141 research outputs found
Incidence and impact on prognosis of peri-procedural myocardial infarction in 2760 elective patients with stable angina pectoris in a historical prospective follow-up study
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2016
- Field of study
BACKGROUND: The clinical significance of myocardial infarction related to treatment with percutaneous coronary intervention (PCI) has been subject of great discussion. This subject has been studied for many years using different definitions of peri-procedural myocardial infarction and different biomarkers, the results have varied greatly depending on methods and time of the study. This study was to determine the incidence and prognostic significance of elevated cardiac biomarkers after elective PCI in patients with stable angina pectoris using the current cut-off set by the Third Universal Definition of Myocardial Infarction and current biomarkers. METHODS: We performed a historical prospective follow-up study of all patients with stable angina pectoris who underwent elective PCI at Aalborg University Hospital, Denmark from January 1(st) 2000 to December 31(st) 2012. We stratified patients according to peak post-PCI troponin T (cTnT) and Creatine Kinase MB mass (CK-MBmass). RESULTS: Follow-up for time to all-cause mortality was mean 5.8 years and total 15,891 years and mean 3.7 years and total 10,160 years for the combined endpoint of all-cause mortality and new onset heart failure. During the follow up period 399 of 2760 patients died (14.5 %) and 1095 (39.7 %) suffered the combined endpoint. Post-PCI concentration of cTnT and CK-MBmass was elevated above the defined cut-off in 419 patients (15.2 %) and 113 patients (4.1 %) respectively. There was no statistically significant difference between the groups in stratified analysis of the hazard rates by time regarding all-cause mortality for cTnT nor CK-MBmass. Regarding the combined endpoint the results were ambiguous. The results were unchanged in multivariable analyses that included age and gender. CONCLUSION: The incidence of elevated biomarkers after elective PCI in patients with stable angina pectoris using the defined cut-off (>5 x URL) was 15.2 % using cTnT and 4.1 % using CK-MBmass. The independent prognostic value for both cardiac biomarkers of any cut-off showed no statistical significance for all-cause mortality, whereas the combined endpoint (all-cause mortality or new-onset heart failure) were ambiguous in both short- and long-term follow-up
Differences in diagnostication, and revascularisation of ischaemic heart disease in Western Denmark
- Author
- Publication venue
- Publication date
- 17/01/2023
- Field of study
Complex geomorphologic assemblage of terrains in association with the banded terrain in Hellas basin, Mars
- Author
- Ahnert
- Albee
- Allen John
- Ansan
- Ansan
- Bandfield
- Bandfield
- Bandfield
- Berman
- Berman
- Bernhardt
- Bloem
- Bouhallier
- Cabrol
- Cabrol
- Carr
- Carr
- Carter
- Chardon
- Chojnacki
- Choukroune
- Choukroune
- Christensen
- Christensen
- Christensen
- Conway
- Crown
- De Hon
- Diot
- Edwards
- Ehlmann
- Ehlmann
- El-Maarry
- Encrenaz
- F. Schlunegger
- Fassett
- Fergason
- Fergason
- Forget
- Forsythe
- Giani
- Graf
- Grassi
- Grohmann
- Haberle
- Haberle
- Hall
- Head
- Head
- Heldmann
- Hon
- Howard
- Hubbard
- Hubbard
- Hudec
- K.P. Norton
- Kirk
- Kirk
- Lin
- Lowe
- M. Chojnacki
- M.R. El-Maarry
- Madeleine
- Malin
- Malin
- Mangold
- Mangold
- Martin
- Matsubara
- Matsuoka
- Maxwell
- McEwen
- McEwen
- Mellon
- Mest
- Mest
- Milliken
- Moore
- Moore
- Moura
- Murchie
- N. Thomas
- Nadin
- Ormö
- Osterloo
- Osterloo
- P.M. Grindrod
- Pappalardo
- Pierce
- Piqueux
- Plaut
- Putzig
- Rathbun
- Read
- Ruff
- Schenk
- Schenk
- Simpson
- Smith
- Smith
- Souness
- Squyres
- Squyres
- Talbot
- Tanaka
- Tanaka
- Tryka
- Vendeville
