Ultralow power voltage reference circuit for implantable devices in standard CMOS technology

This is the peer reviewed version of the following article: Óscar Pereira-Rial, Paula López, Juan M. Carrillo, Victor M. Brea and Diego Cabello (2019) Ultralow power voltage reference circuit for implantable devices in standard CMOS technology. International journal of circuit theory and applications, 47 (7), 991-1005, which has been published in final form at https://doi.org/10.1002/cta.2643. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived VersionsAn ultralow power CMOS voltage reference for body implantable devices is presented in this paper. The circuit core consists of only regular threshold voltage PMOS transistors, thus leading to a very reduced output voltage dispersion, defined as σ/μ, and extremely low power consumption. A mathematical model of the generated reference voltage was obtained by solving circuit equations, and its numerical solution has been validated by extensive electrical simulations using a commercial circuit simulator. The proposed solution incorporates a passive RC low‐pass filter, to enhance power supply rejection (PSR) over a wide frequency range, and a speed‐up section, to accelerate the switching‐on of the circuit. The prototype was implemented in 0.18 μm standard CMOS technology and is able to operate with supply voltages ranging from 0.7 to 1.8 V providing a measured output voltage value of 584.2 mV at the target temperature of 36° C. The measured σ/μ dispersion of the reference voltage generated is 0.65% without the need of trimming. At the minimum supply of 0.7 V, the experimental power consumption is 64.5 pW, while the measured PSR is kept below –60 dB from DC up to the MHz frequency rangeThis work has been partially funded by the Spanish government projects TEC2015‐66878‐C3‐3‐R (MINECO/FEDER) and RTI2018‐097088‐B‐C32 (FEDER), by the Xunta de Galicia under project ED431C2017/69, by the Consellería de Cultura, Educación e Ordenación Universitaria (accreditation 2016‐2019, ED431G/08 and reference competitive group 2017‐2020, ED431C 2017/69), by the Junta de Extremadura R&D Plan, and the European Fund for Regional Development (EFRD) under Grant IB18079S

Wireless Sensor Network With Perpetual Motes for Terrestrial Snail Activity Monitoring

Wireless sensor networks (WSNs) are increasingly adopted in agriculture to monitor environmental variables to predict the presence of pests. Differently from these approaches, this paper introduces aWSN to detect the presence of snails in the field. The network can be used to both trigger an alarm of early pest presence and to further elaborate statistical models with the addition of environmental data as temperature or humidity to predict snail presence. In this paper we also design our own WSN simulator to account for real-life conditions as an uneven spacing of motes in the field or different currents generated by solar cells at the motes. This allows achieving more realistic network deployment in the field. Experimental tests are included in this paper, showing that our motes are perpetual in terms of energy consumptionConsellería de Cultura, Educación e Ordenación Universitaria (accreditation 2016-2019); European Regional Development Fund; Ministerio de Economía, Industria y Competitividad (TEC2015-66878-C3-3-R)S

Distance Measurement Error in Time-of-Flight Sensors Due to Shot Noise

Unlike other noise sources, which can be reduced or eliminated by different signal processing techniques, shot noise is an ever-present noise component in any imaging system. In this paper, we present an in-depth study of the impact of shot noise on time-of-flight sensors in terms of the error introduced in the distance estimation. The paper addresses the effect of parameters, such as the size of the photosensor, the background and signal power or the integration time, and the resulting design trade-offs. The study is demonstrated with different numerical examples, which show that, in general, the phase shift determination technique with two background measurements approach is the most suitable for pixel arrays of large resolutionThis work has been partially funded by Spanish government Project TEC2012-38921-C02-02 MINECO(FEDER) and by the Xunta de Galicia with EM2013/038 and EM2014/012, AE CITIUS(CN2012/151, (FEDER)) and GPC2013/040 (FEDER)S

