Archaeological ceramics from eastern Africa : past approaches and future directions

Ceramics are an essential part of the Holocene archaeology of eastern Africa and the development of increasingly complex typologies has rightly played a key role in our understanding of chronology and social identity. However, this focus on taxonomies can also be restrictive, as we lose sight of the communities who made and used the ceramics in our endless search to classify and re-classify ceramics. Focusing on ceramics from the Great Lakes and Rift Valley (Kansyore, Pastoral Neolithic and Urewe), we critique past approaches to ceramic analysis, and suggest future studies should better recognise their social role.We end with a case study of Kansyore ceramics, emphasising function and use.http://www.tandfonline.com/loi/raza202016-10-31hb2016Anthropology and Archaeolog

A consideration of garden hunting by Iron Age farmers in the Limpopo Valley and surrounding regions of southern Africa

Animals are often attracted to the cultivated gardens of farmers, whowould hunt these pests to protect their crops from damage. This is known as garden hunting. Since the concept of garden hunting was first described more than three decades ago, a number of anthropological studies have been undertaken in different parts of the world on hunting practices of farmers in their fields. Ethnographies from southern Africa also indicate that Bantu-speaking farmers spend a considerable amount of time and energy protecting their gardens from small, medium and even large animals. Archaeologists have also applied the concept of garden hunting to faunal samples in various parts of the world, but not yet in southern Africa. In an effort to highlight the potential archaeological significance of garden hunting in Africa, we investigate faunas from the Limpopo Valley and surrounding regions. While we could not find any conclusive evidence for garden hunting, based on circumstantial evidence we nonetheless suggest that it must have been a regular activity.The National Research Foundationhttp://reference.sabinet.co.za/sa_epublication/nfi_ditsongam2016Anthropology and Archaeolog

Berkenrode : archaeological insights on the history of a 20th century artisanal mine in the Limpopo Valley

Narratives about South African industrialisation, especially regarding the mining sector, have not paid adequate attention to small scale (artisanal) mining operations and the communities who worked them. This article reports on the archaeology of the artisanal copper mining site Berkenrode, also known as MNR211, located on the farm Berkenrode 45 MT, close to Musina in the extreme north of the Limpopo Province. Material culture from the site suggests it was likely active between 1937 and 1946. The architecture and material culture also inform on the industrial activities at the site and the domestic and social distinctions of the mining community on Berkenrode.NRF Grant HSD170606237401.https://journals.co.za/journal/cultureAnthropology and Archaeolog

Convalescent plasma in patients admitted to hospital with COVID-19 (RECOVERY): a randomised controlled, open-label, platform trial

SummaryBackground Azithromycin has been proposed as a treatment for COVID-19 on the basis of its immunomodulatoryactions. We aimed to evaluate the safety and efficacy of azithromycin in patients admitted to hospital with COVID-19.Methods In this randomised, controlled, open-label, adaptive platform trial (Randomised Evaluation of COVID-19Therapy [RECOVERY]), several possible treatments were compared with usual care in patients admitted to hospitalwith COVID-19 in the UK. The trial is underway at 176 hospitals in the UK. Eligible and consenting patients wererandomly allocated to either usual standard of care alone or usual standard of care plus azithromycin 500 mg once perday by mouth or intravenously for 10 days or until discharge (or allocation to one of the other RECOVERY treatmentgroups). Patients were assigned via web-based simple (unstratified) randomisation with allocation concealment andwere twice as likely to be randomly assigned to usual care than to any of the active treatment groups. Participants andlocal study staff were not masked to the allocated treatment, but all others involved in the trial were masked to theoutcome data during the trial. The primary outcome was 28-day all-cause mortality, assessed in the intention-to-treatpopulation. The trial is registered with ISRCTN, 50189673, and ClinicalTrials.gov, NCT04381936.Findings Between April 7 and Nov 27, 2020, of 16 442 patients enrolled in the RECOVERY trial, 9433 (57%) wereeligible and 7763 were included in the assessment of azithromycin. The mean age of these study participants was65·3 years (SD 15·7) and approximately a third were women (2944 [38%] of 7763). 2582 patients were randomlyallocated to receive azithromycin and 5181 patients were randomly allocated to usual care alone. Overall,561 (22%) patients allocated to azithromycin and 1162 (22%) patients allocated to usual care died within 28 days(rate ratio 0·97, 95% CI 0·87–1·07; p=0·50). No significant difference was seen in duration of hospital stay (median10 days [IQR 5 to >28] vs 11 days [5 to >28]) or the proportion of patients discharged from hospital alive within 28 days(rate ratio 1·04, 95% CI 0·98–1·10; p=0·19). Among those not on invasive mechanical ventilation at baseline, nosignificant difference was seen in the proportion meeting the composite endpoint of invasive mechanical ventilationor death (risk ratio 0·95, 95% CI 0·87–1·03; p=0·24).Interpretation In patients admitted to hospital with COVID-19, azithromycin did not improve survival or otherprespecified clinical outcomes. Azithromycin use in patients admitted to hospital with COVID-19 should be restrictedto patients in whom there is a clear antimicrobial indication

