Tolerabilidad del resveratrol y efectos sobre parámetros bioquímicos sanguíneos

El resveratrol es un polifenol aislado de la uva al cual se le ha adjudicado actividad terapéutica antitumoral, incremento de longevidad, disminución de peso y protección cardiovascular. Se encuentra disponible como suplemento alimenticio y se vende sin prescripción médica. Evaluar la tolerabilidad de resveratrol, efectos adversos y efectos sobre pruebas de función hepática, renal y perfil de lípidos. Se administró resveratrol 500 mg, vía oral a 8 sujetos sanos durante 30 días y se realizó evaluación clínica, perfil bioquímico y de lípidos al inicio y final del estudio. No se observaron efectos adversos ni alteración en el perfil bioquímico ni de lípidos. El resveratrol fue bien tolerado, mostró ser seguro en dosis diarias de 500 mg, sin embargo se requieren estudios con mayor número de sujetos para confirmarl

Automatic Burst Detection in Solar Radio Spectrograms Using Deep Learning: deARCE Method

We present in detail an automatic radio-burst detection system, based on the AlexNet con- volutional neural network, for use with any kind of solar spectrogram. A full methodology for model training, performance evaluation, and feedback to the model generator has been developed with special emphasis on i) robustness tests against stochastic and overfitting ef- fects, ii) specific metrics adapted to the unbalanced nature of the solar-burst scenario, iii) tunable parameters for probability-threshold optimization, and iv) burst-coincidence cross match among e-Callisto stations and with external observatories (NOAA-SWPC). The re- sulting neural network configuration has been designed to accept data from observatories other than e-Callisto, either ground- or spacecraft-based. Typical False Negative and False Positive Scores in single-observatory mode are, respectively, in the 10 ? 16% and 6 ? 8% ranges, which improve further in cross-match mode. This mode includes new services ( deARCE , Xmatch ) allowing the end-user to check at a glance if a solar radio burst has taken place with a high level of confidence.Junta de Comunidades de Castilla La Mancha; European Unio

Global urban environmental change drives adaptation in white clover

Urbanization transforms environments in ways that alter biological evolution. We examined whether urban environmental change drives parallel evolution by sampling 110,019 white clover plants from 6169 populations in 160 cities globally. Plants were assayed for a Mendelian antiherbivore defense that also affects tolerance to abiotic stressors. Urban-rural gradients were associated with the evolution of clines in defense in 47% of cities throughout the world. Variation in the strength of clines was explained by environmental changes in drought stress and vegetation cover that varied among cities. Sequencing 2074 genomes from 26 cities revealed that the evolution of urban-rural clines was best explained by adaptive evolution, but the degree of parallel adaptation varied among cities. Our results demonstrate that urbanization leads to adaptation at a global scale

Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries

Abstract Background Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres. Methods This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and low–middle-income countries. Results In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of ‘single-use’ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for low–middle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia. Conclusion This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both high– and low–middle–income countries

Impact of climate change on sustainable management of gray whale (Eschrichtius robustus) populations: Whale-watching and conservation

Some pods of gray whales (Eschrichtius robustus) breed every winter at three lagoons along the Baja California Peninsula and then migrate to feeding grounds on the Bering and Chukchi Seas. The number of whales arriving to the lagoons fluctuates yearly and is related to climate variability. We analyzed the documented climate effects on the whales over their distribution range and discuss the potential effects of global climate warming in their breeding areas. Our analysis indicates that global warming will be favorable for gray whale populations, but unfavorable for the Mexican whale-watching industry: favorable, because fluctuations in calf production have been positively correlated with the length of time that the primary feeding habitat was free of seasonal ice during the previous year. However, if gray whales change their breeding areas to northern bays, they will be exposed to new challenges, which will have repercussions on the whale-watching industry. We discuss these new challenges

Validación de un procedimiento para la cuantificación de Simvastatina en plasma humano por LC-MS-MS

