49 research outputs found
Genotype-Phenotype Correlation in NF1: Evidence for a More Severe Phenotype Associated with Missense Mutations Affecting NF1 Codons 844â848
- Author
- Balasubramanian M. (Meena)
- Barnett C.P. (Christopher P.)
- Becker T.A. (Troy A.)
- Ben-Shachar S. (Shay)
- Bertola D.R. (DĂ©bora Romeo)
- Blakeley J.O. (Jaishri O.)
- Burkitt-Wright E.M.M. (Emma M.M.)
- Callaway A. (Alison)
- Callens T. (Tom)
- Chen Y. (Yunjia)
- Chen Z. (Zhenbin)
- Claes K. (Kathleen)
- Crenshaw M. (Melissa)
- Cunha K.S. (Karin S.)
- Cunningham M. (Mitch)
- D'Agostino M.D. (Maria Daniela)
- Dahan K. (Karin)
- De Luca A. (Alessandro)
- Destrée A. (Anne)
- Dhamija R. (Radhika)
- Eoli M. (Marica)
- Evans D.G.R. (D. Gareth R.)
- Galvin-Parton P. (Patricia)
- George-Abraham J.K. (Jaya K.)
- Gomes A. (Alicia)
- Gripp K.W. (Karen)
- Guevara-Campos J. (Jose)
- Hanchard N.A. (Neil A.)
- HernĂĄndez-Chico C. (Concepcion)
- Hsiao M.-C. (Meng-Chang)
- Immken L. (LaDonna)
- Janssens S. (Sandra)
- Johnson S. (Sherrell)
- Jones K.J. (Kristi)
- Keena B.A. (Beth A.)
- Kochhar A. (Aaina)
- Koczkowska M. (Magdalena)
- Korf B. (Bruce)
- Legius E. (Eric)
- Liebelt J. (Jan)
- Mahoney M.J. (Maurice J.)
- Martin Y. (Yolanda)
- Martir-Negron A. (Arelis)
- Maystadt I. (Isabelle)
- McDougall C. (Carey)
- McEntagart M. (Meriel)
- Mendelsohn N.J.
- Messiaen L.M. (Ludwine)
- Miller D.T. (David T.)
- Mortier G. (Geert)
- Morton J. (Jenny)
- Pappas J. (John)
- Plotkin S.R. (Scott R.)
- Pond D. (Dinel)
- Rosenbaum K. (Kenneth)
- Rubin K. (Karol)
- Russell L. (Laura)
- Rutledge L.S. (Lane S.)
- Saletti V. (Veronica)
- Schonberg R. (Rhonda)
- Schreiber A. (Allison)
- Seidel M. (Meredith)
- Sharp A. (Angela)
- Siqveland E. (Elizabeth)
- Stockton D.W. (David)
- Thornton A.S. (Andrew)
- Trevisson E. (Eva)
- Ullrich N.J. (Nicole J.)
- Upadhyaya M. (Meena)
- Verhelst H. (H.)
- Wallace M.R. (Margaret)
- Yap Y.-S. (Yoon-Sim)
- Zackai E. (Elaine)
- Zonana J. (Jonathan)
- Zurcher V. (Vickie)
- Publication venue
- 'Elsevier BV'
- Publication date
- 04/01/2018
- Field of study
Neurofibromatosis type 1 (NF1), a common genetic disorder with a birth incidence of 1:2,000â3,000, is characterized by a highly variable clinical presentation. To date, only two clinically relevant intragenic genotype-phenotype correlations have been reported for NF1 missense mutations affecting p.Arg1809 and a single amino acid deletion p.Met922del. Both variants predispose to a distinct mild NF1 phenotype with neither externally visible cutaneous/plexiform neurofibromas nor other tumors. Here, we report 162 individuals (129 unrelated probands and 33 affected relatives) heterozygous for a constitutional missense mutation affecting one of five neighboring NF1 codonsâLeu844, Cys845, Ala846, Leu847, and Gly848âlocated in the cysteine-serine-rich domain (CSRD). Collectively, these recurrent missense mutations affect âŒ0.8% of unrelated NF1 mutation-positive probands in the University of Alabama at Birmingham (UAB) cohort. Major superficial plexiform neurofibromas and symptomatic spinal neurofibromas were more prevalent in these individuals compared with classic NF1-affected cohorts (both p < 0.0001). Nearly half of the individuals had symptomatic or asymptomatic optic pathway gliomas and/or skeletal abnormalities. Additionally, variants in this region seem to confer a high predisposition to develop malignancies compared with the general NF1-affected population (p = 0.0061). Our results demonstrate that these NF1 missense mutations, although located outside the GAP-related domain, may be an important risk factor for a severe presentation. A genotype-phenotype correlation at the NF1 region 844â848 exists and will be valuable in the management and genetic counseling of a significant number of individuals
Mitochondrial Structure, Function and Dynamics Are Temporally Controlled by c-Myc
- Author
- A Macho
- A Olichon
- A Perl
- A Santel
- A Zorzano
- Bennett Van Houten
- BM Spiegelman
- C Grandori
- C Jose
- C Sauvanet
- CE Nesbit
- CJ Lin
- CR Chang
- CV Dang
- CV Dang
- DG Nicholls
- Donna Beer-Stolz
- E Smirnova
- Edward Cherok
- Edward V. Prochownik
- EV Prochownik
- F Legros
- F Li
- F Morrish
- F Morrish
- G Benard
- G Lenaz
- H Chen
- H Chen
- H Chen
- H Chen
- H Chen
- H Otera
- H Zhang
- H Zhang
- HJ Chung
- I Wittig
- J Kim
- J Prachar
- J. Anthony Graves
- JA Graves
- JA Graves
- Jennifer Elster
- Jerry Vockley
- JJ Lemasters
- JS Isenberg
- K Gilmore
- K Takeda
- KI Zeller
- Kristi Rothermund
- M Eilers
- M Strauss
- M Wu
- Maria F. Branca
- MG Vander Heiden
- MK Mateyak
- N Gomez-Roman
- N Meyer
- N Yadava
- O Vafa
- P Ahuja
- R Acin-Perez
- RJ Deberardinis
- S Cipolat
- S Ray
- S Rimbaud
- SM Prouty
- ST Smiley
- Sunder Sims-Lucas
- Surinder K. Batra
- SX Zhang
- T Fukazawa
- T Koshiba
- TD Littlewood
- V Saks
- V Zinchuk
- V Zinchuk
- Y Li
- Y Liu
- Y Wang
- Y Wang
- Y Yoon
- Yudong Wang
- Z Li
- Publication venue
- Public Library of Science
- Publication date
- 01/05/2012
- Field of study
Although the c-Myc (Myc) oncoprotein controls mitochondrial biogenesis and multiple enzymes involved in oxidative phosphorylation (OXPHOS), the coordination of these events and the mechanistic underpinnings of their regulation remain largely unexplored. We show here that re-expression of Myc in mycâ/â fibroblasts is accompanied by a gradual accumulation of mitochondrial biomass and by increases in membrane polarization and mitochondrial fusion. A correction of OXPHOS deficiency is also seen, although structural abnormalities in electron transport chain complexes (ETC) are not entirely normalized. Conversely, the down-regulation of Myc leads to a gradual decrease in mitochondrial mass and a more rapid loss of fusion and membrane potential. Increases in the levels of proteins specifically involved in mitochondrial fission and fusion support the idea that Myc affects mitochondrial mass by influencing both of these processes, albeit favoring the latter. The ETC defects that persist following Myc restoration may represent metabolic adaptations, as mitochondrial function is re-directed away from producing ATP to providing a source of metabolic precursors demanded by the transformed cell
Molecular Determinants and Dynamics of Hepatitis C Virus Secretion
- Author
- A Codran
- A Merz
- A Ploss
- AR Mensenkamp
- B Bartosch
- B Bartosch
- B Boson
- B Toth
- BA Li Q
- BD Lindenbach
- BD Lindenbach
- BM Söllner T
- C Mancone
- CI Popescu
- CK Lai
- CL Murray
- CT Jones
- D Egger
- D Lavillette
- D Moradpour
- DD Mire CE
- DM Owen
- E Blanchard
- E Steinmann
- EA Bruce
- FY Chen W
- G Barba
- G Egea
- G Mateu
- G Randall
- GA Smith
- GB Martin BR
- Glenn Randall
- H Folsch
- H Huang
- I Wacker
- J Jiang
- J Witteveldt
- J Zhong
- Jacob D. Cooper
- JE Casanova
- Jessica L. Saunders
- Jing-hsiung James Ou
- JJ Cun W
- JM Mackenzie
- JM Timpe
- K Gousset
- KA Stapleford
- KE Coller
- Kelly E. Coller
- KG Hadlock
- KL Berger
- Kristi L. Berger
- KS Chang
- L Meertens
- L-SJ Bonifacino JS
- M Hughes
- M Trotard
- MA Welte
- MJ Evans
- MJLM Bamberger
- N Appel
- N Arhel
- Nicholas S. Heaton
- O Diaz
- P Andre
- P Gastaminza
- P Gastaminza
- PD Das SC
- R Chambers
- R Gosert
- RK Rowe
- RL Hamilton
- RPF Bartenschlager
- RS Ullrich O
- S Boulant
- S Boulant
- S Fazio
- S Fazio
- SG Amako Y
- SG Turville
- SJ Gusarova V
- ST Shi
- SU Nielsen
- T Hishiki
- T Kato
- T Masaki
- T Wakita
- T-TG Tran K
- TH-J Lindenbach BD
- TL Tellinghuisen
- TP Borawski J
- V Icard
- V Jirasko
- WJ Benga
- Y Ma
- Y Ma
- Y Miyanari
- Y Rouille
- ZA Knight
- Publication venue
- Public Library of Science
- Publication date
- 01/01/2011
- Field of study
The current model of hepatitis C virus (HCV) production involves the assembly of virions on or near the surface of lipid droplets, envelopment at the ER in association with components of VLDL synthesis, and egress via the secretory pathway. However, the cellular requirements for and a mechanistic understanding of HCV secretion are incomplete at best. We combined an RNA interference (RNAi) analysis of host factors for infectious HCV secretion with the development of live cell imaging of HCV core trafficking to gain a detailed understanding of HCV egress. RNAi studies identified multiple components of the secretory pathway, including ER to Golgi trafficking, lipid and protein kinases that regulate budding from the trans-Golgi network (TGN), VAMP1 vesicles and adaptor proteins, and the recycling endosome. Our results support a model wherein HCV is infectious upon envelopment at the ER and exits the cell via the secretory pathway. We next constructed infectious HCV with a tetracysteine (TC) tag insertion in core (TC-core) to monitor the dynamics of HCV core trafficking in association with its cellular cofactors. In order to isolate core protein movements associated with infectious HCV secretion, only trafficking events that required the essential HCV assembly factor NS2 were quantified. TC-core traffics to the cell periphery along microtubules and this movement can be inhibited by nocodazole. Sub-populations of TC-core localize to the Golgi and co-traffic with components of the recycling endosome. Silencing of the recycling endosome component Rab11a results in the accumulation of HCV core at the Golgi. The majority of dynamic core traffics in association with apolipoprotein E (ApoE) and VAMP1 vesicles. This study identifies many new host cofactors of HCV egress, while presenting dynamic studies of HCV core trafficking in infected cells
Genetic Drivers of Heterogeneity in Type 2 Diabetes Pathophysiology
- Author
- Adair Linda S
- Adeyemo Adebowale
- Aguilar-Salinas Carlos A
- Ahlqvist Emma
- Ahluwalia Tarunveer S
- Ahsan Habibul
- An Ping
- Anand Sonia S
- Arruda Ana Luiza
- Becker Diane M
- Below Jennifer E
- Bertoni Alain
- Bharadwaj Dwaipayan
- Bielak Lawrence F
- Bocher Ozvan
- Boehnke Michael
- Bonnefond Amélie
- Bork-Jensen Jette
- Bowden Donald W
- Bragg Fiona
- Brandslund Ivan
- Broadaway K Alaine
- Brody Jennifer A
- Buchanan Thomas A
- Burant Charles F
- Butterworth Adam S
- Cade Brian E
- Canouil Mickaël
- Chai Jin-Fang
- Chambers John C
- Chan Juliana C N
