Entrepreneurial Behaviour of the Agriculture Students-A review

The present study aimed to investigate the factors that influence the entrepreneurial behavior of college students. The study identified various personal and situational factors that may affect entrepreneurial behavior. The results showed that personality traits, such as openness, extraversion, and conscientiousness, had a significant positive impact on entrepreneurial behavior. Specific motivational traits, such as entrepreneurial self-efficacy, internal locus of control, and risk-taking propensity, were also significant predictors of entrepreneurial behavior. Situational factors, such as entrepreneurship education, were found to have a significant positive impact on entrepreneurial behavior, with entrepreneurial self-efficacy playing a key mediating role in this relationship. Attitudes towards entrepreneurship were found to be a significant driver of entrepreneurial intention, with perceived desirability and feasibility, as well as perceived individual and collective efficacy, also significant predictors of entrepreneurial intention. Sustainable entrepreneurial intention was found to be influenced by attitude towards the behavior variable, with subjective norms playing an indirect role in mediating this effect. Overall, the study suggests that personal traits, such as personality and motivational factors, as well as situational factors, such as education and attitudes towards entrepreneurship, are significant predictors of entrepreneurial behavior. These findings have important implications for educators and policymakers who seek to promote entrepreneurial behavior among college students. Future research should continue to explore the complex relationships between personal and situational factors and entrepreneurial behavior to further enhance our understanding of this important phenomenon. &nbsp

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Not AvailableNeurobrucellosis is a most serious complication of brucellosis which has neither a typical clinical picture nor specific cerebrospinal fluid (CSF) findings and mimics other neurological disorders leading to clinical diagnostic dilemmas. Accurate diagnosis is a great challenge for physicians, neurologists and researchers. A retrospective study was conducted to highlight the importance of the integrated diagnostics and clinical approaches to describe and categorize different clinical pictures of patients with neurobrucellosis in Indian scenario. We reviewed the medical records of twelve patients who were diagnosed as cases of neurobrucellosis from January 2010 to September 2013. Clinical details, associated risk factors, image findings were recorded. The serum and CSF Brucellosis work up by Rose Bengal Plate Test (RBPT) Indirect Enzyme Linked Immunosorbent Assay (iELISA), polymerase chain reaction (PCR), was performed and results analysed. Chronic meningitis (33.3%) was the most common form of presentation, followed by infective cerebro venous thrombosis (CVT) (25%), demyelination (16.6%), myelitis (16.6%) and myeloradiculopathy (8.33%). Epidemiological risk factor was present in 59% of the cases. All the twelve cases were positive for serum IgG antibrucella antibodies by ELISA. Two cases had brucella antibodies in the CSF as well. Brucella genus specific PCR was positive in four cases. Neurobrucellosis may be considered as one of the differential diagnoses in unusual cases of neurologic disorders and in cases of neurological dysfunction in absence of any other suitable alternative diagnosis. Multimodal differential diagnostic approaches are essential for accurate diagnosis, effective treatment and to prevent morbidity and mortality associated with neurobrucellosis.Not Availabl

ANTIOXIDANT AND ANTICANCER ACTIVITY OF EXTRACT AND FRACTIONS OBTAINED FROM DIOSPYROS MELANOXYLON ROXB. LEAVES AND CORRELATION WITH THEIR POLYPHENOLIC PROFILES

Objective: The current study evaluates the antioxidant and cytotoxic prospective of the leaves from Diospyros melanoxylon Roxb. (D. melanoxylon).Methods: Qualitative phytochemical analysis of the samples from D. melanoxylon was carried out for the detection of secondary metabolites. Total content of flavonoids, phenolics, triterpenoids, and tannins in D. melanoxylon was evaluated using colorimetric assay. Qualitative analysis of polyphenolic compounds was performed using HPLC method. The antioxidant activity was examined by assessing the various free radical scavenging assays. Five human cancerous cell lines (HeLa, MCF-7, HCT-116, PC-3, and HEK293), one rat colon cancer cell line (RCC 45) and two normal cell lines (NKE and WI-38) were used for evaluating the anticancer activity through methylene blue assay.Results: The results indicated that ethyl acetate fraction (EAF) and aqueous fraction (AQF) exhibited the remarkable content of flavonoids, phenolics, triterpenoids, and tannins. Both EAF and AQF have cytotoxic activity with significant IC50 values but not showed significant antioxidant activity. However, the most powerful anticancer activity was recorded by EAF followed by AQF in a dose-dependent manner. It was also revealed that EAF and AQF were biocompatible with the normal cell lines.Conclusion: Our principal finding exhibited a potent anticancer activity. Furthermore, it was also indicated that samples contain secondary metabolites like flavonoids, phenolics, triterpenoids, and tannins. We suggest that the further investigation on this herb is effective against various types of ailments including cancer.Keywords: Diospyros melanoxylon Roxb., Scanning Electron Microscopy (SEM), High-Pressure Liquid Chromatography (HPLC), Polyphenols, Antioxidant, Anticance

