207 research outputs found
An integrated structural and magnetic fabric study to constrain the progressive extensional tectonics of the Rio do Peixe Basin, Brazil
We constrained the tectonic evolution of the intracratonic Cretaceous Rio do Peixe Basin (RPB) in NE Brazil, combining structural and Anisotropy of Magnetic Susceptibility (AMS) data. We analyzed the structural features of four sites along two major faults bordering the basin, the NE-striking Portalegre Fault and the E-W-striking Malta Fault. AMS data from 42 sites in the syn-rift sandstone suggest two stretching directions driving the opening of the RPB. The early syn-rift phase I resulted from N-S to NNE-SSW stretching direction with vertical sigma 1, producing normal fault displacement along the E-W-striking Malta Fault and right-lateral transtension along the NE-striking Portalegre Fault, Sitio Sagui and Lagoa do Forno faults. The syn-rift phase II resulted from NW-SE stretching direction with vertical sigma 1, causing normal displacement on NE-striking major faults and left-lateral transtension on E-W-striking major faults. Additionally, the NW-SE extension was responsible for forming NE-striking extensional faults and deformation bands in sedimentary units. The RPB developed due to the intraplate deformation of the Borborema Province during the early stage of the Pangea Breakup and recorded two stretching directions that gradually shifted from NNE-SSW to NW-SE as a consequence of the South America clockwise rotation. The extensional stress orthogonal to the main E-W-striking and NE-striking Precambrian shear zones facilitated the opening and evolution of the RPB
WRF Simulations of the 20-22 January 2007 Snow Events over Eastern Canada: Comparison with In-Situ and Satellite Observations
One of the grand challenges of the Global Precipitation Measurement (GPM) mission is to improve cold season precipitation measurements in middle and high latitudes through the use of high-frequency passive microwave radiometry. For this, the Weather Research and Forecasting (WRF) model with the Goddard microphysics scheme is coupled with a satellite data simulation unit (WRF-SDSU) that has been developed to facilitate over-land snowfall retrieval algorithms by providing a virtual cloud library and microwave brightness temperature (Tb) measurements consistent with the GPM Microwave Imager (GMI). This study tested the Goddard cloud microphysics scheme in WRF for two snowstorm events, a lake effect and a synoptic event, that occurred between 20 and 22 January 2007 over the Canadian CloudSAT/CALIPSO Validation Project (C3VP) site in Ontario, Canada. The 24h-accumulated snowfall predicted by the WRF model with the Goddard microphysics was comparable to the observed accumulated snowfall by the ground-based radar for both events. The model correctly predicted the onset and ending of both snow events at the CARE site. WRF simulations capture the basic cloud properties as seen by the ground-based radar and satellite (i.e., CloudSAT, AMSU-B) observations as well as the observed cloud streak organization in the lake event. This latter result reveals that WRF was able to capture the cloud macro-structure reasonably well
HL-1 cells express an inwardly rectifying K+ current activated via muscarinic receptors comparable to that in mouse atrial myocytes
An inwardly rectifying K^+ current is present in atrial cardiac myocytes that is activated by acetylcholine (I_{KACh}). Physiologically, activation of the current in the SA node is important in slowing the heart rate with increased parasympathetic tone. It is a paradigm for the direct regulation of signaling effectors by the GÎČÎł G-protein subunit. Many questions have been addressed in heterologous expression systems with less focus on the behaviour in native myocytes partly because of the technical difficulties in undertaking comparable studies in native cells. In this study, we characterise a potassium current in the atrial-derived cell line HL-1. Using an electrophysiological approach, we compare the characteristics of the potassium current with those in native atrial cells and in a HEK cell line expressing the cloned Kir3.1/3.4 channel. The potassium current recorded in HL-1 is inwardly rectifying and activated by the muscarinic agonist carbachol. Carbachol-activated currents were inhibited by pertussis toxin and tertiapin-Q. The basal current was time-dependently increased when GTP was substituted in the patch-clamp pipette by the non-hydrolysable analogue GTPÎłS. We compared the kinetics of current modulation in HL-1 with those of freshly isolated atrial mouse cardiomyocytes. The current activation and deactivation kinetics in HL-1 cells are comparable to those measured in atrial cardiomyocytes. Using immunofluorescence, we found GIRK4 at the membrane in HL-1 cells. Real-time RT-PCR confirms the presence of mRNA for the main G-protein subunits, as well as for M2 muscarinic and A1 adenosine receptors. The data suggest HL-1 cells are a good model to study IKAch
