Investimento ambiental em indústrias sujas e intensivas em recursos naturais e energia

O crescimento industrial brasileiro, a partir do final dos anos setenta, ocorreu com o aumento da participação de indústrias intensivas em recursos naturais, em detrimento da participação de indústrias intensivas em trabalho e dos setores intensivos em atividades tecnológicas mais complexas. Essas transformações, tornando o setor de bens intermediários dominante na estrutura industrial, implicaram em consideráveis mudanças tanto de ordem espacial quanto na relação com o meio ambiente, o que acarretou no desenvolvimento de uma indústria com maior potencial poluidor. O artigo apresenta os resultados sobre investimentos da indústria brasileira para o controle ambiental, tendo como informação básica os gastos realizados nas aquisições e melhorias de máquinas e equipamentos industriais destinados à redução de resíduos, controle da poluição ou para o atendimento de normas ambientais. As informações foram captadas pela Pesquisa Industrial Anual, realizada pelo IBGE que, relativa aos anos de 1997 e 2002, coletou informações sobre este tipo de investimento. Observa-se que nos anos pesquisados ocorreu um crescimento na ordem de 71% do número de empresas e de 98% no valor investido. O estudo mostra que, em ambos os anos, há uma alta concentração do valor investido pelos setores que mais podem ter contribuído para a degradação ambiental no país.The growth industry Brazilian, within the end of the 1970s, occurs with the expention of the participation of industries in intensive exploitation of natural resources in detriment from participation of industries intensity in work and from the sectors intensity in activities technological more complex. Those transformations becomes the sector of intermediete goods dominant in the structure of the industry, resulting in insignificant gains compered with its order of magnitude in relation to the environment, thus leading to the development of an industry with great potential pollute. The article presents the investments results of Brazilian industry for environmental control, with the basic information about the expenditures incurred, acquisitions and improvements in machinery and industrial equipment interded to reduce waste, pollution control, or for the care of environmental standards. Information was received by the Annual Industrial Research held by the IBGE, on the years 1997 and 2002, collected information about this type of investment. It is observe that in the years studied occurred growth of around 71% of the number of enterprises and 98% in the amount invested. The study shows that in both years, there is a high concentration of the amount invested by most of the sectors that may have contributed to environmental degradation

Trehalose alleviates the phenotype of Machado–Joseph disease mouse models

Machado-Joseph disease (MJD), also known as spinocerebellar ataxia type 3, is the most common of the dominantly inherited ataxias worldwide and is characterized by mutant ataxin-3 aggregation and neuronal degeneration. There is no treatment available to block or delay disease progression. In this work we investigated whether trehalose, a natural occurring disaccharide widely used in food and cosmetic industry, would rescue biochemical, behavioral and neuropathological features of an in vitro and of a severe MJD transgenic mouse model.This work was funded by BioBlast Pharma, the ERDF through the Regional Operational Program Center 2020, Competitiveness Factors Operational Program (COMPETE 2020) and National Funds through FCT (Foundation for Science and Technology) - SFRH/BD/87404/2012, BrainHealth2020 projects (CENTRO-01-0145-FEDER-000008), ViraVector (CENTRO-01-0145FEDER-022095), CortaCAGs (POCI-01-0145-FEDER-016719), SpreadSilenc‑ing POCI-01-0145-FEDER-029716 and POCI-01-0145-FEDER-007440, as well as the SynSpread, ESMI and ModelPolyQ under the EU Joint ProgramNeurodegenerative Disease Research (JPND), the last two co-funded bythe European Union H2020 program, GA No. 643417; by National Ataxia Foundation (USA), the American Portuguese Biomedical Research Fund (APBRF) and the Richard Chin and Lily Lock Machado–Joseph Disease Research Fund.info:eu-repo/semantics/publishedVersio

Urbanizaçâo, impactos ambientais e governança no complexo regional Centro-Sul

A palavra governança vem servindo para designar diferentes formas de governar, particularmente aquelas mais sensíveis às demandas da população e que estimulem a inserção dos movimentos sociais nos processos decisórios. No Brasil, “governança ambiental” é usado, em geral, para se referir a processos de exercício de poder que, na área do meio ambiente, estejam ampliando os espaços de participação dos diversos segmentos da sociedade civil organizada. Este artigo analisa aspectos da governança ambiental no contexto do complexo regional Centro-Sul a partir dos resultados obtidos em pesquisa do Instituto Brasileiro de Geografia e Estatística (IBGE). Examinou-se a relação porventura existente entre os problemas ambientais detectados e as medidas que, em nível local, vinham sendo tomadas pelo gestor. O estudo considerou duas faixas diferenciadas de urbanização dos municípios do Centro-Sul e, como indicadores clássicos, o IDH e o PIB. O objetivo foi identificar diferenças com relação à inserção da participação popular na gestão ambiental, mediante a análise de algumas variáveis específicas, como participação em Comitês de bacia, existência e composição do Conselho Municipal de Meio Ambiente e do Fórum da Agenda 21 local.governança ambiental; impactos ambientais; urbanização; PIB; IDH

