Production of 4-ethylphenol in alperujo by Lactobacillus pentosus

© 2014 Society of Chemical Industry. BACKGROUND: Alperujo is the paste generated from the two-phase extraction system of olive oil. This wet pomace must be stored for several months and, during this period, the formation of 4-ethyphenol provokes a strong off-odour. The aim of this work was to identify the microorganisms able to produce this volatile phenol. RESULTS: Yeast and bacterial strains were isolated from stored alperujo and tested for their ability to metabolize p-coumaric acid and form 4-ethylphenol. Among them, Lactobacillus pentosus was the microorganism that both in synthetic medium and alperujo gave rise to 4-ethylphenol formation. This microorganism did not grow in alperujo acidified to pH 2, thereby confirming that acidification as the best method to control odour emissions during alperujo storage. CONCLUSION: Lactic acid bacteria, particularly Lactobacillus pentosus, can be responsible for the formation of the off-odour caused by 4-ethylphenol during the storage of alperujo. This odour can be prevented by acidifying the alperujo.This research was supported by the Spanish Government and the European Union FEDER funds through the project AGL-2009-07512. The authors are grateful to Irene de la Rosa for technical help and Oleícola el Tejar SCA for providing the alperujo samples.Peer Reviewe

Procedimiento para la obtención de una solución favorecedora del crecimiento de plantas a partir de aguas de lavado del proceso de elaboración de aceitunas verdes estilo español y uso de dicha solución

La presente invención se refiere a un procedimiento para la obtención de una solución favorecedora del crecimiento de plantas a partir de aguas de lavado del proceso de elaboración de aceitunas verdes estilo español o sevillano, caracterizado porque comprende las siguientes etapas: (a) acidificación del agua de lavado hasta un valor de pH inferior a 3 unidades; (b) almacenamiento del agua en condiciones anaeróbicas; y (c) elevación del pH del concentrado hasta un valor superior a 4 unidades. Así mismo se refiere a la solución obtenida a partir de dicho procedimiento y a su uso para favorecer el crecimiento de plantas.Peer reviewedConsejo Superior de Investigaciones Científicas (España), Instituto Andaluz de Investigación y Formación Agraria, Pesquera, Alimentaria y de la Producción EcológicaA1 Solicitud de patente con informe sobre el estado de la técnic

SARS-CoV-2 Infection in Multiple Sclerosis

To understand COVID-19 characteristics in people with multiple sclerosis (MS) and identify high-risk individuals due to their immunocompromised state resulting from the use of disease-modifying treatments. Retrospective and multicenter registry in patients with MS with suspected or confirmed COVID-19 diagnosis and available disease course (mild = ambulatory; severe = hospitalization; and critical = intensive care unit/death). Cases were analyzed for associations between MS characteristics and COVID-19 course and for identifying risk factors for a fatal outcome. Of the 326 patients analyzed, 120 were cases confirmed by real-time PCR, 34 by a serologic test, and 205 were suspected. Sixty-nine patients (21.3%) developed severe infection, 10 (3%) critical, and 7 (2.1%) died. Ambulatory patients were higher in relapsing MS forms, treated with injectables and oral first-line agents, whereas more severe cases were observed in patients on pulsed immunosuppressors and critical cases among patients with no therapy. Severe and critical infections were more likely to affect older males with comorbidities, with progressive MS forms, a longer disease course, and higher disability. Fifteen of 33 patients treated with rituximab were hospitalized. Four deceased patients have progressive MS, 5 were not receiving MS therapy, and 2 were treated (natalizumab and rituximab). Multivariate analysis showed age (OR 1.09, 95% CI, 1.04-1.17) as the only independent risk factor for a fatal outcome. This study has not demonstrated the presumed critical role of MS therapy in the course of COVID-19 but evidenced that people with MS with advanced age and disease, in progressive course, and those who are more disabled have a higher probability of severe and even fatal diseas

Çédille, revista de estudios franceses

Presentació

Risk profiles and one-year outcomes of patients with newly diagnosed atrial fibrillation in India: Insights from the GARFIELD-AF Registry.