Archaeological ceramics from eastern Africa: past approaches and future directions

Ceramics are an essential part of the Holocene archaeology of eastern Africa and the development of increasingly complex typologies has rightly played a key role in our understanding of chronology and social identity. However, this focus on taxonomies can also be restrictive, as we lose sight of the communities who made and used the ceramics in our endless search to classify and re-classify ceramics. Focusing on ceramics from the Great Lakes and Rift Valley (Kansyore, Pastoral Neolithic and Urewe), we critique past approaches to ceramic analysis, and suggest future studies should better recognise their social role.We end with a case study of Kansyore ceramics, emphasising function and use.http://www.tandfonline.com/loi/raza202016-10-31hb2016Anthropology and Archaeolog

Mapping the human genetic architecture of COVID-19

The genetic make-up of an individual contributes to the susceptibility and response to viral infection. Although environmental, clinical and social factors have a role in the chance of exposure to SARS-CoV-2 and the severity of COVID-191,2, host genetics may also be important. Identifying host-specific genetic factors may reveal biological mechanisms of therapeutic relevance and clarify causal relationships of modifiable environmental risk factors for SARS-CoV-2 infection and outcomes. We formed a global network of researchers to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity. Here we describe the results of three genome-wide association meta-analyses that consist of up to 49,562 patients with COVID-19 from 46 studies across 19 countries. We report 13 genome-wide significant loci that are associated with SARS-CoV-2 infection or severe manifestations of COVID-19. Several of these loci correspond to previously documented associations to lung or autoimmune and inflammatory diseases3–7. They also represent potentially actionable mechanisms in response to infection. Mendelian randomization analyses support a causal role for smoking and body-mass index for severe COVID-19 although not for type II diabetes. The identification of novel host genetic factors associated with COVID-19 was made possible by the community of human genetics researchers coming together to prioritize the sharing of data, results, resources and analytical frameworks. This working model of international collaboration underscores what is possible for future genetic discoveries in emerging pandemics, or indeed for any complex human disease

Mapping the human genetic architecture of COVID-19

The genetic make-up of an individual contributes to the susceptibility and response to viral infection. Although environmental, clinical and social factors have a role in the chance of exposure to SARS-CoV-2 and the severity of COVID-191,2, host genetics may also be important. Identifying host-specific genetic factors may reveal biological mechanisms of therapeutic relevance and clarify causal relationships of modifiable environmental risk factors for SARS-CoV-2 infection and outcomes. We formed a global network of researchers to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity. Here we describe the results of three genome-wide association meta-analyses that consist of up to 49,562 patients with COVID-19 from 46 studies across 19 countries. We report 13 genome-wide significant loci that are associated with SARS-CoV-2 infection or severe manifestations of COVID-19. Several of these loci correspond to previously documented associations to lung or autoimmune and inflammatory diseases3,4,5,6,7. They also represent potentially actionable mechanisms in response to infection. Mendelian randomization analyses support a causal role for smoking and body-mass index for severe COVID-19 although not for type II diabetes. The identification of novel host genetic factors associated with COVID-19 was made possible by the community of human genetics researchers coming together to prioritize the sharing of data, results, resources and analytical frameworks. This working model of international collaboration underscores what is possible for future genetic discoveries in emerging pandemics, or indeed for any complex human disease