VLTI observations of the dust geometry around R Coronae Borealis stars

We are investigating the formation and evolution of dust around the hydrogen-deficient supergiants known as R Coronae Borealis (RCB) stars. We aim to determine the connection between the probable merger past of these stars and their current dust-production activities. We carried out high-angular resolution interferometric observations of three RCB stars, namely RY Sgr, V CrA, and V854 Cen with the mid-IR interferometer, MIDI on the VLTI, using two telescope pairs. The baselines ranged from 30 to 60 m, allowing us to probe the dusty environment at very small spatial scales (~ 50 mas or 400 stellar radii). The observations of the RCB star dust environments were interpreted using both geometrical models and one-dimensional radiative transfer codes. From our analysis we find that asymmetric circumstellar material is apparent in RY Sgr, may also exist in V CrA, and is possible for V854 Cen. Overall, we find that our observations are consistent with dust forming in clumps ejected randomly around the RCB star so that over time they create a spherically symmetric distribution of dust. However, we conclude that the determination of whether there is a preferred plane of dust ejection must wait until a time series of observations are obtained.Comment: Accepted for publication in MNRAS; 14 pages, 10 figures, 6 table

Is there appropriate weight given to the Abrahamic religious beliefs of patients and healthcare professionals in English Medical Law?

Is the legal protection that is given to the expression of Abrahamic religious belief adequate or appropriate in the context of English medical law? This is the central question that is explored in the thesis. A framework to support judges in the resolution of contentious cases that involve dissension between religious belief and medical law is developed from Alan Gewirth’s Principle of Generic Consistency (PGC). This framework is applied to a number of medical law cases studies: the principle of double effect, ritual male circumcision, female genital mutilation, Jehovah’s Witnesses (adults and children) who refuse blood transfusions, and conscientious objection of healthcare professionals to abortion. The thesis also examines the legal and religious contexts in which these contentious cases are arbitrated. It demonstrates how human rights law and the proposed framework can provide a gauge to measure competing rights and apply legitimate limits to the expression of religious belief, where appropriate. Thus, the original and significant contribution to knowledge is the development of an evaluative framework and its application to distinct case studies. This leads to the conclusion, based upon a stance of principled pragmatism, that some aspects of current legal protections in English medical law require amendment

The solar eclipse: a natural meteorological experiment

A solar eclipse provides a well-characterised reduction in solar radiation, of calculable amount and duration. This captivating natural astronomical phenomenon is ideally suited to science outreach activities, but the predictability of the change in solar radiation also provides unusual conditions for assessing the atmospheric response to a known stimulus. Modern automatic observing networks used for weather forecasting and atmospheric research have dense spatial coverage, so the quantitative meteorological responses to an eclipse can now be evaluated with excellent space and time resolution. Numerical models representing the atmosphere at high spatial resolution can also be used to predict eclipse related changes and interpret the observations. Combining the models with measurements yields the elements of a controlled atmospheric experiment on a regional scale (10 to 1000 km), which is almost impossible to achieve by other means. This modern approach to “eclipse meteorology” as identified here can ultimately improve weather-prediction models and be used to plan for transient reductions in renewable electricity generation. During the 20th March 2015 eclipse, UK electrical energy demand increased by about 3 GWh (11 TJ) or about 4%, alongside reductions in the wind and photovoltaic electrical energy generation of 1.5 GWh (5.5TJ)

SwSt 1: an O-rich planetary nebula around a C-rich central star

The hydrogen-deficient carbon-rich [WCL] type central star HD167362 and its oxygen-rich planetary nebula (PN) SwSt~1 are investigated. The nebular chemistry might indicate a recent origin for the carbon-rich stellar spectrum. Its stellar and nebular properties might therefore provide further understanding of the origin of the [WCL] central star class. The UV-IR stellar spectra are modelled with state of the codes and show ~40kK central star with a wind and a C/O~3, indicative of efficient third dredge-up. The synthetic stellar flux distribution is used to model the high density, compact PN, which has a solar C/O ratio, is still enshrouded by 1200K and 230K dust shells and, reported here for the first time, in molecular hydrogen. Although it appears that the change in C/O ratio has been recent, the published spectroscopy since 1895 has been re-examined and no clear spectral change is seen. If an event occurred that has turned it into a hydrogen-deficient central star, it did not happen in the last 100 years.Comment: 31 pages, 19 figures (some are gif files), MNRAS in pres