BACKGROUND: The Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF) is an ongoing prospective noninterventional registry, which is providing important information on the baseline characteristics, treatment patterns, and 1-year outcomes in patients with newly diagnosed non-valvular atrial fibrillation (NVAF). This report describes data from Indian patients recruited in this registry. METHODS AND RESULTS: A total of 52,014 patients with newly diagnosed AF were enrolled globally; of these, 1388 patients were recruited from 26 sites within India (2012-2016). In India, the mean age was 65.8 years at diagnosis of NVAF. Hypertension was the most prevalent risk factor for AF, present in 68.5% of patients from India and in 76.3% of patients globally (P < 0.001). Diabetes and coronary artery disease (CAD) were prevalent in 36.2% and 28.1% of patients as compared with global prevalence of 22.2% and 21.6%, respectively (P < 0.001 for both). Antiplatelet therapy was the most common antithrombotic treatment in India. With increasing stroke risk, however, patients were more likely to receive oral anticoagulant therapy [mainly vitamin K antagonist (VKA)], but average international normalized ratio (INR) was lower among Indian patients [median INR value 1.6 (interquartile range {IQR}: 1.3-2.3) versus 2.3 (IQR 1.8-2.8) (P < 0.001)]. Compared with other countries, patients from India had markedly higher rates of all-cause mortality [7.68 per 100 person-years (95% confidence interval 6.32-9.35) vs 4.34 (4.16-4.53), P < 0.0001], while rates of stroke/systemic embolism and major bleeding were lower after 1 year of follow-up. CONCLUSION: Compared to previously published registries from India, the GARFIELD-AF registry describes clinical profiles and outcomes in Indian patients with AF of a different etiology. The registry data show that compared to the rest of the world, Indian AF patients are younger in age and have more diabetes and CAD. Patients with a higher stroke risk are more likely to receive anticoagulation therapy with VKA but are underdosed compared with the global average in the GARFIELD-AF. CLINICAL TRIAL REGISTRATION-URL: http://www.clinicaltrials.gov. Unique identifier: NCT01090362

Colombian consensus recommendations for diagnosis, management and treatment of the infection by SARS-COV-2/ COVID-19 in health care facilities - Recommendations from expert´s group based and informed on evidence

La Asociación Colombiana de Infectología (ACIN) y el Instituto de Evaluación de Nuevas Tecnologías de la Salud (IETS) conformó un grupo de trabajo para desarrollar recomendaciones informadas y basadas en evidencia, por consenso de expertos para la atención, diagnóstico y manejo de casos de Covid 19. Estas guías son dirigidas al personal de salud y buscar dar recomendaciones en los ámbitos de la atención en salud de los casos de Covid-19, en el contexto nacional de Colombia

[Montreal 1976] [Material gráfico]

Contiene fotografías pertenecientes al archivo fotográfico del diario "Región", publicadas entre 1974 y 1976, aunque la mayoría en 1976Todas las fotografías firmadas por Foto E. Gar (Oviedo), Cifra Gráfica, y EF

Nurses' perceptions of aids and obstacles to the provision of optimal end of life care in ICU

Contains fulltext : 172380.pdf (publisher's version ) (Open Access

Obtención de sustancias antioxidantes a partir de soluciones del proceso de elaboración de aceitunas de mesa

Referencia OEPM: P200000516.-- Fecha de solicitud: 03/03/2000.-- Titular: Consejo Superior de Investigaciones Científicas (CSIC).Obtención de sustancias antioxidantes a partir de soluciones del proceso de elaboración de aceitunas de mesa. El procedimiento para la obtención de un extracto fenólico, con alta concentración en sustancias antioxidantes, consiste en ultrafiltrar diferentes soluciones del proceso de elaboración de aceitunas de mesa conservadas durante meses (soluciones del tratamiento con hidróxido sódico, aguas de lavado, salmueras) mediante membranas de tamaño de poro entre 1000-10000 daltons, adsorber las sustancias fenólicas en resinas no-iónicas, recuperar los fenoles mediante el empleo de etanol, evaporar el disolvente orgánico, tratar con carbón activo la solución acuosa resultante, congelar el líquido a temperaturas inferiores a 0ºC y liofilizar. Mediante este procedimiento se consigue obtener un extracto sólido con un contenido en hidroxitirosol superior al 60-80%. El procedimiento también permite obtener un extracto rico tanto en hidroxitirosol como en el glucósido del ácido elenólico.Peer reviewe