- Chandak Giriraj R
- Chang Kyong-Mi
- Chang Li-Ching
- Chee Miao-Li
- Chen Chien-Hsiun
- Chen Guanjie
- Chen Ji
- Chen Shyh-Huei
- Chen Wei-Min
- Chen Yii-Der Ida
- Chen Yuan-Tsong
- Chen Zhengming
- Cheng Ching-Yu
- Cho Yoon Shin
- Choi Hyeok Sun
- Chuang Lee-Ming
- Collins Francis S
- Cook James P
- Cruz Miguel
- Cui Jinrui
- Cushman Mary
- Danesh John
- Das Swapan K
- de Silva H Janaka
- Dedoussis George
- Denny Joshua C
- Dimitrov Latchezar
- Doumatey Ayo P
- Du Shufa
- Duan Qing
- Dupuis Josee
- Eckardt Kai-Uwe
- Emery Leslie S
- Engert James C
- Evans Daniel S
- Evans Michele K
- Finer Sarah
- Fischer Krista
- Florez Jose C
- Floyd James S
- Ford Ian
- Fornage Myriam
- Franco Oscar H
- Frayling Timothy M
- Freedman Barry I
- Froguel Philippe
- Genter Pauline
- Gerstein Hertzel C
- Ghanbari Mohsen
- Giedraitis Vilmantas
- Gieger Christian
- GonzĂĄlez-Villalpando Clicerio
- GonzĂĄlez-Villalpando Maria Elena
- Goodarzi Mark O
- Gordon-Larsen Penny
- Graff Mariaelisa
- Grallert Harald
- Grarup Niels
- Gross Myron
- Guare Lindsay A
- Guo Xiuqing
- Hackinger Sophie
- Hai Yang
- Haiman Christopher A
- Hakaste Liisa
- Han Sohee
- Hanis Craig L
- Hansen Torben
- Hattersley Andrew T
- Hatzikotoulas Konstantinos
- Hayes M Geoffrey
- Herder Christian
- Horikoshi Momoko
- Howard Annie-Green
- Hsueh Willa
- Huang Mengna
- Huang Wei
- Huerta-Chagoya Alicia
- Hung Yi-Jen
- Hwang Mi Yeong
- Hwu Chii-Min
- Ichihara Sahoko
- Igase Michiya
- Ikram Mohammad Arfan
- Ingelsson Erik
- Ingelsson Martin
- Ipp Eli
- Islam Md Tariqul
- Isono Masato
- Jang Hye-Mi
- Jasmine Farzana
- Jiang Guozhi
- Jonas Jost B
- Joo Yoonjung Yoonie
- Jukema J Wouter
- JĂžrgensen Torben
- Kabagambe Edmond
- Kadowaki Takashi
- Kals Mart
- Kamali Zoha
- Kamanu Frederick K
- Kandeel Fouad R
- Kanoni Stavroula
- Kardia Sharon L R
- Kasturiratne Anuradhani
- Kato Norihiro
- Katsuya Tomohiro
- Kaur Varinderpal
- Kawaguchi Takahisa
- Keaton Jacob M
- Kho Abel N
- Khor Chiea-Chuen
- Kibriya Muhammad G
- Kim Bong-Jo
- Kim Duk-Hwan
- Kim Young Jin
- Koh Woon-Puay
- Kooner Jaspal S
- Kooperberg Charles
- Kronenberg Florian
- Kuusisto Johanna
- Kwak Soo-Heon
- Köttgen Anna
- Laakso Markku
- Lamri Amel
- Lange Leslie A
- Langenberg Claudia
- Lee Jung-Jin
- Lee Juyoung
- Lee Kyung Min
- Lee Myung-Shik
- Lee Nanette R
- Lee Simon S K
- Leong Aaron
- Li Liming
- Li Yun
- Li-Gao Ruifang
- Ligthart Symen
- Lim Victor J Y
- Lin Kuang
- Lind Lars
- Lindgren Cecilia M
- Linneberg Allan
- Liu Ching-Ti
- Liu Jianjun
- Liu Simin
- Liu Yongmei
- Locke Adam E
- Long Jirong
- Loos Ruth J F
- Lorenz Kim M
- Louie Tin
- Luan Jian\u27an
- Luk Andrea O
- Luo Xi
- Lv Jun
- Lynch Julie A
- Lyssenko Valeriya
- LĂ€ll Kristi
- Ma Ronald C W
- Maeda Shiro
- Mahajan Anubha
- Mamakou Vasiliki
- Mandla Ravi
- Mansuri Sohail Rafik
- Marston Nicholas A
- Matsuda Fumihiko
- Matsuda Koichi
- McCarthy Mark I
- McKean-Cowdin Roberta
- Meigs James B
- Meitinger Thomas
- Melander Olle
- Melloni Giorgio E M
- Mercader Josep M
- Metspalu Andres
- Millwood Iona Y
- Mo Huan
- Mohlke Karen L
- Mook-Kanamori Dennis O
- Moon Sanghoon
- Morris Andrew D
- Morris Andrew P
- Motala Ayesha A
- Moura Filipe A
- MĂ€gi Reedik
- Nadler Jerry L
- Nakatochi Masahiro
- Nalls Michael A
- Namba Shinichi
- Nano Jana
- Nayak Uma
- Ng Maggie C Y
- Nicolas Aude
- Nongmaithem Suraj S
- Noordam Raymond
- North Kari E
- Nousome Darryl
- Ntalla Ioanna
- Okada Yukinori
- Orozco Lorena
- Palmer Colin N A
- Pan Ian
- Pankow James S
- Park Kyong-Soo
- Parra Esteban J
- Paré Guillaume
- Patel Sanjay R
- Patil Snehal
- Pedersen Oluf
- Pei Pei
- Pereira Mark A
- Peters Annette
- Petty Lauren E
- Peyser Patricia A
- Pirie Fraser J
- Polikowsky Hannah G
- Porneala Bianca
- Prasad Gauri
- Preuss Michael H
- Prins Bram Peter
- Province Michael A
- Psaty Bruce M
- Rader Daniel J
- Raffel Leslie J
- Raffield Laura M
- Rasmussen-Torvik Laura J
- Rayner Nigel W
- Redline Susan
- Reiner Alexander P
- Rich Stephen S
- Ritchie Marylyn D
- Roden Michael
- Rohde Rebecca
- Roll Katheryn
- Rotimi Charles N
- Rotter Jerome I
- Ruff Christian T
- Sabanayagam Charumathi
- Sale MichĂšle M
- Saleheen Danish
- Sandow Kevin
- Sankareswaran Alagu
- Sarnowski Chloé
- Sattar Naveed
- Schroeder Philip
- Schönherr Sebastian
- Scott Robert A
- Shahriar Mohammad
- Shen Botong
- Sheu Wayne H H
- Shi Jinxiu
- Shin Dong Mun
- Shojima Nobuhiro
- Shu Xiao-Ou
- Sim Xueling
- Smith Jennifer A
- So Wing Yee
- Sofer Tamar
- Sonehara Kyuto
- Southam Lorraine
- Spracklen Cassandra N
- StanÄĂĄkovĂĄ Alena
- Stefansson Kari
- Steinthorsdottir Valgerdur
- Stilp Adrienne M
- Strauch Konstantin
- Sun Meng
- Suzuki Ken
- Tabara Yasuharu
- Tai E-Shyong
- Takeuchi Fumihiko
- Taliun Daniel
- Tam Claudia H T
- Tan Jingyi
- Taylor Henry J
- Taylor Kent D
- Thangam Manonanthini
- Thorand Barbara
- Thorleifsson Gudmar
- Thorsteinsdottir Unnur
- Tomlinson Brian
- Tong Lin
- Tran Tam C
- Trompet Stella
- Tsai Fuu-Jen
- Tsao Philip S
- Tuomi Tiinamaija
- Tuomilehto Jaakko
- Tusie-Luna Teresa
- Udler Miriam S
- Valladares-Salgado Adan
- van Dam Rob M
- van Dijk Ko Willems
- van Heel David A
- van Klinken Jan B
- Vanderwerff Brett
- Varma Rohit
- Voight Benjamin F
- Vujkovic Marijana
- Wacher-Rodarte Niels
- Walters Robin G
- Wang Ya-Xing
- Wareham Nicholas J
- Wheeler Eleanor
- Wickremasinghe Ananda R
- Williamson Alice
- Wilson James G
- Witte Daniel R
- Wong Tien-Yin
- Wu Jer-Yuarn
- Wuttke Matthias
- Xiang Anny H
- Yajnik Chittaranjan S
- Yamamoto Ken
- Yamamoto Kenichi
- Yamauchi Toshimasa
- Yanek Lisa R
- Yao Jie
- Yin Xianyong
- Yokota Mitsuhiro
- Yoon Kyungheon
- Yu Canqing
- Yuan Jian-Min
- Yusuf Salim
- Zawistowski Matthew
- Zeggini Eleftheria
- Zhang Liang
- Zhang Weihua
- Zheng Wei
- Zonderman Alan B
- Zöllner Sebastian
- Publication venue
- DigitalCommons@TMC
- Publication date
- 01/03/2024
- Field of study
Type 2 diabetes (T2D) is a heterogeneous disease that develops through diverse pathophysiological processes1,2 and molecular mechanisms that are often specific to cell type3,4. Here, to characterize the genetic contribution to these processes across ancestry groups, we aggregate genome-wide association study data from 2,535,601 individuals (39.7% not of European ancestry), including 428,452 cases of T2D. We identify 1,289 independent association signals at genome-wide significance (P \u3c 5 Ă 10-8) that map to 611 loci, of which 145 loci are, to our knowledge, previously unreported. We define eight non-overlapping clusters of T2D signals that are characterized by distinct profiles of cardiometabolic trait associations. These clusters are differentially enriched for cell-type-specific regions of open chromatin, including pancreatic islets, adipocytes, endothelial cells and enteroendocrine cells. We build cluster-specific partitioned polygenic scores5 in a further 279,552 individuals of diverse ancestry, including 30,288 cases of T2D, and test their association with T2D-related vascular outcomes. Cluster-specific partitioned polygenic scores are associated with coronary artery disease, peripheral artery disease and end-stage diabetic nephropathy across ancestry groups, highlighting the importance of obesity-related processes in the development of vascular outcomes. Our findings show the value of integrating multi-ancestry genome-wide association study data with single-cell epigenomics to disentangle the aetiological heterogeneity that drives the development and progression of T2D. This might offer a route to optimize global access to genetically informed diabetes care
SARS-CoV-2 susceptibility and COVID-19 disease severity are associated with genetic variants affecting gene expression in a variety of tissues
- Author
- Abd Elghafar Mohamed S.
- Abdel-Aziz Mahmoud
- Abdollahi Hamed
- Abdullah Tala
- Abecasis Goncalo R.
- Abedalthagafi Malak
- Abul-Husn Noura S.
- Acquilini Donatella
- Adams Emma L.
- Adamsara Alireza
- Adeleye Olumide
- Adra Darin
- Afilalo Jonathan
- Afilalo Marc
- Afrasiabi Zaman
- AguÌero Daiana
- Ahmadi Saeideh
- Aksentijevich Alexandra
- Al Harthi Fawz
- Al Mutairi Amal
- Al-Afghani Hani
- Al-Awdah Laila
- Alaamery Manal
- Alahmadey Ziab Z.
- Alaverdian Diana
- Alavere Helene
- Albader Anoud
- Albaiceta Guillermo M.
- Albakri Jehad K.
- AlBardis Hadeel
- Albeladi Maha
- Albesher Nour
- Albrich Werner
- AlDhawi Nouf
- Aleagha Afshar Etemadi
- Alghamdi Bader
- Alghamdi Jahad
- Ali Altaf
- Aliannejad Rasoul
- Aljawini Nora
- AlJohani Sameera
- Alkwai Sarah
- Allos Raili
- AlMalik Abdulaziz
- Almalki Faisal
- Almohammed Iman
- Almutairi Mansour
- Alotaibi Sara
- Alowayn Albandary M.
- Alqahtani Saleh
- Alqubaishi Fatimah
- Alrashed May
- Alshareef Abdulraheem
- Alsolm Ebtehal
- Alswailm Moneera
- AlZahrani Deema
- Amirsavadkouhi Ali
- Amitrano Sara
- Andolfo Immacolata
- Andretta Francesca
- Andreucci Elena
- Andrews Shea J.
- Andrews Shea J.
- Andrews Shea J.
- Anedda Federico
- Anemoli Valentina
- Anne Feng Yen-Chen
- Annis Aubrey
- Antinori Andrea
- Antoni Melania Degli
- Aprile von Hohenstaufen Kathrin
- Arabi Yaseen M.
- Armstrong Jacob
- Arning Nicolas
- Arranz Maria J.
- Arribas Elisa
- Arthur Timothy D.
- Artuso Rosangela
- Arumugam Prabhu
- Ascolillo Steven
- Atkinson Elizabeth G.
- Aucella Filippo
- Auld Daniel
- Azarzar Samira
- AÌsvold BjĂžrn Olav
- Bachetti Tiziana
- Balaconis Mary K.
- Baldassarri Margherita
- Ball Catherine A.
- Baltzell Asher Haug
- Band Gavin
- Bandini Maria
- Baraka Dona
- Baras Aris
- Baratti Stefano
- Barbieri Chiara
- Bargagli Elena
- Barhoush Eman
- Barnes Kathleen C.
- Baroni Silvia
- Bartels Meike
- Bassetti Matteo
- Batini Chiara
- Baya Nikolas
- Beck Andrew
- Beckmann Noam D.
- Bedini Josep L.
- Bee Catherine E.
- Beguin Yves
- Belbin Gillian M.
- Belhaj Yasmine
- Beligni Giada
- Belisle Alexandre
- Belli Mary Ann
- Below Jennifer
- Benetti Elisa
- Bennett David
- Bergantini Laura
- Bergomi Paola
- Berkowitz Nathan
- Bernardo David
- Bibert SteÌphanie
- Biscarini Filippo
- Blay Natalia
- Bochud Pierre-Yves
- Boillat NoeÌmie
- BottaÌ Giordano
- Bouab Meriem
- Boughton Andrew P.
- Bradford Yuki
- Branka Vulesevic Nardin Rezk
- Brassard Nathalie
- Brenner Bluma
- Britvan Bari
- Brumpton Ben M.
