Das saudades que se tem: a representação paterna na escrita autobiográfica de Bartolomeu Campos de Queirós

In our work, we analyze some works of Bartolomeu Campos de Queirós that compose the “autobiographical cycle”, especially those ones that bring the image of father’s absence/presence, the relationship between life and writing, as well as the father’s figurations and his intermediates and substitutes. We especially investigated the aspect of repetition about how the family relations are articulated, highlighting those ones that happen between father and son and that appear in these texts. This problematic interested us as a research object, a priori, because the works of Bartholomeu Campos de Queirós are an exponent of literature for children field, as far as they show that the childhood is not always “colorful”, happy and perfect as several productions supposedly made “for children” seek to have us believe. In addition, the selected texts that have an autobiographical characteristic and put the issue of child suffering because of the father’s absence are configured as a very rich corpus for studies related to the relation between life/work and investigations in the dialogue between Literature and Psychoanalysis. These aspects will permit us to understand why the pain of missing father be repetitive and insistent in these books. Thus, we problematize, by the selected works for this study, the concept of literature for children and young people and the notion of literary reading. We also analyzed in the “statements” given by the author the relationship between life and writing and we investigated, based on psychoanalytic studies, the literary writing as a possibility of both unconscious development of memory marked by the father’s absence – remedy – as of a perpetuation of this same conflict – poison. Furthermore, we analyzed how the relationship between son and father are processed considering the mother’s absence, since the works that have this person’s presence, she seems to mediate such relationships in a certain way.Dissertação (Mestrado)Em nosso trabalho, analisamos em algumas obras de Bartolomeu Campos de Queirós que compõem o chamado “ciclo autobiográfico”, em especial as que trazem a imagem da ausência/presença do pai, a relação entre vida e escrita, bem como as figurações do pai e de seus intermediários e substitutos. Investigamos, sobretudo, o caráter da repetição no modo como se articulam as relações familiares, com destaque para as que ocorrem entre pai e filho e que aparecem nesses textos. Essa problemática interessou-nos como objeto de pesquisa, a priori, porque as obras de Bartolomeu Campos de Queirós são um expoente no campo da literatura infantil, na medida em que mostram que nem sempre a infância é “colorida”, feliz e perfeita como nos procuram fazer crer diversas produções supostamente feitas “para crianças”. Além disso, os textos selecionados de caráter autobiográfico, que trazem a questão do sofrimento da criança devido à ausência do pai, configuram-se como riquíssimo corpus para estudos referentes à relação entre vida/obra e as investigações no diálogo entre Literatura e Psicanálise. Isso nos permitirá entender o porquê de a dor da falta do pai ser repetitiva e insistente nesses livros. Dessa forma, problematizamos, por meio das obras selecionadas para este estudo, o conceito de literatura infantil e juvenil e a noção de leitura literária. Também analisamos nos “depoimentos” dados pelo autor a relação entre vida e escrita e investigamos, com base em estudos psicanalíticos, a escrita literária enquanto possibilidade tanto de elaboração inconsciente da memória marcada pela ausência do pai – remédio –, quanto de perpetuação desse mesmo conflito – veneno. Ademais, analisamos como se processam as relações entre o filho e o pai considerando a ausência da mãe, já que, nas obras em que há a presença desse personagem, ela parece mediar de certa forma tais relacionamentos

Exacerbação aguda da fibrose pulmonar idiopática

AbstractSome patients with Idiopathic Pulmonary Fibrosis (IPF) have disease accelerated deterioration without identifiable cause referred as “acute exacerbation” or “accelerated stage”. It is characterized by severe worsening of dyspnea, hypoxemia and new or progressive opacities on imaging studies. The typical histological findings are diffuse alveolar damage in addition to the features of usual interstitial pneumonia pattern. Mortality in this clinical entity is very high and no efficacious therapeutic have been described.The authors describe the clinical, functional and radiological features, treatment and evolution of five patients with IPF acute exacerbation. A discussion will be carry out concerning the IPF acute exacerbation usual features comparing with the alterations noticed in those patients.Rev Port Pneumol 2009; XV (2): 305-31

PELA CRIANÇA QUE AINDA EXISTE NA GENTE: A LITERATURA INFANTIL E JUVENIL SEGUNDO BARTOLOMEU CAMPOS DE QUEIRÓS

No trabalho, pretendemos problematizar os conceitos de literatura e de literatura infantil e juvenil por meio da análise de “depoimentos” de Bartolomeu Campos de Queirós. Para tanto, investigaremos, por meio de textos teóricos sobre o assunto, as discussões já realizadas sobre esses conceitos, em diálogo com o que Bartolomeu Campos de Queirós postula em seus textos reflexivos. Essa investigação mostra-se relevante porque o autor em questão é considerado um escritor de livros infantis, assim é interessante observar como esses depoimentos fornecidos por ele apontam para um posicionamento sobre a ideia de literatura que norteia e se reflete em suas obras, fazendo dele, ao lado de outros autores, um expoente no campo da literatura infantil contemporânea, à medida em que mostra que nem sempre a infância é “colorida”, feliz e perfeita, e a criança, um ser “menos inteligente”, como nos procuram fazer crer diversas produções supostamente feitas “para crianças”

