12 research outputs found
Study of polymeric micelles as a drug delivery system for carrier internalisation and cargo release in epithelial cell barriers
- Publication venue
- Publication date
- 28/11/2019
- Field of study
Goodbye Hartmann trial: a prospective, international, multicenter, observational study on the current use of a surgical procedure developed a century ago
- Author
- Abate Emmanuele
- Abbassi Imed
- Abdoun Ahmed K.
- Abdullaev Abakar
- Abu-Zidan Fikri
- Acheimastos Vasileios
- Agackiran Ibrahim
- Agnoletti Vanni
- Agrusa Antonino
- Agundez María Carmona
- Agus Marcello
- Aizza Giada
- Akin Emrah
- Alconchel Felipe
- Alegre Javier Martínez
- Alemanno Giovanni
- Ali Ali Ben
- Almeida Filipe
- Altinel Yuksel
- Altıntaş Yasemin
- Altintoprak Fatih
- Ambrosi Antonio
- Ammar Houssem
- Anania Gabriele
- Andreuccetti Jacopo
- Andrés María Inmaculada Pérez
- Anestiadou Elissavet
- Ansaloni Luca
- Antona Francisco Blanco
- Aparicio-Sánchez Daniel
- Aprea Giovanni
- Aranaz-Ostariz Veronica
- Aranda-Narváez Jose Manuel
- Ardito Antonella
- Argenio Giulio
- Armellino Mariano Fortunato
- Armento Isabella
- Asti Emanuele Luigi Giuseppe
- Atanasov Boyko
- Atici Semra Demirli
- Augustin Goran
- Aurélien Venara
- Austin Tyler R.
- Avgerinos Konstantinos
- Ayed Karim
- Azzinnaro Antonio
- Bagolini Francesco
- Baili Efstratia
- Bains Lovenish
- Baiocchi Gian Luca
- Bajul Melinda
- Bala Miklosh
- Balık Emre
- Balla Andrea
- Banchini Filippo
- Bañolas-Suarez Raquel
- Baraket Oussama
- Barberis Andrea
- Bardes James M.
- Bayhan Zulfu
- Bayrak Mehmet
- Belev Nikolay
- Belvedere Angela
- Benzoni Ilaria
- Bernardi Daniele Tiziano
- Berti Stefano
- Bertino Vanessa
- Bertoli Paolo
- Bianchi Valentina
- Biffl Walter L.
- Biloslavo Alan
- Boati Paolo
- Bogdanić Branko
- Bolzon Stefano
- Bombardini Cristina
- Bonati Elena
- Bonilauri Stefano
- Bonomi Alessandro
- Borghi Felice
- Bosch-Ramírez Marina
- Bougard Marie
- Bouliaris Konstantinos
- Boura Maria
- Bourbouteli Eirini
- Bozkurt Mehmet Abdussamet
- Brachini Gioia
- Bradley Alison
- Bravi Francesca
- Bravo Altea Arango
- Buffone Angelica
- Buonfantino Massimo
- Buscemi Salvatore
- Caamaño Aloia Guerreiro
- Cadeo Alessandro
- Cairl Nicholas
- Calu Valentin
- Campa Rossella Domenica
- Campana Juan P.
- Campos-Serra Andrea
- Cannavera Alessandro
- Canton Cassio Alfred Brattig
- Capelli Patrizio
- Capolupo Gabriella Teresa
- Capponi Michela Giulii
- Capuano Marianna
- Carannante Filippo
- Cardamone Eugenia
- Cardoso Paulo Sebastião
- Caricato Marco
- Carmona Zahira Gómez
- Carneiro Carla
- Carvas João
- Casadei Massimiliano
- Casati Massimiliano
- Casiraghi Silvia
- Casole Giovanni
- Castaldo Pasquale
- Catena Fausto
- Cattaneo Gaetano Maria
- Cavallo Fabio
- Cellerino Paola
- Cereda Marco
- Ceresoli Marco
- Chahrour Ali Chaouki
- Chamzin Alexandros
- Charalabopoulos Alexandros
- Chierici Andrea
- Chouillard Elie
- Chrysos Emmanuel
- Cianci Pasquale
- Cicconi Simone
- Cillara Nicola
- Clarizia Guglielmo
- Clerici Federico
- Cloquell Miriam Moratal
- Coccolini Federico
- Coffua Lauren S.
- Coimbra Raul
- Colak Elif
- Conti Luigi
- Corbellini Carlo
- Cordeiro-Fonseca Vinicius
- Cotsoglou Christian
- Cruz Daniel Rios
- Cuellar Jose Aurelio Navas
- Cumplido Paola Lora
- Curtiss William
- Czyżykowski Łukasz
- da Costa Silvia Dantas
- Das Koray
- Dawoud Christopher
- de León Laura Román García
- de los Ángeles Gil Olarte-Marquez Ma
- De Luca Maurizio
- de Manzoni Garberini Andrea
- de Mendonça Nuno Gonçalo Gonçalves
- de Mesquita Tauil Renato
- De Palma Giovanni Domenico
- de Quiros Javier Tomas Morales Bernaldo
- De Sario Giuseppina
- De Simone Belinda
- Degiuli Maurizio
- Del Monte Simone Rossi
- del Pozo Eduardo Perea
- Delgado Edward
- Delvecchio Antonella
- Demetrashvili Zaza
- Demirbas Eren
- Depalma Norma
- Di Buono Giuseppe
- Di Salvo Maria
- Dimov Stefan
- Dimova Ana
- Dinuzzi Vincenza Paola
- Díez-Alonso Manuel
- Domínguez Carlota López
- Dorken Ander
- Dos Barbeito Sandra
- Doudakmanis Christos
- Du Bois María Esther
- Dziakova Jana
- D’Acapito Fabrizio
- D’Alessio Rossella
- D’Ugo Stefano
- Echeverria-Rosario Karla
- Edwards Sara
- Egodage Tanya
- Elizalde Aurea Barbara Rodriguez
- Ercolani Giorgio
- Esposito Francesco
- Esposito Giuseppe
- Esposito Marialusia
- Estaire-Gómez Mercedes
- Fabbri Anna
- Fabbri Nicolò
- Farré Silvia Pérez
- Favi Francesco
- Felsenreich Daniel M.
- Feo Carlo V.
- Fernandes Urânia
- Fernández Rocio Torres
- Ferrara Francesco
- Ferrari Davide
- Ferreira Ana Rita Oliveira
- Ferreira Cátia
- Filippelli Alice
- Firat Necattin
- Fleres Francesco
- Florence Charlotte
- Fnaiech Iskander
- Fogato Luisella
- Fontana Michele
- Fradelos Evangelos
- Fraga Gustavo P.
- Fransvea Pietro
- Frontali Alice
- Frountzas Maximos
- Fumagalli Chiara
- Gachabayov Mahir
- Gambino Giovanni
- García Juan Jesús Rubio
- Garulli Gianluca
- Gasser Elisabeth
- Gattulli Domenico
- Gebran Anthony
- Germani Paola
- Gil-Martínez José
- Gioco Rossella
- Giraudo Giorgio
- Giuffrida Mario
- Gomes Carlos Augusto
- Gomes Felipe Couto
- Gomez Maite Santamaria
- Gonullu Emre
- Gonzaga Ricardo Alessandro Teixeira
- González-Castillo Ana María
- Goulart André
- Grassi Carmine
- Gràcia-Roman Raquel
- Guaitoli Eleonora
- Guercioni Gianluca
- Guerra Enrico
- Guerra Martina
- Guner Ali
- Gupta Rahul
- Hacım Nadir Adnan
- Hamid Hytham K. S.
- Hemmila Mark
- Hentati Hassen
- Hernandez Edgard Efren Lozada
- Hinojosa-Ugarte Diego
- Huguet Jose Mugüerza
- Hyman Theodore S.
- Iglesias Eva
- Ilhan Onur
- Inama Marco
- Ioannidis Orestis
- Isernia Roberta Maria
- Isik Arda
- Jakubauskas Matas
- Jalal-Eldin Sami
- Jimenez-Riera Granada
- Jimenez-Vega Javier
- Jiménez Beatriz Muñoz
- Jovine Elio
- Jusoh Asri Che
- Kafka-Ritsch Reinhold
- Kara Yasin
- Karavokyros Ioannis
- Katunin Jevgeni
- Kavalieratos George
- Kaya Tayfun
- Kchaou Ali
- Kechagias Aristotelis
- Kedar Asaf
- Khalil Hany
- Khan Mansoor
- Khanduri Archana
- Kimpizi Despina
- Kobe Yoshiro
- Kocataş Ali
- Kokkinakis Stamatios
- Korkolis Dimitrios
- Koukoulis Georgios
- Kovachev Nikola
- Koylu Zehra Alan
- Kruger Vitor F.
- Kryzauskas Marius
- Kuzeridis Harilaos
- Kwiatkowski Andrzej
- Lacko Vladimír
- Laforgia Rita
- Lantone Giuliano
- Lantone Giulio
- Lapolla Pierfrancesco
- Latifi Rifat
- Latorraca José
- Lauka Lelde
- Látečková Zuzana
- Leao Pedro
- Lecchi Francesca
- Leo Cosimo Alex
- Lepiane Pasquale
- Lepre Luca
- Lesko Dusan
- Letizia Laface
- Liasis Lampros
- Litvin Andrey
- Livrini Marco
- Lohsiriwat Varut
- Lombardi Raffaele
- Lopez Ana
- Lorusso Leonardo
- Lostoridis Eftychios
- Loutzidou Lydia
- Lovisetto Federico
- Lozano Rafael Calleja
- López Joaquín Ruiz
- López-Sánchez Jaime
- Luppi Davide
- Luzzi Andrea-Pierre
- Magnone Stefano
- Major Piotr
- Manatakis Dimitrios K.
- Manca Giuseppe
- Manigrasso Michele
- Manso Maria Isabel Cerqueira
- Mantoglu Baris
- Manunza Romina
- Margaris Ioannis
- Maria Sotiropoulou
- Marinis Athanasios
- Marino Fabio
- Maroulis Ioannis
- Marques Rita
- Martines Gennaro
- Martínez Manuel Durán
- Martínez-López Elías
- Martínez-Pérez Aleix
- Massucco Paolo
- Mazzini Federico N.
- McClure Amanda
- Meléndez L. Juan José
- Membrilla-Fernández Estela
- Memis Ufuk
- Mendoza-Moreno Fernando
- Mentz Ricardo
- Merabishvili Giorgi
- Meric Serhat
- Michalopoulos Nikolaos
- Micó Silvia Sevila
- Milone Marco
- Mingoli Andrea
- Miron Adrian
- Mitei Mercy
- Moller Elsa García
- Mongkhonsupphawan Aitsariya
- Monroy Jose maria Victor Palomo
- Monsellato Igor
- Morais Henrique Manuel Cardoso
- Morales-Sevillano Xavier
- Moreira Claudia Cristina Lopes
- Moreno Cristina Ruiz
- Moreno Verónica Polaino
- Moretto Gianluigi
- Morić Trpimir
- Mulita Francesk
- Muñoz-Campaña Anna
- Musa Nicola
- Nagliati Carlo
- Nagorni Eleni-Aikaterini
- Napolitano Lena M.
- Nechay Taras
- Nicolás-López Tatiana
- Nisa Francisca García-Moreno
- Nita Gabriela Elisa
- Notarnicola Margherita
- Oliva Alba
- Olmi Stefano
- Omarov Nail
- Oragano Luigi
- Orio Gianluca
- Osella Giulia
- Oury Jeffrey
- Ozer Nazmi
- Ozkan Zeynep
- O’Sullivan Sara Nuñez
- Palini Gian Marco
- Palisi Marco
- Palmer Amanda
- Palmieri Francesco
- Palomba Giuseppe
- Panebianco Annunziata
- Panis Yves
- Pantalone Desire
- Panyko Arpád
- Papacostantinou Ioannis
- Papagni Vincenzo
- Papis Davide
- Pardo Pablo Sancho
- Parini Dario
- Parker Robert
- Patrocínio Sara Daniela Direito
- Pattacini Gianmaria Casoni
- Pauzas Henrikas
- Pavone Giovanna
- Pellino Gianluca
- Pelloni María
- Pereira Bela
- Pereira Bruno Monteiro
- Pereira Rita Gonçalves
- Perez Aintzane Lizarazu
- Perez Diego Pita
- Perrone Fabrizio
- Perrone Gennaro
- Pesce Antonio
- Petit Nuria Mestres
- Petracca Gabriele Luciano
- Petrakis Georgios
- Petropoulou Thalia
- Petruzzelli Luca
- Pezzoli Isabella
- Pezzolla Angela
- Pędziwiatr Michał
- Picardi Biagio
- Picariello Erika
- Picciariello Arcangelo
- Piccoli Micaela
- Picheo Roberto
- Pighin Marina
- Pignata Giusto
- Pinto Francisca Lima
- Pipia Irakli
- Pisano Marcello
- Pisano Michele
- Pisanu Adolfo
- Pisarska-Adamczyk Magdalena
- Podda Mauro
- Polat Suleyman
- Polenta Eleni
- Polydorou Andreas
- Ponce Iñigo Augusto
- Pontarolo Nicholas
- Pontillo Marcelo
- Portale Giuseppe
- Poskus Tomas
- Prando Daniela
- Pujante Antonio
- Quick Jacob A.
- Quiodettis Martha
- Radonak Jozef
- Rahy-Martin Aida Cristina
- Rampini Alessia
- Rana Mridul
- Ranieri Valerio
- Ranketi Sinkeet
- Ratnasekera Asanthi
- Reames Summer
- Reddavid Rossella
- Reis Murat Emre
- Restini Enrico
- Reynaud Alejandro Bañon
- Ricci Claudio
- Riss Stefan
- Rivera-Alonso Daniel
- Rocha Catarina
- Rocha Ricardo
- Rodas María Elisa Valle
- Romacho-López Laura
- Ronconi Maurizio
- Roscio Francesco
- Rossi Giorgio
- Rossi Stefano
- Rottoli Matteo
- Roulet Maxime
- Ruiz Enrique Colás
- Russo Iris Shari
- Salazar Yeniffer Tatiana Moreno
- Salvans Silvia
- Sampietro Gianluca Matteo
- Sangji Naveen F.
- Sarnari Jlenia
- Sarro Giuliano
- Sartelli Massimo
- Sasia Diego
- Sánchez-Guillén Luis
- Scandroglio Ildo
- Scaramuzzo Rosa
- Schaffer Kathryn
- Scheiterle Maximilian
- Schifano Domenico
- Schizas Dimitrios
- Sebastián-Tomás Juan Carlos
- Seker Ahmet
- Sena Giuseppe
- Seng Sirivan Suon
- Serradilla-Martín Mario
- Sganga Gabriele
- Shimamura Fumihiko
- Siannis Ioannis
- Sierra Isabel Blesa
- Simó Ignacio Rey
- Singh Sudhir K.