- Werner
- Willmes
- Wilson
- Wilson
- X. Diot
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2016
- Field of study
Hellas basin acts as a major sink for the southern highlands of Mars and is likely to have recorded several episodes of sedimentation and erosion. The north-western part of the basin displays a potentially unique Amazonian landscape domain in the deepest part of Hellas, called “banded terrain”, which is a deposit characterized by an alternation of narrow band shapes and inter-bands displaying a sinuous and relatively smooth surface texture suggesting a viscous flow origin. Here we use high-resolution (HiRISE and CTX) images to assess the geomorphological interaction of the banded terrain with the surrounding geomorphologic domains in the NW interior of Hellas to gain a better understanding of the geological evolution of the region as a whole. Our analysis reveals that the banded terrain is associated with six geomorphologic domains: a central plateau named Alpheus Colles, plain deposits (P1 and P2), reticulate (RT1 and RT2) and honeycomb terrains. Based on the analysis of the geomorphology of these domains and their cross-cutting relationships, we show that no widespread deposition post-dates the formation of the banded terrain, which implies that this domain is the youngest and latest deposit of the interior of Hellas. Therefore, the level of geologic activity in the NW Hellas during the Amazonian appears to have been relatively low and restricted to modification of the landscape through mechanical weathering, aeolian and periglacial processes. Thermophysical data and cross-cutting relationships support hypotheses of modification of the honeycomb terrain via vertical rise of diapirs such as ice diapirism, and the formation of the plain deposits through deposition and remobilization of an ice-rich mantle deposit. Finally, the observed gradual transition between honeycomb and banded terrain suggests that the banded terrain may have covered a larger area of the NW interior of Hellas in the past than previously thought. This has implications on the understanding of the evolution of the deepest part of Hellas
Avian foraging patterns in crop field edges adjacent to woody habitat
- Author
- Beecher
- Benton
- Besser
- Best
- Best
- Bianchi
- Brandle
- Brennan
- Cavitt
- Christensen
- Cimprich
- Dix
- Dolbeer
- Ehler
- Erin E. Blankenship
- Grant
- Green
- Heidi L. Puckett
- Henningsen
- James R. Brandle
- Johnson
- Johnson
- Johnson
- Johnson
- Jones
- Kirk
- Knopf
- Martin
- Murphy
- Perkins
- Robbins
- Rodenhouse
- Ron J. Johnson
- SAS Institute Inc.
- Sorensen
- Sotherton
- Tremblay
- Tsitsilas
- Publication venue
- 'Elsevier BV'
- Publication date
- Field of study
Characterization of Ectomycorrhizal species through molecular biology tools and morphotyping
- Author
- Agerer R.
- Anderson C.I.
- Anderson I.C.
- Anderson I.C.
- Anderson I.C.
- Andreazza R.
- Andressa de Oliveira Silveira
- Baldoni D.B.
- Boucher N.L.
- Brundrett M.
- Brundrett M.
- Brundrett M.
- Brundrett M.C.
- Bárbara Estevão Clasen
- Cairney J.W.G.
- Carvalho M.P.
- Castellano M.A.
- Chen D.M.
- Christensen M.
- Daiana Bortoluzzi Baldoni
- Daiane Fiuza Montagner
- Gao C.
- Guzmán G.
- Harley J.L.
- Hart M.M.
- Harvey A.E.
- Hunt G.A.
- Izzo A.
- Jesus E.C.
- Jumpponen A.
- Kanchanaprayudh J.
- Kelley A.P.
- Kirk P.M.
- Krugner T.L.
- Kõljalg U.
- Landeweert R.
- Largent D.L.
- Largent D.L.
- Larsen P.E.
- Lupatini M
- Lupatini M.
- Lupatini M.
- Marks G.C.
- Martin F.
- Mello A.H.
- Meyer F.H.
- Midgley D.J.
- Moreira F.M.S.
- Morris M.H.
- Pennanen T.
- Peterson R.L.
- Rillig M.C.
- Rodrigo Josemar Seminoti Jacques
- Rosling A.
- Sanon K.B.
- Sebastiana M.
- Silva R.F.
- Silva R.F.
- Siqueira J.O.
- Smit E.
- Smith S.E.
- Smith S.E.
- Sulzbacher M.A.
- Sulzbacher M.A.
- Wainwright M.
- Xiang X.
- Yang Z.L.
