Design Optimization of 3D Steel Frameworks Under Constraints of Natural Frequencies of Vibration

Steel multistorey 3D frames are commonly used in business and residential buildings, industrial sheds, warehouses, etc. The design optimization of tall steel buildings is usually governed by horizontal loadings, such as, wind load, as well as its dynamic behavior, for which the structure must have the stiffness and stability in accordance with the safety criteria established by codes. This chapter deals with sizing structural optimization problems, concerning weight minimization of 3D steel frames, considering natural frequencies of vibration as well as allowable displacements as the constraints of the optimization problem. The discrete design variables are to be chosen from commercial profiles tables. A differential evolution (DE) is the search algorithm adopted coupled to an adaptive penalty method (APM) to handle the constraints. Three different 3D frames are optimized, presenting very interesting results

Searching for optimal variables in real multivariate stochastic data

By implementing a recent technique for the determination of stochastic eigendirections of two coupled stochastic variables, we investigate the evolution of fluctuations of NO2 concentrations at two monitoring stations in the city of Lisbon, Portugal. We analyze the stochastic part of the measurements recorded at the monitoring stations by means of a method where the two concentrations are considered as stochastic variables evolving according to a system of coupled stochastic differential equations. Analysis of their structure allows for transforming the set of measured variables to a set of derived variables, one of them with reduced stochasticity. For the specific case of NO2 concentration measures, the set of derived variables are well approximated by a global rotation of the original set of measured variables. We conclude that the stochastic sources at each station are independent from each other and typically have amplitudes of the order of the deterministic contributions. Such findings show significant limitations when predicting such quantities. Still, we briefly discuss how predictive power can be increased in general in the light of our methods

Aproveitamento de um fosfato natural parcialmente solubilizado pela cultura da cana-de-açúcar: I. Cana-planta

The relative efficiency of a partially acidulated and granulated rock phosphate, FAPS, containing 26% total P2O5, 10% citric acid soluble P2O5, 13% ammonium citrate soluble P2O5, 27% total CaO and 7% total S, was compared with that of both simple superphosphate (SS) and ground rock phosphate (FA). The experiment with the sugar cane variety NA 56-79 was set in a red yellow latosol, pH 5.1-5.5, low in P (4 ppm), and with and average available sulphur content (5 ppm as sul fate). The main conclusions were as follows: a) FAPS gave the same yield results provided by SS when used at the same rates based on total P2O5 content; b) sucrose content in the juice was increased by the highest level (16a kg P2O5 of application of FAPS; c) leaf analyses data suggest that FAPS has incre ased yield by supplying both P2O5 and S to the sugar-cane crop.Em um latossolo, com teor de P disponível entre baixo e médio foi instalado um ensaio destinado a comparar a eficiência de um fosfato natural parcialmente acidulado (FAPS) com a do super simples (SS) e a do fosfato de Araxá (FA) original, na cultura da cana-de-açúcar (cana-planta). Os dados obtidos mostraram que: (1) o FAPS deu uma produção que não diferiu estatisticamente da obtida com o SS, sendo superior ao FA como fonte de P2O5; (2) os dados de diagnose foliar sugerem que o FAPS e o SS funcionam como fonte de P e de S; (3) o teor de açúcares redutores no caldo aumentou em consequência da adubação fosfatada; (4) o FAPS, na dose mais alta, elevou o teor de sacarose do caldo

Controversies and priorities in amyotrophic lateral sclerosis

Two decades after the discovery that 20% of familial amyotrophic lateral sclerosis (ALS) cases were linked to mutations in the superoxide dismutase-1 (SOD1) gene, a substantial proportion of the remainder of cases of familial ALS have now been traced to an expansion of the intronic hexanucleotide repeat sequence in C9orf72. This breakthrough provides an opportunity to re-evaluate longstanding concepts regarding the cause and natural history of ALS, coming soon after the pathological unification of ALS with frontotemporal dementia through a shared pathological signature of cytoplasmic inclusions of the ubiquitinated protein TDP-43. However, with profound clinical, prognostic, neuropathological, and now genetic heterogeneity, the concept of ALS as one disease appears increasingly untenable. This background calls for the development of a more sophisticated taxonomy, and an appreciation of ALS as the breakdown of a wider network rather than a discrete vulnerable population of specialised motor neurons. Identification of C9orf72 repeat expansions in patients without a family history of ALS challenges the traditional division between familial and sporadic disease. By contrast, the 90% of apparently sporadic cases and incomplete penetrance of several genes linked to familial cases suggest that at least some forms of ALS arise from the interplay of multiple genes, poorly understood developmental, environmental, and age-related factors, as well as stochastic events

Electron transmission and phase time in semiconductor superlattices

We discuss the time spent by an electron propagating through a finite periodic system such as a semiconductor superlattice. The relation between dwell-time and phase-time is outlined. The envelopes of phase-time at maximum and minimum transmission are derived, and it is shown that the peaks and valleys of phase-time can be well described by parameters fitted at the extrema. For a many-period system this covers most of the allowed band. Comparison is made to direct numerical solutions of the time-dependent Schr\"odinger equation by Veenstra et al. [cond-mat/0411118] who compared systems with and without addition of an anti-reflection coating (ARC). With an ARC, the time delay is consistent with propagation at the Bloch velocity of the periodic system, which significantly reduces the time delay, in addition to increasing the transmissivity.Comment: 8 pages, 10 figures, based on a talk at Theory-Canada 3 in Edmonton AB, June 200

Interaction of Genetic Variations in NFE2L2 and SELENOS Modulates the Risk of Hashimoto's Thyroiditis.