- Sofia Silvia
- Solaini Leonardo
- Soltes Marek
- Spampinato Marcello
- Spinelli Stefano
- Spolini Alessandro
- Spolverato Ylenia
- Stylianos Kapiris
- Svagzdys Saulius
- Swaminathan Christie
- Syllaios Athanasios
- Tanzanu Marta
- Tarasconi Antonio
- Tartaglia Nicola
- Tasis Nikolaos
- Tebala Giovanni D.
- Termes-Serra Roser
- Theodorou Dimitrios
- Tian Brian W. C. A.
- Titos-García Alberto
- Tlili Ahmed
- Toma Elena Adelina
- Toma Takayuki
- Tonucci Tommaso Panici
- Torre Beatrice
- Torres Álvaro Naranjo
- Totaro Luigi
- Toutouzas Konstantinos
- Triantafyllou Tania
- Trigiante Giuseppe
- Troian Marina
- Trostchansky Ivan
- Truong Hung P.
- Tsouknidas Ioannis
- Tuncer Korhan
- Turrado-Rodriguez Victor
- Tyagunov Alexander
- Uccelli Matteo
- Usta Mehmet Arif
- Uymaz Derya Salim
- Uzunoglu Mustafa Yener
- Vailas Michail
- Valcárcel Cristina Rey
- Valle Naila Pagès
- Vallicelli Carlo
- Vassiliu Panteleimon
- Velmahos George
- Veneroni Simone
- Veroux Gastone
- Veroux Massimiliano
- Vincenti Leonardo
- Visconti Diego
- Vitón-Herrero Rebeca
- Walędziak Maciej
- Watfah Josef
- Wilson Michael
- Wong Michael Pak-Kai
- Xenaki Sofia
- Yuldashev Anvar
- Zakaria Andee Dzulkarnaen
- Zakaria Muhammad Nazreen
- Zakaria Zaidi
- Zanzi Federico
- Zelić Zdravko
- Zem Leticia Gonçalves
- Zese Monica
- Zilinskas Justas
- Zonta Sandro
- Zribi Imen
- Zuin Matteo
- Publication venue
- Publication date
- 01/01/2024
- Field of study
Background: Literature suggests colonic resection and primary anastomosis (RPA) instead of Hartmann's procedure (HP) for the treatment of left-sided colonic emergencies. We aim to evaluate the surgical options globally used to treat patients with acute left-sided colonic emergencies and the factors that leading to the choice of treatment, comparing HP and RPA. Methods: This is a prospective, international, multicenter, observational study registered on ClinicalTrials.gov. A total 1215 patients with left-sided colonic emergencies who required surgery were included from 204 centers during the period of March 1, 2020, to May 31, 2020. with a 1-year follow-up. Results: 564 patients (43.1%) were females. The mean age was 65.9 ± 15.6 years. HP was performed in 697 (57.3%) patients and RPA in 384 (31.6%) cases. Complicated acute diverticulitis was the most common cause of left-sided colonic emergencies (40.2%), followed by colorectal malignancy (36.6%). Severe complications (Clavien-Dindo ≥ 3b) were higher in the HP group (P < 0.001). 30-day mortality was higher in HP patients (13.7%), especially in case of bowel perforation and diffused peritonitis. 1-year follow-up showed no differences on ostomy reversal rate between HP and RPA. (P = 0.127). A backward likelihood logistic regression model showed that RPA was preferred in younger patients, having low ASA score (≤ 3), in case of large bowel obstruction, absence of colonic ischemia, longer time from admission to surgery, operating early at the day working hours, by a surgeon who performed more than 50 colorectal resections. Conclusions: After 100 years since the first Hartmann's procedure, HP remains the most common treatment for left-sided colorectal emergencies. Treatment's choice depends on patient characteristics, the time of surgery and the experience of the surgeon. RPA should be considered as the gold standard for surgery, with HP being an exception
The Helicobacter pylori Genome Project : insights into H. pylori population structure from analysis of a worldwide collection of complete genomes
- Author
- Abad-Baroja Daniel
- Abiodun Olumide
- Abnet Christian C.
- Abreu José Jiménez
- Adinortey Cynthia Ayefoumi
- Adinortey Michael Buenor
- Aftab Hafeza
- Aguilar Mynor
- Akada Junko
- Akande Kolawole Oluseyi
- Alcoba Laura
- Alfaray Ricky Indra
- Ally Reid
- Alonso-Larraga Juan Octavio
- Altayeb Hisham N.
- Ansari Shamshul
- Arita Masanori
- Asare Emmanuel
- Assumpção Paulo Pimentel
- Azrad Maya
- Backert Steffen
- Ballal Mamatha
- Barreiro-Alonso Eva
- Bartelli Thais F.
- Benejat Lucie
- Bentolila Federico
- Berg Douglas E.
- Bernal Giuliano
- Binh Tran Thanh
- Björnsson Einar S.
- Blaser Martin J.
- Bockarie Ansumana Sandy
- Bollag Roni
- Bordin Dmitry S.
- Boscolo Agostini Rajiv
- Botargues Josep
- Bravo Luis E.
- Bravo Maria Mercedes
- Brunet-Mas Eduard
- Bujanda Luis
- Calvet Xavier
- Camargo M. Constanza
- Campos-Núñez Christian
- Cannizzaro Renato
- Canzonieri Vincenzo
- Castaneda Carlos
- Castillo Francisco
- Castillo Miluska
- Chanock Stephen J.
- Chaves-Cervantes Manuel
- Chen Xiongfong
- Cherry Joshua L.
- Chiner-Oms Álvaro
- Choi Il Ju
- Cichoz-Lach Halina
- Colanzi Rony P.
- Comas Iñaki
- Corvalan Alejandro H.
- Cover Timothy L.
- Cromarty Taylor J.
- Cruz Modesto
- Cruz-Correa Marcia
- de Jesus Ngoma-Kisoko Patrick
- De Re Valli
- Dekker John P.
- Delgado-Guillena Pedro
- Demiryas Süleyman
- Dias-Neto Emmanuel
- Didelot Xavier
- Dominguez Ricardo L.
- Domper-Arnal María José
- Dung Ho Dang Quy
- Durán-Bermúdez Sundry
- Engstrand Lars
- Enroth Helena
- Falush Daniel
- Fauzia Kartika Afrida
- Fernández-Reyes María
- Ferreira Rui M.
- Fields Patricia I.
- Figueiredo Ceu
- Fischer Wolfgang
- Fleitas-Kanonnikoff Tania
- Flores Virginia
- Fox James G.
- Fukuyo Masaki
- Gao Yang
- García-Cancino Apolinaria
- García-Mateo Sandra
- Geary Janis
- Georgopoulos Sotirios
- Ghirotto Silvia
- Gilman Robert H.
- Gisbert Javier P.
- Gold Benjamin D.
- Goldstein Alisa M.
- Gonzalez Robinson
- Gonzalez-Hormazabal Patricio
- González-Pons María
- Goodman Karen J.
- Gościniak Grażyna
- Graham David Y.
- Gunnarsdóttir Anna Ingibjörg
- Gutiérrez-Escobar Andrés J.
- Guðjónsson Hallgrímur
- Haas Rainer
- Haesebrouck Freddy
- Harðardóttir Hjördís
- Hernandez Elisa
- Herrera-Goepfert Roberto
- Hicks Belynda
- Hosking Celso
- Htet Kyaw
- Hu Nan
- Huang Robert J.
- Hutchinson Amy
- Hwang Joo Ha
- Igissinov Nurbek
- In Haejin
- Jacobs William R.
- Jadallah Khaled
- Jehanne Quentin
- Jemilohun Christopher
- Johnson Deborah
- Jonaitis Laimas
- Jonaitis Paulius
- Jones Kristie
- Jónasson Jón Gunnlaugur
- Kamiya Shigeru
- Katsura Yukako
- Keller Peter M.
- Kepil Nuray
- Kessing Bailey
- Kikuste Ilze
- Kim Jae Gyu
- Kim Nayoung
- Kiudelis Gediminas
- Kiudelis Vytautas
- Kobayashi Ichizo
- Kocazeybek Bekir
- Korona-Glowniak Izabela
- Krishna Uma
- Kruse Edward J.
- Krzyżek Paweł
- Kupcinskas Juozas
- Lane Charlotte
- Lario Sergio
- Lee Yi-Chia
- Lehours Philippe
- Leja Mārcis
- Linares Pedro
- Link Alexander
- Liou Jyh-Ming
- Livzan Maria A.
- Lizasoain Jacobo
- Loh John T.
- Loke Mun Fai
- Lopez Aileen
- Luo Wen
- Mabeku Laure Brigitte Kouitcheu
- Machado Jose C.
- Magaji Francis Ajang
- Malekzadeh Reza
- Malfertheiner Peter
- Mariño-Ramírez Leonardo
- Martin Vicente
- Martinez-Gonzalez Beatriz
- Martínez-Martínez Francisco José
- Matalka Ismail
- Matsuhisa Takeshi
- Matsumoto Takashi
- Maulahela Hasan
- Megraud Francis
- Michopoulos Spyridon
- Miftahussurur Muhammad
- Moldobaeva Mariia Satarovna
- Molina-Castro Silvia
- Montes Milagrosa
- Moreira Leticia
- Morgan Douglas R.
- Morgan Richard D.
- Muro Edurne Amorena
- Muñoz-Ramírez Zilia Y.
- Naumann Michael
- Ngoyi Dieudonné Mumba
- Norton Morgan
- Noureen Mehwish
- Nunes Diana Noronha
- Ofori Eric Gyamerah
- Okonkwo Uchenna
- Oleastro Monica
- Olu-Abiodun Oluwatosin
- Omotoso Ayodele
- On Avi
- Osada Naoki
- Osaki Takako
- Osuagwu Chukwuemeka Chukwunwendu
- Owoseni Opeyemi O.
- Parra-Sepúlveda Cristian
- Pawełka Dorota
- Pazos Alvaro
- Peek Richard M.
- Pelosof Adriane
- Peretz Avi
- Piazuelo M. Blanca
- Pohl Daniel
- Price Nancy L.
- Pérez-Martínez Isabel
- Quiel Luis
- Quilty Douglas
- Raaf Naïma
- Rabkin Charles S.
- Rajagopalan Saranathan
- Rakhat Attokurova
- Raley Castle
- Ramírez-Lázaro María José
- Ramírez-Mayorga Vanessa
- Riquelme Arnoldo
- Roberts Richard J.
- Rodriguez Luz M.
- Romero-Gallo Judith
- Rudzīte Dace
- Rūdule Aiga
- Sandoval-Motta Santiago
- Sarıbas Suat
- Secka Ousman
- Serrano Carolina A.
- Sgouras Dionyssios N.
- Sheppard Sam
- Shetty Vignesh
- Shimura Takaya
- Shrestha Pradeep Krishna
- Skieceviciene Jurgita
- Smet Annemieke
- Song Minkyo
- Sotoudeh Masoud
- Sugihartono Titong
- Syam Ari Fahrial
- Sztokfisz Claudia Zitron
- Szymczak Wendy
- Tacatic Braulio Volga
- Tamayo Esther
- Tan Patrick
- Tarazona-Santos Eduardo
- Tasçı İhsan
- Taylor Philip R.
- Teshome Kedest
- Thorell Kaisa
- Tishkov Ivan
- Tokunaga Kengo
- Torres Javier
- Torres Roberto C.
- Tran Bao
- Trang Tran Thi Huyen
- Tshibangu-Kabamba Evariste
- Tshimpi-Wola Antoine
- Tsukanov Vladislav V.
- Tuan Vo Phuoc
- Tumba Ghislain Disashi
- Uchiyama Ikuo
- Vadivelu Jamuna
- Vale Filipa F.
- Van Khien Vu
- Vanags Aigars
- Vangravs Reinis
- Varkalaite Greta
- Varon Christine
- Velapatino Billie
- Vellasamy Kumutha Malar
- Villagra Miguel
- Vincze Tamas
- Wagner Karoline
- Wan Yunhu
- Wang Difei
- Waskito Langgeng Agung
- White Joseph
- Wilson Keith T.
- Wu Ming-Shiang
- Yahara Koji
- Yamaoka Yoshio
- Yeager Meredith
- Yee Than Than
- Yeoh Khay Guan
- Yu Kai
- Zamudio Roxana
- Zanussi Stefania
- Zhao Yongmei
- Zhu Bin
- Zhu Bin
- Zhu Feng
- Šķenders Ģirts
- Publication venue
- Nature Publishing Group
- Publication date
- 11/12/2023
- Field of study
Helicobacter pylori, a dominant member of the gastric microbiota, shares co-evolutionary history with humans. This has led to the development of genetically distinct H. pylori subpopulations associated with the geographic origin of the host and with differential gastric disease risk. Here, we provide insights into H. pylori population structure as a part of the Helicobacter pylori Genome Project (HpGP), a multi-disciplinary initiative aimed at elucidating H. pylori pathogenesis and identifying new therapeutic targets. We collected 1011 well-characterized clinical strains from 50 countries and generated high-quality genome sequences. We analysed core genome diversity and population structure of the HpGP dataset and 255 worldwide reference genomes to outline the ancestral contribution to Eurasian, African, and American populations. We found evidence of substantial contribution of population hpNorthAsia and subpopulation hspUral in Northern European H. pylori. The genomes of H. pylori isolated from northern and southern Indigenous Americans differed in that bacteria isolated in northern Indigenous communities were more similar to North Asian H. pylori while the southern had higher relatedness to hpEastAsia. Notably, we also found a highly clonal yet geographically dispersed North American subpopulation, which is negative for the cag pathogenicity island, and present in 7% of sequenced US genomes. We expect the HpGP dataset and the corresponding strains to become a major asset for H. pylori genomics
Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks, 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015
- Author
- Aasvang Gunn Marit
- Abajobir Amanuel Alemu
- Abate Kalkidan Hassen
- Abbafati Cristiana
- Abbas Kaja M.
- Abd-Allah Foad
- Abdulle Abdishakur M.
- Abera Semaw Ferede
- Abraham Biju
- Abu-Raddad Laith J.
- Abyu Gebre Yitayih
- Adebiyi Akindele Olupelumi
- Adedeji Isaac Akinkunmi
- Ademi Zanfina
- Adou Arsene Kouablan
- Adsuar Jose C.
- Afshin Ashkan
- Agardh Emilie Elisabet
- Agarwal Arnav
- Agrawal Anurag
- Ahmad Kiadaliri Aliasghar
- Ajala Oluremi N.
- Akinyemiju Tomi F.
- Al-Aly Ziyad
- Alam Khurshid
- Alam Noore K. M.
