On the nonlinear relationship between wall shear stress topology and multi-directionality in coronary atherosclerosis

Background and Objective: In this paper we investigate twelve multi-directional/topological wall shear stress (WSS) derived metrics and their relationships with the formation of coronary plaques in both computational fluid dynamics (CFD) and dynamic fluid-structure interaction (FSI) frameworks. While low WSS is one of the most established biomechanical markers associated with coronary atherosclerosis progression, alone it is limited. Multi-directional and topological WSS derived metrics have been shown to be important in atherosclerosis related mechanotransduction and near-wall transport processes. However, the relationships between these twelve WSS metrics and the influence of both FSI simulations and coronary dynamics is understudied. Methods: We first investigate the relationships between these twelve WSS derived metrics, stenosis percentage and lesion length through a parametric, transient CFD study. Secondly, we extend the parametric study to FSI, both with and without the addition of coronary dynamics, and assess their correlations. Finally, we present the case of a patient who underwent invasive coronary angiography and optical coherence tomography imaging at two time points 18 months apart. Associations between each of the twelve WSS derived metrics in CFD, static FSI and dynamic FSI simulations were assessed against areas of positive/negative vessel remodelling, and changes in plaque morphology. Results: 22–32% stenosis was the threshold beyond which adverse multi-directional/topological WSS results. Each metric produced a different relationship with changing stenoses and lesion length. Transient haemodynamics was impacted by coronary dynamics, with the topological shear variation index suppressed by up to 94%. These changes appear more critical at smaller stenosis levels, suggesting coronary dynamics could play a role in the earlier stages of atherosclerosis development. In the patient case, both dynamics and FSI vs CFD changes altered associations with measured changes in plaque morphology. An appendix of the linear fits between the various FSI- and CFD-based simulations is provided to assist in scaling CFD-based results to resemble the compliant walled characteristics of FSI more accurately. Conclusions: These results highlight the potential for coronary dynamics to alter multidirectional/topological WSS metrics which could impact associations with changes in coronary atherosclerosis over time. These results warrant further investigation in a wider range of morphological settings and longitudinal cohort studies in the future.Harry J. Carpenter, Mergen H. Ghayesha, Anthony C. Zander, Peter J. Psalti

CCD BV and 2MASS photometric study of the open cluster NGC 1513

We present CCD BV and JHK$_{s}$ 2MASS photometric data for the open cluster NGC 1513. We observed 609 stars in the direction of the cluster up to a limiting magnitude of $V\sim19$ mag. The star count method shows that the centre of the cluster lies at $\alpha_{2000}=04^{h}09^{m}36^{s}$, $\delta_{2000}=49^{\circ}28^{'}43^{''}$ and its angular size is $r=10$ arcmin. The optical and near-infrared two-colour diagrams reveal the colour excesses in the direction of the cluster as $E(B-V)=0.68\pm0.06$, $E(J-H)=0.21\pm0.02$ and $E(J-K_{s})=0.33\pm0.04$ mag. These results are consistent with normal interstellar extinction values. Optical and near-infrared Zero Age Main-Sequences (ZAMS) provided an average distance modulus of $(m-M)_{0}=10.80\pm0.13$ mag, which can be translated into a distance of $1440\pm80$ pc. Finally, using Padova isochrones we determined the metallicity and age of the cluster as $Z=0.015\pm 0.004$ ($[M/H]=-0.10 \pm 0.10$ dex) and $\log (t/yr) = 8.40\pm0.04$, respectively.Comment: 15 pages, 12 figures and 4 tables, accepted for publication in Astrophysics & Space Scienc

Anthropogenic Space Weather

Anthropogenic effects on the space environment started in the late 19th century and reached their peak in the 1960s when high-altitude nuclear explosions were carried out by the USA and the Soviet Union. These explosions created artificial radiation belts near Earth that resulted in major damages to several satellites. Another, unexpected impact of the high-altitude nuclear tests was the electromagnetic pulse (EMP) that can have devastating effects over a large geographic area (as large as the continental United States). Other anthropogenic impacts on the space environment include chemical release ex- periments, high-frequency wave heating of the ionosphere and the interaction of VLF waves with the radiation belts. This paper reviews the fundamental physical process behind these phenomena and discusses the observations of their impacts.Comment: 71 pages, 35 figure

Shape coexistence from lifetime and branching-ratio measurements in 68,70Ni

© 2016 The Author(s) Shape coexistence near closed-shell nuclei, whereby states associated with deformed shapes appear at relatively low excitation energy alongside spherical ones, is indicative of the rapid change in structure that can occur with the addition or removal of a few protons or neutrons. Near 68Ni (Z=28, N=40), the identification of shape coexistence hinges on hitherto undetermined transition rates to and from low-energy 0+ states. In 68,70Ni, new lifetimes and branching ratios have been measured. These data enable quantitative descriptions of the 0+ states through the deduced transition rates and serve as sensitive probes for characterizing their nuclear wave functions. The results are compared to, and consistent with, large-scale shell-model calculations which predict shape coexistence. With the firm identification of this phenomenon near 68Ni, shape coexistence is now observed in all currently accessible regions of the nuclear chart with closed proton shells and mid-shell neutrons

