418 research outputs found
Implications of the Precautionary Principle for Environmental Regulation in the United States: Examples from the Control of Hazardous Air Pollutants in the 1990 Clean Air Act Amendments
Goldstein and Carruth argue that the hazardous air pollutant provisions of the 1990 Clean Air Act Amendments provide an example of the Precautionary Principle incorporated into US environmental legislation. Evaluating the outcome thus far leads them to the conclusion that utilizing the Precautionary Principle as a basis for legislation can be problematic to public-health goals
An Environment Monitoring Package for the International Space Station
The first elements of the International Space Station (ISS) will soon be launched into space and over the next few years ISS will be assembled on orbit into its final configuration. Experiments will be performed on a continuous basis both inside and outside the station. External experiments will be mounted on attached payload locations specifically designed to accommodate experiments, provide data and supply power from ISS. From the beginning of the space station program it has been recognized that experiments will require knowledge of the external local environment which can affect the science being performed and may impact lifetime and operations of the experiment hardware. Recently an effort was initiated to design and develop an Environment Monitoring Package (EMP). This paper describes the derivation of the requirements for the EMP package, the type of measurements that the EMP will make and types of instruments which will be employed to make these measurements
Semigroup Closures of Finite Rank Symmetric Inverse Semigroups
We introduce the notion of semigroup with a tight ideal series and
investigate their closures in semitopological semigroups, particularly inverse
semigroups with continuous inversion. As a corollary we show that the symmetric
inverse semigroup of finite transformations of the rank
is algebraically closed in the class of (semi)topological inverse
semigroups with continuous inversion. We also derive related results about the
nonexistence of (partial) compactifications of classes of semigroups that we
consider.Comment: With the participation of the new coauthor - Jimmie Lawson - the
manuscript has been substantially revised and expanded. Accordingly, we have
also changed the manuscript titl
The continuity of the inversion and the structure of maximal subgroups in countably compact topological semigroups
In this paper we search for conditions on a countably compact
(pseudo-compact) topological semigroup under which: (i) each maximal subgroup
in is a (closed) topological subgroup in ; (ii) the Clifford part
(i.e. the union of all maximal subgroups) of the semigroup is a
closed subset in ; (iii) the inversion is continuous; and (iv) the projection ,
, onto the subset of idempotents of ,
is continuous
Titan's lakes chemical composition: sources of uncertainties and variability
Between 2004 and 2007 the instruments of the CASSINI spacecraft discovered
hydrocarbon lakes in the polar regions of Titan. We have developed a
lake-atmosphere equilibrium model allowing the determination of the chemical
composition of these liquid areas. The model is based on uncertain
thermodynamic data and precipitation rates of organic species predicted to be
present in the lakes and seas that are subject to spatial and temporal
variations. Here we explore and discuss the influence of these uncertainties
and variations. The errors and uncertainties relevant to thermodynamic data are
simulated via Monte-Carlo simulations. Global Circulation Models (GCM) are also
employed in order to investigate the possibility of chemical asymmetry between
the south and the north poles, due to differences in precipitation rates. We
find that mole fractions of compounds in the liquid phase have a high
sensitivity to thermodynamic data used as inputs, in particular molar volumes
and enthalpies of vaporization. When we combine all considered uncertainties,
the ranges of obtained mole fractions are rather large (up to ~8500%) but the
distributions of values are narrow. The relative standard deviations remain
between 10% and ~300% depending on the compound considered. Compared to other
sources of uncertainties and variability, deviation caused by surface pressure
variations are clearly negligible, remaining of the order of a few percent up
to ~20%. Moreover no significant difference is found between the composition of
lakes located in north and south poles. Because the theory of regular solutions
employed here is sensitive to thermodynamic data and is not suitable for polar
molecules such as HCN and CH3CN, our work strongly underlines the need for
experimental simulations and the improvement of Titan's atmospheric models.Comment: Accepted in Planetary and Space Scienc