- Aldhahri Saleh Fahed
- Aldridge Robert William
- Alemu Zewdie Aderaw
- Alexander Lily T.
- Ali Raghib
- Alkerwi Ala’a
- Alla Francois
- Allebeck Peter
- Alsharif Ubai
- Altirkawi Khalid A.
- Alvarez Martin Elena
- Alvis-Guzman Nelson
- Amare Azmeraw T.
- Amberbir Alemayehu
- Amegah Adeladza Kofi
- Amini Heresh
- Ammar Walid
- Amrock Stephen Marc
- Andersen Hjalte H.
- Anderson Benjamin O.
- Anderson H. Ross
- Antonio Carl Abelardo T.
- Anwari Palwasha
- Arnlov Johan
- Artaman Al
- Asayesh Hamid
- Asghar Rana Jawad
- Assadi Reza
- Atique Suleman
- Avokpaho Euripide Frinel G. Arthur
- Awasthi Ashish
- Ayala Quintanilla Beatriz Paulina
- Azzopardi Peter
- Bacha Umar
- Badawi Alaa
- Bahit Maria C.
- Balakrishnan Kalpana
- Barac Aleksandra
- Barber Ryan M.
- Barker-Collo Suzanne L.
- Barnighausen Till
- Barquera Simon
- Barregard Lars
- Barrero Lope H.
- Basu Sanjay
- Batis Carolina
- Bazargan-Hejazi Shahrzad
- Beardsley Justin
- Bedi Neeraj
- Beghi Ettore
- Bell Brent
- Bell Michelle L.
- Bello Aminu K.
- Bennett Derrick A.
- Bensenor Isabela M.
- Berhane Adugnaw
- Bernabe Eduardo
- Betsu Balem Demtsu
- Beyene Addisu Shunu
- Bhala Neeraj
- Bhansali Anil
- Bhatt Samir
- Bhutta Zulfiqar A.
- Biadgilign Sibhatu
- Bikbov Boris
- Biryukov Stan
- Bisanzio Donal
- Bjertness Espen
- Blore Jed D.
- Borschmann Rohan
- Boufous Soufiane
- Bourne Rupert R. A.
- Brainin Michael
- Brauer Michael
- Brazinova Alexandra
- Breitborde Nicholas J. K.
- Brenner Hermann
- Broday David M.
- Brugha Traolach S.
- Brunekreef Bert
- Burnett Richard
- Butt Zahid A.
- Cahill Leah E.
- Calabria Bianca
- Campos-Nonato Ismael Ricardo
- Cardenas Rosario
- Carpenter David O.
- Carrero Juan Jesus
- Casey Daniel C.
- Castaneda-Orjuela Carlos A.
- Castillo Rivas Jacqueline
- Castro Ruben Estanislao
- Catala-Lopez Ferran
- Cercy Kelly
- Chang Jung-Chen
- Charlson Fiona J.
- Chiang Peggy Pei-Chia
- Chibalabala Mirriam
- Chimed-Ochir Odgerel
- Chisumpa Vesper Hichilombwe
- Chitheer Abdulaal A.
- Choi Jee-Young Jasmine
- Christensen Hanne
- Christopher Devasahayam Jesudas
- Ciobanu Liliana G.
- Coates Matthew M.
- Cohen Aaron J.
- Colquhoun Samantha M.
- Contreras Manzano Alejandra G.
- Cooper Leslie Trumbull
- Cooperrider Kimberly
- Cornaby Leslie
- Cortinovis Monica
- Crump John A.
- Cuevas-Nasu Lucia
- Damasceno Albertino
- Dandona Lalit
- Dandona Rakhi
- Darby Sarah C.
- Dargan Paul I.
- das Neves Jose
- Davis Adrian C.
- Davletov Kairat
- de Castro E Filipa
- De la Cruz-Gongora Vanessa
- De Leo Diego
- Degenhardt Louisa
- Del Gobbo Liana C.
- del Pozo-Cruz Borja
- Dellavalle Robert P.
- Deribew Amare
- Des Jarlais Don C.
- Dharmaratne Samath D.
- Dhillon Preet K.
- Diaz-Torne Cesar
- Dicker Daniel
- Ding Eric L.
- Dorsey E. Ray
- Doyle Kerrie E. (Aunty) (R19631)
- Driscoll Tim R.
- Duan Leilei
- Dubey Manisha
- Duncan Bruce Bartholow
- Elyazar Iqbal
- Endries Aman Yesuf
- Ermakov Sergey Petrovich
- Erskine Holly E.
- Eshrati Babak
- Esteghamati Alireza
- Estep Kara
- Fahimi Saman
- Faraon Emerito Jose Aquino
- Farid Talha A.
- Farinha Carla Sofiae Sa
- Faro Andre
- Farvid Maryam S.
- Farzadfar Farshad
- Feigin Valery L.
- Fereshtehnejad Seyed-Mohammad
- Fernandes Jefferson G.
- Ferrari Alize J.
- Fischer Florian
- Fitchett Joseph R. A.
- Fleming Tom
- Foigt Nataliya
- Foreman Kyle
- Forouzanfar Mohammad H.
- Fowkes F Gerry R.
- Franklin Richard C.
- Frostad Joseph J.
- Fullman Nancy
- Furst Thomas
- Futran Neal D.
- Gakidou Emmanuela
- Garcia-Basteiro Alberto L.
- Gebrehiwot Tsegaye Tewelde
- Gebremedhin Amanuel Tesfay
- Geleijnse Johanna M.
- Gessner Bradford D.
- Gething Peter W.
- Giref Ababi Zergaw
- Giroud Maurice
- Gishu Melkamu Dedefo
- Giussani Giorgia
- Godwin William W.
- Goenka Shifalika
- Gomez-Cabrera Mari Carmen
- Gomez-Dantes Hector
- Gona Philimon
- Goodridge Amador
- Gopalani Sameer Vali
- Gotay Carolyn C.
- Goto Atsushi
- Gouda Hebe N.
- Griswold Max
- Gugnani Harish Chander
- Guillemin Francis
- Guo Yuming
- Gupta Rahul
- Gupta Rajeev
- Gutierrez Reyna A.
- Haagsma Juanita A.
- Hafezi-Nejad Nima
- Haile Demewoz
- Hailu Gessessew Bugssa
- Halasa Yara A.
- Hamadeh Randah Ribhi
- Hamidi Samer
- Handal Alexis J.
- Hankey Graeme J.
- Hao Yuantao
- Harb Hilda L.
- Harikrishnan Sivadasanpillai
- Haro Josep Maria
- Hassanvand Mohammad Sadegh
- Hassen Tahir Ahmed
- Havmoeller Rasmus
- Hay Simon I.
- Heredia-Pi Ileana Beatriz
- Hernandez-Llanes Norberto Francisco
- Heydarpour Pouria
- Hoek Hans W.
- Hoffman Howard J.
- Horino Masako
- Horita Nobuyuki
- Hosgood H. Dean
- Hoy Damian G.
- Hsairi Mohamed
- Htet Aung Soe
- Hu Guoqing
- Huang John J.
- Husseini Abdullatif
- Hutchings Sally J.
- Huybrechts Inge
- Iburg Kim Moesgaard
- Idrisov Bulat T.
- Ileanu Bogdan Vasile
- Inoue Manami
- Jacobs Troy A.
- Jacobsen Kathryn H.
- Jahanmehr Nader
- Jakovljevic Mihajlo B.
- Jansen Henrica A. F. M.
- Jassal Simerjot K.
- Javanbakht Mehdi
- Jayaraman Sudha P.
- Jayatilleke Achala Upendra
- Jee Sun Ha
- Jeemon Panniyammakal
- Jha Vivekanand
- Jiang Ying
- Jibat Tariku
- Jin Ye
- Johnson Catherine O.
- Jonas Jost B.
- Kabir Zubair
- Kalkonde Yogeshwar
- Kamal Ritul
- Kan Haidong
- Karch Andre
- Karema Corine Kakizi
- Karimkhani Chante
- Kasaeian Amir
- Kaul Anil
- Kawakami Norito
- Kazi Dhruv S.
- Keiyoro Peter Njenga
- Kemmer Laura
- Kemp Andrew Haddon
- Kengne Andre Pascal
- Keren Andre
- Kesavachandran Chandrasekharan Nair
- Khader Yousef Saleh
- Khan Abdur Rahman
- Khan Ejaz Ahmad
- Khan Gulfaraz
- Khang Young-Ho
- Khatibzadeh Shahab
- Khera Sahil
- Khoja Tawfik Ahmed Muthafer
- Khubchandani Jagdish
- Kieling Christian
- Kim Cho-il
- Kim Daniel
- Kimokoti Ruth W.
- Kinfu Yohannes
- Kissoon Niranjan
- Kivipelto Miia
- Knibbs Luke D.
- Kokubo Yoshihiro
- Kopec Jacek A.
- Koul Parvaiz A.
- Koyanagi Ai
- Kravchenko Michael
- Kromhout Hans
- Krueger Hans
- Ku Tiffany
- Kuate Defo Barthelemy
- Kuchenbecker Ricardo S.
- Kucuk Bicer Burcu
- Kuipers Ernst J.
- Kumar G. Anil
- Kwan Gene F.
- Kyu Hmwe H.
- Lal Dharmesh Kumar
- Lalloo Ratilal
- Lallukka Tea
- Lan Qing
- Larson Heidi J.
- Larsson Anders
- Latif Asma Abdul
- Lawrynowicz Alicia Elena Beatriz
- Leasher Janet L.
- Leigh James
- Leung Janni
- Levi Miriam
- Li Xiaohong
- Li Yichong
- Liang Juan
- Liang Xiaofeng
- Lim Stephen S.
- Liu Patrick Y.
- Liu Shiwei
- Lloyd Belinda K.
- Logroscino Giancarlo
- Lopez Alan D.
- Lotufo Paulo A.
- Lozano Rafael
- Lunevicius Raimundas
- MacIntyre Michael
- Mahdavi Mahdi
- Majdan Marek
- Majeed Azeem
- Malekzadeh Reza
- Malta Deborah Carvalho
- Manamo Wondimu Ayele Ayele
- Mapoma Chabila C.
- Marcenes Wagner
- Marczak Laurie
- Martin Randall V.
- Martinez-Raga Jose
- Masiye Felix
- Matsushita Kunihiro
- Matzopoulos Richard
- Mayosi Bongani M.
- McGrath John J.
- McKee Martin
- Meaney Peter A.
- Medina Catalina
- Mehari Alem
- Mejia-Rodriguez Fabiola
- Mekonnen Alemayehu B.
- Melaku Yohannes Adama
- Memish Ziad A.
- Mendoza Walter
- Mensah George A.
- Mensink Gert B. M.
- Meretoja Atte
- Meretoja Tuomo J.
- Mesfin Yonatan Moges
- Mhimbira Francis Apolinary
- Millear Anoushka
- Miller Ted R.
- Mills Edward J.
- Mirarefin Mojde
- Misganaw Awoke
- Mock Charles N.
- Mohammadi Alireza
- Mohammed Shafiu
- Mokdad Ali H.
- Mola Glen Liddell D.
- Monasta Lorenzo
- Montanez Hernandez Julio Cesar
- Montico Marcella
- Moradi-Lakeh Maziar
- Morawska Lidia
- Mori Rintaro
- Mozaffarian Dariush
- Mueller Ulrich O.
- Mullany Erin
- Mumford John Everett
- Murray Christopher J. L.
- Murthy Gudlavalleti Venkata Satyanarayana
- Nachega Jean B.
- Naghavi Mohsen
- Naheed Aliya
- Nangia Vinay
- Nassiri Nariman
- Neal Bruce
- Newton John N.
- Ng Marie
- Nguyen Quyen Le
- Nisar Muhammad Imran
- Nkamedjie Pete Patrick Martial
- Norheim Ole F.
- Norman Rosana E.
- Norrving Bo
- Nyakarahuka Luke
- Obermeyer Carla Makhlouf
- Ogbo Felix A. (S31810)
- Oh In-Hwan
- Oladimeji Olanrewaju
- Olivares Pedro R.
- Olsen Helen
- Olusanya Bolajoko Olubukunola
- Olusanya Jacob Olusegun
- Opio John Nelson
- Oren Eyal
- Orozco Ricardo
- Ortiz Alberto
- Ota Erika
- Pa Mahesh
- Pana Adrian
- Park Eun-Kee
- Parry Charles D.
- Parsaeian Mahboubeh
- Patel Tejas
- Paternina Caicedo Angel J.
- Patil Snehal T.
- Patten Scott B.
- Patton George C.
- Pearce Neil
- Pereira David M.
- Perico Norberto
- Pesudovs Konrad
- Petzold Max
- Phillips Michael Robert
- Piel Frederic B.
- Pillay Julian David
- Plass Dietrich
- Polinder Suzanne
- Pond Constance D.
- Pope C. Arden
- Pope Daniel
- Popova Svetlana
- Poulton Richie G.
- Pourmalek Farshad
- Prasad Noela M.
- Qorbani Mostafa
- Rabiee Rynaz H. S.
- Radfar Amir
- Rafay Anwar
- Rahimi-Movaghar Vafa
- Rahman Mahfuzar
- Rahman Mohammad Hifz Ur
- Rahman Sajjad Ur
- Rai Rajesh Kumar
- Rajsic Sasa
- Raju Murugesan
- Ram Usha
- Rana Saleem M.
- Ranganathan Kavitha
- Rao Puja
- Razo Garcia Christian Aspacia
- Refaat Amany H.
- Rehm Colin D.
- Rehm Jurgen
- Reinig Nikolas
- Reitsma Marissa B.
- Remuzzi Giuseppe
- Resnikoff Serge
- Ribeiro Antonio L.
- Rivera Juan A.
- Roba Hirbo Shore
- Rodriguez Alina
- Rodriguez-Ramirez Sonia
- Rojas-Rueda David
- Roman Yesenia
- Ronfani Luca
- Roshandel Gholamreza
- Roth Gregory A.
- Rothenbacher Dietrich
- Roy Ambuj
- Saleh Muhammad Muhammad
- Salomon Joshua A.
- Sanabria Juan R.
- Sanchez-Nino Maria Dolores
- Sanchez-Pimienta Tania G.
- Sanchez-Riera Lidia
- Sandar Logan
- Santomauro Damian F.
- Santos Itamar S.
- Sarmiento-Suarez Rodrigo
- Sartorius Benn
- Satpathy Maheswar
- Savic Miloje
- Sawhney Monika
- Schmidhuber Josef
- Schmidt Maria Ines
- Schneider Ione J. C.
- Schottker Ben
- Schutte Aletta E.
- Schwebel David C.
- Scott James G.
- Seedat Soraya
- Sepanlou Sadaf G.
- Servan-Mori Edson E.
