Miraculous Prints in Early-Modern Emilia-Romagna

This doctoral thesis focuses on a selection of rare Italian early-modern prints from Emilia-Romagna which are believed to be miraculous images and have functioned as local cult objects since the sixteenth and seventeenth centuries. By analysing these prints and the circumstances of their veneration, the thesis attempts to shed light on the impact that prints had within the context of miraculous imagery. While the use of prints in the dispersion of cult images is well-known, less attention has been paid to prints that became miraculous images in their own right. By analysing prints within the broader category of miraculous imagery produced in more permanent media, my research examines relatively neglected but crucially important aspects of the print medium, thus contributing a new chapter to the history of printmaking as well as to the discussion of miraculous imagery

Estrés laboral y estado de ánimo en colaboradores de una institución educativa privada de Ica 2021

Objetivo: Determinar la relación entre estrés laboral y estado de ánimo en colaboradores de una institución educativa privada de Ica, 2021. Metodología: observacional, prospectiva, descriptiva-correlacional, en 50 colaboradores. Instrumento: cuestionario de estrés laboral con 7 dimensiones y 25 items validado por OIT-OMS, Alfa de Cronbach 0.97 y cuestionario de estado de ánimo EVEA con 16 items validado por Sanz, Alfa de Cronbach 0.92. Resultados: Existe relación entre estrés laboral y estado de ánimo en colaboradores de una institución educativa privada de Ica 2021, siendo el estrés laboral mayor en colaboradores con estado de ánimo Ira-hostilidad. El clima organizacional es mayor en colaboradores con estado de ánimo Ira-hostilidad. La estructura organizacional es mayor en colaboradores con estado de ánimo Ira-hostilidad. El territorio organizacional es mayor en colaboradores con estado de ánimo Ansioso, Tristeza-depresión. La tecnología es mayor en colaboradores con estado de ánimo Ansioso, Tristeza depresión. La influencia del líder es mayor en colaboradores con estado de ánimo Ira-hostilidad. La falta de cohesión es mayor en colaboradores con estado de ánimo Ira-hostilidad, Tristeza-depresión. El respaldo del grupo es mayor en colaboradores con estado de ánimo Ansioso, Tristeza-depresión. Conclusiones: El estado de ánimo se ve afectado por el estrés en diferentes medidas

Are rheumatoid factor, anti-citrullinated, and anti-carbamylated protein antibodies linked by post-translational modification of IgG?

This is the author accepted manuscript. The final version is available from the publisher via the DOI in this record.Accepted manuscript online: 2 August 2016No abstract is available.Support for this project was provided by the Cornwall Arthritis Trust

The global distribution of comorbid depression and anxiety in people with diabetes mellitus: risk-adjusted estimates

Background: Previous reports suffer from the problem that they simply pooled data using aggregate means or standard meta-analytic method. The aim of the current study was to re-estimate the point prevalence of comorbid depression and anxiety in people with diabetes. Methods: The estimates were calculated using recently introduced directly standardized effect estimate method, which gives corrected risk-adjusted estimates for the population of interests. Reported are global and regional burden of prevalence, presented as risk-adjusted prevalence estimates with 95% confidence intervals. Results: Globally, the burden of comorbid depression was higher than the burden of anxiety (23.36% vs. 17.58%) symptoms and/or disorder in people with diabetes. There was a higher burden of comorbid depression in people living in developing regions (26.32%), in women (15.41%), and when assessed by self-report scales (SRS) (22.66%). The burden of anxiety was higher in developed regions in people with Type 2 diabetes mellitus (20.15%) and when assessed by SRS (20.75%). No statistically significant differences were observed due to gross heterogeneity across countries. Conclusions: There are wide-ranging differences in studies in developed and developing regions, regarding the burden of comorbid depression and of anxiety among people with diabetes and both conditions affect approximately a fifth of the diabetic population

Long term impact of the WHI studies on information-seeking and decision-making in menopause symptoms management: a longitudinal analysis of questions to a medicines call centre

