Roadmap to a Comprehensive Clinical Data Warehouse for Precision Medicine Applications in Oncology

Leading institutions throughout the country have established Precision Medicine programs to support personalized treatment of patients. A cornerstone for these programs is the establishment of enterprise-wide Clinical Data Warehouses. Working shoulder-to-shoulder, a team of physicians, systems biologists, engineers, and scientists at Rutgers Cancer Institute of New Jersey have designed, developed, and implemented the Warehouse with information originating from data sources, including Electronic Medical Records, Clinical Trial Management Systems, Tumor Registries, Biospecimen Repositories, Radiology and Pathology archives, and Next Generation Sequencing services. Innovative solutions were implemented to detect and extract unstructured clinical information that was embedded in paper/text documents, including synoptic pathology reports. Supporting important precision medicine use cases, the growing Warehouse enables physicians to systematically mine and review the molecular, genomic, image-based, and correlated clinical information of patient tumors individually or as part of large cohorts to identify changes and patterns that may influence treatment decisions and potential outcomes

A Node Location Method in Wireless Sensor Networks Based on a Hybrid Optimization Algorithm

Wireless sensor networks (WSN) have gradually integrated into the concept of the Internet of Things (IoT) and become one of the key technologies. This paper studies the optimization algorithm in the field of artificial intelligence (AI) and effectively solves the problem of node location in WSN. Specifically, we propose a hybrid algorithm WOA-QT based on the whale optimization (WOA) and the quasi-affine transformation evolutionary (QUATRE) algorithm. It skillfully combines the strengths of the two algorithms, not only retaining the WOA’s distinctive framework advantages but also having QUATRE’s excellent coevolution ability. In order to further save optimization time, an auxiliary strategy for dynamically shrinking the search space (DSS) is introduced in the algorithm. To ensure the fairness of the evaluation, this paper selects 30 different types of benchmark functions and conducts experiments from multiple angles. The experiment results demonstrate that the optimization quality and efficiency of WOA-QT are very prominent. We use the proposed algorithm to optimize the weighted centroid location (WCL) algorithm based on received signal strength indication (RSSI) and obtain satisfactory positioning accuracy. This reflects the high value of the algorithm in practical applications

Roadmap to a Comprehensive Clinical Data Warehouse for Precision Medicine Applications in Oncology

Leading institutions throughout the country have established Precision Medicine programs to support personalized treatment of patients. A cornerstone for these programs is the establishment of enterprise-wide Clinical Data Warehouses. Working shoulder-to-shoulder, a team of physicians, systems biologists, engineers, and scientists at Rutgers Cancer Institute of New Jersey have designed, developed, and implemented the Warehouse with information originating from data sources, including Electronic Medical Records, Clinical Trial Management Systems, Tumor Registries, Biospecimen Repositories, Radiology and Pathology archives, and Next Generation Sequencing services. Innovative solutions were implemented to detect and extract unstructured clinical information that was embedded in paper/text documents, including synoptic pathology reports. Supporting important precision medicine use cases, the growing Warehouse enables physicians to systematically mine and review the molecular, genomic, image-based, and correlated clinical information of patient tumors individually or as part of large cohorts to identify changes and patterns that may influence treatment decisions and potential outcomes

Anassociation study of TOLL and CARD with leprosy susceptibility in Chinese population

10.1093/hmg/ddt286Human Molecular Genetics22214430-4437HMGE

Identification of two new loci at IL23R and RAB32 that influence susceptibility to leprosy

10.1038/ng.973Nature Genetics43121247-1251NGEN