- Shaddick Gavin
- Shaheen Amira
- Shahraz Saeid
- Shaikh Masood Ali
- Shamah Levy Teresa
- Sharma Rajesh
- She Jun
- Sheikhbahaei Sara
- Shen Jiabin
- Sheth Kevin N.
- Shi Peilin
- Shibuya Kenji
- Shigematsu Mika
- Shin Min-Jeong
- Shiri Rahman
- Shishani Kawkab
- Shiue Ivy
- Shrime Mark G.
- Sigfusdottir Inga Dora
- Silva Diego Augusto Santos
- Silveira Dayane Gabriele Alves
- Silverberg Jonathan I.
- Simard Edgar P.
- Sindi Shireen
- Singh Abhishek
- Singh Jasvinder A.
- Singh Prashant Kumar
- Slepak Erica Leigh
- Soljak Michael
- Soneji Samir
- Sorensen Reed J. D.
- Sposato Luciano A
- Sreeramareddy Chandrashekhar T.
- Stathopoulou Vasiliki
- Steckling Nadine
- Steel Nicholas
- Stein Dan J.
- Stein Murray B.
- Stockl Heidi
- Stranges Saverio
- Stroumpoulis Konstantinos
- Sunguya Bruno F.
- Sur Patrick J.
- Swaminathan Soumya
- Sykes Bryan L.
- Szoeke Cassandra E. I.
- Tabares-Seisdedos Rafael
- Takahashi Ken
- Talongwa Roberto Tchio
- Tandon Nikhil
- Tanne David
- Tavakkoli Mohammad
- Taye Belaynew Wasie
- Taylor Hugh R.
- Tedla Bemnet Amare
- Tefera Worku Mekonnen
- Tegegne Teketo Kassaw
- Tekle Dejen Yemane
- Terkawi Abdullah Sulieman
- Thakur J. S.
- Thomas Bernadette A.
- Thomas Matthew Lloyd
- Thomson Alan J.
- Thorne-Lyman Andrew L.
- Thrift Amanda G.
- Thurston George D.
- Tillmann Taavi
- Tobe-Gai Ruoyan
- Tobollik Myriam
- Topor-Madry Roman
- Topouzis Fotis
- Towbin Jeffrey Allen
- Tran Bach Xuan
- Tsala Dimbuene Zacharie
- Tsilimparis Nikolaos
- Tura Abera Kenay
- Tuzcu Emin Murat
- Tyrovolas Stefanos
- Ukwaja Kingsley N.
- Undurraga Eduardo A.
- Uneke Chigozie Jesse
- Uthman Olalekan A.
- van Donkelaar Aaron
- van Os Jim
- Varakin Yuri Y.
- Vasankari Tommi
- Veerman J. Lennert
- Venketasubramanian Narayanaswamy
- Violante Francesco S.
- Vollset Stein Emil
- Vos Theo
- Wagner Gregory R.
- Wagner Joseph A.
- Waller Stephen G.
- Wang Haidong
- Wang Jian Li
- Wang Linhong
- Wang Yanping
- Weichenthal Scott
- Weiderpass Elisabete
- Weintraub Robert G.
- Werdecker Andrea
- Westerman Ronny
- Whiteford Harvey A.
- Wijeratne Tissa
- Wiysonge Charles Shey
- Wolfe Charles D. A.
- Won Sungho
- Woolf Anthony D.
- Wubshet Mamo
- Xavier Denis
- Xu Gelin
- Yadav Ajit Kumar
- Yakob Bereket
- Yalew Ayalnesh Zemene
- Yano Yuichiro
- Yaseri Mehdi
- Ye Pengpeng
- Yip Paul
- Yonemoto Naohiro
- Yoon Seok-Jun
- Younis Mustafa Z.
- Yu Chuanhua
- Zaidi Zoubida
- Zaki Maysaa El Sayed
- Zhao Yi
- Zhou Maigeng
- Zhu Jun
- Zipkin Ben
- Zodpey Sanjay
- Zuhlke Liesl Joanna
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2016
- Field of study
Forouzanfar MH, Afshin A, Alexander LT, et al. Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks, 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015. LANCET. 2016;388(10053):1659-1724.Background The Global Burden of Diseases, Injuries, and Risk Factors Study 2015 provides an up-to-date synthesis of the evidence for risk factor exposure and the attributable burden of disease. By providing national and subnational assessments spanning the past 25 years, this study can inform debates on the importance of addressing risks in context. Methods We used the comparative risk assessment framework developed for previous iterations of the Global Burden of Disease Study to estimate attributable deaths, disability-adjusted life-years (DALYs), and trends in exposure by age group, sex, year, and geography for 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks from 1990 to 2015. This study included 388 risk-outcome pairs that met World Cancer Research Fund-defined criteria for convincing or probable evidence. We extracted relative risk and exposure estimates from randomised controlled trials, cohorts, pooled cohorts, household surveys, census data, satellite data, and other sources. We used statistical models to pool data, adjust for bias, and incorporate covariates. We developed a metric that allows comparisons of exposure across risk factors-the summary exposure value. Using the counterfactual scenario of theoretical minimum risk level, we estimated the portion of deaths and DALYs that could be attributed to a given risk. We decomposed trends in attributable burden into contributions from population growth, population age structure, risk exposure, and risk-deleted cause-specific DALY rates. We characterised risk exposure in relation to a Socio-demographic Index (SDI). Findings Between 1990 and 2015, global exposure to unsafe sanitation, household air pollution, childhood underweight, childhood stunting, and smoking each decreased by more than 25%. Global exposure for several occupational risks, high body-mass index (BMI), and drug use increased by more than 25% over the same period. All risks jointly evaluated in 2015 accounted for 57.8% (95% CI 56.6-58.8) of global deaths and 41.2% (39.8-42.8) of DALYs. In 2015, the ten largest contributors to global DALYs among Level 3 risks were high systolic blood pressure (211.8 million [192.7 million to 231.1 million] global DALYs), smoking (148.6 million [134.2 million to 163.1 million]), high fasting plasma glucose (143.1 million [125.1 million to 163.5 million]), high BMI (120.1 million [83.8 million to 158.4 million]), childhood undernutrition (113.3 million [103.9 million to 123.4 million]), ambient particulate matter (103.1 million [90.8 million to 115.1 million]), high total cholesterol (88.7 million [74.6 million to 105.7 million]), household air pollution (85.6 million [66.7 million to 106.1 million]), alcohol use (85.0 million [77.2 million to 93.0 million]), and diets high in sodium (83.0 million [49.3 million to 127.5 million]). From 1990 to 2015, attributable DALYs declined for micronutrient deficiencies, childhood undernutrition, unsafe sanitation and water, and household air pollution; reductions in risk-deleted DALY rates rather than reductions in exposure drove these declines. Rising exposure contributed to notable increases in attributable DALYs from high BMI, high fasting plasma glucose, occupational carcinogens, and drug use. Environmental risks and childhood undernutrition declined steadily with SDI; low physical activity, high BMI, and high fasting plasma glucose increased with SDI. In 119 countries, metabolic risks, such as high BMI and fasting plasma glucose, contributed the most attributable DALYs in 2015. Regionally, smoking still ranked among the leading five risk factors for attributable DALYs in 109 countries; childhood underweight and unsafe sex remained primary drivers of early death and disability in much of sub-Saharan Africa. Interpretation Declines in some key environmental risks have contributed to declines in critical infectious diseases. Some risks appear to be invariant to SDI. Increasing risks, including high BMI, high fasting plasma glucose, drug use, and some occupational exposures, contribute to rising burden from some conditions, but also provide opportunities for intervention. Some highly preventable risks, such as smoking, remain major causes of attributable DALYs, even as exposure is declining. Public policy makers need to pay attention to the risks that are increasingly major contributors to global burden. Copyright (C) The Author(s). Published by Elsevier Ltd
Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries
- Author
- Abad-Motos Ane
- Abbas Ahmed M.
- Abbas Mostafa
- Abbasi Mujeeb
- Abbott Tom
- Abd Karim Muhammad Fairuz Shah
- Abdalaal Ibrahim
- Abdel-Galil Khalid
- Abdelemam Rania
- Abdelgawad Abdalrahman
- Abdelkarim Maryam
- Abdelkhalek Mohamed
- Abdelmageed Abdelfatah
- Abdelmawgoud Sherif
- Abdelmohsen Sarah
- Abdelrahman Ahmed Saber
- Abdelrahman Mostafa
- Abdelwahab Khaled
- Abdou Hossam
- Abdulai Darling Ramatu
- Abdulkhaleq Marwa
- Abdullah Bahiyah
- Abdulsalam Khalifa
- Abdulsalam Shuaib
- Abdur-Rahman Lukman
- Abdus-Salam Rukiyat
- Abdussalam Hameedat Opeyemi
- Abebrese John Tabiri
- Abeldaño Ariel
- Abou-Khalil Jad
- Abou-Taleb Hisham
- Abozid Anwaar
- Abozied Hesham
- Abrate Alberto
- Abu-Zaid Ahmed
- Abubakar Mohammed Kabir
- Abud Burçin
- Abuzaid Mohammed
- Adam Albushra Altayeb
- Adamina Michel
- Adamou Harissou
- Adamu Auwal
- Adamu Kabir Musa
- Adanu Kekeli
- Adebara Idowu
- Adebola Oluwaseyi
- Ademuyiwa Adesoji
- Adeniran Abiodun
- Adepiti Akinfolarin
- Aderogba Adeleke Akeem
- Adesunkanmi Abdulhafiz
- Adeyeye Ademola
- Adisa Adewale
- Adjeso Theophilus Justus Kofi
- Ads Adel Mohamed
- Ads Alaa Mohamed
- Adu-Aryee Nii Armah
- Adumah Collins
- Afzal Irrum
- Agapov Mikhail
- Agarwal Gaurav
- Agarwal Ravi
- Agbeko Anita Eseenam
- Agbeno Evans Kofi
- Agbonrofo Peter
- Agboola Oluseyi
- Aggarwal Gaurav
- Aghadi Ifeanyi
- Aghtarafi Natasha
- Agrawal Amit
- Agresta Ferdinando
- Aguado Héctor J.
- Aguilera-Arevalo Maria-Lorena
- Aherne Thomas
- Ahmad Aline
- Ahmad Maleeha
- Ahmad Misbahu
- Ahmad Sarwat
- Ahmad Shahzaib
- Ahmad Shoaib
- Ahmed Hayat Tarig Abdelhafiz
- Ahmed Khalid
- Ahmed Sharwany
- Ahmed Shima
- Ahmed Usama
- Aisuodionoe-Shadrach Oseremen
- Aitken Sarah
- Ajenifuja Kayode
- Ajiya Abdulrazak
- Akeel Nouf
- Akin Emrah
- Akinajo Opeyemi
- Akinyemi Tosin
- Akrida Ioanna
- Aktokmakyan Talar Vartanoglu
- Akwaisah Ayoub
- Al Bettar Osama
- Al-Badawi Ismail A.
- Al-Juaifari Maytham
- Al-Khyatt Waleed
- Al-Mallah Abdullah
- Al-Nusairi Ahmed
- Al-Saadi Nina
- Al-Sayaghi Khaled
- Al-Shaiji Tariq
- Al-Shehari Mohammed
- Al-Touny Aiman
- Al-Touny Shimaa A.
- Aladawi Omar
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- Sica Giuseppe
- Siddig Esra
- Siddiqui M. Tayyab
- Sidiropoulos Theodoros
- Sievers Denise
- Sigamoney Kohila
- Silvestri Vania
- Simoes Joana
- Simon Natalie
- Simoncini Tommaso
- Simões Joana Filipa Ferreira
- Singer Georg
- Singh Abhinav
- Singh Baljit
- Singh Kathryn
- Singh Rajdeep
- Singh Tanveer
- Sinnerton Robert
- Siragusa Leandro
- Sivaprakasam Rajesh
- Skipworth Richard Je
- Slavchev Mihail
- Sleem Adham
- Smati Ismail
- Smelt Jeremy
- Smith A.
- Smolle-Juettner Freyja-Maria
- Sodhai Vivek
- Sofi Khalid
- Sohrabi Catrin
- Soibiharry Adaiah
- Sokolov Manol
- Solaini Leonardo
- Sole Oriol Martin
- Sole-Sedeno Josep M.
- Soljic Martina
- Solli Piergiorgio
- Soon Wai Cheong
- Sorbi Flavia
- Sotiropoulou Maria
- Sotudeh Mohadeseh
- Souadka Amine
- Soucheiron Maria Coronas
- Soytas Mustafa
- Sozzi Giulio
- Sparavigna Marco
- Spartalis Michael
- Spellar Kayleigh
- Spiers Harry V. M.
- Spina Alfio
- Spriano Giuseppe
- Squiers John
- Stabler Robert
- Stamatakis Emmanouil
- Stamatis Konstantinos
- Starr Nichole
- Stather Philip
- Stevens Sean
- Stevenson Andrew
- Stewart Grant D.
- Stijns Jasper
- Stogowski Piotr Tomasz
- Stoleriu Mircea Gabriel
- Stoyanov Vladislav
- Street John
- Strotmann Johanna Josefine
- Stroumpoulis Konstantinos
- Su Yu-Xiong
- Suarez Sara Busto
- Subramani Yamini
- Subramaniam Sentilnathan
- Sue-Chue-Lam Colin
- Suer Muhammed Salih
- Sulaiman Bilal
- Sultania Mahesh
- Sundarraju Shalini
- Sungurtekin Hulya
- Suresh Sreelakshmi
- Surya Ilham Utama
- Swed Sarya
- Syllaios Athanasios
- Symeonidis Dimitrios
- Szabómihályová Katarína
- Szakmany Tamas
- Szatmary Peter
- Sztipits Tamás
- Szyluk Karol
- Sá-Marta Eduarda
- Sánchez Alberto Cabañero
- Sánchez Rosa
- Sánchez-Guillén Luis
- Süleyman Marlen
- Tadic Boris
- Taha Anas
- Taha-Mehlitz Stephanie
- Tailor Bhavesh
- Taj Eldeen Samaher Taj Eldeen Hassan
- Takeda Flavio Roberto
- Takkenberg Marijn
- Talat Nabila
- Tallon-Aguilar Luis
- Talwar Rishi
- Tamayo Beatriz Villota
- Tamburello Sara
- Tamini Nicolò
- Tammo Ömer
- Tamoos Khalil
- Tampaki Ekaterini Christina
- Tampakis Athanasios
- Tan Chih Ying
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- Tanal Mert
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- Tang Alethea
- Tang Yita
- Tani Sobhana Iftekhar
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- Tarek Ahmed
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- Tatsis Dimitris
- Tawalbeh Ra'Fat
- Tawiah Augustine
- Tebha Sameer
- Techapongsatorn Suphakarn
- Teixeira Pedro
- Tejero-Pintor Francisco J.