i) Introducción. La Simvastatina, miembro del grupo de las estatinas, es un fármaco de primera línea utilizado para disminuir los niveles de colesterol y para prevención riesgo cardiovascular, tanto primario como secundario ii) Objetivo. El objetivo de este trabajo fue el desarrollo y la validación de un procedimiento analítico para la cuantificación de Simvastatina en plasma humano en apego a la NOM-177-SSA1-2013 para su implementación en estudios de biodisponibilidad y/o bioequivalencia. iii) Metodología. Como procesamiento de muestra: 100 µL de Formato de amonio 0.1 M pH 4.5 se adicionan a 300 µL de plasma y se agitan, posteriormente se adicionan 400 µL de MTBE, las muestras se agitan en vortex y se centrifugan a 3,000 rpm. La fase acusa se congela una temperatura inferior a -20°C y la fase orgánica es decantada a un tubo de vidrio para evaporación a sequedad a 40°C bajo corriente de nitrógeno. El sobrenadante se recupera en 300 µL de Metanol y se transfiere a un vial. Para la separación cromatográfica se utiliza una columna Agilent Poroshell 120 C-18 SB 3.0x100 mm x 2.7 µm. y como eluente una mezcla (85/15 Formato de amonio 0.01M pH 4.5 % Vol) a un flujo de 0.65 mL/min. Para la medición se utiliza una fuente de Ionización por Electro Spray a Presión Atmosférica (ESI) modo Positivo, siendo monitoreados los iones 419.3 199.2 m/z. El tiempo de análisis fue de 2.7 minutos. iv) Resultados. El intervalo de trabajo validado fue de 0.38 ng/mL a 23.96 ng/mL. El coeficiente de correlación fue mayor a 0.995, la precisión y el % de error a condiciones de repetibidlidad y reproducibilidad a niveles de concentración bajo, medio y alto fueron menores a 15%. No se observaron interferencias en muestras lipémicas, o hemolizadas, así como con posibles fármacos concomitantes. v) Conclusiones Con base en los resultados anteriores, se considera que el método analítico cumple con los parámetros de validación establecidos en la Norma Oficial Mexicana y por lo tanto es confiable para el análisis de Simvatatina en plasma del presente estudio de Biodisponibilidad y/o bioequivalencia en voluntarios sanos

The relation between QRS complex fragmentation and segmental abnormalities of the myocardial contractility in patients with coronary artery disease

Background: Fragmented QRS (fQRS) is defined as any QRS complex with duration of less than 120 ms (ms) and at least one notch in the R or S wave in two or more leads belonging to the same coronary territory. The fQRS represents a delay in ventricular conduction caused by a myocardial scar associated to arrhythmic events. Methods: This is a descriptive, retrospective, cross-sectional study of a total of 123 patientsadmitted with ischemic heart disease. The aim was to correlate the presence of fQRS in a conventional 12-leads electrocardiogram (ECG) with myocardial regional motility disorders. Results: A total of 62% of the patients were male, the mean age was 63 ± 12 SD. fQRS was observed in 44% (64% men and 36% women), the most frequent location being the inferior wall (61%), followed by the anteroseptal and lateral walls (14% for both). Of the 36 patients with fQRS, 30 had segmental disorders, while 6 did not. Of the 45 patients without fQRS, 28 had segmental disorders, but 17 did not, which gives us a sensitivity of 52% (moderate SnNout) and specificity of 74% (high SpPin), with a positive predictive value of 83%, a negative predictive value of 38% and a prevalence of 72%. Conclusion: The presence of fQRS in the ECG has high specificity and a high positive predictive value of the existence of segmental myocardial motility disorders in patients with documented coronary artery disease

Fabrication of Multilayered Composite Nanofibers Using Continuous Chaotic Printing and Electrospinning: Chaotic Electrospinning

ChE is proposed for the creation of multi-material and multilayered nanostructures. This technology allows for the precise, continuous, and deterministic generation of internal nano-striations. The potential of ChE is shown through the fabrication of a nano-striated carbon electrode that shows a significant increase in capacitance. ChE has the potential of creating multifunctional architectures with enhanced properties for numerous applications.</p

Equidad e inclusividad en la educación superior en los países andinos : los casos de Bolivia, Chile, Colombia y Perú

El presente libro analiza y discute cómo han evolucionado los sistemas de educación superior en los países andinos (Bolivia, Chile, Colombia y Perú) en la última década y como las normativas, políticas, programas de acción y distintos instrumentos impulsados desde los gobiernos nacionales y desde las propias instituciones han facilitado o entrabado la consecución de sistemas más equitativos e inclusivos

Octubre y el derecho a la resistencia : revuelta popular y neoliberalismo autoritario en Ecuador

Entre defensivo y anticipatorio, el Paro Nacional repuso al pueblo en el campo político. La vía neoliberal, abierta sorpresivamente desde 2017, había conseguido asentar cierta idea del Estado austero como única forma de reparación social y ética ante los "excesos del dispendioso y corrupto gobierno populista" (sic.). En su progresiva implantación, sin embargo, la austeridad combinó el desfinanciamiento de sectores de provisión de servicios públicos masivos, política de precarización del trabajo y recurrentes exenciones tributarias para grandes grupos económicos. Dicho combo de políticas fue ratificado con el Decreto 883. Quienes comparten más o menos similares experiencias de injusticia o entornos de privación como efecto de tales políticas se encontraron en Octubre