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Tethered capsule endomicroscopy enables less-invasive imaging of gastrointestinal tract microstructure
Here, we introduce “tethered capsule endomicroscopy,” that involves swallowing an optomechanically-engineered pill that captures cross-sectional, 30 μm (lateral) × 7 μm (axial) resolution, microscopic images of the gut wall as it travels through the digestive tract. Results in human subjects show that this technique rapidly provides three-dimensional, microstructural images of the upper gastrointestinal tract in a simple and painless procedure, opening up new opportunities for screening for internal diseases
Anthropologists Respond to The Lancet EAT Commission
The Lancet Commissions are widely known as aspirational pieces, providing the mechanisms for consortia and networks of researchers to organize, collate, interrogate and publish around a range of subjects. Although the Commissions are predominantly led by biomedical scientists and cognate public health professionals, many address social science questions and involve social science expertise. Medical anthropologist David Napier was lead author of the Lancet Commission on Culture and Health (2014), for example, and all commissions on global health (https://www.thelancet.com/global-health/commissions) address questions of social structure, everyday life, the social determinants of health, and global inequalities.The Nutrire CoLab: Diana Burnett; Megan A. Carney; Lauren Carruth; Sarah Chard; Maggie Dickinson: Diana Burnett, Megan A. Carney, Lauren Carruth, Sarah Chard, Maggie Dickinson, Alyshia Gálvez, Hanna Garth, Jessica Hardin, Adele Hite, Heather Howard, Lenore Manderson, Emily Mendenhall, Abril Saldaña-Tejeda, Dana Simmons, Natali Valdez, Emily Vasquez, Megan Warin, Emily Yates-Doer
Rare single gene disorders:estimating baseline prevalence and outcomes worldwide
As child mortality rates overall are decreasing, non-communicable conditions, such as genetic disorders, constitute an increasing proportion of child mortality, morbidity and disability. To date, policy and public health programmes have focused on common genetic disorders. Rare single gene disorders are an important source of morbidity and premature mortality for affected families. When considered collectively, they account for an important public health burden, which is frequently under-recognised. To document the collective frequency and health burden of rare single gene disorders, it is necessary to aggregate them into large manageable groupings and take account of their family implications, effective interventions and service needs. Here, we present an approach to estimate the burden of these conditions up to 5 years of age in settings without empirical data. This approaches uses population-level demographic data, combined with assumptions based on empirical data from settings with data available, to provide population-level estimates which programmes and policy-makers when planning services can use
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Comprehensive confocal endomicroscopy of the esophagus in vivo
Background and study aims: Biopsy sampling error can be a problem for the diagnosis of certain gastrointestinal tract diseases. Spectrally-encoded confocal microscopy (SECM) is a high-speed reflectance confocal microscopy technology that has the potential to overcome sampling error by imaging large regions of gastrointestinal tract tissues. The aim of this study was to test a recently developed SECM endoscopic probe for comprehensively imaging large segments of the esophagus at the microscopic level in vivo. Methods: Topical acetic acid was endoscopically applied to the esophagus of a normal living swine. The 7 mm diameter SECM endoscopic probe was transorally introduced into the esophagus over a wire. Optics within the SECM probe were helically scanned over a 5 cm length of the esophagus. Confocal microscopy data was displayed and stored in real time. Results: Very large confocal microscopy images (length = 5 cm; circumference = 2.2 cm) of swine esophagus from three imaging depths, spanning a total area of 33 cm2, were obtained in about 2 minutes. SECM images enabled the visualization of cellular morphology of the swine esophagus, including stratified squamous cell nuclei, basal cells, and collagen within the lamina propria. Conclusions: The results from this study suggest that the SECM technology can rapidly provide large, contiguous confocal microscopy images of the esophagus in vivo. When applied to human subjects, the unique comprehensive, microscopic imaging capabilities of this technology may be utilized for improving the screening and surveillance of various esophageal diseases
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