Real time architectures for the scale Invariant feature transform algorithm

Feature extraction in digital image processing is a very intensive task for a CPU. In order to achieve real time image throughputs, hardware parallelism must be exploited. The speed-up of the system is constrained by the degree of parallelism of the implementation and this one at the same time, by programmable device size and the power dissipation. In this work, issues related to the synthesis of the Scale-Invariant Feature Transform (SIFT) algorithm on a FPGA to obtain target processing rates faster than 50 frames per second for VGA images, are analyzed. In order to increase the speedup of the algorithm, the work includes the analysis of feasible simplifications of the algorithm for a tracking application and the results are synthesized on an FPGA.This work has been partially funded by Spanish government projects TEC2015-66878-C3-2-R (MINECO/FEDER, UE) and TEC2015- 66878-C3-3-R (MINECO/FEDER, UE)

On-Chip Solar Energy Harvester and PMU With Cold Start-Up and Regulated Output Voltage for Biomedical Applications

This paper presents experimental results from a system that comprises a fully autonomous energy harvester with a solar cell of 1 mm 2 as energy transducer and a Power Management Unit (PMU) on the same silicon substrate, and an output voltage regulator. Both chips are implemented in standard 0.18 μm CMOS technology with total layout areas of 1.575 mm 2 and 0.0126 mm 2 , respectively. The system also contains an off-the-shelf 3.2 mm × 2.5 mm × 0.9 mm supercapacitor working as an off-chip battery or energy reservoir between the PMU and the voltage regulator. Experimental results show that the fast energy recovery of the on-chip solar cell and PMU permits the system to replenish the supercapacitor with enough charge as to sustain Bluetooth Low Energy (BLE) communications even with input light powers of 510 nW. The whole system is able to self-start-up without external mechanisms at 340 nW. This work is the first step towards a self-supplied sensor node with processing and communication capabilities. The small form factor and ultra-low power consumption of the system components is in compliance with biomedical applications requirementsThis work was supported in part by the Spanish Government (Ministerio de Ciencia, Innovación y Universidades) under Project RTI2018-097088-B-C32 and Project RTI2018-095994-B-I00 (MICINN/FEDER), in part by the Xunta de Galicia, in part by the Consellería de Cultura, Educación e Ordenación Universitaria (accreditation 2016-2019, ED431G/08 and reference competitive group 2017-2020, ED431C 2017/69) and European Regional Development Fund (ERDF), and in part by the Junta de Extremadura and the ERDF, under Grant IB 18079S

The evolution of the ventilatory ratio is a prognostic factor in mechanically ventilated COVID-19 ARDS patients

Background: Mortality due to COVID-19 is high, especially in patients requiring mechanical ventilation. The purpose of the study is to investigate associations between mortality and variables measured during the first three days of mechanical ventilation in patients with COVID-19 intubated at ICU admission. Methods: Multicenter, observational, cohort study includes consecutive patients with COVID-19 admitted to 44 Spanish ICUs between February 25 and July 31, 2020, who required intubation at ICU admission and mechanical ventilation for more than three days. We collected demographic and clinical data prior to admission; information about clinical evolution at days 1 and 3 of mechanical ventilation; and outcomes. Results: Of the 2,095 patients with COVID-19 admitted to the ICU, 1,118 (53.3%) were intubated at day 1 and remained under mechanical ventilation at day three. From days 1 to 3, PaO2/FiO2 increased from 115.6 [80.0-171.2] to 180.0 [135.4-227.9] mmHg and the ventilatory ratio from 1.73 [1.33-2.25] to 1.96 [1.61-2.40]. In-hospital mortality was 38.7%. A higher increase between ICU admission and day 3 in the ventilatory ratio (OR 1.04 [CI 1.01-1.07], p = 0.030) and creatinine levels (OR 1.05 [CI 1.01-1.09], p = 0.005) and a lower increase in platelet counts (OR 0.96 [CI 0.93-1.00], p = 0.037) were independently associated with a higher risk of death. No association between mortality and the PaO2/FiO2 variation was observed (OR 0.99 [CI 0.95 to 1.02], p = 0.47). Conclusions: Higher ventilatory ratio and its increase at day 3 is associated with mortality in patients with COVID-19 receiving mechanical ventilation at ICU admission. No association was found in the PaO2/FiO2 variation