Abstract Background While women are taking a greater role in decisions about menopause symptom management, the legacy of the Women’s Health Initiative (WHI) studies persist. Despite hormone therapy (HT) being effective in reducing all-cause mortality, many women seeking relief of menopausal symptoms exaggerate HT harms and overstate the perceived benefits or ignore the risks of alternative therapies. We aimed to explore the longitudinal impact of the widely-publicised WHI 2002 study on women’s information-seeking and describe determinants of decision-making about managing menopausal symptoms. Methods In a longitudinal analysis of both quantitative and qualitative data, we explored consumer questions about menopause-related medicines received by two Australian medicines call centres (1996–2010) before, during, and after WHI 2002. We analysed calls by age and gender of caller and patient, their relationship, postcode, enquiry type, and motivation to help-seek. We compared calls regarding HT and herbal medicines (HM) with the rest of calls, and thematically analysed question narratives across the three time-periods. Results There were 1,829 menopause-related calls received of over this time-period, with a call surge, primarily from women in their mid-fifties, in the two months after the WHI 2002 publication. Two in three calls were motivated by negative media reports as women sought support for decision-making, primarily reassurance to cease HT. While HT safety concerns persisted for eight years post-publication, the nature of information-seeking changed over time. Callers subsequently sought reassurance to use menopause treatments together with their other medicines; and pursued HT substitutes, including HM, in response to HT product discontinuation. Conclusions Women sought information or reassurance to support a decision, based on dynamic changes in internal (symptom or risk intolerance, attitude towards menopause and treatment preferences) and external factors (perceived source trust and changes in treatment availability). In assessing HT benefit versus risk, women tend to overestimate risk with HT safety concerns persisting over time. Decision-making in managing menopause symptoms is complex and dynamic. Reassurance to reach or justify decisions from a perceived trusted source can support informed decision-making

Regulation of translation is required for dendritic cell function and survival during activation

In response to inflammatory stimulation, dendritic cells (DCs) have a remarkable pattern of differentiation (maturation) that exhibits specific mechanisms to control antigen processing and presentation. Here, we show that in response to lipopolysaccharides, protein synthesis is rapidly enhanced in DCs. This enhancement occurs via a PI3K-dependent signaling pathway and is key for DC activation. In addition, we show that later on, in a manner similar to viral or apoptotic stress, DC activation leads to the phosphorylation and proteolysis of important translation initiation factors, thus inhibiting cap-dependent translation. This inhibition correlates with major changes in the origin of the peptides presented by MHC class I and the ability of mature DCs to prevent cell death. Our observations have important implications in linking translation regulation with DC function and survival during the immune response

Gestión por procesos para mejorar los tiempos del proceso de ventas en una inmobiliaria del Dpto. de Ica

La investigación tuvo como objetivo implementar la gestión por procesos para mejorar los tiempos del proceso de ventas en una inmobiliaria en el dpto. de Ica; desarrollándose en el área de marketing y ventas. La empresa pertenece al sector inmobiliario, el cual se encarga de adquirir amplios terrenos para acondicionarlo y urbanizarlo para su venta por lotes. Su desarrollo tiene un enfoque cuantitativo, tipo aplicada, de nivel explicativo y diseño cuasi experimental; donde se recolectó datos a través del análisis documental y el registro de contenido. Asimismo, para la evaluación pre, aplicación y posevaluación, se consideró el periodo comprendido entre el mes de marzo a setiembre del 2023. La teoría aplicada es la mejora de procesos el cual comprende la gestión de los mismos, donde se utilizaron las herramientas: Control de Tiempos, Políticas y procedimientos de ventas y estrategias de gestión. La mejora de procesos permitió realizar un reconocimiento de los procesos de la empresa, de manera que se pudieron seleccionar los procesos claves y que tienen participación directa con el proceso de ventas a los clientes. Además, se pudo identificar a los responsables de estos procesos, facilitándose la revisión y análisis de los tres procesos involucrados. En relación a los logros obtenidos por la aplicación de la teoría, se logró reducir en un 95.5% el tiempo de captación de un cliente, un 70.32% en el tiempo para concretar una venta y un 81.5% en el tiempo de atención postventa, donde se reconoce el compromiso de los trabajadores de la inmobiliaria quienes formaron parte de la solución