Application of a Key Events Dose-Response Analysis to Nutrients: A Case Study with Vitamin A (Retinol)
The methodology used to establish tolerable upper intake levels (UL) for nutrients borrows heavily from risk assessment methods used by toxicologists. Empirical data are used to identify intake levels associated with adverse effects, and Uncertainty Factors (UF) are applied to establish ULs, which in turn inform public health decisions and standards. Use of UFs reflects lack of knowledge regarding the biological events that underlie response to the intake of a given nutrient, and also regarding the sources of variability in that response. In this paper, the Key Events Dose-Response Framework (KEDRF) is used to systematically consider the major biological steps that lead from the intake of the preformed vitamin A to excess systemic levels, and subsequently to increased risk of adverse effects. Each step is examined with regard to factors that influence whether there is progression toward the adverse effect of concern. The role of homeostatic mechanisms is discussed, along with the types of research needed to improve understanding of dose-response for vitamin A. This initial analysis illustrates the potential of the KEDRF as a useful analytical tool for integrating current knowledge regarding dose-response, generating questions that will focus future research efforts, and clarifying how improved knowledge and data could be used to reduce reliance on UFs
Hygienisation, gentrification, and urban displacement in Brazil
This article engages recent debates over gentrification and urban displacement in the global South. While researchers increasingly suggest that gentrification is becoming widespread in âSouthernâ cities, others argue that such analyses overlook important differences in empirical context and privilege EuroAmerican theoretical frameworks. To respond to this debate, in this article, we outline the concept of higienização (hygienisation), arguing that it captures important contextual factors missed by gentrification. Hygienisation is a Brazilian term that describes a particular form of urban displacement, and is directly informed by legacies of colonialism, racial and class stigma, informality, and state violence. Our objective is to show how âSouthernâ concepts like hygienisation help urban researchers gain better insight into processes of urban displacement, while also responding to recent calls to decentre and provincialise urban theory
Deep time diversity of metatherian mammals: Implications for evolutionary history and fossil-record quality
Despite a global fossil record, Metatheria are now largely restricted to Australasia and South America. Most metatherian paleodiversity studies to date are limited to particular subclades, time intervals, and/or regions, and few consider uneven sampling. Here, we present a comprehensive new data set on metatherian fossil occurrences (Barremian to end Pliocene). These data are analyzed using standard rarefaction and shareholder quorum subsampling (including a new protocol for handling LagerstĂ€tte-like localities). Global metatherian diversity was lowest during the Cretaceous, and increased sharply in the Paleocene, when the South American record begins. Global and South American diversity rose in the early Eocene then fell in the late Eocene, in contrast to the North American pattern. In the Oligocene, diversity declined in the Americas, but this was more than offset by Oligocene radiations in Australia. Diversity continued to decrease in Laurasia, with final representatives in North America (excluding the later entry of Didelphis virginiana) and Europe in the early Miocene, and Asia in the middle Miocene. Global metatherian diversity appears to have peaked in the early Miocene, especially in Australia. Following a trough in the late Miocene, the Pliocene saw another increase in global diversity. By this time, metatherian biogeographic distribution had essentially contracted to that of today. Comparison of the raw and sampling-corrected diversity estimates, coupled with evaluation of "coverage" and number of prolific sites, demonstrates that the metatherian fossil record is spatially and temporally extremely patchy. Therefore, assessments of macroevolutionary patterns based on the raw fossil record (as in most previous studies) are inadvisable.Fil: Bennett, C. Verity. University College London; Estados UnidosFil: Upchurch, Paul. University College London; Estados UnidosFil: Goin, Francisco Javier. Universidad Nacional de La Plata. Facultad de Ciencias Naturales y Museo. DivisiĂłn PaleontologĂa Vertebrados; Argentina. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas; ArgentinaFil: Goswami, Anjadi. University College London; Estados Unido