- Zaida Inês Antoniolli
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
Incidence and impact on prognosis of peri-procedural myocardial infarction in 2760 elective patients with stable angina pectoris in a historical prospective follow-up study
- Author
- A Jeremias
- A Prasad
- A Prasad
- AE Abdelmeguid
- AF Grann
- AS Jaffe
- C Cavallini
- C-H Lee
- CB Pedersen
- Christian Torp-Pedersen
- D-W Park
- DN Feldman
- E Giannitsis
- FS Apple
- HD White
- Hui Huang
- HW Kildemoes
- ID Moussa
- J Hallén
- Jan Ravkilde
- JB Lindsey
- JB Selvanayagam
- K Thygesen
- K Thygesen
- KM Akkerhuis
- L Testa
- M Schmidt
- Martin Kirk Christensen
- PK Kanaparti
- R Development Core Team
- RM Califf
- S Savonitto
- T Kümler
- Torleif Trydal
- X Muschart
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Dissecting the Shared Genetic Architecture of Suicide Attempt, Psychiatric Disorders, and Known Risk Factors
- Author
- Abdellaoui Abdel
- Abramova Liliya
- Adams Mark
- Adams Mark J.
- Adan Roger A. H.
- Adolfsson Rolf
- Adolfsson Rolf
- Adorjan Kristina
- Agartz Ingrid
- Agartz Ingrid
- Agerbo Esben
- Agerbo Esben
- Agerbo Esben
- Aguayo Samuel
- Ahuja Sunil
- Air Tracy M.
- Air Tracy M.
- Al Eissa Mariam
- Albani Diego
- Alda Martin
- Alda Martin
- Alfredsson Lars
- Alfredsson Lars
- Alfredsson Lars
- Alliey-Rodriguez Ney
- Als Thomas D.
- Andlauer Till F. M.
- Ando Tetsuya
- Andreassen Ole A.
- Andreassen Ole A.
- Andreassen Ole A.
- Anjorin Adebayo
- Anjorin Adebayo
- Antilla Verneri
- Antoniou Anastasia
- Appadurai Vivek
- Argyres Dean P.
- Arolt Volker
- Artigas Maria Soler
- Aschauer Harald
- Ashley-Koch Allison E.
- Aslan Mihaela
- Awasthi Swapnil
- Awasthi Swapnil
- Awasthi Swapnil
- Azevedo M. Helena
- Babadjanova Gulja
- Bacanu Silviu-Alin
- Backlund Lena
- Baek Ji Hyun
- Baker Jessica H.
- Ballas Zuhair
- Bass Nicholas
- Bass Nicholas
- Bau Claiton H. D.
- Bauer Michael
- Baune Bernhard T.
- Baune Bernhard T.
- Baune Bernhard T.
- Beckham Jean
- Beckham Jean
- Beckham Jean C.
- Beekman Aartjan T. F.
- Beins Eva C.
- Bellivier Frank
- Bellivier Frank
- Bencko Vladimir
- Bengesser Susanne
- Bergen Andrew W.
- Bergen Andrew W.
- Bergen Sarah E.
- Berger Klaus
- Berger Klaus
- Berrettini Wade H.
- Berrettini Wade H.
- Berrettini Wade H.
- Bhushan Sujata
- Biernacka Joanna M.
- Biernacka Joanna M.
- Bigdeli Tim B.
- Bigdeli Tim B.
- Bigdeli Tim B.
- Binder Elisabeth B.
- Binder Elisabeth B.
- Birgegård Andreas
- Birner Armin
- Blackwood Douglas H. R.
- Boden Joseph M.
- Boehm Ilka
- Boehnke Michael
- Boehnke Michael
- Bohus Martin
- Bohus Martin
- Boks Marco P.
- Boks Marco P.
- Boni Claudette
- Boomsma Dorret I.
- Bosch Rosa
- Bosch Rosa
- Boyko Edward
- Braff David L.
- Brandt Harry
- Brandt Harry
- Breeling James
- Breen Gerome
- Breen Gerome
- Breen Gerome
- Breen Gerome
- Brewer Jessica V.
- Brophy Mary T.
- Brum Murielle
- Brumpton Ben M.
- Brunkhorst-Kanaan Nathalie
- Bryant Richard
- Bryois Julien
- Bryois Julien
- Bryois Julien
- Budde Monika
- Budde Monika
- Buehren Katharina
- Bulik Cynthia M.
- Bulik Cynthia M.
- Burghardt Roland
- Buttenschøn Henriette N.
- Bybjerg-Grauholm Jonas
- Bybjerg-Grauholm Jonas
- Byerley William
- Byrne Enda M.
