Why dig looted tombs? Two examples and some answers from Keushu (Ancash highlands, Peru)

Looted tombs at Andean archaeological sites are largely the result of a long tradition of trade in archaeological artefacts coupled with the 17th century policy of eradicating ancestor veneration and destroying mortuary evidence in a bid to “extirpate idolatry”. On the surface, looted funerary contexts often present abundant disarticulated and displaced human remains as well as an apparent absence of mortuary accoutrements. What kind of information can archaeologists and biological anthropologists hope to gather from such contexts? In order to gauge the methodological possibilities and interpretative limitations of targeting looted tombs, we fully excavated two collective funerary contexts at the archaeological site of Keushu (district and province of Yungay, Ancash, Peru; c. 2000 B.C.-A.D. 1600), which includes several dozen tombs, many built under large boulders or rock shelters, all of which appear disturbed by looting. The first is located in the ceremonial sector and excavation yielded information on four individuals; the second, in the funerary and residential sector, held the remains of seventy individuals - adults and juveniles. Here, we present and discuss the recovered data and suggest that careful, joint excavations by archaeologists and biological anthropologists can retrieve evidence of past mortuary practices, aid the biological characterisation of mortuary populations and help distinguish between a broad range of looting practices and post-depositional processes

Development and Validation of a Risk Score for Chronic Kidney Disease in HIV Infection Using Prospective Cohort Data from the D:A:D Study

Ristola M. on työryhmien DAD Study Grp ; Royal Free Hosp Clin Cohort ; INSIGHT Study Grp ; SMART Study Grp ; ESPRIT Study Grp jäsen.Background Chronic kidney disease (CKD) is a major health issue for HIV-positive individuals, associated with increased morbidity and mortality. Development and implementation of a risk score model for CKD would allow comparison of the risks and benefits of adding potentially nephrotoxic antiretrovirals to a treatment regimen and would identify those at greatest risk of CKD. The aims of this study were to develop a simple, externally validated, and widely applicable long-term risk score model for CKD in HIV-positive individuals that can guide decision making in clinical practice. Methods and Findings A total of 17,954 HIV-positive individuals from the Data Collection on Adverse Events of Anti-HIV Drugs (D:A:D) study with >= 3 estimated glomerular filtration rate (eGFR) values after 1 January 2004 were included. Baseline was defined as the first eGFR > 60 ml/min/1.73 m2 after 1 January 2004; individuals with exposure to tenofovir, atazanavir, atazanavir/ritonavir, lopinavir/ritonavir, other boosted protease inhibitors before baseline were excluded. CKD was defined as confirmed (>3 mo apart) eGFR In the D:A:D study, 641 individuals developed CKD during 103,185 person-years of follow-up (PYFU; incidence 6.2/1,000 PYFU, 95% CI 5.7-6.7; median follow-up 6.1 y, range 0.3-9.1 y). Older age, intravenous drug use, hepatitis C coinfection, lower baseline eGFR, female gender, lower CD4 count nadir, hypertension, diabetes, and cardiovascular disease (CVD) predicted CKD. The adjusted incidence rate ratios of these nine categorical variables were scaled and summed to create the risk score. The median risk score at baseline was -2 (interquartile range -4 to 2). There was a 1: 393 chance of developing CKD in the next 5 y in the low risk group (risk score = 5, 505 events), respectively. Number needed to harm (NNTH) at 5 y when starting unboosted atazanavir or lopinavir/ritonavir among those with a low risk score was 1,702 (95% CI 1,166-3,367); NNTH was 202 (95% CI 159-278) and 21 (95% CI 19-23), respectively, for those with a medium and high risk score. NNTH was 739 (95% CI 506-1462), 88 (95% CI 69-121), and 9 (95% CI 8-10) for those with a low, medium, and high risk score, respectively, starting tenofovir, atazanavir/ritonavir, or another boosted protease inhibitor. The Royal Free Hospital Clinic Cohort included 2,548 individuals, of whom 94 individuals developed CKD (3.7%) during 18,376 PYFU (median follow-up 7.4 y, range 0.3-12.7 y). Of 2,013 individuals included from the SMART/ESPRIT control arms, 32 individuals developed CKD (1.6%) during 8,452 PYFU (median follow-up 4.1 y, range 0.6-8.1 y). External validation showed that the risk score predicted well in these cohorts. Limitations of this study included limited data on race and no information on proteinuria. Conclusions Both traditional and HIV-related risk factors were predictive of CKD. These factors were used to develop a risk score for CKD in HIV infection, externally validated, that has direct clinical relevance for patients and clinicians to weigh the benefits of certain antiretrovirals against the risk of CKD and to identify those at greatest risk of CKD.Peer reviewe

Embodying bioarchaeology: theory and practice

Bioarchaeolog

Integrating identities: An innovative bioarchaeological and biogeochemical approach to analyzing the multiplicity of identities in the mortuary record

Despite our instinctive understanding of the importance of “identity,” archaeologists and bioarchaeologists continue to struggle to rigorously investigate this complex phenomenon. Here, we present a contextualized multiscalar bioarchaeological approach to studying identities in the past—individual and group, mutable and immutable—through the mortuary record. We argue that, while many scholars have moved beyond the single-focus study, archaeological individuals themselves are still neglected. A contextualized bioarchaeological approach brings together a variety of methods to investigate aspects of individual and group identities, provides a means of accessing biological facets of identity, and allows for more nuanced understanding of the complexities of social identities. We illustrate the utility of our model with a case study using archaeological, bioarchaeological, and biogeochemical data from northern Chile, stressing both the fixed and the dynamic aspects of different identities. We focus on the tumultuous transition between the Middle Horizon (AD 500–1100) and Late Intermediate Period (AD 1100–1400) in northern Chile’s San Pedro de Atacama oases and the neighboring upper Loa River Valley. Our research demonstrates a shift toward homogenizing representations of social identities as well as biological aspects of identities as societies began reformulating their social groups following the end of the complex and cosmopolitan Middle Horizon

The sequence of human occupation in the atacama oases, chile: A radiocarbon chronology based on human skeletal remains

The San Pedro de Atacama oases have been permanently occupied since ca. 2500 B.P. and over this time developed a rich culture that was intertwined with social developments in the south-central Andes. However, despite decades of archaeological research, the region still lacks a strong chronological framework based on absolute dates. Here we present 53 new AMS ,14C dates from osteological remains from San Pedro de Atacama, in order to contribute to an understanding of the Atacameno cultural sequence. These dates suggest that some cemeteries were occupied for long periods, frequently transcending cultural phases, and that in fact a number of cemeteries within the same ayllu were in use concurrently. We also show that, not surprisingly, population displacement through time primarily follows oscillations in the sources of water. The new information presented here suggests that future work in the region should emphasize detailed analyses that consider intra-ayllu variability, given that diversity within periods is masked by the uniform use of cultural phases to describe human development. © 2013 by the Society for American Archaeology

The sequence of human occupation in the atacama oases, chile: A radiocarbon chronology based on human skeletal remains

The San Pedro de Atacama oases have been permanently occupied since ca. 2500 B.P. and over this time developed a rich culture that was intertwined with social developments in the south-central Andes. However, despite decades of archaeological research, the region still lacks a strong chronological framework based on absolute dates. Here we present 53 new AMS , C dates from osteological remains from San Pedro de Atacama, in order to contribute to an understanding of the Atacameno cultural sequence. These dates suggest that some cemeteries were occupied for long periods, frequently transcending cultural phases, and that in fact a number of cemeteries within the same ayllu were in use concurrently. We also show that, not surprisingly, population displacement through time primarily follows oscillations in the sources of water. The new information presented here suggests that future work in the region should emphasize detailed analyses that consider intra-ayllu variability, given that diversity within periods is masked by the uniform use of cultural phases to describe human development. © 2013 by the Society for American Archaeology. 1

Eating out or dining in: modeling diverse dietary strategies in the Middle Period, San Pedro de Atacama, Chile

The Middle Period of the Atacama oases, North Chile, has been characterized as a time of peace, uniform abundance, and widespread access to exotic materials. In the present work, we test this notion through a comparison of Middle Period human isotopic data (δ13Cco, δ15Nco, and δ13Cap) representing two distinct ayllus, Solcor and Tchecar, in the San Pedro de Atacama oases. We employ Bayesian mixture modeling of individual-level isotopic data to quantify and compare dietary composition within and between the cemetery populations of these two contemporary locales. Ultimately, our research shows that dietary diversity, which we take as a proxy for differential levels of participation in long-distance exchange or the access to the products thereof, was unequally distributed, and that the supposedly uniform richness of the Middle Period was similarly discontinuous. While average isotopic values for the two ayllus were similar, variance within each differed significantly, as did variance in dietary composition arrived at through modeling. By all measures, the individuals interred in Solcor 3 had more varied diets, particularly in terms of carbohydrate-rich plants, than their contemporaries interred at Tchecar Túmulo Sur, suggesting that more individuals from Solcor 3 had greater participation in/access to long-distance exchange networks. Besides providing novel insights into the lived experience of the Middle Period residents of far northern Chile, this work also demonstrates the power of Bayesian mixture modeling for the reconstruction of individual paleodiet