Treatment of diabetes in Malaysia and Australia

Background Once a disease of developed countries, type 2 diabetes mellitus (T2DM) has become widespread worldwide. For people with T2DM, achievement of therapeutic outcomes demands the rational and quality use of medicine. Aims The primary aim of this study was to examine the prevalence of diabetes and prescribing patterns of anti-diabetic medications in Australia and Malaysia. Methods The most recent, publicly available, statistical reports (2004–2008) on the use of medicines published in Australia and in Malaysia were evaluated. Defined daily doses (DDDs/1,000 population/day) were derived from the reports and used to rank and compare individual drug use. Results There was an increasing trend in the prevalence of diabetes in Australia, although there is a greater predicted increase in prevalence for Malaysia. While drugs used for the treatment of diabetes were not the most highly used drugs in Australia, their use increased during the study period, from 42.64 to 48.61 DDD/1,000/day. Anti-diabetic drugs were the most frequently dispensed class of drugs in Malaysia. Although the total consumption of anti-diabetic drugs in Malaysia decreased between 2006 and 2007 (from 40.30 to 39.72), this was followed by a marked increase to 46.69 in 2008. There was a marked reduction in the dispensing of insulin in Malaysia from 2004 to 2007 (7.77 to 3.23). Conclusion The use of drugs to treat diabetes does not reflect the usage patterns of found in Australia. Effective drug use reviews are required to ensure impartial access in middle- and low-income countries

Histological Chages of Testis and Caput Epididymis in the Goat after Cannulation of the Rete Testis

雄ヤギ5頭を用い, 精巣網カテーテル装着手術後の精巣および精巣上体頭の組織構造を観察するとともに精巣静脈血中のテストステロン濃度を調べた。カテーテル装着手術後の精巣は, いずれも萎縮し, 正常な精子形成過程が観察される精細管は少なかった。また, ライディヒ細胞の形態や染色性には異常は認められなかった。一方, 精巣上体頭では, 精巣上体管が萎縮し, 主細胞の高さは無傷のものよりも有意に減少した。同様の組織構造の変化は, 精巣輸出管を切除した場合の精巣および精巣上体頭でも認められた。精巣静脈血中のテストステロン濃度は無傷の場合94.4ng/mlであり, カテーテル装着手術後では86.5∿342.8ng/mlであった。 / The testis and caput epididymis of the goat after cannulation of the rete testis or efferentiectomy were examined histologically. The concentration of testosterone in testicular venous blood collected from the same animals was also measured by radioimmunoassay. After cannulation, seminiferous tubules showed a sign of degeneration, although no morphological change of Leydig cells was observed. Epididymal ducts were severely atrophied and the height of principal epithelial cells was significantly decreased. A similar damage was observed in the testis and epididymis after efferentiectomy. When the efferent duct bundle had been incompletely ligated at cannulation, or rete testis catheter was kept in place until sampling time, damages in the testis were less severe. And in the former case the epididymis was impaired less severely. The concentration of testosterone in testicular venous blood collected from an intact animal was 94.4ng/ml, while that obtained after cannulation was 86.5-342.8ng/ml. These results suggest that degeneration of germ cells in seminiferous tubules observed after cannulation of the rete testis or efferentiectomy may be caused by stagnation of rete testicular fluid in the tubules, and that testosterone in the fluid plays important roles in the maintenance of morphology and function of the principal cells in the caput epididymis

Ribosomal protein mRNAs are translationally-regulated during human dendritic cells activation by LPS

International audienceBACKGROUND: Dendritic cells (DCs) are the sentinels of the mammalian immune system, characterized by a complex maturation process driven by pathogen detection. Although multiple studies have described the analysis of activated DCs by transcriptional profiling, recent findings indicate that mRNAs are also regulated at the translational level. A systematic analysis of the mRNAs being translationally regulated at various stages of DC activation was performed using translational profiling, which combines sucrose gradient fractionation of polysomal-bound mRNAs with DNA microarray analysis. RESULTS: Total and polysomal-bound mRNA populations purified from immature, 4 h and 16 h LPS-stimulated human monocyte-derived DCs were analyzed on Affymetrix microarrays U133 2.0. A group of 375 transcripts was identified as translationally regulated during DC-activation. In addition to several biochemical pathways related to immunity, the most statistically relevant biological function identified among the translationally regulated mRNAs was protein biosynthesis itself. We singled-out a cluster of 11 large ribosome proteins mRNAs, which are disengaged from polysomes at late time of maturation, suggesting the existence of a negative feedback loop regulating translation in DCs and linking ribosomal proteins to immuno-modulatory function. CONCLUSION: Our observations highlight the importance of translation regulation during the immune response, and may favor the identification of novel protein networks relevant for immunity. Our study also provides information on the potential absence of correlation between gene expression and protein production for specific mRNA molecules present in DCs