Treatment with tocilizumab or corticosteroids for COVID-19 patients with hyperinflammatory state: a multicentre cohort study (SAM-COVID-19)

Objectives: The objective of this study was to estimate the association between tocilizumab or corticosteroids and the risk of intubation or death in patients with coronavirus disease 19 (COVID-19) with a hyperinflammatory state according to clinical and laboratory parameters. Methods: A cohort study was performed in 60 Spanish hospitals including 778 patients with COVID-19 and clinical and laboratory data indicative of a hyperinflammatory state. Treatment was mainly with tocilizumab, an intermediate-high dose of corticosteroids (IHDC), a pulse dose of corticosteroids (PDC), combination therapy, or no treatment. Primary outcome was intubation or death; follow-up was 21 days. Propensity score-adjusted estimations using Cox regression (logistic regression if needed) were calculated. Propensity scores were used as confounders, matching variables and for the inverse probability of treatment weights (IPTWs). Results: In all, 88, 117, 78 and 151 patients treated with tocilizumab, IHDC, PDC, and combination therapy, respectively, were compared with 344 untreated patients. The primary endpoint occurred in 10 (11.4%), 27 (23.1%), 12 (15.4%), 40 (25.6%) and 69 (21.1%), respectively. The IPTW-based hazard ratios (odds ratio for combination therapy) for the primary endpoint were 0.32 (95%CI 0.22-0.47; p < 0.001) for tocilizumab, 0.82 (0.71-1.30; p 0.82) for IHDC, 0.61 (0.43-0.86; p 0.006) for PDC, and 1.17 (0.86-1.58; p 0.30) for combination therapy. Other applications of the propensity score provided similar results, but were not significant for PDC. Tocilizumab was also associated with lower hazard of death alone in IPTW analysis (0.07; 0.02-0.17; p < 0.001). Conclusions: Tocilizumab might be useful in COVID-19 patients with a hyperinflammatory state and should be prioritized for randomized trials in this situatio

Micro-Energy Harvesting System including a PMU and a Solar Cell on the same Substrate with Cold Start-Up from 2.38 nW and Input Power Range up to 10μW using Continuous MPPT

This paper presents a Power Management Unit (PMU) powered by a 1 mm $^2$ solar cell on the same substrate to rise up the harvested voltage above 1.1 V. The on-chip solar cell and the PMU are fabricated in standard 0.18 μm CMOS technology achieving a form factor of 1.575 mm $^2$ . The PMU is able to start up from a harvested power of 2.38 nW without any external kick off or control signal. The PMU features a continuous and two-dimensional Maximum Power Point Tracking (MPPT) working in open-loop mode to handle a harvested power range from nW to $\mu$ W, by modifying both the charge pump topology and the switching frequency. The MPPT is based on four voltage level detectors that define five working regions depending on the illumination and on a self-tuning reference current for a fine adjustment of the switching frequency. The chip also includes an auxiliary charge pump to generate the voltage level necessary for the control circuit, implemented as a Pelliconi charge pump of 8 stages with NMOS transistors in Pwell as diodes. A Dickson charge pump with transmission gates as switches and with variable gain and capacitance per stage is also designed as the main charge pump. Finally, two relaxation oscillators are implemented to drive both charge pumps. This paper is accompanied by a video file demonstrating the PMU operation by powering an off-chip NAND gateThis work has been partially funded by Spanish government project TEC2015-66878-C3-3-R MINECO (FEDER), in part by Xunta de Galicia under Project ED431C2017/69, in part by the Consellería de Cultura, Educación e Ordenación Universitaria (accreditation 2016-2019, ED431G/08) and the European Regional Development Fund (ERDF), and in part by Xunta de Galicia and the European Union (European Social Fund - ESF)S