The Fabry disease-associated lipid Lyso-Gb3 enhances voltage-gated calcium currents in sensory neurons and causes pain

Fabry disease is an X-linked lysosomal storage disorder characterised by accumulation of glycosphingolipids, and accompanied by clinical manifestations, such as cardiac disorders, renal failure, pain and peripheral neuropathy. Globotriaosylsphingosine (lyso-Gb3), a deacylated form of globotriaosylceramide (Gb3), has emerged as a marker of Fabry disease. We investigated the link between Gb3, lyso-Gb3 and pain. Plantar administration of lyso-Gb3 or Gb3 caused mechanical allodynia in healthy mice. In vitro application of 100nM lyso-Gb3 caused uptake of extracellular calcium in 10% of sensory neurons expressing nociceptor markers, rising to 40% of neurons at 1μM, a concentration that may occur in Fabry disease patients. Peak current densities of voltage-dependent Ca(2+) channels were substantially enhanced by application of 1μM lyso-Gb3. These studies suggest a direct role for lyso-Gb3 in the sensitisation of peripheral nociceptive neurons that may provide an opportunity for therapeutic intervention in the treatment of Fabry disease-associated pain

A dense disk of dust around the born-again Sakurai's object

In 1996, Sakurai's object (V4334 Sgr) suddenly brightened in the centre of a faint Planetary Nebula (PN). This very rare event was interpreted as the reignition of a hot white dwarf that caused a rapid evolution back to the cool giant phase. From 1998 on, a copious amount of dust has formed continuously, screening out the star which has remained embedded in this expanding high optical depth envelope. The new observations, reported here, are used to study the morphology of the circumstellar dust in order to investigate the hypothesis that Sakurai's Object is surrounded by a thick spherical envelope of dust. We have obtained unprecedented, high-angular resolution spectro-interferometric observations, taken with the mid-IR interferometer MIDI/VLTI, which resolve the dust envelope of Sakurai's object. We report the discovery of a unexpectedly compact (30 x 40 milliarcsec, 105 x 140 AU assuming a distance of 3.5 kpc), highly inclined, dust disk. We used Monte Carlo radiative-transfer simulations of a stratified disk to constrain its geometric and physical parameters, although such a model is only a rough approximation of the rapidly evolving dust structure. Even though the fits are not fully satisfactory, some useful and robust constraints can be inferred. The disk inclination is estimated to be 75+/-3 degree with a large scale height of 47+/-7 AU. The dust mass of the disk is estimated to be 6 10^{-5} solar mass. The major axis of the disk (132+/-3 degree) is aligned with an asymmetry seen in the old PN that was re-investigated as part of this study. This implies that the mechanism responsible for shaping the dust envelope surrounding Sakurai's object was already at work when the old PN formed.Comment: A&A Letter, accepte

Stochastic analysis of global traveltime data: mantle heterogeneity and random errors in the ISC data

