Evaluation of metaperception of goal orientation and moral functioning in soccer spectators

La violencia en el fútbol es un grave problema social. Algunas de sus manifestaciones están relacionadas con el espectáculo deportivo y su tratamiento en los medios de comunicación. La finalidad de este estudio ha sido analizar las propiedades psicométricas de dos escalas en español que miden la meta-percepción de orientación de meta y el funcionamiento moral en espectadores de fútbol. Los participantes fueron estudiantes universitarios (N = 616) que completaron cuestionarios valorando el tiempo dedicado al consumo de programas deportivos sobre fútbol, la meta-percepción de orientación de meta y el funcionamiento moral. Las escalas definitivas mostraron una adecuada validez de constructo, validez convergente y validez concurrente. Estos resultados indican que las nuevas escalas poseen adecuadas propiedades psicométricas, lo que permite una evaluación válida y fiable que mejore el entendimiento de los procesos que operan en los espectadores de deportes como el fútbolSoccer violence is a serious social problem. Some of its manifestations are related to competitive sport and its treatment by the mass media. The purpose of this study was to analyze the psychometric properties of two Spanish scales which measure the metaperception of goal orientation and moral functioning in soccer spectators. Participants (N = 616) reported the time spent viewing soccer sport programming, and rated metaperception of goal orientation and moral functioning. The scales exhibited adequate construct, convergent and concurrent validity. These results indicate that the new scales have adequate psychometric properties, allowing a valid and reliable assessment in order to explain the processes that take place in sport spectators like soccer viewer

Factores no infecciosos de variación del recuento celular de la leche de oveja

El rebaño, el estado y número de lactación, el tipo de parto, las variaciones diurnas, diarias y entre ordeños, la alimentación, etc. tienen una influencia significativa sobre el recuento celular de la leche de oveja, aunque de menor importancia que la infección. La curva del recuento en la lactación es inversa a la de la producción lechera; los valores celulares son elevados al comienzo de la lactación (especialmente en el calostro), disminuyen rápidamente y alcanzan sus valores mínimos coincidiendo con las producciones más elevadas, aumentando de nuevo progresivamente hasta el final de la lactación. Por otra parte, el recuento aumenta significativamente con el número de lactación y en las ovejas de parto múltiple. Así mismo, es más elevado en la leche de repaso que en la leche de los primeros chorros y en la leche del ordeño de la tarde que en el de la mañana, para desiguales intervalos entre ordeños. El conocimiento de estos factores no infecciosos resulta de interés de cara a una correcta interpretación del recuento celular de la leche

Chronic excitotoxin-induced axon degeneration in a compartmented neuronal culture model

Glutamate excitotoxicity is a major pathogenic process implicated in many neurodegenerative conditions, including AD (Alzheimer's disease) and following traumatic brain injury. Occurring predominantly from over-stimulation of ionotropic glutamate receptors located along dendrites, excitotoxic axonal degeneration may also occur in white matter tracts. Recent identification of axonal glutamate receptor subunits within axonal nanocomplexes raises the possibility of direct excitotoxic effects on axons. Individual neuronal responses to excitotoxicity are highly dependent on the complement of glutamate receptors expressed by the cell, and the localization of the functional receptors. To enable isolation of distal axons and targeted excitotoxicity, murine cortical neuron cultures were prepared in compartmented microfluidic devices, such that distal axons were isolated from neuronal cell bodies. Within the compartmented culture system, cortical neurons developed to relative maturity at 11 DIV (days in vitro) as demonstrated by the formation of dendritic spines and clustering of the presynaptic protein synaptophysin. The isolated distal axons retained growth cone structures in the absence of synaptic targets, and expressed glutamate receptor subunits. Glutamate treatment (100 μM) to the cell body chamber resulted in widespread degeneration within this chamber and degeneration of distal axons in the other chamber. Glutamate application to the distal axon chamber triggered a lesser degree of axonal degeneration without degenerative changes in the untreated somal chamber. These data indicate that in addition to current mechanisms of indirect axonal excitotoxicity, the distal axon may be a primary target for excitotoxicity in neurodegenerative conditions

