good conversation; AMVA visits Vet Tech; FCC Oks PC radio; Letters to the Editor: Sad lot of the parker, Different frequencies?; Editorial: Tickets deny \u27due process\u27; Editorial: Education can be different; Staff editorial: Death penalty more murder; Library assistants take it with smiles; Readers Theatre: Rehearsals start for series; English teachers confer; Audubon film set for October 25th; Gibson nursing session today; SIU Home Ec will host guest day; First in line: Sally will finally see Elvis Presley; Pam Fritz: Music frees the soul; Charlie K. moving on down; Thursday college forums set; Facts for Transferring PC students; A \u27mystic feeling\u27; Nadia: Belly dancing; Mrs. Warren\u27s Profession: Shaw\u27s message is strong; Uncle Bob: Armory plays free; PC faculty concert Sunday; Parkland women outnumber men; Mediaseen: Community Broadcasters to meet; Classifieds; Know your athletes: Ike: \u27I like to do everything\u27; IM Football Schedules; Faculty bowling: Watch out for \u27Excess\u27; Duffers place 14th at Joliet: Harriers take 5th in PC Invit.; \u27Terrible outing\u27; Green grabs Fast Freddy again; Fast Freddy\u27s Football Forecast; This Week\u27s Scores; Spikers lose to EIU first loss of the season; Games of October 16https://spark.parkland.edu/prospectus_1976/1008/thumbnail.jp

Fiction Fix 08

https://digitalcommons.unf.edu/fiction_fix/1005/thumbnail.jp

A survey for redshifted molecular and atomic absorption lines I

We are currently undertaking a large survey for redshifted atomic and molecular absorption ... only one clear and one tentative detection were obtained: HI absorption at z = 0.097 in PKS 1555-140 and OH absorption at z =0.126 in PKS 2300-189, respectively... In order to determine why no clear molecular absorption was detected in any of the 13 sources searched, we investigate the properties of the five redshifted systems currently known to exhibit OH absorption. In four of these, molecules were first detected via millimetre-wave transitions and the flat radio spectra indicate compact background continuum sources, which may suggest a high degree of coverage of the background source by the molecular clouds in the absorber. Furthermore, for these systems we find a relationship between the molecular line strength and red optical--near infrared (V-K) colours, thus supporting the notion that the reddening of these sources is due to dust, which provides an environment conducive to the formation of molecules. Upon comparison with the V-K colours of our sample, this relationship suggests that, presuming the reddening occurs at the host galaxy redshift at least in some of the targets, many of our observations still fall short of the sensitivityrequired to detect OH absorption, although a confirmation of the ``detection'' of OH in 2300-189 could contravene this.Comment: 13 pages, loads of figures, accepted by MNRA

Test of CPT Symmetry and Quantum Mechanics with Experimental data from CPLEAR

We use fits to recent published CPLEAR data on neutral kaon decays to $\pi^+\pi^-$ and $\pi e\nu$ to constrain the CPT--violation parameters appearing in a formulation of the neutral kaon system as an open quantum-mechanical system. The obtained upper limits of the CPT--violation parameters are approaching the range suggested by certain ideas concerning quantum gravity.Comment: 9 pages of uuencoded postscript (includes 3 figures

On the absence of molecular absorption in high redshift millimetre-band searches

We have undertaken a search for millimetre-wave band absorption (through the CO and HCO+ rotational transitions) in the host galaxies of reddened radio sources (z = 0.405-1.802). Despite the colour selection (optical-near infrared colours of V - K > 5 in all but one source), no absorption was found in any of the eight quasars for which the background continuum flux was detected. On the basis of the previous (mostly intervening) H2 and OH detections, the limits reached here and in some previous surveys should be deep enough to detect molecular absorption according to their V - K colours. However, our survey makes the assumption that the reddening is associated with dust close to the emission redshift of the quasar and that the narrow millimetre component of this emission is intercepted by the compact molecular cores. By using the known millimetre absorbers to define the colour depth and comparing this with the ultra-violet luminosities of the sources, we find that, even if these assumptions are valid, only twelve of the forty objects (mainly from this work) are potentially detectable. This is assuming an excitation temperature of 10 K at z=0, with the number decreasing with increasing temperatures (to zero detectable at 100 K).Comment: 11 pages accepted by MNRA