- Bruno Raffaele
- Bruttini Mirella
- Bryant Sam
- Bryant Sam
- Buring Julie E.
- Busani Stefano
- Bussotti Maurizio
- Butler-Laporte Guillaume
- Butler-Laporte Guillaume
- Butterworth Adam S.
- Buxbaum Joseph D.
- Cal-Sabater Paloma de la
- Caldarelli Gian Piero
- Callier Shawneequa
- Cameli Paolo
- Campbell Archie
- Campbell Archie
- Canaccini Anna
- Cantarini Luca
- Cantor Michael N.
- Capasso Mario
- Capitani Katia
- Cappelli Silvia
- Carella Massimo
- Carey Dave J.
- Carreras Anna
- Carriero Miriam Lucia
- CastanÌo-Vinyals Gemma
- Castelli Francesco
- Castori Marco
- Catena Emanuele
- Caulfield Mark J.
- CaÌrcel-MaÌrquez Jara
- Ceri Stefano
- Chamnanphon Monpat
- Chan Georgia
- Chang Xiao
- Chang Xiao
- Chariyavilaskul Pajaree
- Charney Alexander W.
- Chasman Daniel I.
- ChasseÌ MichaeÌl
- Chaudhary Kumardeep
- Chavan Sameer
- Chen Hung-Hsin
- Cheng Nathan
- Chetruengchai Wanna
- Chittoor Geetha
- Cho Judy H.
- Cho Kelly
- Choi Sam
- Churchhouse Claire
- Chwialkowska Karolina
- Claassen Sabine
- Claringbould Annique
- Coignet Marie
- Coiro Gabriella
- Collins Brett L.
- ColobraÌn Roger
- Colombo Riccardo
- Conticini Edoardo
- Cordioli Mattia
- Cordioli Mattia
- Cordioli Mattia
- Cordioli Mattia
- Cordioli Mattia
- Cordioli Mattia
- Cordioli Mattia
- Cordioli Mattia
- Corridi Marta
- CorteÌs Beatriz
- Cossarizza Andrea
- Coto Eliecer
- Coviello Domenico A.
- CRiPSI null
- Croci Leonardo
- Croci Susanna
- Crook Derrick W.
- Crooks Kristy
- Crotti Lia
- Cullell Natalia
- Cusick Caroline
- Daga Sergio
- Dalmau David
- Daly Mark
- Danesh John
- Darcis Gilles
- Daya Michelle
- de Cid Rafael
- de Felipe Mimbrera Alicia
- de geus Eco (E. J. C. )
- De Vivo Oreste
- DeDiego Marta L.
- Deelen Patrick
- Dei Simona
- Della Monica Matteo
- Desanctis Elena
- Di Angelantonio Emanuele
- Di Biagio Antonio
- Di Domenico Paolo
- Di Pietro Massimo
- Di Sarno Laura
- Dietl Beatriz
- Do Ron
- DobanÌo Carlota
- Doddato Gabriella
- Domingo Carlos
- DomiÌnguez-Mayoral Anna
- Donati Alice
- Donner Kati
- Durand Madeleine
- DâAlessandro Miriana
- DâAntonio Matteo
- DâAntonio-Chronowska Agnieszka
- DâArminio Monforte Antonella
- DâMellow Kenton
- Earle Sarah G.
- Eid Mohammed A.
- El-Jawhari Jehan J.
- El-Lawaty Walaa M.
- El-shanshory Mohamed R.
- El-Sherbiny Yasser M.
- Elhadidy Tamer A.
- Elnagdy Marwa H.
- Eltoukhy Madonna M.
- Emiliozzi Arianna
- Emma Duncan
- Erard VeÌronique
- Esko ToÌnu
- Fabbiani Massimiliano
- Falcone Marco
- Fallerini Chiara
- FarreÌ Xavier
- Fava Francesca
- Fawns-Ritchie Chloe
- Fawns-Ritchie Chloe
- Fawzy Mohammad S.
- Felemban Walaa A.
- Feri Marco
- Fernandez-Cadenas Israel
- Ferreira Manuel A. R.
- Ferri Claudio
- FHoGID null
- Finer Sarah
- FinnGen null
- Finucane Hilary
- Fiorentino Giuseppe
- Fiz-LoÌpez Aida
- Forgetta Vincenzo
- Forgetta Vincenzo
- Fowler Tom
- Francesco Bianchi Antonio Perrella
- Franchi Federico
- Francisci Daniela
- Franco Giulianini
- Frazer Kelly A.
- Frediani Bruno
- Free Robert C.
- Frippiat Frederic
- Frithiof Robert
- Frullanti Elisa
- Furini Simone
- Gabbi Chiara
- Gabrieli Arianna
- Gaddis Michael
- GalvaÌn-FemeniÌa IvaÌn
- Ganna Andrea
- Ganna Andrea
- Garcia-Aymerich Judith
- GarciÌa-Clemente Marta
- GarciÌa-Madrona Sebastian
- Gass Matthew C.
- Gatti Francesca
- Gaziano J. Michael
- Genes &
- Georges Michel
- Gettler Kyle
- Ghosh Biswarup
- Giannattasio Ferdinando
- Gignoux Christopher R.
- Giliberti Annarita
- Giorli Alessia
- Giot Jean-Baptiste
- Girardis Massimo
- Girshick Ahna
- Glessner Joseph R.
- Glessner Joseph T.
- Gofflot SteÌphanie
- Goldstein Jacqueline I.
- Gomez Juan
- GonzaÌlez-Villa Esther
- Gori Marco
- Grassi Davide
- Green Robert C.
- Griffiths Christopher J.
- Grip Jonathan
- Guarnaccia Alessandra
- Guerrini Susanna
- Guidelli Luca
- Guindo-Martinez Marta
- Guiot Julien
- Guntz Julien
- Gupta Rahul
- Guturu Harendra
- Guyatt Anna L.
- Guzman Charlotte
- Hakonarson Hakon
- Hakonarson Hakon
- Halawani Roaa T.
- Harerimana Nadia
- Harris Jennifer R.
- Hasanato Rana
- Hayward Caroline
- Hayward Caroline
- Health Research Team null
- Hegazy Mohamed A. F.
- Helgeland Ăyvind
- Henry Danielle
- Hensen Kati
- Hiester Liam L.
- Hirankarn Nattiya
- Ho Yuk-Lam
- Hoggart Clive
- Hollox Edward J.
- Hong Eurie L.
- Horowitz Julie E.
- Hosseini Abdolmajid
- Hottenga Jouke Jan
- Huang Qin Qin
- Huckins Laura M.
- Huffman Jennifer E.
- HultstroÌm Michael
- Hunt Karen A.
- Huynen Pascale
- Hveem Kristian
- Iglesias Lara Lloret
- Ikram M. Arfan
- Iolascon Achille
- Itan Yuval
- Jacques Jessica
- Jantarabenjakul Watsamon
- JimeÌnez-XarrieÌ Elena
- John Catherine
- Jordan Daniel M.
- Josyula Navya Shilpa
- Jung Junghyun
- Justice Anne E.
- Kallaste Anne
- Kamdar Dhryata
- Kanai Masahiro
- Kanai Masahiro
- Kanai Masahiro
- Karczewski Konrad J.
- Karjalainen Juha
- Karlson Elizabeth W.
- Karp Avromie
- Kaufmann Daniel E.
- Kaunisto Mari
- Keller Katherine
- Kenny Eimear E.
- Kerr Shona M.
- Khafaga Walid T.
- Khattab Amin K.
- Kimchi Nofar
- King Daniel
- Kisand Kai
- Kivinen Katja
- Knight Spencer
- Koelling Nils
- Kogevinas Manolis
- Koskelainen Sami
- Kosmicki Jack A.
- Kousathanas Athanasios
- Kristiansson Kati
- La Rovere Maria Teresa
- Laane Edward
- Labkowsky Alexander
- Laisk Triin
- Lambermont Bernard
- Lanting Pauline
- Lathrop G. Mark
- Lauren Petty E.
- Laurent Laetitia
- LaÌll Kristi
- Leader Joseph B.
- Lee Paul H.
- Lee Yunsung
- LeFaive Jonathon
- Lena Fabio
- Lepage Pierre
- Lepamets Maarja
- Levy Tess
- LeÌonard Philippe
- Li Binglan
- Li Kevin W.
- Li Rui
- Liao Rachel G.
- Lin Shang-Kuan
- Lipcsey Miklos
- Lista Mirjam
- LluciaÌ-Carol Laia
- Lo Rizzo Caterina
- Loos Ruth J. F.
- Lopera Esteban
- Lorubbio Maria
- Lozano Francisco
- Lu Wenhan
- Lucas Anastasia
- Luchi Sauro
- Ludovisi Serena
- Maggiolo Franco
- Magnus Per
- Mahmoud Ebrahim S.
- Malaise Olivier
- Mamlouk Noor
- Mancarella Sandro
- MandalaÌ Marco
- Mangino Massimo
- Mangul Serghei
- Manson JoAnn E.
- Mantovani Stefania
- Marcantonio Simona
- Marciano Carmen
- Mari Francesca
- Maricic Tomislav
- Marike Boezen Lude Franke
- Martin Alicia R.
- Martin Hilary C.
- Martinelli Enrico
- MartiÌ-FaÌbregas Joan
- MartiÌn-Nalda Andrea
- MartiÌnez Alba Parra
- Masjuan Jaime
- Mason Dan
- Massadeh Salam
- Masucci Luca
- Matsui Hiroko
- Mazzei Maria Antonietta
- MaÌrquez Leonardo
- MaÌgi Reedik
- McCormick Joseph B.
- McCurdy Shannon
- Medina-Gomez Carolina
- Meigs James B.
- Meloni Ilaria
- Menatti Elisabetta
- Mencarelli Maria Antonietta
- MeneÌndez-Valladares Paloma
- Mercader Josep
- Mercader Josep Maria
- Merla Giuseppe
- Metsalu Kristjan
- Metspalu Andres
- Meuris Christelle
- Milani Lili
- Miraglia Federica Gaia
- Mirshahi Tooraj
- Misset Benoit
- Moahmed Hanteera S.
- Mohamed Attia A. S.
- Mohseni Moghaddam Seyed Behrooz
- Mondelli Mario Umberto
- Montagnani Francesca
- Mooser Vincent
- Moreno Victor
- Morris Marcela
- Morrison David R.
- Moutschen Michel
- Moutsianas Loukas
- MuinÌo Elena
- Murphy Shawn N.
- Mussini Cristina
- Naaber Paul
- Naderpour Zeinab
- Nadkarni Girish N.
- Nakanishi Tomoko
- Nakanishi Tomoko
- Neale Benjamin M.
- Nencioni Cesira
- Neofytos Dionysios
- Nguyen Huy
- Nguyen Jennifer P.
- Niavarani Ahmadreza
- Niblo Kristi
- Niemi Mari E. K.
- Niemi Mari E. K.
- Niemi Mari E. K.
- Niemi Mari E. K.
- Niemi Mari E. K.
- Nilaratanakul Voraphoj
- Nivard Michel (M. G. )
- Nkambul Lindo
- Nkambul Lindokuhle
- Nkambul Lindokuhle
- Nkambule Lindokuhle
- Nkambule Lindokuhle
- North Kari
- Noto Keith
- Nussle Semira Gonseth
- Odhams Christopher A.
- Ognibene Agostino
- Okasha Kamal
- Oliveira Maureen
- Ori Anil P. S.
- OâConnell Anne Marie
- OâDonnell Christopher J.
- OâReilly Paul
- P-PredictUs null
- Paciosi Francesco
- Paciosi Francesco
- Packer Richard J.
- Palmer Duncan S.
- Palmieri Maria
- Palotie Aarno
- Pancrazzi Alessandro
- Panese Sandro
- Parati Gianfranco
- Parisi Saverio Giuseppe
- Park Danny
- Parravicini Pierpaolo
- Partha Raghavendran
- Pasko Dorota
- Pathak Gita A.
- Pathak Gita A.
- Pavlovic Milos
- Peloso Gina
- Perez Emma F.
- Perez-Tur Jordi
- Perna Rita
- Perola Markus
- Peruggia Michael
- Pessina Gloria
- Pesukova Jaana
- Peterson PaÌrt
- Petitjean Louis
- Petrocelli Paola
- Phokaew Chureerat
- Piacentini Paolo
- Picchiotti Nicola
- Pigazzini Sara
- Pigazzini Sara
- Pigazzini Sara
- Pigazzini Sara
- Pinoli Pietro
- Pinto Anna Maria
- Pirinen Matti
- Piscopo Carmelo
- Planas Anna M.
- Polikowski Hannah
- Polimanti Renato
- Polymeropoulos Christos
- Polymeropoulos Mihael H.
- Polymeropoulos Vasilios
- Pongpanich Monnat
- Porteous David J.
- Porteous David J.
- Poscente Monica
- Preuss Michael
- Przychodzen Bartlomiej P.
