Herschel Extreme Lensing Line Observations: Dynamics of two strongly lensed star forming galaxies near redshift z = 2

We report on two regularly rotating galaxies at redshift z=2, using high resolution spectra of the bright [CII] 158 micron emission line from the HIFI instrument on the Herschel Space Observatory. Both SDSS090122.37+181432.3 ("S0901") and SDSS J120602.09+514229.5 ("the Clone") are strongly lensed and show the double-horned line profile that is typical of rotating gas disks. Using a parametric disk model to fit the emission line profiles, we find that S0901 has a rotation speed v sin(i) = 120 +/- 7 km/s and gas velocity dispersion sigma < 23 km/s. The best fitting model for the Clone is a rotationally supported disk having v sin(i) = 79 +/- 11 km/s and sigma < 4km/s. However the Clone is also consistent with a family of dispersion-dominated models having sigma = 92 +/- 20 km/s. Our results showcase the potential of the [CII] line as a kinematic probe of high redshift galaxy dynamics: [CII] is bright; accessible to heterodyne receivers with exquisite velocity resolution; and traces dense star-forming interstellar gas. Future [CII] line observations with ALMA would offer the further advantage of spatial resolution, allowing a clearer separation between rotation and velocity dispersion.Comment: 20 pages, 4 figures; in press at The Astrophysical Journa

Can circumcision be avoided in adult male with phimosis? Results of the PhimoStopTM prospective trial

Background: Circumcision as surgical treatment of adult phimosis is not devoid of complications. Efficacy of alternative non-surgical options is unclear. PhimoStop (TM) is a therapeutic protocol which involves the use of appropriately shaped silicone tuboids of increasing size to obtain a non-forced dilation of the prepuce. The aim of the study was to evaluate the efficacy and durability of results of PhimoStop (TM) device for the treatment of adult male phimosis.Methods: A prospective trial was conducted between 2018 and 2020 on 85 consecutive adult male patients affected by phimosis and with an indication for circumcision. Patients were treated with PhimoStop (TM) protocol and they were evaluated at baseline and after treatment through a subjective (patient self-reported information on various domains of his sexual function) and an objective assessment (evaluation of phimosis severity grade according to the Kikiros scale pre- and post-treatment, re-assessment of indication for circumcision post-treatment and validated questionnaires scores). Primary endpoint was to avoid the scheduled circumcision in 33% of the patients enrolled.Results: Seventy-one patients (84%) completed the device usage phase as per study protocol. Median duration of tuboid application was 60 days. Thirty-seven patients (52.1%) had no indication for circumcision after treatment. Even considering patients lost to follow-up as failures, primary endpoint was reached in 43.5% of cases. There was a significant reduction of the grade of phimosis after treatment (P&lt;0.001). Moreover IIEF-5 showed a statistically significant improvement after treatment (P&lt; 0.001). Thirty/37 patients who met the primary endpoint (81%) still have a successful resolution of their phimosis avoiding circumcision at a median follow-up of 24 months.Conclusions: PhimoStop (TM) device is effective for the treatment of adult male phimosis of Kikiros grade &lt; 2. The results seem to be durable in most patients at a median follow-up of 24 months. Randomized clinical trials are necessary in order to confirm our results and assess cost-efficacy

The VLA-COSMOS Survey: V. 324 MHz continuum observations

We present 90 cm VLA imaging of the COSMOS field, comprising a circular area of 3.14 square degrees at 8.0"x6.0" angular resolution with an average rms of 0.5 mJy/beam. The extracted catalog contains 182 sources (down to 5.5sigma), 30 of which are multi-component sources. Using Monte Carlo artificial source simulations we derive the completeness of the catalog, and we show that our 90 cm source counts agree very well with those from previous studies. Using X-ray, NUV-NIR and radio COSMOS data to investigate the population mix of our 90 cm radio sample, we find that our sample is dominated by active galactic nuclei (AGN). The average 90-20 cm spectral index (S_nu~nu**alpha, where S_nu is the flux density at frequency nu, and alpha the spectral index) of our 90 cm selected sources is -0.70, with an interquartile range of -0.90 to -0.53. Only a few ultra-steep-spectrum sources are present in our sample, consistent with results in the literature for similar fields. Our data do not show clear steepening of the spectral index with redshift. Nevertheless, our sample suggests that sources with spectral indices steeper than -1 all lie at z>1, in agreement with the idea that ultra-steep-spectrum radio sources may trace intermediate-redshift galaxies (z>1).Comment: 10 pages, 12 figures, accepted for publication in MNRA

Axion-Like Particles, Cosmic Magnetic Fields and Gamma-Ray Astrophysics

Axion-Like Particles (ALPs) are predicted by many extensions of the Standard Model and give rise to characteristic dimming and polarization effects in a light beam travelling in a magnetic field. In this Letter, we demonstrate that photon-ALP mixing in cosmic magnetic fields produces an observable distortion in the energy spectra of distant gamma-ray sources (like AGN) for ranges of the ALP parameters allowed by all available constraints. The resulting effect is expected to show up in the energy band 100 MeV - 100 GeV, and so it can be serched with the upcoming GLAST mission.Comment: 17 pages, 6 figures; accepted for publication in Physics Letters B. Revised versio

