Effect of match-related contextual factors on positional performance in the national rugby league

Objectives: To examine the effects of match-related contextual variables on positional groups and success in the National Rugby League (NRL). Methods: Data relating to match location, match outcome, quality of opposition and match type (absolute score differential) from all matches across the 2015–2019 NRL seasons were collected, in addition to 14 previously identified Factors (technical performance indicators). A decision tree, grown using the Exhaustive Chi-square Automatic Interaction Detector (CHAID) algorithm, was used to model the effect of each of these match-related contexts on positional contribution according to match outcome. Results: The accuracy of the exhaustive CHAID model in explaining the influence of positional groups on match outcome was 66%. The model revealed four primary splits: interchange forwards, utility backs, adjustables and a group containing the remaining three positional groups (forwards, backs, and interchange). Conclusions: Results suggest that interchange forwards, utility backs and adjustables could have a definitive role within the team compared to the remaining positional groups in determining match outcome. In contrast to team-level research, there is a greater emphasis on the importance of defensive actions (e.g. try causes, tackles made) at a positional level than attacking performance indicators. The moderate classification accuracy justifies the use of this approach for examination of the interactions between match-related contextual variables, performance indicators and positional groups

Change-of-direction performance in elite soccer players:Preliminary analysis according to their playing positions

International audienceOur objective was to examine the relationship between change of direction (CoD) performance, with (CoDb), and without the ball (CoDwb), and selected measures of physical fitness (jump performance, speed, balance) in elite soccer players, according to players’ positions. Forty elite male soccer players performed the change-of-direction and acceleration test (CODAT) with (CODATb), and without the ball (CODATwb), 5- and 20-m sprint tests, the 5-jump test (5JT), and the Y-balance test (YBT). Analyses of the whole sample showed significant correlations between all CODAT measures (CODATwb and CODATb, respectively) and sprint 5-m (r = 0.72, p < 0.001; r = 0.52, p < 0.01), sprint 20-m (r = 0.54, p < 0.03; r = 0.45, p < 0.05), jump (r = -0.62, p < 0.01; r = -0.64, p < 0.01) and balance (r = -0.50, p < 0.01; r = -0.83, p < 0.001) performances. Correlations were significantly different between player positions (defender, midfielder and striker). When examining the entire sample, the single best predictor of CODATwb was performance in the 5-m test with an explained variance of 52% (p < 0.001). For CODATb, the Y-balance performance explained 68% of the variance of performance (p < 0.001). In conclusion, soccer coaches and fitness trainers are advised to improve players’ CoD using neuromuscular training that mimic crucial match actions. Meanwhile, CoD testing and training should be designed in line with the demands of playing position

Effects of Exercise Training on Bone Health Parameters in Individuals With Obesity:A Systematic Review and Meta-Analysis

International audienceBackground: Osteoporosis causes bone fragility, increasing the risk of fractures. Evidence suggests a strong correlation between obesity and fracture risk. Physical training is known to enhance bone resistance and protect from fracture; however, its osteogenic effect in the presence of obesity remains unknown.and nbsp;Objective: We sought to evaluate the influence of exercise training on bone health indices in individuals with obesity.and nbsp;Methods: This systematic literature search was conducted using common electronic databases from inception - December 2019. The following key terms (and synonyms searched for by the MeSH database) were included and combined using the operators "AND, " "OR, " "NOT ": [( "body mass index " OR obesity OR obese OR overweight OR fat mass) AND ( "bone mineral density " OR "bone mineral content " OR "peak bone mass " OR "mechanical loading " OR "Osteoporosis " OR "bone geometry " OR "bone resistance ") AND ( "exercise training " OR "physical training " OR "strength training, " OR "resistance training " OR "aerobic training " OR "combined training ")].and nbsp;Results: After screening, 10 studies (889 initial records) were included in the final analysis (8 different countries, 263 participants). Two studies investigated males, six females, and two, both sexes. The training duration was at least eight weeks with 2-3 sessions/week. Physical training displayed a significant trivial impact on the whole body (WB) BMD (0.13 SMD; 95% CI [0.00, 0.26], p = 0.046). Subgroup analyses indicated a significant small increase in the WB BMD (0.27 SMD; 95% CI [0.00, 0.53], p = 0.048) in the endurance training group, a non-significant trivial increase in the WB BMD (0.11 SMD; 95% CI [-0.06, 0.29], p = 0.203) in the resistance group, and a non-significant trivial increase in the WB BMD (0.03 SMD; 95% CI [-0.26, 0.32], p = 0.86) in the combined training group. In addition, a significant small decrease was found in the weight of trained subjects (-0.24 SMD; 95% CI [-0.42, -0.05], p = 0.011).and nbsp;Conclusion: Physical training has little to no effect on the WB BMD in subjects with overweight/obesity. Currently, insufficient evidence to advocate for any specific type of exercise for enhancing bone health exists for overweight/obese individuals. Investigations examining the impact of varying types of physical exercise on WB BMD of obese individuals are needed

Introduction: Shakespeare's public spheres

Habermas’ sense of a “cultural Public Sphere” is a notoriously complex term and, when applied to Early Modern cultures, needs careful definition. This essay both introduces the variety of methods by which we might approach playtexts with a view to their public – auditory – impact and contributes to a debate about an audience's understanding of Shakespeare's plays. By selecting two words and their spread of use in one play, Twelfth Night, we might appreciate the potential for meaningful ambiguity latent in how we hear the language of live performance. If we search for how certain terms (in this case, the cluster of semes derived from repetitions of “fancy” and “play”), we might find at times incompatible senses, yet we get near to appreciating the range of Early Modern dramatic language