- Putchareon Opass
- Puthanakit Thanyawee
- Puusepp Mairo
- Quinodoz Mathieu
- Quiros-Roldan Eugenia
- Rader Daniel
- Rafaels Nicholas
- Raggi Pamela
- Ragoussis Jiannis
- Rahmouni Souad
- Raimondi Francesco
- Rancan Ilaria
- Rand Kristin
- Ravaglia Sabrina
- RegCOVID null
- Reimann Ene
- Rendon Augusto
- Renieri Alessandra
- Rhead Brooke
- Rhodes Daniel
- Richards J. Brent
- Richards J. Brent
- Richmond Anne
- Richmond Anne
- Rico Veronica
- Ridker Paul M.
- Ringmets Inge
- Ripamonti Diego
- Ripatti Samuli
- Ritchie Marylyn D.
- Riva Agostino
- Rivolta Carlo
- Rizzi Marco
- Roberts Genevieve
- Robles Veronica
- Rogne Tormod
- Rojo Silvia
- Romani Davide
- Rooyackers Olav
- Rossetti Barbara
- Rudkin Justine K.
- Ruiz Luong
- Ruiz-JaeÌn Francisca
- Ruotsalainen Sanni
- Rusconi Stefano
- Russo Roberta
- Sabrina Ravaglia
- Saeedi Morteza
- Safieh Leen Abu
- Salerni Lorenzo
- Salib Irene
- Samir Amr
- Sanarico Maurizio
- Sanguinetti Maurizio
- Sarma Gopal
- Sarzi-Braga Simona
- Satterstrom F. Kyle
- Sauvage Anne-Sophie
- Sawaji Mona
- Scaggiante Renzo
- Scala Raffaele
- Schadt Eric E.
- Schiaroli Elisabetta
- Schurr Erwin
- Scolletta Sabino
- Scott Richard H.
- Scotton Pier Giorgio
- Sealfon Stuart C.
- Sebastian ZoÌllner Brooke Wolford
- Sebra Robert P.
- Seed Cotton
- Segala Francesco Vladimiro
- Segura TomaÌs
- SeroCOVID null
- Serra-Llovich Alex
- Serrano-Heras Gemma
- Sesso Howard D.
- Shahin Doaa
- Sharififard Bahareh
- Shaw Douglas M.
- Shortt Jonathan
- Shotelersuk Vorasuk
- Shrine Nick
- Siano Matteo
- Sloofman Laura G.
- Smieszek Sandra P.
- Smith Albert V.
- Smoller Jordan W.
- Sobh Ali
- Sodsai Pimpayao
- Soler Pere
- Solligard Erik
- Solomonson Matthew
- Solomonson Matthew
- Soranzo Nicole
- Soriano Alex
- Spargi Genni
- Spector Tim D.
- Spencer Chris C. A.
- Spertilli Chiara
- Squeo Gabriella Maria
- Starkopf Joel
- Stella Alessandra
- Stevens Christine
- Stevens Christine
- Stuckey Alex
- Suardi Claudia
- Suchartlikitwong Pintip
- Suh NoeÌmie
- Suliman Bandar A.
- Sumoy Lauro
- Sun Yan V.
- Suttichet Thitima B.
- Tabri Jekaterina
- Tacconi Danilo
- Tadi Hengameh Ansari
- Tamm Anu
- Tanfoni Marco
- Tang Lara
- Tardif Nicolas
- Tavecchia Luisa
- Tenesa Albert
- Thompson Ryan C.
- Thys Marie
- Timmers Paul R. H. J.
- Tiseo Giusy
- Tita Rossella
- Tobin Martin D.
- Tommasi Andrea
- Torky Mohamed S.
- Torrents David
- Torvorapanit Pattama
- Trankiem Amy
- Trembath Richard C.
- Trivedi Bhavi
- Trogstad Lill-Iren S.
- Trotta Tullio
- Tsao Phil
- Tselios Chris
- Tsuo Kristin
- Tumbarello Mario
- Turley Patrick
- Uitterlinden Andre G.
- Underwood Slayton J.
- Vaghi Massimo
- Valente Serafina
- Valentino Floriana
- van Blokland Irene
- van Heel David A.
- Vecchia Marco
- Veerapen Kumar
- Venn Laura D.
- Venturelli Sophie
- Vergori Alessandra
- Verma Anurag
- Verma Shefali S.
- Verzuri Agnese
- Villalonga Joan Montaner
- Vincenti Antonella
- Voide Cathy
- Von Frenckell Christian
- Vonk Judith. M.
- Wain Louise V.
- Walker Susan
- Walters Raymond K.
- Wang Jiongming
- Wang Xueyang
- Wanying Zhu
- Warmerdam Robert
- Weiss Scott T.
- Wicks Stephen J.
- Willer Cristen
- Williams Alexander T.
- Wilson Daniel J.
- Wilson James F.
- Wolford Brooke
- Wolford Brooke
- Woolley Ann E.
- Wright John
- Wyllie David H.
- Xue Xiaoqing
- Yadav Ashish
- Yassen Amr M.
- Zanella Isabella
- Zeberg Hugo
- Zguro Kristina
- Zhang Miao
- Zhao Jing Hua
- Zhou Wei
- Zhou Wei
- Zlatopolsky Menachem
- Zucchi Patrizia
- Zyndorf Marissa
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2021
- Field of study
Variability in SARS-CoV-2 susceptibility and COVID-19 disease severity between individuals is partly due to
genetic factors. Here, we identify 4 genomic loci with suggestive associations for SARS-CoV-2 susceptibility
and 19 for COVID-19 disease severity. Four of these 23 loci likely have an ethnicity-specific component.
Genome-wide association study (GWAS) signals in 11 loci colocalize with expression quantitative trait loci
(eQTLs) associated with the expression of 20 genes in 62 tissues/cell types (range: 1:43 tissues/gene),
including lung, brain, heart, muscle, and skin as well as the digestive system and immune system. We perform
genetic fine mapping to compute 99% credible SNP sets, which identify 10 GWAS loci that have eight or fewer
SNPs in the credible set, including three loci with one single likely causal SNP. Our study suggests that the
diverse symptoms and disease severity of COVID-19 observed between individuals is associated with variants across the genome, affecting gene expression levels in a wide variety of tissue types
Genetic drivers of heterogeneity in type 2 diabetes pathophysiology
- Author
- Adair Linda S.
- Adeyemo Adebowale
- Aguilar-Salinas Carlos A.
- Ahlqvist Emma
- Ahluwalia Tarunveer S.
- Ahsan Habibul
- An Ping
- Anand Sonia S.
- Arruda Ana Luiza
- Becker Diane M.
- Below Jennifer E.
- Bertoni Alain
- Bharadwaj Dwaipayan
- Bielak Lawrence F.
- Bocher Ozvan
- Boehnke Michael
- Bonnefond Amélie
- Bork-Jensen Jette
- Bowden Donald W.
- Bragg Fiona
- Brandslund Ivan
- Broadaway K. Alaine
- Brody Jennifer A.
- Buchanan Thomas A.
- Burant Charles F.
- Butterworth Adam S.
- Cade Brian E.
- Canouil Mickaël
- Chai Jin-Fang
- Chambers John C.
- Chan Juliana C. N.
- Chandak Giriraj R.
- Chang Kyong-Mi
- Chang Li-Ching
- Chee Miao-Li
- Chen Chien-Hsiun
- Chen Guanjie
- Chen Ji
- Chen Shyh-Huei
- Chen Wei-Min
- Chen Yii-Der Ida
- Chen Yuan-Tsong
- Chen Zhengming
- Cheng Ching-Yu
- Cho Yoon Shin
- Choi Hyeok Sun
- Chuang Lee-Ming
- Collins Francis S.
- Cook James P.
- Cruz Miguel
- Cui Jinrui
- Cushman Mary
- Dam Rob M. van
- Danesh John
- Das Swapan K.
- de Silva H. Janaka
- Dedoussis George
- Denny Joshua C.
- Dijk Ko Willems van
- Dimitrov Latchezar
- Doumatey Ayo P.
- Du Shufa
- Duan Qing
- Dupuis Josee
- Eckardt Kai-Uwe
- Emery Leslie S.
- Engert James C.
- Evans Daniel S.
- Evans Michele K.
- Finer Sarah
- Fischer Krista
- Florez Jose C.
- Floyd James S.
- Ford Ian
- Fornage Myriam
- Franco Oscar H.
- Frayling Timothy M.
- Freedman Barry I.
- Froguel Philippe
- Genter Pauline
- Gerstein Hertzel C.
- Ghanbari Mohsen
- Giedraitis Vilmantas
- Gieger Christian
- GonzĂĄlez-Villalpando Clicerio
- GonzĂĄlez-Villalpando Maria Elena
- Goodarzi Mark O.
- Gordon-Larsen Penny
- Graff Mariaelisa
- Grallert Harald
- Grarup Niels
- Gross Myron
- Guare Lindsay A.
- Guo Xiuqing
- Hackinger Sophie
- Hai Yang
- Haiman Christopher A.
- Hakaste Liisa
- Han Sohee
- Hanis Craig L.
- Hansen Torben
- Hattersley Andrew T.
- Hatzikotoulas Konstantinos
- Hayes M. Geoffrey
- Heel David A. van
- Herder Christian
- Horikoshi Momoko
- Howard Annie-Green
- Hsueh Willa
- Huang Mengna
- Huang Wei
- Huerta-Chagoya Alicia
- Hung Yi-Jen
- Hwang Mi Yeong
- Hwu Chii-Min
- Ichihara Sahoko
- Igase Michiya
- Ikram Mohammad Arfan
- Ingelsson Erik
- Ingelsson Martin
- Ipp Eli
- Islam Md. Tariqul
- Isono Masato
- Jang Hye-Mi
- Jasmine Farzana
- Jiang Guozhi
- Jonas Jost B.
- Joo Yoonjung Yoonie
- Jukema J. Wouter
- JĂžrgensen Torben
- Kabagambe Edmond
- Kadowaki Takashi
- Kals Mart
- Kamali Zoha
- Kamanu Frederick K.
- Kandeel Fouad R.
- Kanona Stavroula
- Kanoni Stavroula
- Kardia Sharon L. R.
- Kasturiratne Anuradhani
- Kato Norihiro
- Katsuya Tomohiro
- Kaur Varinderpal
- Kawaguchi Takahisa
- Keaton Jacob M.
- Kho Abel N.
- Khor Chiea-Chuen
- Kibriya Muhammad G.
- Kim Bong-Jo
- Kim Duk-Hwan
- Kim Young Jin
- Klinken Jan B. van
- Koh Woon-Puay
- Kooner Jaspal S.
- Kooperberg Charles
- Kronenberg Florian
- Kuusisto Johanna
- Kwak Soo-Heon
- Köttgen Anna
- Laakso Markku
- Lamri Amel
- Lange Leslie A.
- Langenberg Claudia
- Lee Jung-Jin
- Lee Juyoung
- Lee Kyung Min
- Lee Myung-Shik
- Lee Nanette R.
- Lee Simon S. K.
- Leong Aaron
- Li Liming
- Li Yun
- Li-Gao Ruifang
- Ligthart Symen
- Lim Victor J. Y.
- Lin Kuang
- Lind Lars
- Lindgren Cecilia M.
- Linneberg Allan
- Liu Ching-Ti
- Liu Jianjun
- Liu Simin
- Liu Yongmei
- Locke Adam E.
- Long Jirong
- Loos Ruth J. F.
- Lorenz Kim M.
- Louie Tin
- Luan Jianâan
- Luk Andrea O.
- Luo Xi
- Lv Jun
- Lynch Julie A.
- Lyssenko Valeriya
- LĂ€ll Kristi
- Ma Ronald C. W.
- Maeda Shiro
- Mahajan Anubha
- Mamakou Vasiliki
- Mandla Ravi
- Mansuri Sohail Rafik
- Marston Nicholas A.
- Matsuda Fumihiko
- Matsuda Koichi
- McCarthy Mark I.
- McKean-Cowdin Roberta
- Meigs James B.
- Meitinger Thomas
- Melander Olle
- Melloni Giorgio E. M.
- Mercader Josep M.
- Metspalu Andres
- Millwood Iona Y.
- Mo Huan
- Mohlke Karen L.
- Mook-Kanamori Dennis O.
- Moon Sanghoon
- Morris Andrew D.
- Morris Andrew P.
- Motala Ayesha A.
- Moura Filipe A.
- MĂ€gi Reedik
- Nadler Jerry L.
- Nakatochi Masahiro
- Nalls Michael A.
- Namba Shinichi
- Nano Jana
- Nayak Uma
- Ng Maggie C. Y.
- Nicolas Aude
- Nongmaithem Suraj S.
- Noordam Raymond
- North Kari E.
- Nousome Darryl
- Ntalla Ioanna
- Okada Yukinori
- Orozco Lorena
- Palmer Colin N. A.
- Pan Ian
- Pankow James S.
- Park Kyong-Soo
- Parra Esteban J.
- Paré Guillaume
- Patel Sanjay R.
- Patil Snehal
- Pedersen Oluf
- Pei Pei
- Pereira Mark A.
- Peters Annette
- Petty Lauren E.
- Peyser Patricia A.
- Pirie Fraser J.
- Polikowsky Hannah G.
- Porneala Bianca
- Prasad Gauri
- Preuss Michael H.
- Prins Bram Peter
- Province Michael A.
- Psaty Bruce M.
- Rader Daniel J.
- Raffel Leslie J.
- Raffield Laura M.
- Rasmussen-Torvik Laura J.