- Tellez Karla Susana Martin
- Tellez Luis Garcia-Sancho
- Thaha Mohamed Adhnan
- Thakar Sumit
- Thaw May Htoo
- Theivendran Kanthan
- Thekkinkattil Dinesh
- Theochari Nikoletta
- Theodoropoulos George
- Theophilidou Elena
- Thereska Dariel
- Thiruchandran Gajendiran
- Thomakos Nikolaos
- Thomas Bradley
- Thomas Jerin Jose
- Thuduvage Vasanthika
- Thumbadoo Ruben
- Tian Sarah
- Tidjane Anisse
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- Tomasicchio Giovanni
- Tomlinson James
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- Uldry Emilie
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- Ulman Hilmican
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- Unsworth Richard
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- Usman Muhammad
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- Vagena Xanthoula
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- Vailas Michail
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- Valioulis Ioannis
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- Van Goor Harry
- Van Vliet Helen
- Van Wyk Naomi Natasha
- Vanni Camilla
- Vas Aurelia
- Vasarhelyi Edward
- Vaschetti Roberto
- Vassiliu Panteleimon
- Vatansever Dogan
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- Verhoeff Kevin
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- Verre Luigi
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- Vijay Vardhini
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- Viola Simona
- Violante Tommaso
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- Vissapragada Ravi
- Vivancos Laura Guillamon
- Vives Josep Maria Muñoz
- Vizzielli Giuseppe
- Vohra Lubna
- Vokshi Ismail
- Vosinakis Christos
- Vásquez Javier Alberto Gutiérrez
- Vázquez Gil
- Vázquez Irene Ortega
- Vǎcǎraşu Andrei Bogdan
- Wade Ryckie
- Wafi Omar
- Wagner Gabriela
- Wallis Christopher
- Wanjara Samuel
- Waqar Shahzad Hussain
- Warden Claire
- Warner Christian
- Wasim D.
- Wason Shaun
- Wasserman Isaac
- Watcyn-Jones Tom
- Waterson Ben
- Watson David
- Watson Matthew
- Weber Clemens
- Wheatstone P.
- Wheeler James
- Wheldon Luke
- White Michelle
- White Stuart
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- Wiedemann Dominik
- Wiesinger Clemens Georg
- Wijekoon Naveen
- Wijenayake Wasantha
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- Wijeysundera Duminda
- Wiles Matthew
- Wilkin Richard
- Wilkins Alex
- Wilkins James
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- Williams Omolara Modupe
- Williams Shekinah
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- Winnand Philipp
- Wittmann Maria
- Wolde Amanuel
- Wolfenden John W. D.
- Wong Benjamin Ngie Xiong
- Wong Enoch
- Wong Evan G.
- Wong George Kwok Chu
- Wong Ho Ying Flora
- Wong Kai Yuen
- Wormald Justin
- Wright Deborah
- Wright Joshua
- Wu Fiona
- Wurm Markus
- Xenaki Sofia
- Yadev Ip
- Yahaya Ahmad Shuib
- Yakubu Mustapha
- Yang Wah
- Yanik Özge
- Yanowsky-Reyes Guillermo
- Yassin Abubaker
- Yates Elizabeth
- Yebes Alvaro
- Yenli Edwin Mwintiereh Ta-Ang
- Yeoh Tien
- Yeung Justin
- Yiallourou Anneza
- Yigit Banu
- Yildirim Asif
- Yim Guang
- Yiu Andrew
- Yonekura Hiroshi
- Yotsov Tsanko
- Younis Muhammad Umar
- Yunus Alif
- Yusefi Hossein
- Zabaleta Jon
- Zabkiewicz Catheriner
- Zaccaria Giulia
- Zacharia Bincy
- Zafar Syed Nabeel
- Zago Mauro
- Zaheen Zakia
- Zahid Zahra
- Zaimis Tilemachos
- Zakaria Andee Dzulkarnaen
- Zambon Martina
- Zamora Lindsey
- Zampogna Biagio
- Zancana Giuseppa
- Zani Augusto
- Zanin Luca
- Zanini Nicola
- Zapardiel Ignacio
- Zapata Carlos Shiraishi
- Zarif Pierre
- Zaránd Attila
- Zehnder Philipp
- Zenger Serkan
- Zenha Horácio
- Zhu Michael Z. L.
- Ziemann Sebastian
- Zimak Danijela Mrazovac
- Zimak Zoran
- Zivkovic Dragana
- Zizzo Maurizio
- Zucker Benjamin
- Zwain Yasir
- Zyskowski Michael
- Ávila Clara Castro
- Älgå Andreas
- Çakici Mehmet Çaǧlar
- Çelik Enes
- Çelik Meryem Nur
- Özçay Necdet
- Şevik Hüsnü
- Šantak Goran
- Šimko Kristián
- Žatecký Jan
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/01/2023
- Field of study
Abstract
Background
Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres.
Methods
This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and low–middle-income countries.
Results
In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of ‘single-use’ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for low–middle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia.
Conclusion
This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both high– and low–middle–income countries
[The effect of low-dose hydrocortisone on requirement of norepinephrine and lactate clearance in patients with refractory septic shock].
- Author
- Abbey Ianthe
- Abdel Rehim Marwa
- Abdel Rehim Marwa
- Abdul Rahman A
- Abduljawwad Emad
- Abduljawwad Emad
- Abe Emuri
- Abe Ryuzo
- Aboab Jerome
- Aboab Jerome
- Acevedo Juan
- Acharya Anand
- Acquarolo Annamaria
- Acquarolo Annamaria
- Adamzik Michael
- Adamzik Michael
- Adembri Chiara
- Adrie Christophe
- Adrie Christophe
- Afessa Bekele
- Ainoda Yusuke
- Aiyar S
- Al Dabbagh Tarek
- Al Dabbagh Tarek
- Al Knawy Bandar A
- Al Knawy Bandar A
- Al-Abdulkareem Abdulmajeed
- Al-Abdulkareem Abdulmajeed
- Al-Abdulkareem Abdulmajeed
- Al-Abdulkareem Abdulmajeed
- Al-Arabi Rida
- Al-Dorzi Hasan M
- Al-Dorzi Hasan M
- Al-Muhamadi Ali
- Al-Naeeb Yasseen
- Al-Naeeb Yasseen
- Al-Shaer Mohammad
- Al-Shaer Mohammad
- Al-Tamimi Waleed
- Al-Tamimi Waleed
- Alaniz Cesar
- Alevizaki Maria
- Alevizaki Maria
- Alinejad Faranak
- AlJumah Abdulrahman
- AlJumah Abdulrahman
- AlJumah Abdulrahman
- AlJumah Abdulrahman
- AlJumah Abdulrahman
- AlJumah Abdulrahman
- Allolio Bruno
- AlNajjar Taghreed
- AlNajjar Taghreed
- Altintas M A
- Alvarez Jean-Claude Claude
- Alvarez Jean-Claude Claude
- Alvarez Jean-Claude Claude
- Amano Kosaku
- Amano Kosaku
- Amathieu Roland
- Amathieu Roland
- Amathieu Roland
- Amathieu Roland
- Ambriz-Plascencia Ana Rosa
- Ameen Abdelbadee
- Ameen Abdelbadee
- Amini Amir
- Amini Amir
- Amini Amir
- Amos Taryn
- Amour Julien
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- Andersson Liane
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- Androulakis Ioannis P
- Aneja Rajesh
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- Anjum Aisha
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- Annane Djillali
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- Annane Djillali
- Annane Djillali
- Annane Djillali
- Annane Djillali
- Annane Djillali
- Annane Djillali
- Annane Djillali
- Annane Djillali
- Annane Djillali
- Annane Djillali
- Annane Djillali
- Annane Djillali
- Annane Djillali
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- Arroyo Vicente
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- Czepielewski Mauro Antonio
- Czepielewski Mauro Antonio
- Czepielewski Mauro Antonio
- Czepielewski Mauro Antonio
- Czeslick Elke
- D'honneur Gilles
- D'honneur Gilles
- D'Silva Celma
- da Cruz Neto Luiz Monteiro
- da Silva Fabiano Pinheiro
- Da Jiping
- Dabbagh Ousama
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- Dalcin Diogo C
- Danner Robert L
- Danner Robert L
- Davidson Fraser
- Davis Alan
- De Backer Daniel
- De Gaudio A Raffaele
- de Jong Margriet Fleur Charlotte
- de Jong Margriet Fleur Charlotte
- de Jong Margriet Fleur Charlotte
- de Jong Margriet Fleur Charlotte
- de Jong Margriet Fleur Charlotte
- de Jong Margriet Fleur Charlotte
- de Sousa Santino Marcelo
- de Souza Heraldo Possolo
- de Wit Marjolein
- Deans Renae V
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- Decaen Allan
- Dee Brian M
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- Defranco Donald B
- Deger Orhan
- Dehne Marius G
- Deja Maria
- Dell-Kuster Salome
- Dellamonica Jean
- Dellamonica Jean
- Dellinger R Phillip
- Dellinger R Phillip
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- Deshmukh C T
- Deutschman Clifford S
- Deutschman Clifford S
- Devaux Christian
- Deymann Andreas
- Dhar Rajat
- Diamantakis Argyris
- Dias Eduardo Pimentel
- Diaz R Franco
- Diconne Eric
- Diener K R
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- Dijstelbloem Hilde M
- Dimopoulou Ioanna
- Dimopoulou Ioanna
- Dimopoulou Ioanna
- Dimopoulou Ioanna
- Dimopoulou Ioanna
- Dimopoulou Ioanna
- Dimopoulou Ioanna
- Dimopoulou Ioanna
- Dimopoulou Ioanna
- Dimopoulou Ioanna
- Dimopoulou Ioanna
- Dizier Stephanie
- Dmello Dayton
- Dobb Geoffrey
- Dobb Geoffrey
- Doctor Allan
- Donal Erwan
- Donal Erwan
- Donal Erwan
- Donati Yannis
- Dondorp Arjen
- Dong Guijuan
- Dong Guijuan
- Donoso F Alejandro
- Dorin Richard I
- Dorin Richard I
- Dorin Richard I
- dos Santos Jose Wellington A
- Douglas Ivor S
- Douglas Ivor S
- Douka Evangelia
- Douka Evangelia
- Douka Evangelia
- Du Bin
- Ducrocq Nicolas
- Ducrocq Nicolas
- Duff John
- Dugas Marc-Andre
- Dumaine Robert
- Dumaine Robert
- Duncan Alan
- Dunser Martin W
- Dunser Martin W
- Dunser Martin W
- Dunser Martin W
- Dunser Martin W
- Dunser Martin W
- Dupuis Clement
- Durand Francois
- Durand Marie-Christine
- Dutta Pinaki
- Dyer Arron
- Edwards J
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- Edwards Ray
- Ehrhart-Bornstein Monika
- Eichacker Peter Q
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- Eijsvogels Thijs M H
- Eikermann Matthias
- Einav Sharon
- Einav Sharon
- El Malki Hadj Omar
- Elatar Sayed L
- Elder Peter A
- Elhadd Tarik A
- Elsenbruch Sigrid
- Elsenbruch Sigrid
- Elsenbruch Sigrid
- Elsenbruch Sigrid
- Elsouri Naser
- Emonts Marieke
- Engel Christoph
- Engel Christoph
- Engeland William C
- Engelbrecht Elisa
- Engler Harald
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- Engler Harald
- Engler Harald
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- Erard Veronique
- Erdman Michael J
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- Eriksson Mats B
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- Escorsell Angels
- Estrada-Y-Martin Rosa M
- Estrada-Y-Martin Rosa M
- Evans Barry
- Faivre V
- Fang Ji-Tseng
- Fartoukh Muriel
- Fartoukh Muriel
- Fatemi Mohammad Javad
- Faure Patrice
- Faure Patrice
- Fede Giuseppe
- Fede Giuseppe
- Fede Giuseppe
- Fede Giuseppe
- Feldman Jonathan
- Felipe Vanessa
- Felmet Kathryn
- Ferguson D C
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- Fernandez Javier
- Fernandez Javier
- Fernandez-Balsells Mercedes
- Fernandez-de-Castillo Ana G
- Fernandez-de-Castillo Ana G
- Ferreira Jason A
- Ferreira Jason A
- Festic Emir
- Festti Josiane
- Festti Josiane
- Festti Luciana
- Festti Luciana
- Fiaccadori E
- Fick Wilhelmina F
- Fiedler Fritz
- Finfer Simon
- Finfer Simon
- Finkielman Javier D
- Fiorese Bertilla
- Fiorese Bertilla
- Fisher Gene
- Fleseriu Maria
- Flores-Barrientos Oscar Israel
- Forceville Xavier
- Forceville Xavier
- Forst Helmuth
- Forsting Michael
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- Fortenberry James D
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- Fortenberry James D
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- Fouassier Marc
- Fouda Ossama M
- Fougerou Claire
- Frankel Lorry
- Fraser Gilles L
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- Frasko R
- Fratto Melanie A
- Frazier Gregory J
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- Freche Annie
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- Freichet M
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- Freire Amado X
- Freivogel Klaus
- Freivogel Klaus
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- French C
- Frere-Meunier Delphine
- Frey Ulrich H
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- Friedman Gilberto
- Friedman Gilberto
- Friedman Gilberto
- Friedman Gilberto
- Fries Michael
- Fritz H
- Frontera Guillem
- Frostell Claes
- Frostell Claes
- Fuchs Paul Ch
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- Fujita Motoki
- Fujita Motoki
- Fujita Takahiro
- Fuller Brian M
- Gaillard Jean-Luis
- Gallix Benoit
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- Gallo-Payet Nicole
- Gallo-Payet Nicole
- Gan Quan
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- Ganbat Tsenddorj
- Garcia Audwin J
- Garcia Laura
- Garcovich Matteo
- Garcovich Matteo
- Garfield Mark
- Garfield Mark
- Gaspari R
- Geffner Mitchell E
- Gellert M
- Gentilhomme Anne
- Gentilhomme Anne
- Genty Celine
- Gerlach Herwig
- Gerlach Herwig
- Gerlach Herwig
- Gerlach Herwig
- Gerlach Herwig
- Gerlach Herwig
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- Germani Giacomo
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- Gessner Sophia
- Geurts-Moespot Anneke
- Ghosh Sujoy Shubhra
- Ghosh Sujoy Shubhra
- Ghosh Sujoy Shubhra
- Giamarellos-Bourboulis Evangelos J
- Giamarellos-Bourboulis Evangelos J
- Giamarellos-Bourboulis Evangelos J
- Giannakopoulou Dimitra
- Giannoni Eric
- Gibbs Toby
- Gibson Mary