Functional Characterization of N297A, A Murine Surrogate for low-Fc Binding Anti-Human CD3 Antibodies

Several low- or non-FcR binding anti-human CD3 monoclonal antibodies have been under investigation for the treatment of autoimmune diseases. To model the mechanism of action of these anti-human CD3 mAbs in the murine system, an Fc-modified anti-mouse CD3 antibody (N297A) was generated. N297A exhibited similar biological effects as Fc-modified anti-human CD3 antibodies including rapid, reversible reduction in peripheral leukocyte numbers, differential modulation of activated versus resting T cells, and reduced levels of induced cytokine release compared to the non-Fc-modified parent antibody. In an in vivo model of colitis induced by adoptive transfer of IL–10-deficient cells, administration of N297A significantly reduced body weight loss. As N297A shared many functional characteristics of non-FcR binding anti-human CD3 mAbs both in vitro and in vivo, it provides a means to model the mechanisms of action of Fc-modified anti-human CD3 antibodies in mouse

Five principles for the practice of knowledge exchange in environmental management

This paper outlines five principles for effective practice of knowledge exchange, which when applied, have the potential to significantly enhance the impact of environmental management research, policy and practice. The paper is based on an empirical analysis of interviews with 32 researchers and stakeholders across 13 environmental management research projects, each of which included elements of knowledge co-creation and sharing in their design. The projects focused on a range of upland and catchment management issues across the UK, and included Research Council, Government and NGO funded projects. Preliminary findings were discussed with knowledge exchange professionals and academic experts to ensure the emerging principles were as broadly applicable as possible across multiple disciplines. The principles suggest that: knowledge exchange needs to be designed into research; the needs of likely research users and other stakeholders should be systematically represented in the research where possible; and long-term relationships must be built on trust and two-way dialogue between researchers and stakeholders in order to ensure effective co-generation of new knowledge. We found that the delivery of tangible benefits early on in the research process helps to ensure continued motivation and engagement of likely research users. Knowledge exchange is a flexible process that must be monitored, reflected on and continuously refined, and where possible, steps should be taken to ensure a legacy of ongoing knowledge exchange beyond initial research funding. The principles have been used to inform the design of knowledge exchange and stakeholder engagement guidelines for two international research programmes. They are able to assist researchers, decision-makers and other stakeholders working in contrasting environmental management settings to work together to co-produce new knowledge, and more effectively share and apply existing knowledge to manage environmental change

Detector Description and Performance for the First Coincidence Observations between LIGO and GEO

For 17 days in August and September 2002, the LIGO and GEO interferometer gravitational wave detectors were operated in coincidence to produce their first data for scientific analysis. Although the detectors were still far from their design sensitivity levels, the data can be used to place better upper limits on the flux of gravitational waves incident on the earth than previous direct measurements. This paper describes the instruments and the data in some detail, as a companion to analysis papers based on the first data.Comment: 41 pages, 9 figures 17 Sept 03: author list amended, minor editorial change

β-decay of odd-A Ti57 and V59

The β-decay of odd-A, neutron-rich Ti57 and V59 are studied. More precise β-decay half-lives of 98±5 and 97±2 ms are deduced for Ti57 and V59, respectively. In addition, β-delayed γ-ray spectroscopy is used to deduce β-decay branching ratios and establish the low-energy-level structures of the daughter nuclides. The new data for levels in V57 and Cr59 are compared with the results of shell-model calculations completed in the full pf model space. Both V57 and Cr59 show evidence of modest oblate deformation near the ground state

Development of new shell structure in pf-shell nuclei

β-delayed γ-ray measurements have been part of an experimental program at the NSCL to understand the role of the πf7/2 - νf5/2 proton-neutron monopole interaction in neutron-rich pf-shell nuclei above 48Ca. Central to this study has been an attempt to observe the development of new shell structure at N 32, 34 through the systematic observation of E(2+1 ) as a function of neutron number. Additionally, the ground state spin and parity of odd-odd and odd-A nuclei were interpreted in an extreme single-particle model to follow the monopole migration of the νf5/2 as protons are removed from the πf7/2state

Beta-delayed γ-ray studies of φf7/2 - νpf shell nuclei

We have utilized the selective process of β decay to populate low-energy excited states in the neutron-rich 22Ti, 23V, 24Cr, and 25Mn nuclei. The goal was to systematically track the monopole shift of the νf5/2 single-particle level with increased occupancy of the φf7/2 orbital.The β-decay properties of the parent nuclides, along with the low-energy structure of the daughters, are presented and compared with the results of shell model calculations employing the GXPF1 interaction