- Rayner Nigel W.
- Redline Susan
- Reiner Alexander P.
- Rich Stephen S.
- Ritchie Marylyn D.
- Roden Michael
- Rohde Rebecca
- Roll Katheryn
- Rotimi Charles N.
- Rotter Jerome I.
- Ruff Christian T.
- Sabanayagam Charumathi
- Sale MichĂšle M.
- Saleheen Danish
- Sandow Kevin
- Sankareswaran Alagu
- Sarnowski Chloé
- Sattar Naveed
- Schroeder Philip
- Schönherr Sebastian
- Scott Robert A.
- Shahriar Mohammad
- Shen Botong
- Sheu Wayne H. H.
- Shi Jinxiu
- Shin Dong Mun
- Shojima Nobuhiro
- Shu Xiao-Ou
- Sim Xueling
- Smith Jennifer A.
- So Wing Yee
- Sofer Tamar
- Sonehara Kyuto
- Southam Lorraine
- Spracklen Cassandra N.
- StanÄĂĄkovĂĄ Alena
- Stefansson Kari
- Steinthorsdottir Valgerdur
- Stilp Adrienne M.
- Strauch Konstantin
- Sun Meng
- Suzuki Ken
- Tabara Yasuharu
- Tai E-Shyong
- Takeuchi Fumihiko
- Taliun Daniel
- Tam Claudia H. T.
- Tan Jingyi
- Taylor Henry J.
- Taylor Kent D.
- Thangam Manonanthini
- Thorand Barbara
- Thorleifsson Gudmar
- Thorsteinsdottir Unnur
- Tomlinson Brian
- Tong Lin
- Tran Tam C.
- Trompet Stella
- Tsai Fuu-Jen
- Tsao Philip S.
- Tuomi Tiinamaija
- Tuomilehto Jaakko
- Tusie-Luna Teresa
- Udler Miriam S.
- Valladares-Salgado Adan
- van Heel David A.
- Vanderwerff Brett
- Varma Rohit
- Voight Benjamin F.
- Vujkovic Marijana
- Wacher-Rodarte Niels
- Walters Robin G.
- Wang Ya-Xing
- Wareham Nicholas J.
- Wheeler Eleanor
- Wickremasinghe Ananda R.
- Williamson Alice
- Wilson James G.
- Witte Daniel R.
- Wong Tien-Yin
- Wu Jer-Yuarn
- Wuttke Matthias
- Xiang Anny H.
- Yajnik Chittaranjan S.
- Yamamoto Ken
- Yamamoto Kenichi
- Yamauchi Toshimasa
- Yanek Lisa R.
- Yao Jie
- Yin Xianyong
- Yokota Mitsuhiro
- Yoon Kyungheon
- Yu Canqing
- Yuan Jian-Min
- Yusuf Salim
- Zawistowski Matthew
- Zeggini Eleftheria
- Zhang Liang
- Zhang Weihua
- Zheng Wei
- Zonderman Alan B.
- Zöllner Sebastian
- Publication venue
- Publication date
- 01/01/2024
- Field of study
Type 2 diabetes (T2D) is a heterogeneous disease that develops through diverse pathophysiological processes1,2 and molecular mechanisms that are often specific to cell type3,4. Here, to characterize the genetic contribution to these processes across ancestry groups, we aggregate genome-wide association study data from 2,535,601 individuals (39.7% not of European ancestry), including 428,452 cases of T2D. We identify 1,289 independent association signals at genome-wide significance (Pâ<â5âĂâ10-8) that map to 611 loci, of which 145 loci are, to our knowledge, previously unreported. We define eight non-overlapping clusters of T2D signals that are characterized by distinct profiles of cardiometabolic trait associations. These clusters are differentially enriched for cell-type-specific regions of open chromatin, including pancreatic islets, adipocytes, endothelial cells and enteroendocrine cells. We build cluster-specific partitioned polygenic scores5 in a further 279,552 individuals of diverse ancestry, including 30,288 cases of T2D, and test their association with T2D-related vascular outcomes. Cluster-specific partitioned polygenic scores are associated with coronary artery disease, peripheral artery disease and end-stage diabetic nephropathy across ancestry groups, highlighting the importance of obesity-related processes in the development of vascular outcomes. Our findings show the value of integrating multi-ancestry genome-wide association study data with single-cell epigenomics to disentangle the aetiological heterogeneity that drives the development and progression of T2D. This might offer a route to optimize global access to genetically informed diabetes care.</p
The trans-ancestral genomic architecture of glycemic traits
- Author
- Abecasis Gonçalo
- Adair Linda
- Aguilar-Salinas Carlos Alberto
- Ahluwalia Tarunveer
- AlarcĂłn-Riquelme Marta
- Amin Najaf
- An Ping
- Anasanti Mila
- Appel Emil
- Arzumanyan Zorayr
- Astrup Arne
- Aviles-Santa Larissa
- Bakker Stephan
- Baldassarre Damiano
- Barroso InĂȘs
- Becker Diane
- Beekman Marian
- Beilin Lawrence
- Bergman Richard
- Bergmann Sven
- Bertoni Alain
- Bielak Lawrence
- Bisgaard Hans
- Black Corri
- BlĂŒher Matthias
- Boehnke Michael
- Boerwinkle Eric
- Bonnycastle Lori
- Boomsma D.
- Bornstein Stefan
- Bottinger Erwin
- Boutin Thibaud
- Bowden Donald
- Brody Jennifer
- Buchanan Thomas
- Burtt Noël
- Böhm Bernhard
- BĂžnnelykke Klaus
- Cabrera Claudia
- Cade Brian
- Cai Qiuyin
- Campbell Archie
- Campbell Harry
- Canouil Mickaël
- Caulfield Mark
- Chai Jin Fang
- Chai Xiaoran
- Chambers John
- Chan Kei Hang Katie
- Chang Li-Ching
- Chang Yi Cheng
- Chasman Daniel
- Chen Brian
- Chen Chien-Hsiun
- Chen Ji
- Chen Yii-Der Ida
- Cheng Ching-Yu
- Chitrala Kumaraswamy Naidu
- Chiu Yen-Feng
- Chu Audrey
- Claringbould Annique
- Collins Francis
- Corbin Laura
- Correa Adolfo
- Cucca Francesco
- de Geus Eco
- de Geus Eco
- de Haan Hugoline
- de Haan Hugoline
- de Silva H. Janaka
- de Silva H. Janaka
- Dedoussis George
- Dehghan Abbas
- Delgado Graciela
- Demirkan Ayse
- Du Shufa
- Duan Qing
- Dupuis Josée
- Eiriksdottir Gudny
- ElmstÄhl Sölve
- Engmann Jorgen
- Evans Michele
- Farmaki Aliki Eleni
- Fatumo Segun
- Ferrannini Ele
- Ferrucci Luigi
- Florez Jose
- Franks Paul
- Frayling Timothy
- Froguel Philippe
- FrÄnberg Mattias
- Fuchsberger Christian
- Gao Yutang
- GayĂĄn Javier
- Gigante Bruna
- Giulianini Franco
- Gjesing Anette
- Gloyn Anna
- Goel Anuj
- Gong Jung Ho
- Goodarzi Mark
- Gordon-Larsen Penny
- Grallert Harald
- Grarup Niels
- Grimsgaard Sameline
- Groop Leif
- Gudnason Vilmundur
- Guo Xiuqing
- Gustafsson Stefan
- Hai Yang
- Hamsten Anders
- Han Sohee
- Hansen Torben
- Hartman Catharina
- Hartwig Fernando
- Hayward Caroline
- He Jing
- Heckbert Susan
- Heianza Yoriko
- Heikkinen Jani
- Herder Christian
- Hicks Andrew
- Hong Jaeyoung
- Horikoshi Momoko
- Horta Bernardo
- Hottenga Jouke-Jan
- Hsieh Chang-Hsun
- Hsueh Willa
- Huang Tao
- Huang Wei
- Huerta-Chagoya Alicia
- Huo Shaofeng
- Hwang Mi Yeong
- Ichihara Sahoko
- Igase Michiya
- Ikram M. Arfan
- Ingelsson Erik
- James Pankow
- Jarvelin Marjo-Ritta
- Jensen Richard
- Johnson W. Craig
- Jonas Jost
- Joshi Peter
- Jukema J. Wouter
- JĂžrgensen Marit
- Kaakinen Marika
- Kaleebu Pontiano
- Kalyani Rita
- Kandeel Fouad
- Kaplan Robert
- Kardia Sharon
- Kato Norihiro
- Katsuya Tomohiro
- Kawaguchi Takahisa
- Keinanen-Kiukaanniemi Sirkka
- Kentistou Katherine
- Khor Chiea Chuen
- Kiess Wieland
- Kim Bong-Jo
- Kim Young Jin
- Kivimaki Mika
- Kleber Marcus
- Koistinen Heikki
- Kolcic Ivana
- Kooner Ishminder
- Kooner Jaspal
- Kovacs Peter
- Kuh Diana
- Kumari Meena
- Kutalik Zoltan
- Kuulasmaa Teemu
- Kuusisto Johanna
- Körner Antje
- Laakso Markku
- Lai Shuiqing
- Lakka Timo
- Lam Kelvin
- Lange Leslie
- Langefeld Carl
- Langenberg Claudia
- Launer Lenore
- Lauzon Marie
- Lawlor Deborah
- Leander Karin
- Lee Nanette
- Lemaitre Rozenn
- Leong Aaron
- Li Honglan
- Li Huaixing
- Li Man
- Li-Gao Ruifang
- Ligthart Symen
- Lin Shih-Yi
- Lin Xu
- Lind Lars
- Lindgren Cecilia
- Lindström Jaana
- Linneberg Allan
- Liu Ching-Ti
- Liu Jianjun
- Liu Jun
- Liu Simin
- Loh Marie
- Long Jirong
- Loos Ruth
- Lorenzo Carlos
- Louie Tin
- Luan Jianâan
- Lyssenko Valeriya
- LĂ€ll Kristi
- Magnusson Patrik
- Mahajan Anubha
- Mangino Massimo
- Marenne Gaëlle
- Marzi Carola
- Matsubara Tatsuaki
- Matsuda Fumihiko
- Mccarthy Mark
- Meigs James
- Metspalu Andres
- Mingrone Geltrude
- Mohlke Karen
- Montasser May
- Mooijaart Simon
- Mook-Kanamori Dennis
- Moon Sanghoon
- Moreno-Macias Hortensia
- Mori Trevor
- Morris Andrew
- Munroe Patricia
- MĂ€gi Reedik
- MĂ€rz Winfried
- Nabika Toru
- Nadkarni Girish
- Nadler Jerry
- Nag Abhishek
- Nakatochi Masahiro
- Ndungu Anne
- Nelis Mari
- Nelson Sarah
- Neville Matt
- NjĂžlstad Inger
- Noce Damia
- Nolte Ilja
- Noordam Raymond
- Norris Jill
- North Kari
- Ohyagi Yasumasa
- Oldehinkel Albertine
- Ong Ken
- Oâconnell Jeffrey
- Padmanabhan Sandosh
- Palmer Colin
- Palmer Nicholette
- Parker Stephen
- Pedersen Oluf
- Pennell Craig
- Peters Annette
- Peyser Patricia
- Pistis Giorgio
- Polasek Ozren
- Porteous David
- Pramstaller Peter
- Preuss Michael
- Prokopenko Inga
- Province Michael
- Psaty Bruce
- Qi Lu
- Qi Qibin
- Raffel Leslie
- Raffield Laura
- Rasmussen-Torvik Laura
- Raulerson Chelsea
- Rauramaa Rainer
- Raven Dennis
- Ray Debashree
- Redline Susan
- Reilly Dermot
- Reiner Alex
- Rich Stephen
- Ridker Paul
- Rivideneira Fernando
- Robertson Neil
- Rohde Rebecca
- Roll Kathryn
- Rosendaal Frits
- Rotter Jerome
- Rudan Igor
- Rueedi Rico
- Ryan Kathleen
- Rybin Denis
- Saaristo Timo
- Sabanayagam Charumathi
- Sandhu Manjinder
- Sandow Kevin
- Sanna Serena
- Saramies Jouko
- Sattar Naveed
- Saxena Richa
- Schneiderman Neil
- Schraut Katharina
- Schurmann Claudia
- Schwarz Peter
- SchĂŒrmann Annette
- Scott Laura
- Scott Robert
- Selvin Elizabeth
- Sennblad Bengt
- Setoh Kazuya
- Sever Peter
- Shi Jinxiu
- Shu Xiao-Ou
- Sim Xueling
- Slagboom P. Eline
- Small Kerrin
- Smith Albert
- Smith Blair
- Snieder Harold
- Sofer Tamar
- Southam Lorraine
- SparsĂž Thomas
- Spector Tim
- Spracklen Cassandra
- Stanton Alice
- Steves Claire
- Stewart Isobel
- Strawbridge Rona
- Stringham Heather
- Stumvoll Michael
- Sun Liang
- SĂžrensen Thorkild
- Tabara Yasuharu
- Tai E. Shyong
- Takeuchi Fumihiko
- Tan Jingyi
- Taylor Kent
- Teslovich Tanya
- Thuesen Betina
- Timmers Paul
- Timpson Nicholas
- Tremoli Elena
- Trompet Stella
- Tsai Michael
- Tuomilehto Jaakko
- Tusie Teresa
- Tönjes Anke
- Uitterlinden Andre
- Uusitupa Matti
- van Dam Rob
- van Dam Rob
- van den Akker Erik
- van den Akker Erik
- van der Harst Pim
- van der Harst Pim
- van der Most Peter
- van der Most Peter
- van Duijn Cornelia
- van Duijn Cornelia
- van Heemst Diana
- van Heemst Diana
- van Hylckama Vlieg Astrid
- van Hylckama Vlieg Astrid
- van Vliet-Ostaptchouk Jana
- van Willems van Dijk Ko
- Vangipurapu Jagadish
- Varshney Arushi
- Verweij Niek
- Vestergaard Henrik
- Vitart Veronique
- Vogel Mandy
- Vollenweider Peter
- Vrijkotte Tanja
- Waage Johannes
- Wagenknecht Lynne
- Walker Mark
- Wang Carol
- Wang Chaolong
- Wang Heming
- Wang Nan
- Wang Tao
- Wang Ya
- Wang Yujie
- Wareham Nick
- Warren Helen
- Watanabe Richard
- Watkins Hugh
- Wei Wen
- Wen Wanqing
- Wheeler Eleanor
- Wickremasinghe Ananda
- Willems van Dijk Ko
- Willems Sara
- Willemsen Gonneke
- Wilsgaard Tom
- Wilson James
- Wong Andrew
- Wong Tien-Yin
- Wood Andrew
- Wu Jer-Yuarn
- Wu Peitao
- Wu Ying
- Xiang Anny
- Xie Tian
- Yanek Lisa
- Yao Jie
- Yengo LoĂŻc
- Yokota Mitsuhiro
- Zafarmand Mohammad Hadi
- Zeggini Eleftheria
- Zemunik Tatijana
- Zhang Weihua
- Zhang Xiaoshuai
- Zhao Jing-Hua
- Zhao Wei
- Zheng Wei
- Zonderman Alan
- Publication venue
- Publication date
- 01/01/2021
- Field of study
Glycemic traits are used to diagnose and monitor type 2 diabetes and cardiometabolic health. To date, most genetic studies of glycemic traits have focused on individuals of European ancestry. Here we aggregated genome-wide association studies comprising up to 281,416 individuals without diabetes (30% non-European ancestry) for whom fasting glucose, 2-h glucose after an oral glucose challenge, glycated hemoglobin and fasting insulin data were available. Trans-ancestry and single-ancestry meta-analyses identified 242 loci (99 novel; P < 5 x 10(-8)), 80% of which had no significant evidence of between-ancestry heterogeneity. Analyses restricted to individuals of European ancestry with equivalent sample size would have led to 24 fewer new loci. Compared with single-ancestry analyses, equivalent-sized trans-ancestry fine-mapping reduced the number of estimated variants in 99% credible sets by a median of 37.5%. Genomic-feature, gene-expression and gene-set analyses revealed distinct biological signatures for each trait, highlighting different underlying biological pathways. Our results increase our understanding of diabetes pathophysiology by using trans-ancestry studies for improved power and resolution. A trans-ancestry meta-analysis of GWAS of glycemic traits in up to 281,416 individuals identifies 99 novel loci, of which one quarter was found due to the multi-ancestry approach, which also improves fine-mapping of credible variant sets.Peer reviewe
Dissecting the Shared Genetic Architecture of Suicide Attempt, Psychiatric Disorders, and Known Risk Factors
- Author
- Abdellaoui Abdel
- Abramova Liliya
- Adams Mark
- Adams Mark J.