ALMA Observation of a z≳10z\gtrsim10 Galaxy Candidate Discovered with JWST

We report the ALMA observation of a $z\gtrsim10$ galaxy candidate (GHZ1) discovered from the GLASS-JWST Early Release Science Program. Our ALMA program aims to detect the [OIII] emission line at the rest-frame 3393.0062 GHz ($88.36\mu$m) and far-IR continuum emission with the spectral window setup seamlessly covering a 26.125 GHz frequency range ($10.10<z<11.14$). A total of 7 hours of on-source integration was employed, using four frequency settings to cover the full range (1.7 hours per setting), with $0''.7$ angular resolution. No line or continuum is clearly detected, with a 5$\sigma$ upper limit of the line emission of 0.93 mJy beam$^{-1}$ at 25 km s$^{-1}$ channel$^{-1}$ and of the continuum emission of 30$\mu$Jy beam$^{-1}$. We report marginal spectral (at 225 km s$^{-1}$ resolution) and continuum features ($4.1\sigma$ and $2.6\sigma$ peak signal-to-noise ratio, respectively), within $0''.17$ from the JWST position of GHZ1. This spectral feature implies $z=10.38$ and needs to be verified with further observations. Assuming that the best photometric redshift estimate ($z=10.60^{+0.52}_{-0.60}$) is correct, the broadband galaxy spectral energy distribution model for the $3\sigma$ upper limit of the continuum flux from GHZ1 suggests that GHZ1 has a small amount of dust ($M_d\lesssim10^4 M_{\odot}$) with high temperature ($T_d\gtrsim90$K). The $5\sigma$ upper limit of the [OIII]$_{88\mu m}$ line luminosity and the inferred star formation rate of GHZ1 is consistent with the properties of the low metallicity dwarf galaxies. We also report serendipitous clear detections of six continuum sources at the locations of the JWST galaxy counterparts in the field.Comment: Accepted to ApJ after revising the figures and the analysi

"Single-Surgeon" versus "Dual-Surgeon" Robot-Assisted Radical Prostatectomy and Pelvic Lymph-nodes Dissection: Comparative Analysis of Perioperative Outcomes

ABSTRACT Purpose: To compare the perioperative outcomes of robot-assisted radical prostatectomy (RARP) with pelvic lymph-nodes dissection (PLND) when the same surgeon performs RARP and PLND versus one surgeon performs RARP and another surgeon performs PLND. Materials and Methods: From January 2022 to March 2023, data of consecutive patients who underwent RARP with PLND were prospectively collected. The surgeries were performed by two "young" surgeons with detailed profile. Specifically for the study purpose, one surgeon performed RARP, and the other surgeon performed PLND. A set of surgeries performed according to the standard setup (i.e., the same surgeon performing both RARP and PLND) was retrieved from the institutional database and used as comparator arm. To test the study hypothesis, patients were divided into two groups: "dual-surgeon" versus "single-surgeon". Results: Fifty patients underwent RARP and PLND performed according to dual-surgeon setup and were compared to the last 50 procedures performed according to the standard single-surgeon setup. Patients in the groups had comparable baseline characteristics. Dual-surgeon interventions had significantly shorter median total operative (194 [IQR 178–215] versus 174 [IQR 146–195] minutes, p<0.001) and console time (173 [IQR 158–194] versus 154 [IQR 129–170] minutes, p<0.001). No significant differences were found in terms of blood loss, intraoperative complications, postoperative outcomes, and final pathology results. Conclusions: The present analysis found that when RARP and PLND are split onto two surgeons, the operative time is shorter by 20 minutes compared to when a single surgeon performs RARP and PLND. This is an interesting finding that could sponsor further studies

"Single-Surgeon" versus "Dual-Surgeon" Robot-Assisted Radical Prostatectomy and Pelvic Lymph-nodes Dissection: Comparative Analysis of Perioperative Outcomes

Purpose: To compare the perioperative outcomes of robot-assisted radical prostatectomy (RARP) with pelvic lymph-nodes dissection (PLND) when the same surgeon performs RARP and PLND versus one surgeon performs RARP and another surgeon performs PLND. Materials and methods: From January 2022 to March 2023, data of consecutive patients who underwent RARP with PLND were prospectively collected. The surgeries were performed by two "young" surgeons with detailed profile. Specifically for the study purpose, one surgeon performed RARP, and the other surgeon performed PLND. A set of surgeries performed according to the standard setup (i.e., the same surgeon performing both RARP and PLND) was retrieved from the institutional database and used as comparator arm. To test the study hypothesis, patients were divided into two groups: "dual-surgeon" versus "single-surgeon". Results: Fifty patients underwent RARP and PLND performed according to dual-surgeon setup and were compared to the last 50 procedures performed according to the standard single-surgeon setup. Patients in the groups had comparable baseline characteristics. Dual-surgeon interventions had significantly shorter median total operative (194 [IQR 178-215] versus 174 [IQR 146-195] minutes, p&lt;0.001) and console time (173 [IQR 158-194] versus 154 [IQR 129-170] minutes, p&lt;0.001). No significant differences were found in terms of blood loss, intraoperative complications, postoperative outcomes, and final pathology results. Conclusions: The present analysis found that when RARP and PLND are split onto two surgeons, the operative time is shorter by 20 minutes compared to when a single surgeon performs RARP and PLND. This is an interesting finding that could sponsor further studies