- Byrne Enda M.
- Bækvad-Hansen Marie
- Bækvad-Hansen Marie
- Bøen Erlend
- Børglum Anders D.
- Børglum Anders D.
- Børglum Anders D.
- Børte Sigrid
- Cahn Wiepke
- Cai Na
- Cairns Murray
- Campos Adrian I.
- Carlberg Laura
- Carr Vaughan J.
- Carter Bruce W.
- Casas Miguel
- Casas Miquel
- Cassina Matteo
- Castelao Enrique
- Castelao Enrique
- Catts Stanley
- Cervantes Pablo
- Cervilla Jorge A.
- Chang Kyong-Mi
- Chang Xiao
- Charney Alexander W.
- Chaumette Boris
- Chen Hsi-Chung
- Chen Wei J.
- Cho Kelly
- Cho Kelly
- Christensen Jane Hvarregaard
- Cichon Sven
- Cichon Sven
- Cichon Sven
- Cichon Sven
- Clarke Toni-Kim
- Clarke Toni-Kim
- Clementi Maurizio
- Cohen David
- Coleman Jonathan R. I.
- Coleman Jonathan R. I.
- Coleman Jonathan R. I.
- Coleman Jonathan R. I.
- Colodro-Conde Lucía
- Cone Roger D.
- Connor Todd
- Constans Joseph
- Coombes Brandon
- Coon Hilary
- Corvin Aiden
- Corvin Aiden
- Courtet Philippe
- Couvy-Duchesne Baptiste
- Craddock Nicholas
- Craddock Nicholas
- Craddock Nick
- Craig David
- Crawford Gregory E.
- Crawford Steven
- Crawford Steven
- Crivelli Silvia
- Crow Scott
- Crow Scott
- Crowley James J.
- Cruceanu Cristiana
- Cuellar-Barboza Alfredo
- Cunningham Julie
- Curtis David
- Czerski Piotr M.
- Dahmen Norbert
- Dale Anders M.
- Dalkner Nina
- Danner Unna N.
- Dannlowski Udo
- Dannlowski Udo
- David Friederike S.
- Davies Gail
- Davis Oliver S. P.
- de Geus E. J. C.
- de Zwaan Martina
- Dedoussis George
- Degenhardt Franziska
- Degenhardt Franziska
- Degenhardt Franziska
- Degortes Daniela
- Dellitalia Louis
- Demontis Ditte
- Dennis Michelle F.
- Depaulo J. Raymond
- DePaulo J. Raymond
- der Auwera Sandra Van
- Derks Eske M.
- DeSocio Janiece E.
- Di Florio Arianna
- DiBlasi Emily
- Dick Danielle M.
- Dietl Lydie
- Dikeos Dimitris
- Dikeos Dimitris
- Dina Christian
- Direk Nese
- Djurovic Srdjan
- Djurovic Srdjan
- Dmitrzak-Weglarz Monika
- Do Nhan
- Dobbyn Amanda L.
- Docherty Anna R.
- Dolan Conor V.
- Domenici Enrico
- Domschke Katharina
- Douzenis Athanassios
- Drange Ole Kristian
- Duncan Laramie E.
- Dunn Erin C.
- Duriez Philibert
- Edenberg Howard J.
- Edenberg Howard J.
- Edwards Alexis C.
- Egberts Karin
- Ehrlich Stefan
- Eley Thalia C.
- Elvsåshagen Torbjørn
- Erlangsen Annette
- Escaramís Geòrgia
- Escott-Price Valentina
- Escott-Price Valentina
- Esko Tõnu
- Esko Tõnu
- Esko Tõnu
- Esko Tõnu
- Espeseth Thomas
- Estivill Xavier
- Etain Bruno
- Fanous Ayman H.
- Farmer Anne
- Favaro Angela
- Fayad Joseph
- Ferentinos Panagiotis
- Fernández-Aranda Fernando
- Fernández-Aranda Fernando
- Ferrier I. Nicol
- Fichter Manfred M.
- Fichter Manfred M.
- Finucane Hilary K.
- Fiorentino Alessia
- Fischer Krista
- Florez Hermes
- Floyd James A. B.
- Foo Jerome C.
- Foo Jerome C.
- Foretova Lenka
- Foroud Tatiana M.
- Forstner Andreas J.