- Adan Roger A. H.
- Adolfsson Rolf
- Adolfsson Rolf
- Adorjan Kristina
- Agartz Ingrid
- Agartz Ingrid
- Agerbo Esben
- Agerbo Esben
- Agerbo Esben
- Aguayo Samuel
- Ahuja Sunil
- Air Tracy M.
- Air Tracy M.
- Al Eissa Mariam
- Albani Diego
- Alda Martin
- Alda Martin
- Alfredsson Lars
- Alfredsson Lars
- Alfredsson Lars
- Alliey-Rodriguez Ney
- Als Thomas D.
- Andlauer Till F. M.
- Ando Tetsuya
- Andreassen Ole A.
- Andreassen Ole A.
- Andreassen Ole A.
- Anjorin Adebayo
- Anjorin Adebayo
- Antilla Verneri
- Antoniou Anastasia
- Appadurai Vivek
- Argyres Dean P.
- Arolt Volker
- Artigas Maria Soler
- Aschauer Harald
- Ashley-Koch Allison E.
- Aslan Mihaela
- Awasthi Swapnil
- Awasthi Swapnil
- Awasthi Swapnil
- Azevedo M. Helena
- Babadjanova Gulja
- Bacanu Silviu-Alin
- Backlund Lena
- Baek Ji Hyun
- Baker Jessica H.
- Ballas Zuhair
- Bass Nicholas
- Bass Nicholas
- Bau Claiton H. D.
- Bauer Michael
- Baune Bernhard T.
- Baune Bernhard T.
- Baune Bernhard T.
- Beckham Jean
- Beckham Jean
- Beckham Jean C.
- Beekman Aartjan T. F.
- Beins Eva C.
- Bellivier Frank
- Bellivier Frank
- Bencko Vladimir
- Bengesser Susanne
- Bergen Andrew W.
- Bergen Andrew W.
- Bergen Sarah E.
- Berger Klaus
- Berger Klaus
- Berrettini Wade H.
- Berrettini Wade H.
- Berrettini Wade H.
- Bhushan Sujata
- Biernacka Joanna M.
- Biernacka Joanna M.
- Bigdeli Tim B.
- Bigdeli Tim B.
- Bigdeli Tim B.
- Binder Elisabeth B.
- Binder Elisabeth B.
- BirgegÄrd Andreas
- Birner Armin
- Blackwood Douglas H. R.
- Boden Joseph M.
- Boehm Ilka
- Boehnke Michael
- Boehnke Michael
- Bohus Martin
- Bohus Martin
- Boks Marco P.
- Boks Marco P.
- Boni Claudette
- Boomsma Dorret I.
- Bosch Rosa
- Bosch Rosa
- Boyko Edward
- Braff David L.
- Brandt Harry
- Brandt Harry
- Breeling James
- Breen Gerome
- Breen Gerome
- Breen Gerome
- Breen Gerome
- Brewer Jessica V.
- Brophy Mary T.
- Brum Murielle
- Brumpton Ben M.
- Brunkhorst-Kanaan Nathalie
- Bryant Richard
- Bryois Julien
- Bryois Julien
- Bryois Julien
- Budde Monika
- Budde Monika
- Buehren Katharina
- Bulik Cynthia M.
- Bulik Cynthia M.
- Burghardt Roland
- ButtenschĂžn Henriette N.
- Bybjerg-Grauholm Jonas
- Bybjerg-Grauholm Jonas
- Byerley William
- Byrne Enda M.
- Byrne Enda M.
- BĂŠkvad-Hansen Marie
- BĂŠkvad-Hansen Marie
- BĂžen Erlend
- BĂžrglum Anders D.
- BĂžrglum Anders D.
- BĂžrglum Anders D.
- BĂžrte Sigrid
- Cahn Wiepke
- Cai Na
- Cairns Murray
- Campos Adrian I.
- Carlberg Laura
- Carr Vaughan J.
- Carter Bruce W.
- Casas Miguel
- Casas Miquel
- Cassina Matteo
- Castelao Enrique
- Castelao Enrique
- Catts Stanley
- Cervantes Pablo
- Cervilla Jorge A.
- Chang Kyong-Mi
- Chang Xiao
- Charney Alexander W.
- Chaumette Boris
- Chen Hsi-Chung
- Chen Wei J.
- Cho Kelly
- Cho Kelly
- Christensen Jane Hvarregaard
- Cichon Sven
- Cichon Sven
- Cichon Sven
- Cichon Sven
- Clarke Toni-Kim
- Clarke Toni-Kim
- Clementi Maurizio
- Cohen David
- Coleman Jonathan R. I.
- Coleman Jonathan R. I.
- Coleman Jonathan R. I.
- Coleman Jonathan R. I.
- Colodro-Conde LucĂa
- Cone Roger D.
- Connor Todd
- Constans Joseph
- Coombes Brandon
- Coon Hilary
- Corvin Aiden
- Corvin Aiden
- Courtet Philippe
- Couvy-Duchesne Baptiste
- Craddock Nicholas
- Craddock Nicholas
- Craddock Nick
- Craig David
- Crawford Gregory E.
- Crawford Steven
- Crawford Steven
- Crivelli Silvia
- Crow Scott
- Crow Scott
- Crowley James J.
- Cruceanu Cristiana
- Cuellar-Barboza Alfredo
- Cunningham Julie
- Curtis David
- Czerski Piotr M.
- Dahmen Norbert
- Dale Anders M.
- Dalkner Nina
- Danner Unna N.
- Dannlowski Udo
- Dannlowski Udo
- David Friederike S.
- Davies Gail
- Davis Oliver S. P.
- de Geus E. J. C.
- de Zwaan Martina
- Dedoussis George
- Degenhardt Franziska
- Degenhardt Franziska
- Degenhardt Franziska
- Degortes Daniela
- Dellitalia Louis
- Demontis Ditte
- Dennis Michelle F.
- Depaulo J. Raymond
- DePaulo J. Raymond
- der Auwera Sandra Van
- Derks Eske M.
- DeSocio Janiece E.
- Di Florio Arianna
- DiBlasi Emily
- Dick Danielle M.
- Dietl Lydie
- Dikeos Dimitris
- Dikeos Dimitris
- Dina Christian
- Direk Nese
- Djurovic Srdjan
- Djurovic Srdjan
- Dmitrzak-Weglarz Monika
- Do Nhan
- Dobbyn Amanda L.
- Docherty Anna R.
- Dolan Conor V.
- Domenici Enrico
- Domschke Katharina
- Douzenis Athanassios
- Drange Ole Kristian
- Duncan Laramie E.
- Dunn Erin C.
- Duriez Philibert
- Edenberg Howard J.
- Edenberg Howard J.
- Edwards Alexis C.
- Egberts Karin
- Ehrlich Stefan
- Eley Thalia C.
- ElvsÄshagen TorbjÞrn
- Erlangsen Annette
- EscaramĂs GeĂČrgia
- Escott-Price Valentina
- Escott-Price Valentina
- Esko TÔnu
- Esko TÔnu
- Esko TÔnu
- Esko TÔnu
- Espeseth Thomas
- Estivill Xavier
- Etain Bruno
- Fanous Ayman H.
- Farmer Anne
- Favaro Angela
- Fayad Joseph
- Ferentinos Panagiotis
- FernĂĄndez-Aranda Fernando
- FernĂĄndez-Aranda Fernando
- Ferrier I. Nicol
- Fichter Manfred M.
- Fichter Manfred M.
- Finucane Hilary K.
- Fiorentino Alessia
- Fischer Krista
- Florez Hermes
- Floyd James A. B.
- Foo Jerome C.
- Foo Jerome C.
- Foretova Lenka
- Foroud Tatiana M.
- Forstner Andreas J.
- Forstner Andreas J.
- Forstner Andreas J.
- Forstner Andreas J.
- Forty Liz
- Forzan Monica
- Frank Josef
- Frank Josef
- Frank Josef
- Franklin Christopher S.
- Frei Oleksandr
- Freimer Nelson B.
- Frisén Louise
- Frye Mark
- Frye Mark
- Fullerton Janice M.
- Fullerton Janice M.
- Föcker Manuel
- Gaddy Melinda
- Gade Katrin
- Galfalvy Hanga
- Gallinger Steven
- Gallinger Steven
- Gambaro Giovanni
- Gandal Michael
- Gandal Michael J.
- Gappy Saib
- Garnham Julie
- Gaspar Héléna A.
- Gaspar Héléna A.
- Gatt Justine M.
- Gawlik Micha
- Gaziano J. Michael
- Gaziano J. Michael
- Gejman Pablo V.
- Gelernter Joel
- Gelernter Joel
- Gershon Elliot S.
- Gibson Gretchen
- Giegling Ina
- Giegling Ina
- Gill Michael
- Giuranna Johanna
- Giusti-RodrĂquez Paola
- Gizer Ian R.
- Glatt Stephen J.
- Godschalk Michael
- Goes Fernando S.
- Goes Fernando S.
- Gonidakis Fragiskos
- Gordon Scott
- Gordon Scott D.
- Gordon Scott D.
- Gordon-Smith Katherine
- Gorwood Philip
- Gorwood Philip
- Grabe Hans J.
- Grabe Hans J.
- Greco Jennifer
- Green Melissa J.
- Green Melissa J.
- Greenwood Tiffany A.
- Grevet Eugenio H.
- Grigoroiu-Serbanescu Maria
- Grigoroiu-Serbanescu Maria
- Grove Jakob
- Grove Jakob
- Grove Jakob
- Guillaume SĂ©bastien
- Guo Yiran
- Guo Yiran
- Gupta Samir
- Gutierrez Blanca
- Gutierrez Salvador
- Guzman-Parra Jose
- Guzman-Parra José
- Ha Kyooseob
- Hafferty Jonathan D.
- Hagenaars Saskia P.