Induced Biofilm Cultivation Enhances Riboflavin Production by an Intertidally Derived Candida Famata

The aim of the investigation was to ascertain if surface attachment of Candida famata and aeration enhanced riboflavin production. A newly designed polymethylmethacrylate (PMMA) conico-cylindrical flask (CCF) holding eight equidistantly spaced rectangular strips mounted radially on a circular disk allowed comparison of riboflavin production between CCFs with hydrophobic surface (PMMA-CCF), hydrophilic glass surface (GS-CCF), and 500- ml Erlenmeyer flask (EF). Riboflavin production (mg/l) increased from 12.79 to 289.96, from 54.44 to 238.14, and from 36.98 to 158.71 in the GS-CCF, EF, and PMMA-CCF, respectively, when C. famata was grown as biofilm-induced cultures in contrast to traditional planktonic culture. Production was correlated with biofilm formation and planktonic growth was suppressed in cultivations that allowed higher biofilm formation. Enhanced aeration increased riboflavin production in hydrophilic vessels. Temporal pattern of biofilm progression based on two-channel fluorescence detection of extracellular polymeric substances and whole cells in a confocal laser scanning microscope followed by application of PHLIP and ImageJ volume viewer software demonstrated early maturity of a well-developed, stable biofilm on glass in contrast to PMMA surface. A strong correlation between hydrophilic reactor surface, aeration

Yeast Coq9 controls deamination of coenzyme Q intermediates that derive from para-aminobenzoic acid

Coq9 is a polypeptide subunit in a mitochondrial multi-subunit complex, termed the CoQ-synthome, required for biosynthesis of coenzyme Q (ubiquinone or Q). Deletion of COQ9 results in dissociation of the CoQ-synthome, but over-expression of Coq8 putative kinase stabilizes the CoQ-synthome in the coq9 null mutant and leads to the accumulation of two nitrogen containing Q-intermediates, imino-demethoxy-Q(6) (IDMQ(6)) and 3-hexaprenyl-4-aminophenol (4-AP) when para-aminobenzoic acid (pABA) is provided as a ring precursor. To investigate whether Coq9 is responsible for deamination steps in Q biosynthesis, we utilized the yeast coq5-5 point mutant. The yeast coq5-5 point mutant is defective in the C-methyltransferase step of Q biosynthesis, but retains normal steady-state levels of the Coq5 polypeptide. Here we show that when high amounts of (13)C(6)-pABA are provided, the coq5-5 mutant accumulates both (13)C(6)-imino-demethyl-demethoxy-Q(6) ((13)C(6)-IDDMQ(6)) and demethyl-demethoxy-Q(6) ((13)C(6)-DDMQ(6)). Deletion of COQ9 in the yeast coq5-5 mutant along with Coq8 over-expression and (13)C(6)-pABA labeling leads to the absence of (13)C(6)-DDMQ(6), and the nitrogen-containing intermediates (13)C(6)-4-AP and (13)C(6)-IDDMQ(6) persist. We describe a coq9 temperature sensitive mutant and show that at the non-permissive temperature, steady state polypeptide levels of Coq9-ts19 increased, while Coq4, Coq5, Coq6, and Coq7 decreased. The coq9-ts19 mutant had decreased Q(6) content and increased levels of nitrogen-containing intermediates. These findings identify Coq9 as a multi-functional protein that is required for the function of Coq6 and Coq7 hydroxylases, for removal of the nitrogen substituent from pABA-derived Q-intermediates, and is an essential component of the CoQ synthome