Assessment of Virally Vectored Autoimmunity as a Biocontrol Strategy for Cane Toads

BACKGROUND: The cane toad, Bufo (Chaunus) marinus, is one of the most notorious vertebrate pests introduced into Australia over the last 200 years and, so far, efforts to identify a naturally occurring B. marinus-specific pathogen for use as a biological control agent have been unsuccessful. We explored an alternative approach that entailed genetically modifying a pathogen with broad host specificity so that it no longer caused disease, but carried a gene to disrupt the cane toad life cycle in a species specific manner. METHODOLOGY/PRINCIPAL FINDINGS: The adult beta globin gene was selected as the model gene for proof of concept of autoimmunity as a biocontrol method for cane toads. A previous report showed injection of bullfrog tadpoles with adult beta globin resulted in an alteration in the form of beta globin expressed in metamorphs as well as reduced survival. In B. marinus we established for the first time that the switch from tadpole to adult globin exists. The effect of injecting B. marinus tadpoles with purified recombinant adult globin protein was then assessed using behavioural (swim speed in tadpoles and jump length in metamorphs), developmental (time to metamorphosis, weight and length at various developmental stages, protein profile of adult globin) and genetic (adult globin mRNA levels) measures. However, we were unable to detect any differences between treated and control animals. Further, globin delivery using Bohle iridovirus, an Australian ranavirus isolate belonging to the Iridovirus family, did not reduce the survival of metamorphs or alter the form of beta globin expressed in metamorphs. CONCLUSIONS/SIGNIFICANCE: While we were able to show for the first time that the switch from tadpole to adult globin does occur in B. marinus, we were not able to induce autoimmunity and disrupt metamorphosis. The short development time of B. marinus tadpoles may preclude this approach

SARS Surveillance during Emergency Public Health Response, United States, March–July 2003

In response to the emergence of severe acute respiratory syndrome (SARS), the United States established national surveillance using a sensitive case definition incorporating clinical, epidemiologic, and laboratory criteria. Of 1,460 unexplained respiratory illnesses reported by state and local health departments to the Centers for Disease Control and Prevention from March 17 to July 30, 2003, a total of 398 (27%) met clinical and epidemiologic SARS case criteria. Of these, 72 (18%) were probable cases with radiographic evidence of pneumonia. Eight (2%) were laboratory-confirmed SARS-coronavirus (SARS-CoV) infections, 206 (52%) were SARS-CoV negative, and 184 (46%) had undetermined SARS-CoV status because of missing convalescent-phase serum specimens. Thirty-one percent (124/398) of case-patients were hospitalized; none died. Travel was the most common epidemiologic link (329/398, 83%), and mainland China was the affected area most commonly visited. One case of possible household transmission was reported, and no laboratory-confirmed infections occurred among healthcare workers. Successes and limitations of this emergency surveillance can guide preparations for future outbreaks of SARS or respiratory diseases of unknown etiology

The FAIR Guiding Principles for scientific data management and stewardship

There is an urgent need to improve the infrastructure supporting the reuse of scholarly data. A diverse set of stakeholders—representing academia, industry, funding agencies, and scholarly publishers—have come together to design and jointly endorse a concise and measureable set of principles that we refer to as the FAIR Data Principles. The intent is that these may act as a guideline for those wishing to enhance the reusability of their data holdings. Distinct from peer initiatives that focus on the human scholar, the FAIR Principles put specific emphasis on enhancing the ability of machines to automatically find and use the data, in addition to supporting its reuse by individuals. This Comment is the first formal publication of the FAIR Principles, and includes the rationale behind them, and some exemplar implementations in the community

Data from a pre-publication independent replication initiative examining ten moral judgement effects

We present the data from a crowdsourced project seeking to replicate findings in independent laboratories before (rather than after) they are published. In this Pre-Publication Independent Replication (PPIR) initiative, 25 research groups attempted to replicate 10 moral judgment effects from a single laboratory's research pipeline of unpublished findings. The 10 effects were investigated using online/lab surveys containing psychological manipulations (vignettes) followed by questionnaires. Results revealed a mix of reliable, unreliable, and culturally moderated findings. Unlike any previous replication project, this dataset includes the data from not only the replications but also from the original studies, creating a unique corpus that researchers can use to better understand reproducibility and irreproducibility in science

The pipeline project: Pre-publication independent replications of a single laboratory's research pipeline

This crowdsourced project introduces a collaborative approach to improving the reproducibility of scientific research, in which findings are replicated in qualified independent laboratories before (rather than after) they are published. Our goal is to establish a non-adversarial replication process with highly informative final results. To illustrate the Pre-Publication Independent Replication (PPIR) approach, 25 research groups conducted replications of all ten moral judgment effects which the last author and his collaborators had “in the pipeline” as of August 2014. Six findings replicated according to all replication criteria, one finding replicated but with a significantly smaller effect size than the original, one finding replicated consistently in the original culture but not outside of it, and two findings failed to find support. In total, 40% of the original findings failed at least one major replication criterion. Potential ways to implement and incentivize pre-publication independent replication on a large scale are discussed

Shared genetic risk between eating disorder- and substance-use-related phenotypes:Evidence from genome-wide association studies

First published: 16 February 202