Thermal performance of green envelopes in buildings in the Brazilian southeast

The evaluation of the thermal performance of buildings using green roofs, living walls or green walls as envelope protection elements is a very important tool for architects and engineers to minimize heat gain, provide better thermal condition and improve thermal performance. This paper presents three different studies of thermal performance of buildings with green cover: 1) a case study of a green roof, 2) an experimental study of a living wall, and 3) a case study of a green wall; all of which include comparative and concurrent measurements between exposed surfaces and surfaces protected by vegetation. The parameters measured were air temperature, relative humidity, air speed and mean radiant temperature, as well as the inner and outer temperature of the walls. Those analyses led to the conclusion that the use of vegetation as a protection element on roofs and façades acts positively on the heat flows in the envelope, representing an important tool for passive thermal control of high temperatures inside the buildings.A avaliação do desempenho térmico de edificações que utilizam coberturas verdes, paredes vivas ou paredes verdes como elemento de proteção da envoltória é um campo de grande importância para os profissionais de arquitetura e engenharia, por minimizar o ganho de calor, proporcionar melhor condição térmica e aprimorar seu desempenho. Este trabalho apresenta três diferentes estudos de desempenho térmico com revestimentos vegetais: 1) um estudo de caso com cobertura verde, 2) um estudo experimental com parede viva, e 3) um estudo de caso com parede verde, todos com medições comparativas e simultâneas entre superfícies expostas e protegidas pelo verde. Os parâmetros medidos foram temperatura, umidade relativa, velocidade do ar, temperatura radiante média e temperatura das superfícies internas e externas das envoltórias. Tais análises levaram à conclusão de que o uso da vegetação como elemento de proteção em coberturas e fachadas atua positivamente sobre os fluxos de calor na envoltória, representando uma importante ferramenta para o controle térmico passivo de altas temperaturas no interior das edificações.161718

Towards a structural understanding of the fibrillization pathway in Machado-Joseph’s disease: trapping early oligomers of non-expanded ataxin-3

Machado-Joseph’s disease is caused by a CAG trinucleotide repeat expansion that is translated into an abnormally long polyglutamine tract in the protein ataxin-3. Except for the polyglutamine region, proteins associated with polyglutamine diseases are unrelated, and for all of these diseases aggregates containing these proteins are the major components of the nuclear proteinaceous deposits found in the brain. Aggregates of the expanded proteins display amyloid-like morphological and biophysical properties. Human ataxin-3 containing a non-pathological number of glutamine residues (14Q), as well as its Caenorhabditis elegans (1Q) orthologue, showed a high tendency towards self-interaction and aggregation, under nearphysiological conditions. In order to understand the discrete steps in the assembly process leading to ataxin-3 oligomerization, we have separated chromatographically high molecular mass oligomers as well as medium mass multimers of non-expanded ataxin-3. We show that: (a) oligomerization occurs independently of the poly(Q)-repeat and it is accompanied by an increase in b-structure; and (b) the first intermediate in the oligomerization pathway is a Josephin domain-mediated dimer of ataxin- 3. Furthermore, non-expanded ataxin-3 oligomers are recognized by a specific antibody that targets a conformational epitope present in soluble cytotoxic species found in the fibrillization pathway of expanded polyglutamine proteins and other amyloid-forming proteins. Imaging of the oligomeric forms of the non-pathological protein using electron microscopy reveals globular particles, as well as short chains of such particles that likely mimic the initial stages in the fibrillogenesis pathway occurring in the polyglutamine-expanded protein. Thus, they constitute potential targets for therapeutic approaches in Machado-Joseph’s disease, as well as valuable diagnostic markers in disease settings

Desempenho térmico de envoltórias vegetadas em edificações no sudeste brasileiro

A avaliação do desempenho térmico de edificações que utilizam coberturas verdes, paredes vivas ou paredes verdes como elemento de proteção da envoltória é um campo de grande importância para os profissionais de arquitetura e engenharia, por minimizar o ganho de calor, proporcionar melhor condição térmica e aprimorar seu desempenho. Este trabalho apresenta três diferentes estudos de desempenho térmico com revestimentos vegetais: 1) um estudo de caso com cobertura verde, 2) um estudo experimental com parede viva, e 3) um estudo de caso com parede verde, todos com medições comparativas e simultâneas entre superfícies expostas e protegidas pelo verde. Os parâmetros medidos foram temperatura, umidade relativa, velocidade do ar, temperatura radiante média e temperatura das superfícies internas e externas das envoltórias. Tais análises levaram à conclusão de que o uso da vegetação como elemento de proteção em coberturas e fachadas atua positivamente sobre os fluxos de calor na envoltória, representando uma importante ferramenta para o controle térmico passivo de altas temperaturas no interior das edificações