- Giguere Steeve
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- Gines Pere
- Girbes Armand Roelof Johan
- Girbes Armand Roelof Johan
- Girbes Armand Roelof Johan
- Girbes Armand Roelof Johan
- Giroux Leprieur E
- Gizewski Elke R
- Glass Parisa
- Glass Parisa
- Gluud C
- Gogos C H
- Goldberg P
- Golden Emmel
- Goldmann Anton
- Goldmann Anton
- Gomes Marc
- Gonzalez-Reynoso Luis
- Goodman Sergey V
- Goodman Sergey V
- Goodman Sergey V
- Goodman Sergey V
- Gopal Katherason S
- Gopal Palepu B
- Gordon Anthony C
- Gordon Anthony C
- Gordon Anthony C
- Gordon Anthony C
- Gordon Anthony C
- Gordon Anthony C
- Gordon Anthony C
- Gotoh S
- Gottesman Ronald
- Goubaux Bernard
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- Goukos D
- Goukos D
- Goulart Alessandra Carvalho
- Goulet Keith E
- Graham Petra L
- Grander Wilhelm
- Grant Greg
- Granton John T
- Grassin-Delyle Stanislas
- Gray Nicole D
- Gray Sara
- Grebenchtchikov Nicolai
- Grechi Serenella
- Green Robert S
- Green Tajia L
- Green Tajia L
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- Green Tajia L
- Green Tajia L
- Greenberg Steven B
- Greenhalgh David G
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- Greenhalgh David G
- Greenhalgh David G
- Greenhalgh David G
- Greenhalgh David G
- Greenwald Bruce
- Gregg Sara R
- Griesdale Donald E G
- Grigoleit Jan-Sebastian
- Grigoleit Jan-Sebastian
- Grigoleit Jan-Sebastian
- Grion Cintia Magalhaes Carvalho
- Grion Cintia Magalhaes Carvalho
- Groeneveld Arie Bastiaan Johan
- Groeneveld Arie Bastiaan Johan
- Groeneveld Arie Bastiaan Johan
- Groeneveld Arie Bastiaan Johan
- Groeneveld Arie Bastiaan Johan
- Groger Andreas
- Groger Andreas
- Grossman Ashley B
- Grozel J-M
- Grozel J-M
- Guignard Laurence
- Guo Lei
- Guo Lei
- Guo Shubin
- Gur Hanan Guzner
- Gurlich R
- Gustot Thierry
- Gutierrez Juan
- Guyatt Gordon
- Guyomarc'h Stephane
- Guzman Cristina B
- Guzman Jorge A
- Guzman Jorge A
- Haase G
- Habeb Abdelhadi M
- Hajeer Ali H
- Hajeer Ali H
- Hajeer Ali H
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- Hall Jonathan
- Hall Mark
- Hallett David
- Hallett David
- Hallman Mikko
- Hallstrom Lars
- Hallstrom Lars
- Hamalainen Sari
- Hamalainen Sari
- Hamitouche Noureddine
- Hammer Fabian
- Han Seo Goo
- Han Seo Goo
- Han Yong Y
- Handschin A E
- Haniffa Rashan
- Hanson James
- Hart Kelsey A
- Hart Kelsey A
- Hart Kelsey A
- Hart Kelsey A
- Harussani N
- Harward Meg
- Harward Meg
- Hashemzadeh Afshin
- Hattori Noriyuki
- Hattori Takashi
- Hawari Feras
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- Hayashi Motohiro
- Hayashi Motohiro
- Hayball J D
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- Hayes M
- Haymann Jean-Philippe
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- Hazelzet Jan A
- Hazelzet Jan A
- He Chih-Tsueng
- He Huiwei
- He Zhaohui
- Hebbar Kiran B
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- Hebbar Kiran B
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- Hebert Paul C
- Hedenstierna Goran
- Heidrich Manja
- Heijboer Annemieke C
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- Hempen Christel M
- Henderson Vernon J
- Henne-Bruns Doris
- Herman James P
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- Hernan Lynn
- Hernandez Mike
- Hernandez Mike
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- Heusner G L
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- Hickman Ingrid
- Hickman Ingrid
- Hicks Caitlin W
- Hicks Caitlin W
- Hillenbrand Andreas
- Hirai Yuji
- Hirasawa Hiroyuki
- Hirsch T
- Hittle Kristin
- Hizuka Naomi
- Ho Jui T
- Ho Jui T
- Ho Jui T
- Ho Yu-Pin
- Hoedemaekers Cornelia W
- Hoelzl Alwin
- Hogue Bruno
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- Holmes Cheryl L
- Hong Sang-Bum
- Hong Sang-Bum
- Hooper Michael H
- Hopman Maria T E
- Hori Tomokatsu
- Hori Tomokatsu
- Horinouchi H
- Hotta Katsuyuki
- Hotta Katsuyuki
- Hou Kuan-Ting
- Hovilehto Seppo
- Hovilehto Seppo
- Hovilehto Seppo
- Hovilehto Seppo
- Hraiech Sami
- Hsiao Fone-Ching
- Hsieh Chang-Hsun
- Hsieh Susan
- Hsu Hui-Chi
- Hu Bo
- Hu Bo
- Hua Chung-Ching
- Hua Chung-Ching
- Huang Chun-Jui
- Huang Karen E
- Huang Ruolan
- Huang Ruolan
- Huang Tien-Shang
- Huber-Lang Markus
- Hughes Claire R
- Huh Jin Won
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- Hummel Theresia
- Hung Yi-Jen
- Hunter Steven
- Hurley David J
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- Huter Lars
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- Huyghens Luc
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- Hwang Gyu-Sam
- Hyvernat Herve
- Hyvernat Herve
- Hyzy Robert
- Ibanez Jordi
- Ibanez Jordi
- Ibanez Jordi
- Ibanez Jordi
- Ibrahim Fidaa
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- Ilias Ioannis
- Ilias Ioannis
- Ilias Ioannis
- Imamoglu Mustafa
- Imeson Lee
- Indyk Justin A
- Ioakeimidou Aikaterini
- Ioakeimidou Aikaterini
- Ipaktchi K
- Ipser Jonathan C
- Irazuzta Jose
- Ismail A
- Ito Shunichiro
- Iwaki Noriko
- Iwaki Noriko
- Jaalam K
- Jaber Samir
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- Jaeschke Roman
- Jaeschke Roman
- Jager Marcus
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- Janes Jonathan M
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- Jantunen Esa
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- Jap Tjin-Shing
- Jayashree M
- Jeanneret S
- Jeffries Howard
- Jelastopoulou Eleni
- Jeon Kyeongman
- Jeon Kyeongman
- Jessie Elliot M
- Jochberger Stefan
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- Jochberger Stefan
- Johan Groeneveld A B
- Johnen Daniel
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- Jokuszies A
- Jones Andrew
- Jones D
- Jones Mark
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- Joyce Christopher J
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- Juneja Deven
- Jung Boris
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- Jung Boris
- Jung Boris
- Jutla Sukhdeep
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- Juutilainen Auni
- Kache Saraswati
- Kado-Fong Helen
- Kaidomar Michel
- Kaidomar Michel
- Kalafateli Maria
- Kalenka Armin
- Kalpakou Georgia Th
- Kalpakou Georgia Th
- Kamarul Iman Musa K
- Kamisoglu Kubra
- Kaneko Tadashi
- Kaneko Tadashi
- Kang Eun-Hae Eunhae
- Kang Eun-Hae Eunhae
- Kappel Dean
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- Karlsson Sari
- Kasaoka Shunji
- Kasaoka Shunji
- Kashiwabara Moto
- Katagami Hideki
- Katagiri Satosi
- Katagiri Satosi
- Katan M
- Katsenos Chrysostomos S
- Katsenos Chrysostomos S
- Kaufmann Ines
- Kawamata Takakazu
- Kawamata Takakazu
- Keevil Brian G
- Keh Didier
- Keh Didier
- Keh Didier
- Keh Didier
- Keh Didier
- Keh Didier
- Keh Didier
- Keh Didier
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- Keh Didier
- Keh Didier
- Keus F
- Khairani B Siti
- Khangoora Vikramjit
- Khashana Abdelmoneim
- Kiff Jane
- Kikuchi Ken
- Kilger E
- Killian Alley J
- Kim Chol
- Kim Dong Soon
- Kim Dong Soon
- Kim Hojoong
- Kim Hojoong
- Kim Hojoong
- Kim Hojoong
- Kim Woo Sung
- Kim Woo Sung
- Kim Young-Kug
- Kimmoun Antoine
- Kimmoun Antoine
- Kindler J
- Kissoon Niranjan
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- Kiura Katsuyuki
- Kiura Katsuyuki
- Kleine-Borgmann Julian
- Kleinpell Ruth M
- Kleinpell Ruth M
- Kluge Stefan
- Kluge Stefan
- Knaup Reymond Marlies
- Knaup Marlies
- Knawy Bandar Al
- Knawy Bandar Al
- Knippschild Uwe
- Ko Clarence Ching-Huat
- Kobbe Philipp
- Kocak Mehmet
- Kocak Mehmet
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- Kodera Yoshio
- Koh Won-Jung
- Koh Won-Jung
- Koh Won-Jung
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- Koivula Irma
- Koivula Irma
- Kon Alexander
- Konstandelou Evangellia
- Konstandelou Evangellia
- Kopterides Petros
- Kotanidou Anastasia
- Kotanidou Anastasia
- Kotanidou Anastasia
- Kotanidou Anastasia
- Kotanidou Anastasia
- Kotsaki Antigone
- Kox Matthijs
- Kraemer Dale F
- Kraemer Dale F
- Kreth Simone
- Kruger Peter
- Kubo Osami
- Kubo Osami
- Kubo Toshio
- Kubo Toshio
- Kuchel Timothy R
- Kufera Joseph A
- Kuhn Sven-Olaf
- Kuhn Sven-Olaf
- Kuittinen Taru
- Kuittinen Taru
- Kullmann Jennifer S
- Kullmann Jennifer S
- Kuo Chin-Sung
- Kupfer Yizhak
- Kupfer Yizhak
- Kwizera Arthur
- Kwon O Jung
- Kwon O Jung
- Kwon O Jung
- Kwon O Jung
- Kwon Yong Soo
- Kwon Yong Soo
- Kwon Yong Soo
- Kwon Yong Soo
- Kyriazopoulou Venetsana
- Kyriazopoulou Venetsana
- Laborde Kathleen
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- Lacy Antonio M
- Lagu Tara
- Lagu Tara
- Lahmidani Saad
- Laine Fabrice
- Laine Fabrice
- Laine Fabrice
- Lainez Miguel J A
- Laisne Marie-Josephe
- Lam Simon W
- Lam Simon W
- Lam Simon W
- Langeron Olivier
- Langouche Lies
- Larsson Anders
- Larsson Anders
- Lasker Michael V
- Laterre Pierre-Francois Francois
- Laterre Pierre-Francois Francois
- Laterre Pierre-Francois Francois
- Laterre Pierre-Francois Francois
- Laudenslager M L
- Launay Jean-Marie
- Lauzier Francois
- Lavenu A
- Laviolle Bruno
- Laviolle Bruno
- Laviolle Bruno
- Laviolle Bruno
- Laviolle Bruno
- Laviolle Bruno
- Lawson Margaret
- Le Maguet Pascale
- Le Maguet Pascale
- Le Maguet Pascale
- Lebrec Didier
- Lecuyer L
- Ledderose Carola
- Lee Chih-Hsin
- Lee Ming-Chia
- Lee Rita S F
- Lee Sang D O
- Lee Sang D O
- Leemingsawat Chantanij
- Leemingsawat Chantanij
- Lehmann Blandine
- Lehmke Josefa
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- Lehot J-J
- Lehtikangas Maija
- Leishman Amy G
- Leishman Amy G
- Lejeune Julie
- Lejeune Julie
- Lekkou Alexandra A
- Lekkou Alexandra A
- Lemeshow Stanley
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- Leong Chooi-Fun
- Leskinen Markku
- Lesur Olivier
- Lesur Olivier
- Lesur Olivier
- Leventhal Stacey M
- Levy Bruno
- Levy Bruno
- Levy Mitchell M
- Levy Mitchell M
- Levy Mitchell M
- Levy Mitchell M
- Levy Mitchell M
- Levy Mitchell M
- Lewis John G
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- Lewis John G
- Lewis John G
- Lewis John G
- Lewis John G
- Lewis John G
- Li Chun-Sheng Chen
- Li Chun-Sheng Chen
- Li Chun-Sheng Chen
- Li Enyou
- Li Enyou
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- Li Jinyue Jian-guo
- Li Jinyue Jian-guo
- Li Jinyue Jian-guo
- Li Lu
- Li Lu
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- Liang Hui
- Liang Hui
- Liao Kuo-Meng
- Liaudet L
- Lichte Philipp
- Lien Jau-Min
- Lim Chae-Man
- Lim Chae-Man
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- Lim Debora
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- Lim Debora
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- Lim So Yeon
- Lima-Valassi Helena Pantelion
- Lima-Valassi Helena Pantelion
- Limbeck Elisabeth
- Limor Rona
- Lin John
- Lindenauer Peter K
- Lindenauer Peter K
- Liotier Jerome
- Lipcsey Miklos
- Lipcsey Miklos
- Lipiner-Friedman Diane
- Listernick Robert
- Little Anjuli
- Little Anjuli
- Liu Chang
- Liu Chang
- Liu Nai-Jeng
- Liu Yu-Chih
- Liu Yu-Chih
- Livaditi Olga
- Livaditi Olga
- Livaditi Olga
- Livaditi Olga
- Llompart-Pou Juan Antonio
- Llompart-Pou Juan Antonio
- Llompart-Pou Juan Antonio
- Llompart-Pou Juan Antonio
- Lo Yuan-Hao
- Loeffler Markus
- Loeffler Markus
- Lofaso Frederic
- Loisa Pekka
- Loisa Pekka
- Loisa Pekka
- Loisa Pekka
- Loisa Pekka
- London Vanessa
- Lord Janet M
- Lorenz Ingo
- Loriaux D Lynn
- Lorts Angie
- Luckner Gunter
- Luckner Gunter
- Luckner Gunter
- Ludbrook Guy L
- Ludbrook Guy L
- Ludbrook Guy L
- Lukaszewicz Anne Claire
- Lukaszewicz Anne Claire
- Luo Yun
- Luo Yun
- Ma Hongyan
- Ma Hongyan
- Machado Flavia R
- Machado Flavia R
- Machado Marcel Cerqueira Cesar
- Madero Rosario
- Madgundi Venugopal V
- Maekawa Tsuyoshi
- Maekawa Tsuyoshi
- Maggs David J
- Magira E
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- Magnin Christophe
- Magri Silvia
- Magri Silvia
- Maiden Matthew J
- Mair T S
- Makino Hiroshi
- Malik Iqbal A
- Mallat Jihad
- Maluck Janina
- Mandragos Konstantinos E
- Mandragos Konstantinos E
- Maniatis Nikolaos
- Maralihalli M B
- Margeli T
- Marik Paul E
- Marik Paul E
- Marik Paul E
- Mariscalco Michelle
- Marklin Gary
- Marques-Verdier Alain
- Marsch Stephan C U
- Marshall Janene John C
- Marshall Janene John C
- Marshall Janene John C
- Marshall Janene John C
- Martin Claude
- Martin Claude
- Martin Claude
- Martin Greg S
- Martin Greg S
- Martin Linda G
- Martinez-Casanova Elena
- Martins Gloria A R
- Maruna P
- Marx Gernot
- Marx Gernot
- Marzigie Michel
- Mas Antoni
- Maslove David M
- Mason Alexina J
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- Masoodi Shriq Rashid
- Massart Catherine
- Massart Catherine
- Mathonet Armelle
- Mathonet Armelle
- Matsushita Kazuyuki
- Matsutani Takeshi
- Maviglia R
- Mavrommatis Antonis
- Mavrommatis Antonis
- Maxime Virginie
- Maxime Virginie
- Maxime Virginie
- Maxime Virginie