- Hakonarson Hakon
- Hakonarson Hakon
- Hall Lynsey S.
- Halmi Katherine A.
- Halmi Katherine A.
- Hamilton Steven P.
- Hamilton Steven P.
- Hammer Kimberly
- Hamner Mark
- Hamshere Marian L.
- Hanscombe Ken B.
- Hansen Christine SĂžholm
- Hansen Christine SĂžholm
- Hansen Thomas F.
- Haraldsson Magnus
- Harley John
- Hartmann Annette
- Harvey Phillip D.
- Hassan Kiadeh Farnush Farhadi
- Hatzikotoulas Konstantinos
- Hauser Elizabeth
- Hauser Elizabeth R.
- Hauser Joanna
- Hauser Joanna
- Hauser Joanna
- Hauser Michael A.
- Hautzinger Martin
- Hayward Caroline
- Heath Andrew C.
- Hebebrand Johannes
- Heilbronner Urs
- Heilmann-Heimbach Stefanie
- Helder Sietske G.
- Hellgren Dennis
- Henders Anjali K.
- Henskens Frans
- Herms Stefan
- Herms Stefan
- Herms Stefan
- Herpertz-Dahlmann Beate
- Herzog Wolfgang
- Hickie Ian B.
- Hillert Jan
- Hinney Anke
- Hishimoto Akitoyo
- Hoffmann Per
- Hoffmann Per
- Hoffmann Per
- Holmans Peter A.
- Homuth Georg
- Hong Kyung Sue
- Horn Carsten
- Horwood L. John
- Hottenga Jouke-Jan
- Hougaard David M.
- Hougaard David M.
- Hougaard David M.
- Howard David M.
- Huang Grant
- Huckins Laura
- Huckins Laura M.
- Hudson James I.
- Huffman Jennifer E.
- Hultman Christina M.
- Humphries Donald E.
- Hung Adriana
- HUNT All-In Psychiatry
- Huq Mostaqul
- Hurley Robin
- Hveem Kristian
- Hwu Hai-Gwo
- HĂŒbel Christopher
- Ikeda Masashi
- Imgart Hartmut
- Inoko Hidetoshi
- Iruvanti Pran
- Ising Marcus
- Ising Marcus
- Ivins Douglas
- Iwata Nakao
- Jablensky Assen V.
- Jacobson Daniel
- Jacono Frank
- Jain Sonia
- Jamain Stéphane
- Jamain Stéphane
- Janout Vladimir
- Jansen Rick
- Jhala Darshana
- Jiménez-Murcia Susana
- Jiménez-Murcia Susana
- Johnson Craig
- Johnson Craig
- Johnson Jessica S.
- Jones Ian
- Jones Ian
- Jones Ian
- Jones Lisa A.
- Jones Lisa A.
- Jones Lisa A.
- Jonsson Lina
- Jordan Jennifer
- Jorgenson Eric
- JuliĂ Antonio
- Jungkunz Martin
- Kahn René S.
- Kahn René S.
- Kalman Janos L.
- Kalsi Gursharan
- Kamatani Yoichiro
- Kaminsky Laurence
- KaminskĂĄ Deborah
- Kamitaki Nolan
- Kang JooEun
- Kaplan Allan S.
- Kaplan Allan S.
- Kaprio Jaakko
- Karhunen Leila
- Karwautz Andreas
- Kas Martien J. H.
- Kay Yang Jessica Mei
- Kaye Walter H.
- Kaye Walter H.
- Keel Pamela K.
- Kelsoe John R.
- Kelsoe John R.
- Kendler Kenneth S.
- Kendler Kenneth S.
- Kennedy James L.
- Kennedy James L.
- Kennedy James L.
- Kennedy Martin A.
- Keski-Rahkonen Anna
- Kessler Ronald C.
- Kiezebrink Kirsty
- Kim Minsoo
- Kim Minsoo
- Kim Youl-Ri
- Kimbrel Nathan A.
- Kinlay Scott
- Kirk Katherine M.
- Kirov George
- Kittel-Schneider Sarah
- Klareskog Lars
- Klein Jon
- Kloiber Stefan
- Kloiber Stefan
- Klump Kelly L.
- Klump Kelly L.
- Knowles James A.
- Knowles James A.
- Knudsen Gun Peggy S.
- Koenen Karestan C.
- Kogevinas Manolis
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- Thornton Laura M.
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- Willemsen Gonneke
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- Witt Stephanie H.
- Witt Stephanie H.
- Witt Stephanie H.
- Witt Stephanie H.
- Won Hong-Hee
- Woodside D. Blake
- Woodside D. Blake
- Wray Naomi R.
- Wray Naomi R.
- Wray Naomi R.
- Wu Yang
- Xi Hualin S.
- Xi Simon
- Xu Junzhe
- Xu Wei
- Yang Jian
- Yao Shuyang
- Yeh Shing Shing
- Yilmaz Zeynep
- Yilmaz Zeynep
- Young Allan H.
- Young Hannah
- Zablocki Clement J.
- Zai Clement C.
- Zandi Peter P.
- Zeggini Eleftheria
- Zerwas Stephanie
- Zhang Futao
- Zhao Hongyu
- Zhou Hang
- Zillich Lea
- Zillich Lea
- Zipfel Stephan
- Zwart John-Anker
- ĆwiÄ tkowska Beata
- ĆwiÄ tkowska Beata
- ĆwiÄ tkowska Beata
- Publication venue
- Publication date
- 01/01/2021
- Field of study
Background Suicide is a leading cause of death worldwide, and nonfatal suicide attempts, which occur far more frequently, are a major source of disability and social and economic burden. Both have substantial genetic etiology, which is partially shared and partially distinct from that of related psychiatric disorders. Methods We conducted a genome-wide association study (GWAS) of 29,782 suicide attempt (SA) cases and 519,961 controls in the International Suicide Genetics Consortium (ISGC). The GWAS of SA was conditioned on psychiatric disorders using GWAS summary statistics via multitrait-based conditional and joint analysis, to remove genetic effects on SA mediated by psychiatric disorders. We investigated the shared and divergent genetic architectures of SA, psychiatric disorders, and other known risk factors. Results Two loci reached genome-wide significance for SA: the major histocompatibility complex and an intergenic locus on chromosome 7, the latter of which remained associated with SA after conditioning on psychiatric disorders and replicated in an independent cohort from the Million Veteran Program. This locus has been implicated in risk-taking behavior, smoking, and insomnia. SA showed strong genetic correlation with psychiatric disorders, particularly major depression, and also with smoking, pain, risk-taking behavior, sleep disturbances, lower educational attainment, reproductive traits, lower socioeconomic status, and poorer general health. After conditioning on psychiatric disorders, the genetic correlations between SA and psychiatric disorders decreased, whereas those with nonpsychiatric traits remained largely unchanged. Conclusions Our results identify a risk locus that contributes more strongly to SA than other phenotypes and suggest a shared underlying biology between SA and known risk factors that is not mediated by psychiatric disorders.Peer reviewe
Robust estimation of bacterial cell count from optical density
- Author
- Aarnio Tiu
- Aaron Leow Chung Yong
- Abbas Anser
- Abduraimova Aiganym
- Abraham Doris
- Acar Beliz Leyla
- Acosta Joaquin
- Adler Nina
- Adulyanukosol Natthawut
- Agena Ejouan
- Agena Ethan
- Aggarwal Priya
- Aguirre Adriana Lizeth Rubio
- Ahlgren Christopher
- Ahuja Janvi
- Aizik Dror
- Akbary Mina
- Akinfenwa Akinwumi
- Akingbesote Ngozi D.
- Akova Umut
- Aldo Ferdinan
- Alexopoulos Ioannis
- Allen Lucy
- Alonso Alejandro
- Altarawneh Dina
- Alvarado Andres Benjamin Sanchez
- Ambre Sanika
- Ameziane Annissa
- Amheine Khadija
- Amin Ihya Fakhrurizal
- Amir Sayeda Sakina
- Amstel Chiel van
- An Yongyan
- Anand Nithishwer Mouroug
- Ananthakrishnan Sathvik
- Anderson Karl
- Angel Sagi
- Annem Vidhya
- Anson Chung Tsun Ho
- Anwar Mariam
- Appel Alana
- Araya Lucas
- Armstrong Alexander
- Arora Neha
- Arora Vasu
- Arruda Beck
- Ashwin F Amal Jude
- Astapenka Artur
- Astles Ben
- Astorino Gabe
- Aubry Celine
- Avileli Rebecca
- Azad Mahnaz Sabeta
- Babar Rehmat
- Babu Priyanka
- Badalli Turan
- Badash Lior
- Baichman-Kass Amichai
- Baldwin Geoff S.
- Baltensperger Oliver Andreas
- Bao Guanke
- Bao Minyue
- Baronaite Ugne
- Barrat Leon Michael
- Barrington Seth
- Barshap Alon
- Bartzoka Natalia
- Basu Anubhav
- Basulto Cynthia
- Bath Scott
- Battina Rohith
- Bauersachs Daniel
- Beal Jacob
- Beale Renee
- Beard Eleanor
- Beck Selina
- Becker Evan
- Benavides Samantha Ayde Pena
- Bennis Nicole
- Bete Anna
- Bhatt Darshak
- Bhowmick Shilpa
- Bian Weixin
- Bijman Eline Yafele
- Bindt Felix
- Blas Karla Soto
- Bo Tang
- Boada Yadira
- Boer Meine
- Bohner Ariel
- Borovko Irina
- Bott Amie
- Bouwmeester Susan
- Bowman Kyle
- Boxem Mike
- Boxuan Cheng
- Boyce Kira
- Boyer Jess
- Brasas Valentas
- Brewer Mathew
- Briand William
- Brink Matilda
- Browne Emily
- Buckley-Taylor Russell
- Budhan Stephanie
- Buller Lisa
- Burckhardt Nele
- Burgland Zachary
- Burns Frank
- Burridge Matt
- Burud Hanna Nedreberg
- Buson Felipe Xavier
- Butterfield Tom
- Byagathvalli Gaurav
- Byatt Gabriel
- Byun Sumin
- Caballero Amalia
- Cai Fu
- Cai Niangui
- Caldwell Sarah
- Camacho Yazmin
- Camille Monteil
- Campbell Robert
- Cao Qinhao
- Cao Yixin
- Cao Yuze
- Carrillo Leo
- Carter Jonah
- Casas Alexis
- Castillo Nora Esther Torres
- Castillo Sandra
- Cave John
- Chai Ruochen
- Chamiec-Case Elizabeth
- Chan Janice
- Chan Yuan-Yao
- Chandramouli Priyanka
- Chang Annabel
- Chang Catherine
- Chang Kevin
- Chang Thomas
- Chang Ting-Chen
- Chang Yu-Ci
- Chapman Tyler
- Chater Dounia
- Chau Anthony
- Chavez Benjamin
- Chavez Francisco
- Chehade Ibrahim
- Chen Carmen
- Chen Chih-Chiang
- Chen Ching-Wei
- Chen Janice
- Chen Junhong
- Chen Junyang
- Chen Junyu
- Chen Pei-Hong
- Chen Ryan
- Chen Weixuan
- Chen Yan
- Chen Yi-Cian
- Chen Yifei
- Chen Zhuoyang
- Cheng Cheng
- Cheng Haolun
- Cheng Hsuan
- Cheng Yu-Hong
- Cheng Yu-Hsuan
- Chenxi Liang
- Cherupalla Arjun
- Chi Jordi
- Chi Shumei
- Chiang Jason
- Chiang Woody
- Ching Lai Tsz
- Ching Lam Kai
- Ching Law Hiu
- Ching Luk Hau
- Chinnathambi Sathivel
- Cho Sungwoo
- Choi Lee Sze
- Choi Youngeun
- Chou Ryan
- Chou Ryan
- Chu Wai Yan
- Chua Yah Tse Sabrina
- Chuang Yi-Chien
- Chulkova Nadezhda
- Chun Cheung Man
- Chun Emily
- Chun Ng Tsz
- Cifuentes Rodrigo Hernandez
- Clapper Jude
- Clapper Jude
- Clark Brittany
- Clemente Borja Sanchez
- Clerc Valerian
- Clodomir Christina
- Coates Ryan
- Cohen Katherine
- Colant Noelle
- Coleman Sarah
- Colgan Cian
- Cone Eli
- Corre Christophe
- Costa Ben
- Cott Rachel Van
- Craw Darilyn
- Crispim Larissa de Souza
- Crone Michael Andrew
- Crooijmans Marjolein
- Crosby Laurel Constanti
- Crowley Peter
- Cruz Frida
- Cubukcu Hande
- Culfogienis Dylan
- Czekster Clarissa
- Dai Leijie
- Dalangin Rochelin
- Daniel Benjamin
- Daniels Lea
- Das Neves Laura
- Das Diptatanu
- Davis Christina
- De Silva Nimaya
- Deb Shalini S.
- Deepak Kumar S.
- Deibel Emilie
- Dejoie Julianne
- Dejoux Alice
- DeKloe Jackson
- Del Toro Mariano
- Delalez Nicolas
- Delgadillo Sabrina
- Delhomme Jean
- Demchuk Aubrey
- Deng Nian Ruei
- Deng Rui
- Denter Jennifer
- Deshmukh-Reeves Ed
- Despres Philippe C.