Background: Several single-nucleotide polymorphisms (SNPs) are known to increase the risk of Hashimoto's thyroiditis (HT); such SNPs reside in thyroid-specific genes or in genes related to autoimmunity, inflammation, and/or cellular defense to stress. The transcription factor Nrf2, encoded by NFE2L2, is a master regulator of the cellular antioxidant response. This study aimed to evaluate the impact of genetic variation in NFE2L2 on the risk of developing HT. Methods: In a case-control candidate gene association study, functional SNPs in the NFE2L2 promoter (rs35652124, rs6706649, and rs6721961) were examined either as independent risk factors or in combination with a previously characterized HT risk allele (rs28665122) in the gene SELENOS, encoding selenoprotein S (SelS). A total of 997 individuals from the north of Portugal (Porto) were enrolled, comprising 481 HT patients and 516 unrelated healthy controls. SELENOS and NFE2L2 SNPs were genotyped using TaqMan <sup>®</sup> assays and Sanger sequencing, respectively. Odds ratios (ORs) were calculated using logistic regression, with adjustment for sex and age. Expression of SelS was analyzed by immunohistochemistry in thyroid tissue from HT patients and control subjects. Molecular interactions between the Nrf2 and SelS pathways were investigated in thyroid tissues from mice and in rat PCCL3 thyroid follicular cells. Results: When all three NFE2L2 SNPs were considered together, the presence of one or more minor alleles was associated with a near-significant increased risk (OR = 1.43, p = 0.072). Among subjects harboring only major NFE2L2 alleles, there was no increased HT risk associated with heterozygosity or homozygosity for the SELENOS minor allele. Conversely, in subjects heterozygous or homozygous for the SELENOS risk allele, the presence of an NFE2L2 minor allele significantly increased HT risk by 2.8-fold (p = 0.003). Immunohistochemistry showed reduced expression of SelS in thyroid follicular cells of HT patients. In Nrf2 knockout mice, there was reduced expression of SelS in thyroid follicular cells; conversely, in PCCL3 cells, reducing SelS expression caused reduced activity of Nrf2 signaling. Conclusions: The NFE2L2 promoter genotype interacts with the SELENOS promoter genotype to modulate the risk of HT in a Portuguese population. This interaction may be due to a bidirectional positive feedback between the Nrf2 and SelS pathways

Planck 2015 results. XXVII. The Second Planck Catalogue of Sunyaev-Zeldovich Sources

We present the all-sky Planck catalogue of Sunyaev-Zeldovich (SZ) sources detected from the 29 month full-mission data. The catalogue (PSZ2) is the largest SZ-selected sample of galaxy clusters yet produced and the deepest all-sky catalogue of galaxy clusters. It contains 1653 detections, of which 1203 are confirmed clusters with identified counterparts in external data-sets, and is the first SZ-selected cluster survey containing > $10^3$ confirmed clusters. We present a detailed analysis of the survey selection function in terms of its completeness and statistical reliability, placing a lower limit of 83% on the purity. Using simulations, we find that the Y5R500 estimates are robust to pressure-profile variation and beam systematics, but accurate conversion to Y500 requires. the use of prior information on the cluster extent. We describe the multi-wavelength search for counterparts in ancillary data, which makes use of radio, microwave, infra-red, optical and X-ray data-sets, and which places emphasis on the robustness of the counterpart match. We discuss the physical properties of the new sample and identify a population of low-redshift X-ray under- luminous clusters revealed by SZ selection. These objects appear in optical and SZ surveys with consistent properties for their mass, but are almost absent from ROSAT X-ray selected samples

Search for single top quarks in the tau+jets channel using 4.8 fb−1^{-1} of ppˉp\bar{p} collision data

We present the first direct search for single top quark production using tau leptons. The search is based on 4.8 fb$^{-1}$ of integrated luminosity collected in $p\bar{p}$ collisions at $\sqrt{s}$=1.96 TeV with the D0 detector at the Fermilab Tevatron Collider. We select events with a final state including an isolated tau lepton, missing transverse energy, two or three jets, one or two of them $b$ tagged. We use a multivariate technique to discriminate signal from background. The number of events observed in data in this final state is consistent with the signal plus background expectation. We set in the tau+jets channel an upper limit on the single top quark cross section of \TauLimObs pb at the 95% C.L. This measurement allows a gain of 4% in expected sensitivity for the observation of single top production when combining it with electron+jets and muon+jets channels already published by the D0 collaboration with 2.3 fb$^{-1}$ of data. We measure a combined cross section of \SuperCombineXSall pb, which is the most precise measurement to date.Comment: 12 pages, 5 figure

Measurement of Z/gamma*+jet+X angular distributions in ppbar collisions at sqrt{s}=1.96 TeV

We present the first measurements at a hadron collider of differential cross sections for Z+jet+X production in delta phi(Z, jet), |delta y(Z, jet)| and |y_boost(Z, jet)|. Vector boson production in association with jets is an excellent probe of QCD and constitutes the main background to many small cross section processes, such as associated Higgs production. These measurements are crucial tests of the predictions of perturbative QCD and current event generators, which have varied success in describing the data. Using these measurements as inputs in tuning event generators will increase the experimental sensitivity to rare signals.Comment: Published in Physics Letters B 682 (2010), pp. 370-380. 15 pages, 6 figure