- Maxime Virginie
- Maxime Virginie
- Mayaux Julien
- Mayaux Julien
- Mayr Viktoria
- Mazzuco Tania Longo
- Mazzuco Tania Longo
- McArthur Colin
- McArthur Colin
- McCracken Courtney
- McCracken Courtney
- McGree James
- McGree James
- McIntyre Lauralyn
- McLean Anthony S
- McNally Dayre
- McWhinney Brett C
- McWhinney Brett C
- Meduri G Umberto
- Meduri G Umberto
- Meduri G Umberto
- Meduri G Umberto
- Meersseman Philippe
- Megarbane Bruno
- Megarbane Bruno
- Meggison Hilary
- Mehta Renuka
- Mehta Sangeeta K
- Mehta Sangeeta K
- Mehta Sangeeta K
- Mehta Sangeeta K
- Meier-Hellmann Andreas
- Meier-Hellmann Andreas
- Mello Gustavo W
- Mello Romulo Carvalho Vaz de
- Menaker Jay
- Meng Xinke
- Meng Xinke
- Menon Kusum
- Mentzelopoulos Spyros
- Mentzelopoulos Spyros
- Mercier Gregoire
- Mercier Gregoire
- Metherell L A
- Meziani F
- Michaeli Burkhard
- Michalaki Marina
- Michalaki Marina
- Michel Gustavo T
- Miki Nobuhiro
- Miki Nobuhiro
- Millul Valerie
- Minami Daisuke
- Minami Daisuke
- Miranda-Ruiz Rogelio
- Misset Benoit
- Misset Benoit
- Misset Benoit
- Mittelman Steven D
- Miura Hitomi
- Miyashita Masao
- Miyauchi Takashi
- Miyauchi Takashi
- Mohammad Zulfiqar
- Mohnle Patrick
- Mohnle Patrick
- Mohnle Patrick
- Mohnle Patrick
- Mohsine Raouf
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- Molenaar Nienke
- Molenaar Nienke
- Molinari Nicolas
- Molinari Nicolas
- Momeni Mahnoush
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- Mongkolpun Wasineenart
- Monneret Denis
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- Moraes Rafael Barberena
- Moraes Rafael Barberena
- Moraes Rafael Barberena
- Moraes Rafael Barberena
- Moran John L
- Moreau Richard
- Morel Jerome
- Moreno Rui
- Moreno Rui
- Moreno Rui
- Moreno Rui
- Moreno Rui
- Moreno Rui
- Moreno Rui
- Morichika Daisuke
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- Xirouchakis Elias
- Xu Jun
- Xu Mujuan
- Xu Mujuan
- Yamamoto Masakazu
- Yamamoto Masakazu
- Yamashita Kiyohiko
- Yang Chunli
- Yang Chunli
- Yee Kristen S
- Yee Kristen S
- Yeh Timothy
- Yu Chung-Chieh
- Yu Chung-Chieh
- Yu Jihion
- Yu Teng-Jen
- Yu Teng-Jen
- Yu Xuezhong
- Yu Yuan-Bin
- Yu Zhui
- Yu Zhui
- Yuan Ying
- Zabalza Michel
- Zakynthinos Spyros
- Zakynthinos Spyros
- Zaloga Gary
- Zaman Muhammad
- Zampieri Fernando Godinho
- Zamri-Saad M
- Zandstra Durk F
- Zandstra Durk F
- Zaritsky Arno
- Zeni Fabrice
- Zervou Maria
- Zhang Fengmin
- Zhang Fengmin
- Zhang Haibo
- Zhang Haibo
- Zhang Qian
- Zhang Qian
- Zhang Yang
- Zhang Yang
- Zhang Zhong
- Zhang Zhong
- Zhao Xin
- Zhao Xin
- Zheng Juanjuan
- Zheng Juanjuan
- Zheng Liangliang
- Zhou Qing
- Zhou Qing
- Zhu Huadong
- Ziegenfuss Marc
- Ziegenfuss Marc
- Zijlstra J G
- Zimmerman Jerry J
- Zimmerman Jerry J
- Zuckerberg Aaron
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/10/2007
- Field of study
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)
- Author
- Abdel-Aziz Amal Kamal
- Abdelfatah Sara
- Abdellatif Mahmoud
- Abdoli Asghar
- Abel Steffen
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- Reichert Andreas S
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- Reipert Siegfried
- Rekha Rokeya Sultana
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- Vasconcelos M Helena
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- Vega-Rubin-de-Celis Silvia
- VegaNaredo Ignacio
- Velasco Guillermo
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- Vellai Tibor
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- Verdier Mireille
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- Wang Han
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- Wang Hexiang
- Wang Hong-Gang
- Wang Jianrong
- Wang Jigang
- Wang Jiou
- Wang Jundong
- Wang Kui
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- Wang Maggie Haitian
- Wang Meiqing
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- Xiao Lan
- Xiao Shi
- Xiao Yin
- Xie Baoming
- Xie Chuan-Ming
- Xie Min
- Xie Yuxiang
- Xie Zhiping
- Xie Zhonglin
- Xilouri Maria
- Xu Congfeng
- Xu En
- Xu Haoxing
- Xu Jing
- Xu JinRong
- Xu Liang
- Xu Wen Wen
- Xu Xiulong
- Xue Yu
- Yakhine-Diop Sokhna MS
- Yamaguchi Masamitsu
- Yamaguchi Osamu
- Yamamoto Ai
- Yamashina Shunhei
- Yan Shengmin
- Yan Shian-Jang
- Yan Zhen
- Yanagi Yasuo
- Yang Chuanbin
- Yang Dun-Sheng
- Yang Huan
- Yang Huang-Tian
- Yang Hui
- Yang Jin-Ming
- Yang Jing
- Yang Jingyu
- Yang Ling
- Yang Liu
- Yang Ming
- Yang Pei-Ming
- Yang Qian
- Yang Seungwon
- Yang Shu
- Yang Shun-Fa
- Yang Wannian
- Yang Wei Yuan
- Yang Xiaoyong
- Yang Xuesong
- Yang Yi
- Yang Ying
- Yao Honghong
- Yao Shenggen
- Yao Xiaoqiang
- Yao Yong-Gang
- Yao Yong-Ming
- Yasui Takahiro
- Yazdankhah Meysam
- Yen Paul M
- Yi Cong
- Yin Xiao-Ming
- Yin Yanhai
- Yin Zhangyuan
- Yin Ziyi
- Ying Meidan
- Ying Zheng
- Yip Calvin K
- Yiu Stephanie Pei Tung
- Yoo Young H
- Yoshida Kiyotsugu
- Yoshii Saori R
- Yoshimori Tamotsu
- Yousefi Bahman
- Yu Boxuan
- Yu Haiyang
- Yu Jun
- Yu Jun
- Yu Li
- Yu Ming-Lung
- Yu Seong-Woon
- Yu Victor C
- Yu W Haung
- Yu Zhengping
- Yu Zhou
- Yuan Junying
- Yuan Ling-Qing
- Yuan Shilin
- Yuan Shyng-Shiou F
- Yuan Yanggang
- Yuan Zengqiang
- Yue Jianbo
- Yue Zhenyu
- Yun Jeanho
- Yung Raymond L
- Zacks David N
- Zaffagnini Gabriele
- Zambelli Vanessa O
- Zanella Isabella
- Zang Qun S
- Zanivan Sara
- Zappavigna Silvia
- Zaragoza Pilar
- Zarbalis Konstantinos S
- Zarebkohan Amir
- Zarrouk Amira
- Zeitlin Scott O
- Zeng Jialiu
- Zeng Ju-deng
- Zerovnik Eva
- Zhan Lixuan
- Zhang Bin
- Zhang Donna D
- Zhang Hanlin
- Zhang Hong
- Zhang Hong
- Zhang Honghe
- Zhang Huafeng
- Zhang Huaye
- Zhang Hui
- Zhang Hui-Ling
- Zhang Jianbin
- Zhang Jianhua
- Zhang Jing-Pu
- Zhang Kalin YB
- Zhang Leshuai W
- Zhang Lin
- Zhang Lisheng
- Zhang Lu
- Zhang Luoying
- Zhang Menghuan
- Zhang Peng
- Zhang Sheng
- Zhang Wei
- Zhang Xiangnan
- Zhang Xiao-Wei
- Zhang Xiaolei
- Zhang Xiaoyan
- Zhang Xin
- Zhang Xinxin
- Zhang Xu Dong
- Zhang Yang
- Zhang Yanjin
- Zhang Yi
- Zhang Ying-Dong
- Zhang Yingmei
- Zhang Yuan-Yuan
- Zhang Yuchen
- Zhang Zhe
- Zhang Zhengguang
- Zhang Zhibing
- Zhang Zhihai
- Zhang Zhiyong
- Zhang Zili
- Zhao Haobin
- Zhao Lei
- Zhao Shuang
- Zhao Tongbiao
- Zhao Xiao-Fan
- Zhao Ying
- Zhao Yongchao
- Zhao Yongliang
- Zhao Yuting
- Zheng Guoping
- Zheng Kai
- Zheng Ling
- Zheng Shizhong
- Zheng Xi-Long
- Zheng Yi
- Zheng Zu-Guo
- Zhivotovsky Boris
- Zhong Qing
- Zhou Ao
- Zhou Ben
- Zhou Cefan
- Zhou Gang
- Zhou Hao
- Zhou Hong
- Zhou Hongbo
- Zhou Jie
- Zhou Jing
- Zhou Jing
- Zhou Jiyong
- Zhou Kailiang
- Zhou Rongjia
- Zhou Xu-Jie
- Zhou Yanshuang
- Zhou Yinghong
- Zhou Yubin
- Zhou Zheng-Yu
- Zhou Zhou
- Zhu Binglin
- Zhu Changlian
- Zhu Guo-Qing
- Zhu Haining
- Zhu Hongxin
- Zhu Hua
- Zhu WeiGuo
- Zhu Yanping
- Zhu Yushan
- Zhuang Haixia
- Zhuang Xiaohong
- Zientara-Rytter Katarzyna
- Zimmermann Christine M
- Ziviani Elena
- Zoladek Teresa
- Zong Wei-Xing
- Zorov Dmitry B
- Zorzano Antonio
- Zou Weiping
- Zou Zhen
- Zou Zhengzhi
- Zuryn Steven
- Zwerschke Werner
- Publication venue
- 'Informa UK Limited'
- Publication date
- 01/01/2021
- Field of study
In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field
Evaluation of a quality improvement intervention to reduce anastomotic leak following right colectomy (EAGLE): pragmatic, batched stepped-wedge, cluster-randomized trial in 64 countries
- Author
- Aarts Frits
- Ababneh Hazim
- Abad-Motos Ane
- Abaidalla Ahmed
- Abbakar Malaz
- Abd El Aal Ahmed
- Abd-Errazik Mohammad Ahmad
- Abdalradiy Abdalrahmman G
- Abdelkhalek Mohamed
- Abdelkhalek Mostafa
- Abdellatif Ahmed
- Abdellatif Mohamed
- Abdelsaid Kirolas
- Abdou Khaled
- Abdulfatah Mustapha
- Abdullah Mohammad Amer
- Abdullahi Mustapha Miko Mohammed
- Abellán Antonio Melero
- Abeysinghe Nayana
- Abiyere Henry
- Achimas-Cadariu Patriciu Andrei
- Adakaya Sıla
- Adam Nicolas
- Adams Benita
- Adams Ferdinand
- Adegboye Kazeem
- Adeyeye Ademola
- Adra Lama
- Adu-Poku Patricia
- Afuwape Oludolapo
- Afzal Ameer
- Afzal Muhammad Farooq
- Agapov Mihail
- Agara Daniel
- Aggarwal Manisha
- Agger Erika
- Aghadi Ifeanyi Kene
- Ahmed Amjed Yassir
- Ahmed Haleemasahdia
- Ahmed Khalil
- Ahmed Manar
- Ahmed Masood
- Ahmed Safia
- Ahn Hong Min
- Aibe Raquel
- Aigner Felix
- Aissat Abdenour
- Aitbaeva Arai
- Akay Omer
- Akbar Ali
- Akbas Ahmet
- Akere Abidemi
- Akesen Selcan
- Akgun Erhan
- Akhtar Naseem
- Akın Emrah
- Akova Elif
- Aktas Serhat
- Akçay Özlem
- Al Masri Mahmoud
- Al-Alnsi Ahmed
- Al-Hutheifi Roqia'A
- Al-Jarrah Amar
- Al-Naggar Hamza
- Al-Shehari Mohammed
- Alamin Nadeen
- Alawi Raneen
- Alawlaqi Dina
- Alawneh Fade
- Alberola Maria José
- Albers Michael
- Alcolea Natalia González
- Aleem Muhammad
- Alegre Inês
- Alegre Javier Martinez
- Alexandre Flavia
- Alexandrescu Corina
- Alexnder Abelevich
- Alexopoulou Kalliopi
- Alfonso Beatriz Amorós
- Ali Ahmed
- Ali Che Saniati Che
- Ali Danish
- Ali Madeeha
- Ali Mahmoud Abdelwahab
- Ali Manhal Hashim
- Ali Noura Al
- Alikhanli Jhale
- Aliyeva Zumrud
- Aliyu Mohammed
- Aljawder Hasan
- Allen Kate
- Almahmeed Ebrahim
- Alonso Alfredo
- Alonso Javier Etreros
- Alsamneh Muneer
- Alsayadi Ramzi
- Altinel Yuksel
- Altintoprak Fatih
- Altomare Donato F
- Alvarenga Isabella
- Alvarez Laura Jimenez
- Alvarez-Bautista Francisco Emmanuel
- Alvarez-Díez Marcos
- Alves Brenda Chayanny
- Amadigwe Rita
- Amado Andreia
- Amado Fabíola
- Amador Cristina García
- Amanullah Nazli
- Amaral Hélida Aline Tomacheski
- Amaral Luis
- Amin-Tai Hizami
- Aminu Bashiru
- Amir Ahmad Suhaimi
- Ammar Ahmed Siddique
- Ammar Mona Ahmed
- Ammendola Michele
- Ammerata Giorgio
- Amorim Edgar
- Ancans Guntis
- Anderson Tom
- Andrade Diogo
- Andrejevic Predrag
- Andrés Beatriz Díaz San
- Anestiadou Elissavet
- Ang Chin Wee
- Angelo Franceschi
- Anokhin Evgeny
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- Chowdhury Sharfuddin M
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- Christodoulidis Grigorios
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- de Andrés-Asenjo Beatriz
- de Deken Julie
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- Felix Michael Shalzim
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- Golub József
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- Kashchenko Victor A
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- Kopteyev Nikita R
- Korkolis Dimitrios
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- Vijayan Varun
- Vilain Luciano Ferreira
- Villa Gianluca
- Villalobos Santiago
- Villarino-Villa Laura
- Vino Smila
- Viola Marcelo
- Viscosi Francesca
- Vishnoi Jeewan Ram
- Vlad Catalin
- Volkoviene Gerda
- Volturo Lino
- Vural Ummuhan
- Vázquez-Fernández Andrea
- Väyrynen Antti
- Wagdy Michael
- Waha James
- Waheed Mariam
- Waindeskar Vaishali
- Wakkaf Habib
- Walsh Adam
- Walędziak Maciej
- Wang Jaw Yuan
- Wani Rauf
- Wanshantha Dinamulla
- Waqar Usama
- Ward Nicholas
- Watanabe Jun
- Wells Johanna
- Westzaan Natalia
- Wickramarathne Rasika
- Wickramasinghe Dakshitha
- Widatalla Abu Bakr H
- Widyaningsih Rizky
- Wijenayake Wasantha
- Wilson Jeremy
- Wilson Kasmira
- Windels An
- Witjes Caroline
- Wong Siew Ching
- Woodward Andrew
- Wright Deborah
- Wright Jonathan
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- Wątroba Anna
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- Xavier Ruben
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- Xynos Evangelos
- Yadav Ram Kishan
- Yadev I P
- Yague Julio
- Yakout Nadia
- Yakunina Natalia
- Yalkin Ömer
- Yanishev Alexey
- Yao Hongwei
- Yazici Pinar
- Yemez Kursat
- Yew Chor Kuan
- Yılmaz Gülseren
- Yilmazlar Tuncay
- Yiğit Direnç
- Yoldas Tayfun
- Yonekura Hiroshi
- Yorkmui Liu
- Yoshino Kenji
- Younes Lina
- Young Trudi
- Yule Michael
- Yusoff Zakiah Mohd
- Zaari Fatimazahraa
- Zabiyaka Mikhail
- Zadrożna Monika
- Zafar Madiha
- Zagaynov Eugeny
- Zaidi Syed-Nadeem
- Zaimis Tilemachos
- Zain Wan Zainira Wan
- Zainy Rhendra Hardy Mohamad
- Zakaria Andee Dzulkarnaen
- Zakaria Maheen
- Zakaria Zaidi
- Zamudio-Bautista Jorge Luis
- Zanc Loredana
- Zanoni Andrea
- Zanus Giacomo
- Zapparoli Alessandro
- Zappone Anna
- Zarzava Eirini
- Zatari Dirar
- Zawadzki Marek
- Zayakov Georgi
- Zaycev Andrey
- Zazo Aya
- Zazo Rama
- Zdravkovic Maja
- Zengin Abdullah Kağan
- Zeringa Georgia
- Zimmerman David D E
- Zuhdy Mohammad
- Zvirych Vitalii
- Zywicka Ewa
- Álvarez-Llano Laura
- Ângelo Miguel Duarte
- ÓSullivan Sara Nuñez
- Özçelik Mehmet Faik
- Ćoza Ivo
- Şanlı Ahmet Necati
- Publication venue
- Publication date
- 01/01/2023
- Field of study
Background
Anastomotic leak affects 8 per cent of patients after right colectomy with a 10-fold increased risk of postoperative death. The EAGLE study aimed to develop and test whether an international, standardized quality improvement intervention could reduce anastomotic leaks.