- Forstner Andreas J.
- Forstner Andreas J.
- Forstner Andreas J.
- Forty Liz
- Forzan Monica
- Frank Josef
- Frank Josef
- Frank Josef
- Franklin Christopher S.
- Frei Oleksandr
- Freimer Nelson B.
- Frisén Louise
- Frye Mark
- Frye Mark
- Fullerton Janice M.
- Fullerton Janice M.
- Föcker Manuel
- Gaddy Melinda
- Gade Katrin
- Galfalvy Hanga
- Gallinger Steven
- Gallinger Steven
- Gambaro Giovanni
- Gandal Michael
- Gandal Michael J.
- Gappy Saib
- Garnham Julie
- Gaspar Héléna A.
- Gaspar Héléna A.
- Gatt Justine M.
- Gawlik Micha
- Gaziano J. Michael
- Gaziano J. Michael
- Gejman Pablo V.
- Gelernter Joel
- Gelernter Joel
- Gershon Elliot S.
- Gibson Gretchen
- Giegling Ina
- Giegling Ina
- Gill Michael
- Giuranna Johanna
- Giusti-Rodríquez Paola
- Gizer Ian R.
- Glatt Stephen J.
- Godschalk Michael
- Goes Fernando S.
- Goes Fernando S.
- Gonidakis Fragiskos
- Gordon Scott
- Gordon Scott D.
- Gordon Scott D.
- Gordon-Smith Katherine
- Gorwood Philip
- Gorwood Philip
- Grabe Hans J.
- Grabe Hans J.
- Greco Jennifer
- Green Melissa J.
- Green Melissa J.
- Greenwood Tiffany A.
- Grevet Eugenio H.
- Grigoroiu-Serbanescu Maria
- Grigoroiu-Serbanescu Maria
- Grove Jakob
- Grove Jakob
- Grove Jakob
- Guillaume Sébastien
- Guo Yiran
- Guo Yiran
- Gupta Samir
- Gutierrez Blanca
- Gutierrez Salvador
- Guzman-Parra Jose
- Guzman-Parra José
- Ha Kyooseob
- Hafferty Jonathan D.
- Hagenaars Saskia P.
- Hakonarson Hakon
- Hakonarson Hakon
- Hall Lynsey S.
- Halmi Katherine A.
- Halmi Katherine A.
- Hamilton Steven P.
- Hamilton Steven P.
- Hammer Kimberly
- Hamner Mark
- Hamshere Marian L.
- Hanscombe Ken B.
- Hansen Christine Søholm
- Hansen Christine Søholm
- Hansen Thomas F.
- Haraldsson Magnus
- Harley John
- Hartmann Annette
- Harvey Phillip D.
- Hassan Kiadeh Farnush Farhadi
- Hatzikotoulas Konstantinos
- Hauser Elizabeth
- Hauser Elizabeth R.
- Hauser Joanna
- Hauser Joanna
- Hauser Joanna
- Hauser Michael A.
- Hautzinger Martin
- Hayward Caroline
- Heath Andrew C.
- Hebebrand Johannes
- Heilbronner Urs
- Heilmann-Heimbach Stefanie
- Helder Sietske G.
- Hellgren Dennis
- Henders Anjali K.
- Henskens Frans
- Herms Stefan
- Herms Stefan
- Herms Stefan
- Herpertz-Dahlmann Beate
- Herzog Wolfgang
- Hickie Ian B.
- Hillert Jan
- Hinney Anke
- Hishimoto Akitoyo
- Hoffmann Per
- Hoffmann Per
- Hoffmann Per
- Holmans Peter A.
- Homuth Georg
- Hong Kyung Sue
- Horn Carsten
- Horwood L. John
- Hottenga Jouke-Jan
- Hougaard David M.
- Hougaard David M.
- Hougaard David M.
- Howard David M.
- Huang Grant
- Huckins Laura
- Huckins Laura M.
- Hudson James I.
- Huffman Jennifer E.
- Hultman Christina M.
- Humphries Donald E.
- Hung Adriana
- HUNT All-In Psychiatry
- Huq Mostaqul
- Hurley Robin
- Hveem Kristian
- Hwu Hai-Gwo
- Hübel Christopher
- Ikeda Masashi
- Imgart Hartmut
- Inoko Hidetoshi
- Iruvanti Pran
- Ising Marcus
- Ising Marcus
- Ivins Douglas
- Iwata Nakao
- Jablensky Assen V.