What about vaginal extraction of the kidney? results of an online survey

PURPOSE: We aimed to characterize surgeons opinion about the vaginal extraction of the kidney after transperitoneal laparoscopic nephrectomy. Matherial and Methods: A 9-item questionnaire was published online (Survey Monkey TM) and publicized via email to a multidisciplinary pool of surgeons in Portugal. Data was collected and statistical analysis was performed using IBM SPSS Statistics, Version 21.0. RESULTS: Three hundred and fifty nine inquiries were sent, 154 surgeons completed the questionnaires (response rate of 43.0%). Fifty five point eight percent of the participants would choose the transvaginal approach for themselves or for a close relative. The most stated arguments were a better cosmesis (29.0%) expectancy of lower post operative pain (26.0%) and lower rate of incisional hernias (23.0%). Defenders of the transabdominal procedure justified with an expectancy of lower complication rate (39%), namely impairment of sexual function and fertility (22%). The female gender and the familiarity with transvaginal surgery were the stronger predictors of the option for this approach (70.6% vs 48.5%; p=0,016 and 85.3% vs 46.6%; p <0.001 respectively). CONCLUSIONS: Contrasting with similar surveys published on transvaginal NOTES, the vaginal specimen extraction after conventional laparoscopic nephrectomy was fairly accepted by the inquired surgeons.info:eu-repo/semantics/publishedVersio

Investimento ambiental em indústrias sujas e intensivas em recursos naturais e energia

O crescimento industrial brasileiro, a partir do final dos anos setenta, ocorreu com o aumento da participação de indústrias intensivas em recursos naturais, em detrimento da participação de indústrias intensivas em trabalho e dos setores intensivos em atividades tecnológicas mais complexas. Essas transformações, tornando o setor de bens intermediários dominante na estrutura industrial, implicaram em consideráveis mudanças tanto de ordem espacial quanto na relação com o meio ambiente, o que acarretou no desenvolvimento de uma indústria com maior potencial poluidor. O artigo apresenta os resultados sobre investimentos da indústria brasileira para o controle ambiental, tendo como informação básica os gastos realizados nas aquisições e melhorias de máquinas e equipamentos industriais destinados à redução de resíduos, controle da poluição ou para o atendimento de normas ambientais. As informações foram captadas pela Pesquisa Industrial Anual, realizada pelo IBGE que, relativa aos anos de 1997 e 2002, coletou informações sobre este tipo de investimento. Observa-se que nos anos pesquisados ocorreu um crescimento na ordem de 71% do número de empresas e de 98% no valor investido. O estudo mostra que, em ambos os anos, há uma alta concentração do valor investido pelos setores que mais podem ter contribuído para a degradação ambiental no país.Estrutura industrial; indústrias poluidoras; gestão ambiental; investimento ambiental; bens intermediários.

NEFRECTOMIA PARCIAL – A EXPERIÊNCIA DE 10 ANOS DO HOSPITAL DE SANTO ANTÓNIO

A nefrectomia parcial (NP) é uma técnica reconhecida no tratamento de diferentes patologias renais,nomedamente na oncológica. Os autores apresentam a sua casuística dos últimos 10 anos, com avaliação dos índices de recorrência e sobrevivência

The NAD+-dependent deacetylase SIRT2 attenuates oxidative stress and mitochondrial dysfunction and improves insulin sensitivity in hepatocytes