Methods
The internationally intended protocol, iteratively co-developed by a multistage Delphi process, comprised an online educational module introducing risk stratification, an intraoperative checklist, and harmonized surgical techniques. Clusters (hospital teams) were randomized to one of three arms with varied sequences of intervention/data collection by a derived stepped-wedge batch design (at least 18 hospital teams per batch). Patients were blinded to the study allocation. Low- and middle-income country enrolment was encouraged. The primary outcome (assessed by intention to treat) was anastomotic leak rate, and subgroup analyses by module completion (at least 80 per cent of surgeons, high engagement; less than 50 per cent, low engagement) were preplanned.
Results
A total 355 hospital teams registered, with 332 from 64 countries (39.2 per cent low and middle income) included in the final analysis. The online modules were completed by half of the surgeons (2143 of 4411). The primary analysis included 3039 of the 3268 patients recruited (206 patients had no anastomosis and 23 were lost to follow-up), with anastomotic leaks arising before and after the intervention in 10.1 and 9.6 per cent respectively (adjusted OR 0.87, 95 per cent c.i. 0.59 to 1.30; P = 0.498). The proportion of surgeons completing the educational modules was an influence: the leak rate decreased from 12.2 per cent (61 of 500) before intervention to 5.1 per cent (24 of 473) after intervention in high-engagement centres (adjusted OR 0.36, 0.20 to 0.64; P < 0.001), but this was not observed in low-engagement hospitals (8.3 per cent (59 of 714) and 13.8 per cent (61 of 443) respectively; adjusted OR 2.09, 1.31 to 3.31).
Conclusion
Completion of globally available digital training by engaged teams can alter anastomotic leak rates. Registration number: NCT04270721 (http://www.clinicaltrials.gov)
Global variation in postoperative mortality and complications after cancer surgery: a multicentre, prospective cohort study in 82 countries
- Author
- A Yacoub Mina
- A. Adam Mohammed
- A. Nassar Mahmoud
- A.Nemer Ayoob
- Aahlin Eirik Kjus
- Ab Rahim Mohd Fadliyazid
- Abad Gurumeta Alfredo
- Abad-Motos Ane
- Abang Jamari Dyg Zahratul Hamrak
- Abantanga Francis
- Abarca Sol
- Abazid Eias
- Abbas Abbas
- Abbas Khalid
- Abbas Mohammad Monir
- Abbasy Jibran
- Abbosh Ali
- Abd Karim Muhammad Fairuz Shah
- Abd Wahab Haidar Hadri
- Abd Barook
- Abdalei Abdulwahab
- Abdalla Ahmed Elkamel Ahmed
- Abdallah Aya
- AbdAllah Mostafa Salim Mohamed
- Abdel Malik Abu Baker
- Abdelhady Mousa Heba
- Abdelhady Samar
- Abdelhakim Ahmed
- Abdelkader Muhammad
- Abdelkawy Shaza
- Abdelkhalek Mohamed
- Abdellatif Esraa
- Abdelmaksoud Tawakel Noura
- Abdelmohsen Naglaa
- Abdelmotaleb Ibrahem
- Abdelrazek Aly
- Abdelsalam Israa
- Abdelshakour Mahmoud
- Abdelwahed Ahmed Mohamed
- Abdou Abdulrahman Osama
- Abdou Alrawy
- Abdou Hossam
- Abdul Aziz Mohamed Rezal
- Abdul Aziz Nora
- Abdulgawad Almogy Mariam
- Abdulla Mazin A.
- Abdullah Muhammad Tariq
- Abdullahi Lawal
- Abdullayev Seymur
- Abed Saeed
- Abelló David
- Abiola Olajide
- Abo mahadi Asmaa'
- Abo-khammash Areej
- Abou Chaar Mohamad K.
- Abou El.soud Moustafa Ramadan
- Abouelsoad Nervana
- Abraham Joyner
- Abreu da Silva Alberto
- Abu Ahammala Ayman B.
- Abu Al Amrain Mahmoud
- Abu Al-saleem Hasan
- Abu Alamrain Abdulwhhab
- Abu Alqumboz Amjad
- Abu Ataya Ahmed
- Abu hallalah Muad fathi khalleefah
- Abu Jamie Najlaa
- Abu Jayyab Israa
- Abu shua'ib Rana
- Abu Zainah Baraa
- Abu-Nimeh Samar
- Abu-Rous Mohammed R.
- Abu-srour Abrar
- Abuelhatal Hasan
- Abuelqomboz Ayham
- Abuhilal Baseel
- Abuhlaiga Ma'aly
- Abujamra Saleh
- Abukhalaf Sadi A.
- Abusalem Lana
- AbuSirrees Mahmoud
- Acevedo Veronica
- Acharya Rajgopal
- Achkasov Sergey
- Acosta Eric
- Adamo Karin
- Adamou Harissou
- Adams Jamie
- Adams Lawrence
- Adawi Samer
- Adebanjo Ademola
- Adel Marina
- Adel Sawsan
- Ademuyiwa Adesoji
- Ademuyiwa Adesoji
- Adenuga Adedire
- Aderounmu Adewale
- Adesanya Opeoluwa
- Adesina Alaba
- Adesunkanmi Abdul-Rashid
- Adeyeye Ademola
- Adidharma Peter
- Adisa Adewale O
- Adnan Nour
- Afifi Amr Abdelghani
- Afifi Eman
- Afolayan Michael Olatunji
- Afzal Asma
- Agarwal Arnav
- Agarwal Raksheeth
- Agbakwuru Augustine
- Agbeko Anita Eseenam
- Aguilar Martinez Maria Del Mar
- Aguilera Maria Lorena
- Aguilera-Arevalo Maria-Lorena
- Ahlqvist Sandra
- Ahmad Izzuddin Ahmad Imran
- Ahmad Kasim
- Ahmad Sarwat
- Ahmed Ahmedgaber
- Ahmed Hazem Abdelkarem
- Ahmed Mariam
- Ahmed Nabila
- Ahmed Zahra
- Ainoa Eppu
- Aithie Joanna M S
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- Al-Busaidi Ibrahim S.
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- Al-Himyari Hamza S.
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- ElFayoumy Ahmed Moustafa
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- NA N.A.
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- Obery Gareth
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- Perez Rivera Carlos J-
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- Wogensen Fredrik
- Wondoh Paul M.
- Wong Florence
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- Ye Geoffrey
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- Yenli Edwin
- Yeo Jeremy
- Yeoh Andrea
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- You Lucia
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- Yusuf Baasil
- Yüksel Osman
- Zabiyaka Mikhail
- Zachariah Sanoop Koshy
- Zafar Syed Nabeel
- Zaffaroni Gloria
- Zahra Baryab
- Zahran Diaaaldin
- Zakaria Andee Dzulkarnaen
- Zakaria Mai
- Zakaria Omar
- Zakaria Zaidi
- Zambrana Campos Vanesa
- Zammit Matthew
- Zanini Nicola
- Zara Vlu Jean
- Zara Vlu Jean
- Zarti Heba
- Zarzycki Piotr
- Zattoni Davide
- Zavala Gabriela
- Zawahrah Hassan
- Zeiton Asaid
- Zeko Amanda
- Zeng Zhi
- Zeromskas Paulius
- Zhang Geoffrey
- Zhivkov Evgeni
- Zid Esraa
- Zidan Ahmed Mohy
- Zielasek Christian
- Zilinskas Justas
- Zimmermann Bernd
- Ziprin Paul
- Zizzo Maurizio
- Zografos George
- Zoikas Athanasios
- Zorrilla Matilla Laura Patricia
- Zoulamoglou Menelaos
- Zreeg Dafer
- Zub-Pokrowiecka Anna
- Zubiaurre Vanessa
- Zuhdy Mohammed
- Zuikyte Diana
- Zuloaga Fernandez del Valle Carlos Jose
- Zulu Stanley
- Ângelo Miguel
- Älgå Andreas
- Çolak Elif
- Ümarik Toomas
- Šatkauskas Mindaugas
- Škimelyte Monika
- Šlenfuktas Vygintas
- Šuman Oliver
- Žatecký Jan
- Žumbakys Žygimantas
- Župan Domagoj
- Publication venue
- 'Elsevier BV'
- Publication date
- 30/01/2021
- Field of study
© 2021 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY-NC-ND 4.0 licenseBackground: 80% of individuals with cancer will require a surgical procedure, yet little comparative data exist on early outcomes in low-income and middle-income countries (LMICs). We compared postoperative outcomes in breast, colorectal, and gastric cancer surgery in hospitals worldwide, focusing on the effect of disease stage and complications on postoperative mortality. Methods: This was a multicentre, international prospective cohort study of consecutive adult patients undergoing surgery for primary breast, colorectal, or gastric cancer requiring a skin incision done under general or neuraxial anaesthesia. The primary outcome was death or major complication within 30 days of surgery. Multilevel logistic regression determined relationships within three-level nested models of patients within hospitals and countries. Hospital-level infrastructure effects were explored with three-way mediation analyses. This study was registered with ClinicalTrials.gov, NCT03471494. Findings: Between April 1, 2018, and Jan 31, 2019, we enrolled 15 958 patients from 428 hospitals in 82 countries (high income 9106 patients, 31 countries; upper-middle income 2721 patients, 23 countries; or lower-middle income 4131 patients, 28 countries). Patients in LMICs presented with more advanced disease compared with patients in high-income countries. 30-day mortality was higher for gastric cancer in low-income or lower-middle-income countries (adjusted odds ratio 3·72, 95% CI 1·70–8·16) and for colorectal cancer in low-income or lower-middle-income countries (4·59, 2·39–8·80) and upper-middle-income countries (2·06, 1·11–3·83). No difference in 30-day mortality was seen in breast cancer. The proportion of patients who died after a major complication was greatest in low-income or lower-middle-income countries (6·15, 3·26–11·59) and upper-middle-income countries (3·89, 2·08–7·29). Postoperative death after complications was partly explained by patient factors (60%) and partly by hospital or country (40%). The absence of consistently available postoperative care facilities was associated with seven to 10 more deaths per 100 major complications in LMICs. Cancer stage alone explained little of the early variation in mortality or postoperative complications. Interpretation: Higher levels of mortality after cancer surgery in LMICs was not fully explained by later presentation of disease. The capacity to rescue patients from surgical complications is a tangible opportunity for meaningful intervention. Early death after cancer surgery might be reduced by policies focusing on strengthening perioperative care systems to detect and intervene in common complications. Funding: National Institute for Health Research Global Health Research Unit