Exceptional skull of huayqueriana (mammalia, litopterna, macraucheniidae) from the late miocene of Argentina: Anatomy, systematics, and peleobiological implications
The HuayquerĂas Formation (Late Miocene, Huayquerian SALMA) is broadly exposed in westcentral Argentina (Mendoza). The target of several major paleontological expeditions in the first half of the 20th century, the Mendozan HuayquerĂas (badlands) have recently yielded a significant number of new fossil finds. In this contribution we describe a complete skull (IANIGLA-PV 29) and place it systematically as Huayqueriana cf. H. cristata (Rovereto, 1914) (Litopterna, Macraucheniidae). The specimen shares some nonexclusive features with H. cristata (similar size, rostral border of the orbit almost level with distal border of M3, convergence of maxillary bones at the level of the P3/P4 embrasure, flat snout, very protruding orbits, round outline of premaxillary area in palatal view, and small diastemata between I3/C and C/P1). Other differences (e.g., lack of sagittal crest) may or may not represent intraspecific variation. In addition to other features described here, endocast reconstruction utilizing computer tomography (CT) revealed the presence of a derived position of the orbitotemporal canal running below the rhinal fissure along the lateroventral aspect of the piriform lobe. CT scanning also established that the maxillary nerve (CN V2) leaves the skull through the sphenoorbital fissure, as in all other litopterns, a point previously contested for macraucheniids. The angle between the lateral semicircular canal and the plane of the base of the skull is about 26°, indicating that in life the head was oriented much as in modern horses. Depending on the variables used, estimates of the body mass of IANIGLA-PV 29 produced somewhat conflicting results. Our preferred body mass estimate is 250 kg, based on the centroid size of 36 3D cranial landmarks and accompanying low prediction error. The advanced degree of tooth wear in IANIGLA-PV 29 implies that the individual died well into old age. However, a count of cementum lines on the sectioned left M2 is consistent with an age at death of 10 or 11 years, younger than expected given its body mass. This suggests that the animal had a very abrasive diet. Phylogenetic analysis failed to resolve the position of IANIGLA-PV 29 satisfactorily, a result possibly influenced by intraspecific variation. There is no decisive evidence for the proposition that Huayqueriana, or any other litoptern, were foregut fermenters.Fil: Forasiepi, Analia Marta. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Centro CientĂfico TecnolĂłgico Conicet - Mendoza. Instituto Argentino de NivologĂa, GlaciologĂa y Ciencias Ambientales. Provincia de Mendoza. Instituto Argentino de NivologĂa, GlaciologĂa y Ciencias Ambientales. Universidad Nacional de Cuyo. Instituto Argentino de NivologĂa, GlaciologĂa y Ciencias Ambientales; ArgentinaFil: MacPhee, Ross D. E.. American Museum Of Natural History; Estados UnidosFil: HernĂĄndez del Pino, Santiago Ezequiel. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Centro CientĂfico TecnolĂłgico Conicet - Mendoza. Instituto Argentino de NivologĂa, GlaciologĂa y Ciencias Ambientales. Provincia de Mendoza. Instituto Argentino de NivologĂa, GlaciologĂa y Ciencias Ambientales. Universidad Nacional de Cuyo. Instituto Argentino de NivologĂa, GlaciologĂa y Ciencias Ambientales; ArgentinaFil: Schmidt, Gabriela Ines. Provincia de Entre RĂos. Centro de Investigaciones CientĂficas y Transferencia de TecnologĂa a la ProducciĂłn. Universidad AutĂłnoma de Entre RĂos. Centro de Investigaciones CientĂficas y Transferencia de TecnologĂa a la ProducciĂłn. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Centro CientĂfico TecnolĂłgico Conicet - Santa Fe. Centro de Investigaciones CientĂficas y Transferencia de TecnologĂa a la ProducciĂłn; ArgentinaFil: Amson, Eli. Universitat Zurich; SuizaFil: GrohĂ©, Camille. American Museum Of Natural History; Estados Unido
Microphysical evidence of the transition between predominant convective/stratiform rainfall associated with the intraseasonal oscillation in the Southwest Amazon
Decrypting magnetic fabrics (AMS, AARM, AIRM) through the analysis of mineral shape fabrics and distribution anisotropy