Autoimmune cirrhosis treated by liver transplantation using the right hepatic lobe from a living related donor

peer reviewedThe authors describe the case of a 17-year-old girl who suffered from end-stage liver failure due to chronic autoimmune hepatitis. Liver failure was complicated by severe portal hypertension, hypersplenism and refractory ascites. Liver transplantation was indicated. She was listed for cadaveric whole liver transplantation, but her infrequent blood group (B) increased waiting time. Her condition deteriorated to Child C liver failure and living related liver transplant was considered. Her father was compatible and proposed himself for donation. Right lobe procurement was decided in order to provide sufficient liver mass. No transfusion of red cells, platelets, or fresh frozen plasma was used either in the donor or the recipient. Both recipient and donor left the ward at postoperative day 14, without complication. They were both asymptomatic and with normal liver tests at one year follow-up. Living related liver transplantation using the right lobe may offer an alternative to liver transplant candidates in this period of organ donor shortage

Clinical Case of the Month. Autoimmune Cirrhosis Treated by Liver Transplantation Using the Right Hepatic Lobe from a Living Related Donor

peer reviewedThe authors describe the case of a 17-year-old girl who suffered from end-stage liver failure due to chronic autoimmune hepatitis. Liver failure was complicated by severe portal hypertension, hypersplenism and refractory ascites. Liver transplantation was indicated. She was listed for cadaveric whole liver transplantation, but her infrequent blood group (B) increased waiting time. Her condition deteriorated to Child C liver failure and living related liver transplant was considered. Her father was compatible and proposed himself for donation. Right lobe procurement was decided in order to provide sufficient liver mass. No transfusion of red cells, platelets, or fresh frozen plasma was used either in the donor or the recipient. Both recipient and donor left the ward at postoperative day 14, without complication. They were both asymptomatic and with normal liver tests at one year follow-up. Living related liver transplantation using the right lobe may offer an alternative to liver transplant candidates in this period of organ donor shortage

Identification of genetic variants associated with Huntington's disease progression: a genome-wide association study

Background Huntington's disease is caused by a CAG repeat expansion in the huntingtin gene, HTT. Age at onset has been used as a quantitative phenotype in genetic analysis looking for Huntington's disease modifiers, but is hard to define and not always available. Therefore, we aimed to generate a novel measure of disease progression and to identify genetic markers associated with this progression measure. Methods We generated a progression score on the basis of principal component analysis of prospectively acquired longitudinal changes in motor, cognitive, and imaging measures in the 218 indivduals in the TRACK-HD cohort of Huntington's disease gene mutation carriers (data collected 2008–11). We generated a parallel progression score using data from 1773 previously genotyped participants from the European Huntington's Disease Network REGISTRY study of Huntington's disease mutation carriers (data collected 2003–13). We did a genome-wide association analyses in terms of progression for 216 TRACK-HD participants and 1773 REGISTRY participants, then a meta-analysis of these results was undertaken. Findings Longitudinal motor, cognitive, and imaging scores were correlated with each other in TRACK-HD participants, justifying use of a single, cross-domain measure of disease progression in both studies. The TRACK-HD and REGISTRY progression measures were correlated with each other (r=0·674), and with age at onset (TRACK-HD, r=0·315; REGISTRY, r=0·234). The meta-analysis of progression in TRACK-HD and REGISTRY gave a genome-wide significant signal (p=1·12 × 10−10) on chromosome 5 spanning three genes: MSH3, DHFR, and MTRNR2L2. The genes in this locus were associated with progression in TRACK-HD (MSH3 p=2·94 × 10−8 DHFR p=8·37 × 10−7 MTRNR2L2 p=2·15 × 10−9) and to a lesser extent in REGISTRY (MSH3 p=9·36 × 10−4 DHFR p=8·45 × 10−4 MTRNR2L2 p=1·20 × 10−3). The lead single nucleotide polymorphism (SNP) in TRACK-HD (rs557874766) was genome-wide significant in the meta-analysis (p=1·58 × 10−8), and encodes an aminoacid change (Pro67Ala) in MSH3. In TRACK-HD, each copy of the minor allele at this SNP was associated with a 0·4 units per year (95% CI 0·16–0·66) reduction in the rate of change of the Unified Huntington's Disease Rating Scale (UHDRS) Total Motor Score, and a reduction of 0·12 units per year (95% CI 0·06–0·18) in the rate of change of UHDRS Total Functional Capacity score. These associations remained significant after adjusting for age of onset. Interpretation The multidomain progression measure in TRACK-HD was associated with a functional variant that was genome-wide significant in our meta-analysis. The association in only 216 participants implies that the progression measure is a sensitive reflection of disease burden, that the effect size at this locus is large, or both. Knockout of Msh3 reduces somatic expansion in Huntington's disease mouse models, suggesting this mechanism as an area for future therapeutic investigation

DPOC – Gestão de exacerbações

info:eu-repo/semantics/draf