Insulin resistance is a major predictor of the development of metabolic disorders. Sirtuins (SIRTs) have emerged as potential targets that can be manipulated to counteract age-related diseases, including type 2 diabetes. SIRT2 has been recently shown to exert important metabolic effects, but whether SIRT2 regulates insulin sensitivity in hepatocytes is currently unknown. The aim of this study is to investigate this possibility and to elucidate underlying molecular mechanisms. Here, we show that SIRT2 is downregulated in insulin-resistant hepatocytes and livers, and this was accompanied by increased generation of reactive oxygen species, activation of stress-sensitive ERK1/2 kinase, and mitochondrial dysfunction. Conversely, SIRT2 overexpression in insulin-resistant hepatocytes improved insulin sensitivity, mitigated reactive oxygen species production and ameliorated mitochondrial dysfunction. Further analysis revealed a reestablishment of mitochondrial morphology, with a higher number of elongated mitochondria rather than fragmented mitochondria instigated by insulin resistance. Mechanistically, SIRT2 was able to increase fusion-related protein Mfn2 and decrease mitochondrial-associated Drp1. SIRT2 also attenuated the downregulation of TFAM, a key mtDNA-associated protein, contributing to the increase in mitochondrial mass. Importantly, we found that SIRT2 expression in PBMCs of human subjects was negatively correlated with obesity and insulin resistance. These results suggest a novel function for hepatic SIRT2 in the regulation of insulin sensitivity and raise the possibility that SIRT2 activators may offer novel opportunities for preventing or treating insulin resistance and type 2 diabetes.European Regional Development Fund (ERDF), Centro 2020 Regional Operational Programme (CENTRO-01-0145-FEDER-000012: HealthyAging2020); COMPETE 2020 - Operational Programme for Competitiveness and Internationalisation and Portuguese national funds via FCT – Fundação para a Ciência e a Tecnologia (POCI-01-0145-FEDER-007440, SFRH/BPD/109347/2015 to R.M.O., SFRH/BD/86655/2012 to L.N. and SFRH/BPD/111815/2015 to P.G.); FLAD Life Science 2020 Grant to A.C.R.; European Molecular Biology Organization (EMBO Installation Grant to T.F.O.); DFG Center for Nanoscale Microscopy and Molecular Physiology of the Brain (CNMPB) to T.F.O

mHealth in urology

Introduction: Smartphones are increasingly playing a role in healthcare and previous studies assessing medical applications (apps) have raised concerns about lack of expert involvement and low content accuracy. However, there are no such studies in Urology. We reviewed Urology apps with the aim of assessing the level of participation of healthcare professionals (HCP) and scientific Urology associations in their development. Material and Methods: A systematic search was performed on PubMed, Apple's App Store and Google's Play Store, for Urology apps, available in English. Apps were reviewed by three graders to determine the app's platform, target customer, developer, app type, app category, price and the participation of a HCP or a scientific Urology association in the development. Results: The search yielded 372 apps, of which 150 were specific for Urology. A fifth of all apps had no HCP involvement (20.7%) and only a third had been developed with a scientific Urology association (34.7%). The lowest percentage of HCP (13.4%) and urological association (1.9%) involvement was in apps designed for the general population. Furthermore, there was no contribution from an Urology society in "Electronic Medical Record" nor in "Patient Information" apps. A limitation of the study is that only Android and iOS apps were reviewed. Conclusions: Despite the increasing Mobile Health (mHealth) market, this is the first study that demonstrates the lack of expert participation in the design of Urology apps, particularly in apps designed for the general public. Until clear regulation is enforced, the urological community should help regulate app development. Maintaining a register of certified apps or issuing an official scientific seal of approval could improve overall app quality. We propose that urologists become stakeholders in mHealth, shaping future app design and promoting peer-review app validation

Flow characteristics of Newtonian and non-Newtonian fluids in a vessel stirred by a 60° pitched blade impeller

Mean and rms velocity characteristics of two Newtonian flows at Reynolds numbers of 12,800 (glycerin solution) and 48,000 (water) and of a non-Newtonian flow (0.2% CMC solution, at a power number similar to the Newtonian glycerin flow) in a mixing vessel stirred by a 60° pitched blade impeller have been measured by laser Doppler velocimetry (LDV). The velocity measurements, resolved over 360° and 1.08° of impeller rotation, showed that the mean flow of the two power number matched glycerin and CMC flows were similar to within 3% of the impeller tip velocity and the turbulence intensities generally lower in the CMC flow by up to 5% of the tip velocity. The calculated mean flow quantities showed similar discharge coefficient and pumping efficiency in all three flows and similar strain rate between the two power number matched glycerin and CMC flows; the strain rate of the higher Reynolds number Newtonian flow was found to be slightly higher. The energy balance around the impeller indicated that the CMC flow dissipated up to 9% more of the total input power and converted 7% less into the turbulence compared to the glycerin flow with the same power input which could lead to less effective mixing processes where the micro-mixing is important

N-terminal cysteine bioconjugation with (2-cyanamidophenyl)boronic acids enables the direct formation of benzodiazaborines on peptides

Benzodiazaborines (BDABs) have emerged as a valuable tool to produce stable and functional bioconjugates via a click-type transformation. However, the current available methods to install them on peptides lack bioorthogonality, limiting their applications. Here, we report a strategy to install BDABs directly on peptide chains using (2-cyanamidophenyl)boronic acids (2CyPBAs). The resulting BDAB is stabilized through the formation of a key intramolecular B–N bond. This technology was applied in the selective modification of N-terminal cysteine-containing functional peptides