Analysis of global traveltime data has been formulated in terms of the stochastic properties of the Earth's heterogeneity pattern and random errors in the data. The formalism relates the coherency of traveltime residuals within bundles of rays (summary rays) of varying size to the spherical harmonic power spectrum of the slowness field of the medium. It has been applied to mantle P-wave data from the ISC catalogue. The measure of coherency is the variance within summary rays. It is estimated within bins in source depth, epicentral distance and the scale size of the area defining a summary ray. The variance at infinitesimal scale length represents the incoherent component of the data (random errors). The variation of the variance with scale length contains information about the autocorrelation function or power spectrum of slowness perturbations within the Earth. The variation with epicentral distance reflects the depth variation of the spectrum. The formalism accounts for the uneven distribution (clustering) of stations and events. We find that estimates of random errors correlate well with complexities on the traveltime curve of P-waves. The variance peaks at 1.0–2.0 s^2 at Δ ≈ 20°, where triplications occur on the traveltime curve, drops to 0.15–0.8s^2 at teleseismic distances, and rises to 0.4–1.3 s^2 approaching the core shadow, where the traveltime curves of P-waves and PcP-waves merge. These estimates should be considered upper bounds for the random error variance of the data. The signal to random noise ratio in the teleseismic ISC P-wave data is about S/N ≈ 2. Inversion of the scale-dependent structural signal in the data yields models that concentrate heterogeneity strongly in the upper mantle. The product of correlation length and power drops by about two orders of magnitude from the surface of the Earth to the lower mantle. About half of this quantity in the upper mantle is due to small-scale features (<300km). The lower mantle is devoid of small-scale structure. It contains 0.1 per cent velocity variations at a characteristic scale of about 1000km. This corresponds to a spectral band-width of l ≈ 7. The D″ layer at the bottom 100–200 km of the mantle shows up as a distinct layer in our results. It has 0.3 per cent velocity variations at a characteristic scale of 350km. The top of the lower mantle contains 0.3 per cent velocity variations on a scale of 500km and also contains some small-scale power. These results are compatible with previous deterministic lower mantle studies, although some details differ. The strength of heterogeneity in the upper mantle may obscure attempts to model the Earth's deep interior

Molecular epidemiology of human rhinovirus infections in Kilifi, coastal Kenya

This study reports pediatric surveillance over 3 years for human rhinovirus (HRV) at the District Hospital of Kilifi, coastal Kenya. Nasopharyngeal samples were collected from children presenting at outpatient clinic with no signs of acute respiratory infection, or with signs of upper respiratory tract infection, and from children admitted to the hospital with lower respiratory tract infection. Samples were screened by real-time reverse transcriptase polymerase chain reaction (real-time RT-PCR) and classified further to species by nucleotide sequencing of the VP4/VP2 junction. Of 441 HRV positives by real-time RT-PCR, 332 were classified to species, with 47% (155) being HRV-A, 5% (18) HRV-B, and 48% (159) HRV-C. There was no clear seasonal pattern of occurrence for any species. The species were present in similar proportions in the inpatient and outpatient sample sets, and no significant association between species distribution and the severity of lower respiratory tract infection in the inpatients could be determined. HRV sequence analysis revealed multiple but separate clusters in circulation particularly for HRV-A and HRV-C. Most HRV-C clusters were distinct from reference sequences downloaded from GenBank. In contrast, most HRV-A and HRV-B sequences clustered with either known serotypes or strains from elsewhere within Africa and other regions of the world. This first molecular epidemiological study of HRV in the region defines species distribution in accord with reports from elsewhere in the world, shows considerable strain diversity and does not identify an association between any species and disease severity

Targeted Manipulation of Abundant and Rare Taxa in the Daphnia magna Microbiota with Antibiotics Impacts Host Fitness Differentially

Host-associated microbes contribute to host fitness, but it is unclear whether these contributions are from rare keystone taxa, numerically abundant taxa, or interactions among community members. Experimental perturbation of the microbiota can highlight functionally important taxa; however, this approach is primarily applied in systems with complex communities where the perturbation affects hundreds of taxa, making it difficult to pinpoint contributions of key community members. Here, we use the ecological model organism Daphnia magna to examine the importance of rare and abundant taxa by perturbing its relatively simple microbiota with targeted antibiotics. We used sublethal antibiotic doses to target either rare or abundant members across two temperatures and then measured key host life history metrics and shifts in microbial community composition. We find that removal of abundant taxa had greater impacts on host fitness than did removal of rare taxa and that the abundances of nontarget taxa were impacted by antibiotic treatment, suggesting that no rare keystone taxa exist in the Daphnia magna microbiota but that microbe-microbe interactions may play a role in host fitness. We also find that microbial community composition was impacted by antibiotics differently across temperatures, indicating that ecological context shapes within-host microbial responses and effects on host fitness