Value-Sensitive Automatic Code Specialization Embedded Software

The objective of this work is to create a framework for the optimization of embedded software. We present algorithms and a tool flow to reduce the computational effort of programs, using value profiling and partial evaluation. Such a reduction translates into both energy savings and average-case performance improvement, while preserving a tolerable increase of worst case performance and code size. Our tool reduces the computational effort by specializing frequently executed procedures for the most common values of their parameters. The most effective specializations are automatically searched and identified, and the code is transformed through partial evaluation. Experimental results show that their technique improves both energy consumption and performance of the source code up to more than a factor of two, in average about 35% over the original program. Also, their automatic search engine greatly reduces code optimization time with respect to exhaustive search

Thulium laser enucleation of prostate versus laparoscopic trans-vesical simple prostatectomy in the treatment of large benign prostatic hyperplasia: head-to-head comparison

Objectives: To compare thulium laser enucleation of prostate (ThuLEP) versus laparoscopic trans-vesical simple prostatectomy (LSP) in the treatment of benign prostatic hyperplasia (BPH).Materials and Methods: Data of patients who underwent surgery for "large" BPH (&gt;80mL) at three Institutions were collected and analyzed. Two institutions performed ThuLEP only; the third institution performed LSP only. Preoperative (indwelling catheter status, prostate volume (PVol), hemoglobin (Hb), Q(max), post-voiding residual volume (PVR), IPSS, QoL, IIEF-5) and perioperative data (operative time, enucleated adenoma, catheterization time, length of stay, Hb-drop, complications) were compared. Functional (Q(max), PVR, Þlta Q(max)) and patient-reported outcomes (IPSS, QoL, IIEF-5, Þlta IPSS, Þlta QoL) were compared at last follow-up.Results: 80 and 115 patients underwent LSP and ThuLEP, respectively. At baseline, median PVol was 130 versus 120mL, p &lt;0.001; Q(max) 9.6 vs. 7.1mL/s, p=0.005; IPSS 21 versus 25, p &lt;0.001. Groups were comparable in terms of intraoperative complications (1 during LSP vs. 3 during ThuLEP) and transfusions (1 per group). Differences in terms of operative time (156 vs. 92 minutes, p &lt;0.001), Hb-drop (-2.5 vs. -0.9g/dL, p &lt;0.001), catheterization time (5 vs. 2 days, p &lt;0.001) and postoperative complications (13.8% vs. 0, p &lt;0.001) favored ThuLEP. At median follow-up of 40 months after LSP versus 30 after ThuLEP (p &lt;0.001), Q(max) improved by 226% vs. 205% (p=0.5), IPSS decreased by 88% versus 85% (p=0.9), QoL decreased by 80% with IIEF-5 remaining almost unmodified for both the approaches.Conclusions: Our analysis showed that LSP and ThuLEP are comparable in relieving from BPO and improving the patient-reported outcomes. Invasiveness of LSP is more significant

Entry techniques in laparoscopic radical and partial nephrectomy: A multicenter international survey of contemporary practices

BACKGROUND: There is no clear consensus as to the optimal method of entry in laparoscopic renal surgery and no reports have compared them in Urology. To analyze contemporary practice patterns in entry technique and port placement for laparoscopic kidney surgery. METHODS: We identified 60 high volume urological laparoscopic centers. A purpose-built questionnaire was sent to surgeons. The survey included 22 questions regarding access techniques and port configuration during laparoscopic kidney surgery. Data on were collected and retrospectively analyzed. Concordance among port configurations was assessed using Cohen's Kappa statistics. RESULTS: The survey was sent to 60 surgeons and completed by 32 of them. Surgical procedures included were laparoscopic radical nephrectomy (1177 LRN/year) and laparoscopic partial nephrectomy (1047 LPN/year). The transperitoneal route was preferred (85%). Hasson technique was used for the access in 55% of the cases. Patient lateral recumbent position is the most frequently used during the port placement (41%). Although there is a high variability in the port positioning among the surgeons, in more than 90% of cases it was found a specific concordance in triangulation of optics and operating trocars. There were no significant differences between port configuration in LRN and LPN. Limitations include retrospective design and limited sample. CONCLUSIONS: A standard port configuration has not been previously reported in urological literature. Our study suggests that the transperitoneal approach, the Hasson technique and a specific triangulation of optics and operating trocars have a significant concordance in some high volume laparoscopic urologic centers