The fieldwork was supported by the DIPS project (grant no. 240467) and the MIMES project (grant no. 244155) funded by the Norwegian Research Council awarded to O.G. O.P.'s position was funded from Y-TEC.Anisotropy of magnetic susceptibility (AMS) and anisotropy of magnetic remanence (AARM and AIRM) are efficient and versatile techniques to indirectly determine rock fabrics. Yet, deciphering the source of a magnetic fabric remains a crucial and challenging step, notably in the presence of ferrimagnetic phases. Here we use X-ray micro-computed tomography to directly compare mineral shape-preferred orientation and spatial distribution fabrics to AMS, AARM and AIRM fabrics from five hypabyssal trachyandesite samples. Magnetite grains in the trachyandesite are euhedral with a mean aspect ratio of 1.44 (0.24 s.d., long/short axis), and > 50% of the magnetite grains occur in clusters, and they are therefore prone to interact magnetically. Amphibole grains are prolate with magnetite in breakdown rims. We identified three components of the petrofabric that influence the AMS of the analyzed samples: the magnetite and the amphibole shape fabrics and the magnetite spatial distribution. Depending on their relative strength, orientation and shape, these three components interfere either constructively or destructively to produce the AMS fabric. If the three components are coaxial, the result is a relatively strongly anisotropic AMS fabric (Pâ = 1.079). If shape fabrics and/or magnetite distribution are non-coaxial, the resulting AMS is weakly anisotropic (Pâ = 1.012). This study thus reports quantitative petrofabric data that show the effect of magnetite distribution anisotropy on magnetic fabrics in igneous rocks, which has so far only been predicted by experimental and theoretical models. Our results have first-order implications for the interpretation of petrofabrics using magnetic methods.Publisher PDFPeer reviewe
The skull of Epidolops ameghinoi from the early Eocene ItaboraĂ fauna, southeastern Brazil, and the affinities of the extinct marsupialiform order Polydolopimorphia
The skull of the polydolopimorphian marsupialiform Epidolops ameghinoi is described
in detail for the first time, based on a single well-preserved cranium and associated left
and right dentaries plus additional craniodental fragments, all from the early Eocene
(53-50 million year old) ItaboraĂ fauna in southeastern Brazil. Notable craniodental
features of E. ameghinoi include absence of a masseteric process, very small
maxillopalatine fenestrae, a prominent pterygoid fossa enclosed laterally by a
prominent ectopterygoid crest, an absent or tiny transverse canal foramen, a simple,
planar glenoid fossa, and a postglenoid foramen that is immediately posterior to the
postglenoid process. Most strikingly, the floor of the hypotympanic sinus was
apparently unossified, a feature found in several stem marsupials but absent in all
known crown marsupials. "Type II" marsupialiform petrosals previously described from
ItaboraĂ plausibly belong to E. ameghinoi; in published phylogenetic analyses, these
petrosals fell outside (crown-clade) Marsupialia. "IMG VII" tarsals previously referred to
E. ameghinoi do not share obvious synapomorphies with any crown marsupial clade,
nor do they resemble those of the only other putative polydolopimorphians represented
by tarsal remains, namely the argyrolagids. Most studies have placed
Polydolopimorphia within Marsupialia, related to either Paucituberculata, or to
Microbiotheria and Diprotodontia. However, diprotodonty almost certainly evolved
independently in polydolopimorphians, paucituberculatans and diprotodontians, and
Epidolops does not share obvious synapomorphies with any marsupial order.
Epidolops is dentally specialized, but several morphological features appear to be
more plesiomorphic than any crown marsupial. It seems likely Epidolops that falls
outside Marsupialia, as do morphologically similar forms such as Bonapartherium and
polydolopids. Argyrolagids differ markedly in their known morphology from Epidolops
but share some potential apomorphies with paucituberculatans. It is proposed that
Polydolopimorphia as currently recognised is polyphyletic, and that argyrolagids (and
possibly other taxa currently included in Argyrolagoidea, such as groeberiids and
patagoniids) are members of Paucituberculata. This hypothesis is supported by
Bayesian non-clock phylogenetic analyses of a total evidence matrix comprising DNA
sequence data from five nuclear protein-coding genes, indels, retroposon insertions
and morphological characters: Epidolops falls outside Marsupialia, whereas
argyrolagids form a clade with the paucituberculatans Caenolestes and Palaeothentes,
regardless of whether the Type II petrosals and IMG VII tarsals are used to score
characters for Epidolops or not. There is no clear evidence for the presence of crown
marsupials at ItaboraĂ, and it is possible that the origin and early evolution of
Marsupialia was restricted to the "Austral Kingdom" (southern South America,
Antarctica, and Australia)
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