Therapeutic effects of psyllium in type 2 diabetic patients

P. 830-842The study included three phases: phase 1 (1 week), phase 2 (treatment, 14 g fibre=day, 6 weeks) and phase 3 (4 weeks). At the end of each phase a clinical evaluation was performed after the ingestion of a test breakfast of 1824.2 kJ (436 kcal). Measurements included concentrations of blood glucose, insulin, fructosamine, GHbA1c, C-peptide and 24 h urinary glucose excretion. In addition, uric acid, cholesterol and several mineral and vitamin concentrations were also evaluated. Twenty type 2 diabetic patients (12 men and 8 women) participated in the study with a mean age of 67.4 y for men and 66 y for women. The mean body mass index of men was 28.2 kg=m2 and that of women 25.9 kg=m2. Glucose absorption decreased significantly in the presence of psyllium (12.2%); this reduction is not associated with an important change in insulin levels (5%). GHbA1c, C-peptide and 24 h urinary glucose excretion decreased (3.8, 14.9 and 22.5%, respectively) during the treatment with fibre (no significant differences) as well as fructosamine (10.9%, significant differences). Psyllium also reduced total and LDL cholesterol (7.7 and 9.2%, respectively, significant differences), and uric acid (10%, significant difference). Minerals and vitamins did not show important changes, except sodium that increased significantly after psyllium administration.S

Dispersion, solvent and metal effects in the binding of gold cations to alkynyl ligands: implications for Au(i) catalysis.

The coordination modes of the [Au(PPh3)](+) cation to metal alkynyl complexes have been investigated. On addition to ruthenium, a vinylidene complex, [Ru(η(5)-C5H5)(PPh3)2([double bond, length as m-dash]C[double bond, length as m-dash]CPh{AuPPh3})](+), is obtained while addition to a gold(iii) compound gives di- and trinuclear gold complexes depending on the conditions employed. In the trinuclear species, a gold(i) cation is sandwiched between two gold(iii) alkynyl complexes, suggesting that coordination of multiple C-C triple bonds to gold is facile

Retinoid-independent motor neurogenesis from human embryonic stem cells reveals a medial columnar ground state

A major challenge in neurobiology is to understand mechanisms underlying human neuronal diversification. Motor neurons (MNs) represent a diverse collection of neuronal subtypes, displaying differential vulnerability in different human neurodegenerative diseases. The ability to manipulate cell subtype diversification is critical to establish accurate, clinically relevant in vitro disease models. Retinoid signalling contributes to caudal precursor specification and subsequent MN subtype diversification. Here we investigate the necessity for retinoic acid in motor neurogenesis from human embryonic stem cells. We show that activin/nodal signalling inhibition, followed by sonic hedgehog agonist treatment, is sufficient for MN precursor specification, which occurs even in the presence of retinoid pathway antagonists. Importantly, precursors mature into HB9/ChAT-expressing functional MNs. Furthermore, retinoid-independent motor neurogenesis results in a ground state biased to caudal, medial motor columnar identities from which a greater retinoid-dependent diversity of MNs, including those of lateral motor columns, can be selectively derived in vitro

Syndromics: A Bioinformatics Approach for Neurotrauma Research

Substantial scientific progress has been made in the past 50 years in delineating many of the biological mechanisms involved in the primary and secondary injuries following trauma to the spinal cord and brain. These advances have highlighted numerous potential therapeutic approaches that may help restore function after injury. Despite these advances, bench-to-bedside translation has remained elusive. Translational testing of novel therapies requires standardized measures of function for comparison across different laboratories, paradigms, and species. Although numerous functional assessments have been developed in animal models, it remains unclear how to best integrate this information to describe the complete translational “syndrome” produced by neurotrauma. The present paper describes a multivariate statistical framework for integrating diverse neurotrauma data and reviews the few papers to date that have taken an information-intensive approach for basic neurotrauma research. We argue that these papers can be described as the seminal works of a new field that we call “syndromics”, which aim to apply informatics tools to disease models to characterize the full set of mechanistic inter-relationships from multi-scale data. In the future, centralized databases of raw neurotrauma data will enable better syndromic approaches and aid future translational research, leading to more efficient testing regimens and more clinically relevant findings