- Jacobson Daniel
- Jacono Frank
- Jain Sonia
- Jamain Stéphane
- Jamain Stéphane
- Janout Vladimir
- Jansen Rick
- Jhala Darshana
- Jiménez-Murcia Susana
- Jiménez-Murcia Susana
- Johnson Craig
- Johnson Craig
- Johnson Jessica S.
- Jones Ian
- Jones Ian
- Jones Ian
- Jones Lisa A.
- Jones Lisa A.
- Jones Lisa A.
- Jonsson Lina
- Jordan Jennifer
- Jorgenson Eric
- Julià Antonio
- Jungkunz Martin
- Kahn René S.
- Kahn René S.
- Kalman Janos L.
- Kalsi Gursharan
- Kamatani Yoichiro
- Kaminsky Laurence
- Kaminská Deborah
- Kamitaki Nolan
- Kang JooEun
- Kaplan Allan S.
- Kaplan Allan S.
- Kaprio Jaakko
- Karhunen Leila
- Karwautz Andreas
- Kas Martien J. H.
- Kay Yang Jessica Mei
- Kaye Walter H.
- Kaye Walter H.
- Keel Pamela K.
- Kelsoe John R.
- Kelsoe John R.
- Kendler Kenneth S.
- Kendler Kenneth S.
- Kennedy James L.
- Kennedy James L.
- Kennedy James L.
- Kennedy Martin A.
- Keski-Rahkonen Anna
- Kessler Ronald C.
- Kiezebrink Kirsty
- Kim Minsoo
- Kim Minsoo
- Kim Youl-Ri
- Kimbrel Nathan A.
- Kinlay Scott
- Kirk Katherine M.
- Kirov George
- Kittel-Schneider Sarah
- Klareskog Lars
- Klein Jon
- Kloiber Stefan
- Kloiber Stefan
- Klump Kelly L.
- Klump Kelly L.
- Knowles James A.
- Knowles James A.
- Knudsen Gun Peggy S.
- Koenen Karestan C.
- Kogevinas Manolis
- Kogevinas Manolis
- Kohane Isaac S.
- Konte Bettina
- Koromina Maria
- Kraft Julia
- Kranz Thorsten M.
- Kranzler Henry R.
- Kranzler Henry R.
- Krebs Kristi
- Krebs Marie-Odile
- Kretzschmar Warren W.
- Kubo Michiaki
- Kuo Po-Hsiu
- Kupka Ralph
- Kushner Steven A.
- Kutalik Zoltán
- Landén Mikael
- Landén Mikael
- Landén Mikael
- Larsen Janne T.
- Lavebratt Catharina
- Lawrence Jacob
- Lawrence Jacob
- Le Hellard Stephanie
- Leber Markus
- Leboyer Marion
- Leboyer Marion
- Lee Heon-Jeong
- Lee Phil H.
- Lee Phil H.
- Leppä Virpi M.
- Levey Daniel F.
- Levinson Douglas F.
- Levinson Douglas F.
- Levy Shawn E.
- Lewis Cathryn M.
- Lewis Cathryn M.
- Lewis Cathryn M.
- Lewis Catrin
- Lewis Glyn
- Li Dong
- Li Dong
- Li Qingqin S.
- Li Qingqin S.
- Li Qingqin S.
- Li Yihan
- Liangpunsakul Suthat
- Liao Calwing
- Liao Calwing
- Liao Shih-Cheng
- Lichtenstein Paul
- Lichy Jack
- Lieb Klaus
- Lieb Klaus
- Lilenfeld Lisa
- Lilenfeld Lisa
- Lin Bochao Danae
- Lind Penelope A.
- Lindquist Jennifer H.
- Lissowska Jolanta
- Lissowska Jolanta
- Lissowska Jolanta
- Liu Chih-Min
- Lochner Christine
- Lori Adriana
- Loughland Carmel
- Lucae Susanne
- Lucae Susanne
- Lucae Susanne
- Lundberg Martin
- Lundervold Astri
- Luykx Jurjen
- MacIntyre Donald J.
- MacIntyre Donald J.
- MacKinnon Dean F.
- Madden Pamela A. F.
- Madduri Ravi
- Magistretti Pierre J.
- Magistretti Pierre J.
- Magnusson Patrik K.
- Magnusson Sigurdur H.
- Maier Robert M.
- Maier Wolfgang
- Maier Wolfgang
- Maihofer Adam
- Maj Mario
- Malaspina Dolores
- Mann J. John
- Mannik Katrin
- Maratou Eirini
- Marchini Jonathan
- Marsal Sara
- Marshall Christian R.
- Marshall Christian R.
- Martin Nicholas G.
- Martin Nicholas G.
- Martin Nicholas G.
- Martin Nicholas G.
- Martinez Elisa Docampo
- Martinsson Lina
- Mastorides Stephen
- Mathew Roy
- Mathews Carol A.
- Mattheisen Manuel
- Mattheisen Manuel
- Mattheisen Manuel
- Mattingsdal Morten
- Mattocks Kristin
- Mayora Monica Gratacos
- Mayoral Fermin
- Mayoral Fermin
- Mbarek Hamdi
- McArdle Rachel
- McDevitt Sara
- McElroy Susan L.
- McElroy Susan L.
- McGrath Patrick
- McGrath Patrick
- McGregor Nathaniel W.
- McGuffin Peter
- McGuffin Peter
- McGuffin Peter
- McGuffin Peter
- McIntosh Andrew M.
- McIntosh Andrew M.
- McIntosh Andrew M.
- McKay James D.
- McMahon Benjamin
- McMahon Francis J.
- McQuillin Andrew
- McQuillin Andrew
- Medeiros Helena
- Medland Sarah E.
- Medland Sarah E.
- Medland Sarah E.
- Medland Sarah E.
- Mehta Divya
- Mehta Divya
- Melle Ingrid
- Melle Ingrid
- Metspalu Andres
- Metspalu Andres
- Meulenbelt Ingrid
- Meyer Laurence
- Meyer Paul
- Micali Nadia
- Michie Patricia
- Middeldorp Christel M.
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- Zipfel Stephan
- Zwart John-Anker
- Świątkowska Beata
- Świątkowska Beata
- Świątkowska Beata
- Publication venue
- Publication date
- 01/01/2021
- Field of study
Background Suicide is a leading cause of death worldwide, and nonfatal suicide attempts, which occur far more frequently, are a major source of disability and social and economic burden. Both have substantial genetic etiology, which is partially shared and partially distinct from that of related psychiatric disorders. Methods We conducted a genome-wide association study (GWAS) of 29,782 suicide attempt (SA) cases and 519,961 controls in the International Suicide Genetics Consortium (ISGC). The GWAS of SA was conditioned on psychiatric disorders using GWAS summary statistics via multitrait-based conditional and joint analysis, to remove genetic effects on SA mediated by psychiatric disorders. We investigated the shared and divergent genetic architectures of SA, psychiatric disorders, and other known risk factors. Results Two loci reached genome-wide significance for SA: the major histocompatibility complex and an intergenic locus on chromosome 7, the latter of which remained associated with SA after conditioning on psychiatric disorders and replicated in an independent cohort from the Million Veteran Program. This locus has been implicated in risk-taking behavior, smoking, and insomnia. SA showed strong genetic correlation with psychiatric disorders, particularly major depression, and also with smoking, pain, risk-taking behavior, sleep disturbances, lower educational attainment, reproductive traits, lower socioeconomic status, and poorer general health. After conditioning on psychiatric disorders, the genetic correlations between SA and psychiatric disorders decreased, whereas those with nonpsychiatric traits remained largely unchanged. Conclusions Our results identify a risk locus that contributes more strongly to SA than other phenotypes and suggest a shared underlying biology between SA and known risk factors that is not mediated by psychiatric disorders.Peer reviewe
AI is a viable alternative to high throughput screening: a 318-target study
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- Abaffy Tatjana
- Abraham Elena Theres
- Abrahão Jônatas Santos
- Abramyan Tigran M.
- Agianian Bogos
- Agogo-Mawuli Percy
- Agoulnik Alexander I.
- Agrawal Rajendra K.
- Aguilera Elena
- Ahmed Mostafa
- Akk Gustav
- Akopian Tatos
- Al-Yozbaki Minnatallah
- Aldhamen Yasser Ali
- Alkan Cigdem
- Alramadhani Dina
- Alteen Matthew G.
- Alvarez Guzmán
- Ammendola Serena
- Anastasio Noelle C.
- Anderson Brandon M.
- Anderson Deborah H.
- Andricopulo Adriano D.
- Angell Richard M.
- Anthis Nicholas J.
- Antonelli Lorenzo
- Apfel Athena Marie
- Arias Juan Antonio Sanchez
- Arozarena Imanol
- Arrigoni Cristina
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- Austin Richard C.
- Ayachi Aicha Gharbi
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- Tomilov Alexey
- Toogood Peter
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- Wang Jun
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- Wu Xiaoyang
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- Zhuo Ling
- Zochodne Douglas William
- Publication venue
- Publication date
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- Field of study
: High throughput screening (HTS) is routinely used to identify bioactive small molecules. This requires physical compounds, which limits coverage of accessible chemical space. Computational approaches combined with vast on-demand chemical libraries can access far greater chemical space, provided that the predictive accuracy is sufficient to identify useful molecules. Through the largest and most diverse virtual HTS campaign reported to date, comprising 318 individual projects, we demonstrate that our AtomNet® convolutional neural network successfully finds novel hits across every major therapeutic area and protein class. We address historical limitations of computational screening by demonstrating success for target proteins without known binders, high-quality X-ray crystal structures, or manual cherry-picking of compounds. We show that the molecules selected by the AtomNet® model are novel drug-like scaffolds rather than minor modifications to known bioactive compounds. Our empirical results suggest that computational methods can substantially replace HTS as the first step of small-molecule drug discovery
Electronic structures and photophysics of d(8)-d(8) complexes
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- Adamo
- Andrae
- Antonín Vlček
- Atoji
- Blanco-Rodríguez
- Boyd
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- Brown-Xu
- Bryan
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- Christensen
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- El Nahhas
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- Gellene
- Grimme
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- Haldrup
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- Harry B. Gray
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- Hedley
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- Ikeyama
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- Markert
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- Novozhilova
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- Stiegman
- Stoyanov
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- Tomasi
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- Yasuda
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- 'Elsevier BV'
- Publication date
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- Field of study
This work was supported by the NSF CCI Solar Fuels Program (CHE-1305124), the Arnold and Mabel Beckman Foundation, the Ministry of Education of the Czech Republic - grant LH13015, and the COST Action CM1405
Elective cancer surgery in COVID-19-free surgical pathways during the SARS-CoV-2 pandemic: An international, multicenter, comparative cohort study
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- Publication venue
- 'American Society of Clinical Oncology (ASCO)'
- Publication date
- 01/01/2021
- Field of study
PURPOSE As cancer surgery restarts after the first COVID-19 wave, health care providers urgently require data to determine where elective surgery is best performed. This study aimed to determine whether COVID-19–free surgical pathways were associated with lower postoperative pulmonary complication rates compared with hospitals with no defined pathway. PATIENTS AND METHODS This international, multicenter cohort study included patients who underwent elective surgery for 10 solid cancer types without preoperative suspicion of SARS-CoV-2. Participating hospitals included patients from local emergence of SARS-CoV-2 until April 19, 2020. At the time of surgery, hospitals were defined as having a COVID-19–free surgical pathway (complete segregation of the operating theater, critical care, and inpatient ward areas) or no defined pathway (incomplete or no segregation, areas shared with patients with COVID-19). The primary outcome was 30-day postoperative pulmonary complications (pneumonia, acute respiratory distress syndrome, unexpected ventilation). RESULTS Of 9,171 patients from 447 hospitals in 55 countries, 2,481 were operated on in COVID-19–free surgical pathways. Patients who underwent surgery within COVID-19–free surgical pathways were younger with fewer comorbidities than those in hospitals with no defined pathway but with similar proportions of major surgery. After adjustment, pulmonary complication rates were lower with COVID-19–free surgical pathways (2.2% v 4.9%; adjusted odds ratio [aOR], 0.62; 95% CI, 0.44 to 0.86). This was consistent in sensitivity analyses for low-risk patients (American Society of Anesthesiologists grade 1/2), propensity score–matched models, and patients with negative SARS-CoV-2 preoperative tests. The postoperative SARS-CoV-2 infection rate was also lower in COVID-19–free surgical pathways (2.1% v 3.6%; aOR, 0.53; 95% CI, 0.36 to 0.76). CONCLUSION Within available resources, dedicated COVID-19–free surgical pathways should be established to provide safe elective cancer surgery during current and before future SARS-CoV-2 outbreaks
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