- Devi Velvizhi
- Dhaliwal Gurpreet
- Diaz Fernanda
- Ding Shizhi
- Ding Yiming
- Ding Zhipeng
- Dingyue Tang
- Dirven Yvette
- Dissmann Jil-Sophie
- Do Stephanie
- Dogra Arushi
- Dominguez Viana Isabel Perez
- Dong Dongyang
- Dong Haitao
- Dong Jason
- Dong Shan
- Dong Shan
- Dong Shan
- Dong Shangzhi
- Dong Shangzhi
- Doyle David
- Doyle Shannon
- Dube Alexandre
- Dubuc Emilien
- Dunstan Izzy
- Dusseaux Theodore A.
- Dvorkin Steve
- Edelmayer Marco
- Ehrenworth Amy
- Eidloth Franziska
- Eijkens Bruno
- Eilers Keno
- El Moubayed Yorgo
- Elcin Evrim
- Elias Noel
- Elikan Max
- Ellermeier Craig
- Elliott Hannah
- Elsa Yeung Hoi Lam
- Emilov Kristian
- Espinoza Diego
- Evans Rhys
- Faidh Mohammed
- Falgenhauer Elisabeth
- Fan Catherine
- Fang Chengzhu
- Fang Choco
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- Farhi Einan
- Farias Sebastian
- Farny Natalie
- Farny Natalie G.
- Farrell Jennifer
- Fassler Jan
- Faurdal David
- Faustova Ilona
- Feng Xinhua
- Fernandez Cesar Ibrahym Rodriguez
- Fierro Daniela Olono
- Figueroa Ana Cristina
- Figueroa Jose Arnulfo Juarez
- Fikry Clara
- Filzen Rachael
- Fischer Matthew
- Fitzgerald Kevin
- Fitzgerald Liza
- Flores Vinicius
- Foda Asmaa
- Fong Yuhui Deborah
- Forman Victor
- Frank Stefanie
- Frankel Eva
- Freire Paulo J. C.
- Friedman Yonatan
- Frohlich Lisa
- Fu Wenhan
- Fu Yousi
- Fuentes Ernie
- Fulton Leah
- Fung Ip Ning
- Fung Yam Shing
- Gabrielli Jacopo
- Gahagan Maddison
- Gaitt Tobias
- Gaizauskaite Aukse
- Gallegos Isabella
- Gamoneda Diego
- Gandhi Rishi
- Gao Cecily
- Garavito Paula
- Garcia Chrismar
- Garcia David
- Garrido Delia
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- Gaspar Camila
- Gaudi Alex
- Ge Gao
- Ge Yubin
- George Stephan
- Gerard Antoine
- Gershater Markus
- Ghosh Souvik
- Giannopoulos Alexandros Dimitriou
- Giannoula Yvoni
- Gilman Daniel Barber James
- Glockner Eleanor
- Goenka Anushya
- Goetz Marley
- Gogineni Namrata
- Gokul [NO FIRST NAME IN SCOPUS]
- Gonzalo Gonzalo Saiz
- Goodson Michael
- Gopaul Deshmukh
- Gou Yanchen
- Govers Jolijn
- Graaf Floor de
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- Grazulyte Inga
- Greenwald Matthew
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- Guenther James
- Guerassimoff Lea
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- Gupta Shreya
- Guptil Chris
- Guseva Anna
- Ha Jacqueline
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- Zhou Yinchi
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- Zhou Yuxin
- Zhou Zhiyu
- Zhu Chushu
- Zhu Ke
- Zhu Xueqian
- Zi Lihan
- Zilinskaite Nemira
- Zimmermann Andreas
- Zimmermann Jennifer
- Zirong Zeng
- Ziwei Zhou
- Ziyi Zhao
- Zorrilla Francisco
- Zou Jiahua
- Zukauskaite Kristina
- Zulueta Patricia
- Zvirblyte Justina
- Publication venue
- Publication date
- 01/01/2020
- Field of study
Optical density (OD) is widely used to estimate the density of cells in liquid culture, but cannot be compared between instruments without a standardized calibration protocol and is challenging to relate to actual cell count. We address this with an interlaboratory study comparing three simple, low-cost, and highly accessible OD calibration protocols across 244 laboratories, applied to eight strains of constitutive GFP-expressing E. coli. Based on our results, we recommend calibrating OD to estimated cell count using serial dilution of silica microspheres, which produces highly precise calibration (95.5% of residuals <1.2-fold), is easily assessed for quality control, also assesses instrument effective linear range, and can be combined with fluorescence calibration to obtain units of Molecules of Equivalent Fluorescein (MEFL) per cell, allowing direct comparison and data fusion with flow cytometry measurements: in our study, fluorescence per cell measurements showed only a 1.07-fold mean difference between plate reader and flow cytometry data
Finishing the euchromatic sequence of the human genome
- Author
- . Haifeng
- . Magner
- . Yin
- Abbott Scott
- Abbott-Ozersky Amanda
- Abdellah Zahra
- Abouelleil Amr
- Abrajano Anne
- Adachi Tamami
- Adam Catherine
- Adams Charles Q.
- Adamson Aaron
- Adekoya Emmanuel
- Adio-Oduola Babajide
- Aerts Andrea
- Aggarwal Arun
- Ahmadi Alireza
- Ahmed Shahana
- Aimable Matthew
- Ainscough Rachael
- Ait-Zahra Mostafa
- Aizu Tomoyuki
- Alcivare Dana
- Alegria Michelle
- Ali Alla
- Ali Johar
- Allegria-hartmann Michelle
- Alleman Jennifer
- Allen Carlana C.
- Allen Heather
- Allen Nicole R.
- Allen Susan
- Allen Thaddeus
- Almeida Jeff
- Almond Claire
- Alsbrooks Stephen L.
- Altherr Michael R.
- Amaratunge Harshinie C.
- Ambler Andrew
- Ambrose Karen
- Ambrose Kerrie
- Amemiya Chris
- Amico-Keller Gina
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- Wang Shifen
- Wang Shu
- Wang Suzhen
- Wang Wenjun
- Wang Xiaoling
- Wang Xiaoning
- Wang Xuefei
- Wang Xuegang
- Wang Yan
- Wang Yimin
- Wang Ying
- Wang Ying
- Wang Yuanyuan
- Wangchuck Tsering
- Wangdi Tsering
- Ward-Moore Stephanie
- Warren Graham
- Warren James T.
- Warry Georgina
- Watanabe Hidemi
- Watanabe Saki
- Waterston Robert H.
- Watson Andy
- Watt Nicola
- Webb Anthony
- Webb Jeannette
- Webber Caleb
- Weber Ryan J.
- Wehri Edward
- Wei Shulin
- Wei Xuehong
- Weidenbach Richard
- Weinstock George
- Weinstock Keith
- Weir John
- Weissenbach Jean
- Wells Alan
- Wells Sarah
- Welton Robert
- Wen Gaiping
- Wendi Mike
- Weng Li
- Wenning Sarah
- Wentz Sara
- Werler Daniela
- Wesley Mary Melissa
- West Paul
- West Tony
- Wetterstrand Kris
- Wheatley Angela
- Wheatley Carl
- Wheeler David A.
- Wheeler Gideon
- Wheeler Jeremy
- Whitaker Hayley
- White Adam
- White Amelia
- White Brian
- White Catherine
- White Flower
- White Jennifer
- White Johnathon
- White P. Scott
- White Scott P.
- White Simon
- Whitehead Sally
- Whiteley Matthew
- Whitmore Scott
- Whittaker Adam
- Whittaker Charles
- Whittaker Pamela
- Wickremasinghe Manosha I.
- Widaa Sara
- Wiegel Sarah
- Wild Anna
- Wilkinson Jane
- Wilkinson Jane
- Wilkinson Paul
- Willey David
- Williams Albert L.
- Williams Andy
- Williams Bill
- Williams Gabrielle A.
- Williams Leanne
- Williamson Angela L.
- Williamson Helen
- Wills Patricia L.
- Wills Richard
- Wilmer Tamsin
- Wilming Laurens
- Wilson Brian
- Wilson Gareth
- Wilson Margaret
- Wilson Nyree
- Wilson Piers
- Wilson Richard K.
- Wilson Siobhan
- Wilson Steve
- Wilson Wendy
- Wincker Patrick
- Window Philip
- Winster Jenny
- Winzar Claire
- Witt James
- Wleczyk Regina
- Wobus Fred
- Woessner Jeffrey
- Wohldmann Patty
- Wollard Jessica
- Womack Andrew W.
- Wong Benjamin
- Wong Gane K-S
- Wood Diane
- Wood Emma
- Wood Joe
- Wooden Hailey S.
- Wooden Steven H.
- Woodeson Sharon
- Woodfine Kathryn
- Woodmansey Rebecca
- Woods Eric
- Woodwark Cara
- Wooster Richard
- Worley Kim Carlyle
- Woyke Tanja
- Wray Matthew
- Wray Paul
- Wright Charmain
- Wright Debbie
- Wright Kathrine
- Wright Kristin
- Wright Rita A.
- Wu Chungen
- Wu Dongying
- Wu Jiaqian
- Wu Jung-Rung
- Wu Kevin
- Wu Qingfa
- Wu Qingfa
- Wu Ruiming
- Wu Xiao
- Wu Xiaojing
- Wu Zaining
- Wyatt Julia
- Wycoff-Montenegro Melissa
- Wylie Kris
- Wyman Dudley
- Wyman Stacia
- Xi Yan
- Xi Yingying
- Xie Fei
- Xie Gary
- Xie Jane
- Xiong Hui
- Xiong Yuqing
- Xu Alex
- Xu Jing
- Xu Jing
- Xu Ruqin
- Xu Shuhua
- Xu Wei
- Xu Xinlai
- Xu Yan
- Xu Yuning
- Xu Zhihong
- Xu Zuyuan
- Xuan Yali
- Xuan Zhenyu
- Xue Rui
- Yada Tetsushi
- Yadav Shailendra
- Yakub Syed
- Yamamoto Lynn
- Yamamoto Noriko
- Yamamoto Yuko
- Yamashita Yasue
- Yamazaki Satoru
- Yang Hao
- Yang Huanming
- Yang Huanming
- Yang Joan
- Yang Shiaw-Pyng
- Yang Shudong
- Yang Xiaonan
- Yang Xiaonan
- Yang Xiaoping
- Yang Yongkui
- Yano Candance
- Yao Zhijian
- Yao Zhijian
- Yaspo Marie-Laure
- Ye Chen
- Yeager Shane
- Yeh Mimi
- Yen Jennifer
- Yeshitela Rahel Retta
- Yoakum Martin
- Yokobata Kathy
- Yokoyama Jennifer
- Yonezawa Miho
- Yoon Lillienne
- Yoon Vivienne
- Yoshida Satoru
- You Bo
- Young Geneva
- Young Louise
- Young Shelia
- Younger Ruth
- Yu Bing
- Yu Charles
- Yu Fuli
- Yu Jun
- Yu Jun
- Yu Jun
- Yuan Kaiwen
- Yuan Ye
- Yuan Yida
- Yue Shujie
- Yumae Brian
- Yun Rui
- Zainoun Joanne
- Zembeck Lisa
- Zeng Yixin
- Zhai Dong
- Zhan Guoping
- Zhang Bo
- Zhang Caimin
- Zhang Fengmei
- Zhang Guangyu
- Zhang Guohua
- Zhang Guohua
- Zhang Haiqing
- Zhang Haiqing
- Zhang Haiqing
- Zhang Hongbo
- Zhang Hongbo
- Zhang Jingjing
- Zhang Jingjing
- Zhang Jingkun
- Zhang Jiuchun
- Zhang Jiuchun
- Zhang Lanzhi
- Zhang Li
- Zhang Li
- Zhang Meihua
- Zhang Meng
- Zhang Ming
- Zhang Qing
- Zhang Ruhua
- Zhang Shaojie
- Zhang Tiezhen
- Zhang Wei
- Zhang Wei
- Zhang Xianglin
- Zhang Xianglin
- Zhang Xiaoliang
- Zhang Xiuqing
- Zhang Yan
- Zhang Yi
- Zhang Yilin
- Zhang Yilin
- Zhang Ying
- Zhang Yuansen
- Zhang Yuzhi
- Zhang Zhengdong
- Zhao Hongmei
- Zhao Lijian
- Zhao Shenru
- Zhao Zhijing
- Zhen Zhicheng
- Zheng Haibo
- Zhong Ming
- Zhou Carol
- Zhou Haixia
- Zhou Jianling
- Zhou Nannan
- Zhou Xinfeng
- Zhou Yan
- Zhou Yang
- Zhou Yi
- Zhu Bingying
- Zhu Bofeng
- Zhu Fenghua
- Zhu Genfeng
- Zhu Genfeng
- Zhu Miao
- Zhu Ning
- Zhu Yongge
- Zhu Zhen
- Zhuang Shitao
- Zierten Deborah
- Zimmer Andrew
- Zody Michael C.
- Zollo Massimo
- Zorrilla Sara E.
- Zuo Lin
- Publication venue
- LSU Digital Commons
- Publication date
- 21/10/2004
- Field of study
The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers âŒ99% of the euchromatic genome and is accurate to an error rate of âŒ1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead