Novel functions for Rab GTPases in multiple aspects of tumour progression

Rab GTPases are master regulators of intracellular trafficking and, in recent years, their role in the control of different aspects of tumour progression has emerged. In the present review, we show that Rab GTPases are disregulated in many cancers and have central roles in tumour cell migration, invasion, proliferation, communication with stromal cells and the development of drug resistance. As a consequence, Rab proteins may be novel potential candidates for the development of anticancer drugs and, in this context, the preliminary results obtained with an inhibitor of Rab function are also discussed

The [alpha/Fe] Ratios in Dwarf Galaxies: Evidence for a Non-universal Stellar Initial Mass Function?

It is well established that the [alpha/Fe] ratios in elliptical galaxies increase with galaxy mass. This relation holds also for early-type dwarf galaxies, although it seems to steepen at low masses. The [alpha/Fe] vs. mass relation can be explained assuming that smaller galaxies form over longer timescales (downsizing), allowing a larger amount of Fe (mostly produced by long-living Type Ia Supernovae) to be released and incorporated into newly forming stars. Another way to obtain the same result is by using a flatter initial mass function (IMF) in large galaxies, increasing in this way the number of Type II Supernovae and therefore the production rate of alpha-elements. The integrated galactic initial mass function (IGIMF) theory predicts that the higher the star formation rate, the flatter the IMF. We have checked, by means of semi-analytical calculations, that the IGIMF theory, combined with the downsizing effect (i.e. the shorter duration of the star formation in larger galaxies), well reproduces the observed [alpha/Fe] vs. mass relation. In particular, we show a steepening of this relation in dwarf galaxies, in accordance with the available observations.Comment: 4 pages, 2 figures; to appear in the proceedings of the JENAM 2010 Symposium on Dwarf Galaxies (Lisbon, September 9-10, 2010

Is the interstellar gas of starburst galaxies well mixed?

The extent to which the ISM in galaxies is well mixed is not yet settled. Measured metal abundances in the diffuse neutral gas of star--forming gas--rich dwarf galaxies are deficient with respect to that of the ionized gas. The reasons, if real, are not clear and need to be based on firm grounds. Far-UV spectroscopy of giant HII regions such as NGC604 in the spiral galaxy M33 using FUSE allows us to investigate possible systematic errors in the metallicity derivation. We still find underabundances of nitrogen, oxygen, argon, and iron in the neutral phase by a factor of~6. This could either be explained by the presence of less chemically evolved gas pockets in the sightlines or by dense clouds out of which HIIregions form. Those could be more metallic than the diffuse medium.Comment: 4 pages, 2 figures;contribution to Starbursts: from 30 Dor to Lyman Break Galaxies, 6 -10 September 2004, Institute of Astronomy, University of Cambridge, U

Everyday cosmopolitanism in representations of Europe among young Romanians in Britain

The paper presents an analysis of everyday cosmopolitanism in constructions of Europe among young Romanian nationals living in Britain. Adopting a social representations approach, cosmopolitanism is understood as a cultural symbolic resource that is part of everyday knowledge. Through a discursively-oriented analysis of focus group data, we explore the ways in which notions of cosmopolitanism intersect with images of Europeanness in the accounts of participants. We show that, for our participants, representations of Europe are anchored in an Orientalist schema of West-vs.-East, whereby the West is seen as epitomising European values of modernity and progress, while the East is seen as backward and traditional. Our findings further show that representations of cosmopolitanism reinforce this East/West dichotomy, within a discourse of ‘Occidental cosmopolitanism’. The paper concludes with a critical discussion of the diverse and complex ideological foundations of these constructions of European cosmopolitanism and their implications

The stellar and sub-stellar IMF of simple and composite populations

The current knowledge on the stellar IMF is documented. It appears to become top-heavy when the star-formation rate density surpasses about 0.1Msun/(yr pc^3) on a pc scale and it may become increasingly bottom-heavy with increasing metallicity and in increasingly massive early-type galaxies. It declines quite steeply below about 0.07Msun with brown dwarfs (BDs) and very low mass stars having their own IMF. The most massive star of mass mmax formed in an embedded cluster with stellar mass Mecl correlates strongly with Mecl being a result of gravitation-driven but resource-limited growth and fragmentation induced starvation. There is no convincing evidence whatsoever that massive stars do form in isolation. Various methods of discretising a stellar population are introduced: optimal sampling leads to a mass distribution that perfectly represents the exact form of the desired IMF and the mmax-to-Mecl relation, while random sampling results in statistical variations of the shape of the IMF. The observed mmax-to-Mecl correlation and the small spread of IMF power-law indices together suggest that optimally sampling the IMF may be the more realistic description of star formation than random sampling from a universal IMF with a constant upper mass limit. Composite populations on galaxy scales, which are formed from many pc scale star formation events, need to be described by the integrated galactic IMF. This IGIMF varies systematically from top-light to top-heavy in dependence of galaxy type and star formation rate, with dramatic implications for theories of galaxy formation and evolution.Comment: 167 pages, 37 figures, 3 tables, published in Stellar Systems and Galactic Structure, Vol.5, Springer. This revised version is consistent with the published version and includes additional references and minor additions to the text as well as a recomputed Table 1. ISBN 978-90-481-8817-

The interplay between ionized gas and massive stars in the HII galaxy IIZw70: integral field spectroscopy with PMAS

We performed an integral field spectroscopic study for the HII galaxy IIZw70 in order to investigate the interplay between its ionized interstellar medium (ISM) and the massive star formation (SF). Observations were taken in the optical spectral range (3700-6800 A) with the Potsdam Multi-Aperture Spectrophotometer (PMAS) attached to the 3.5 m telescope at CAHA. We created and analysed maps of spatially distributed emission-lines, continuum emission and properties of the ionized ISM (e.g. physical-chemical conditions, dust extinction, kinematics). We investigated the relation of these properties to the spatial distribution and evolutionary stage of the massive stars. For the first time we have detected the presence of Wolf-Rayet (WR) stars in this galaxy. The peak of the ionized gas emission coincides with the location of the WR bump. The region of the galaxy with lower dust extinction corresponds to the region that shows the lowest values of velocity dispersion and radial velocity. The overall picture suggests that the ISM of this region is being disrupted via photoionization and stellar winds, leading to a spatial decoupling between gas+stars and dust clouds. The bulk of dust appears to be located at the boundaries of the region occupied by the probable ionizing cluster. We also found that this region is associated to the nebular emission in HeII4686 and to the intensity maximum of most emission lines. This indicates that the hard ionizing radiation responsible for the HeII4686 nebular emission can be related to the youngest stars. Within $\sim$ 0.4 x 0.3 kpc^2 in the central burst, we derived O/H using direct determinations of Te[OIII]. We found abundances in the range 12+log(O/H)=7.65-8.05, yielding an error-weighted mean of 12+log(O/H)=7.86 $\pm$0.05.Comment: 10 pages, 10 figures, accepted for publication in A&A, minor changes adde

On the dust abundance gradients in late-type galaxies: I. Effects of destruction and growth of dust in the interstellar medium

We present basic theoretical constraints on the effects of destruction by supernovae (SNe) and growth of dust grains in the interstellar medium (ISM) on the radial distribution of dust in late-type galaxies. The radial gradient of the dust-to-metals ratio is shown to be essentially flat (zero) if interstellar dust is not destroyed by SN shock waves and all dust is produced in stars. If there is net dust destruction by SN shock waves, the dust-to-metals gradient is flatter than or equal to the metallicity gradient (assuming the gradients have the same sign). Similarly, if there is net dust growth in the ISM, then the dust-to-metals gradient is steeper than or equal to the metallicity gradient. The latter result implies that if dust gradients are steeper than metallicity gradients, i.e., the dust-to-metals gradients are not flat, then it is unlikely dust destruction by SN shock waves is an efficient process, while dust growth must be a significant mechanism for dust production. Moreover, we conclude that dust-to-metals gradients can be used as a diagnostic for interstellar dust growth in galaxy discs, where a negative slope indicates dust growth.Comment: 12 pages, 4 figures. Accepted for publication in MNRA

Color and stellar population gradients in galaxies. Correlation with mass

We analyze the color gradients (CGs) of ~50000 nearby SDSS galaxies. From synthetic spectral models based on a simplified star formation recipe, we derive the mean spectral properties, and explain the observed radial trends of the color as gradients of the stellar population age and metallicity (Z). The most massive ETGs (M_* > 10^{11} Msun) have shallow CGs in correspondence of shallow (negative) Z gradients. In the stellar mass range 10^(10.3-10.5) < M_* < 10^(11) Msun, the Z gradients reach their minimum of ~ -0.5 dex^{-1}. At M_* ~ 10^{10.3-10.5} Msun, color and Z gradient slopes suddenly change. They turn out to anti-correlate with the mass, becoming highly positive at the very low masses. We have also found that age gradients anti-correlate with Z gradients, as predicted by hierarchical cosmological simulations for ETGs. On the other side, LTGs have gradients which systematically decrease with mass (and are always more negative than in ETGs), consistently with the expectation from gas infall and SN feedback scenarios. Z is found to be the main driver of the trend of color gradients, especially for LTGs, but age gradients are not negligible and seem to play a significant role too. We have been able to highlight that older galaxies have systematically shallower age and Z gradients than younger ones. Our results for high-mass galaxies are in perfect agreement with predictions based on the merging scenario, while the evolution of LTGs and younger and less massive ETGs seems to be mainly driven by infall and SN feedback. (Abridged)Comment: 20 pages, 16 figures, accepted for publication on MNRAS. This version includes revisions after the referee's report

Star forming dwarf galaxies

Star forming dwarf galaxies (SFDGs) have a high gas content and low metallicities, reminiscent of the basic entities in hierarchical galaxy formation scenarios. In the young universe they probably also played a major role in the cosmic reionization. Their abundant presence in the local volume and their youthful character make them ideal objects for detailed studies of the initial stellar mass function (IMF), fundamental star formation processes and its feedback to the interstellar medium. Occasionally we witness SFDGs involved in extreme starbursts, giving rise to strongly elevated production of super star clusters and global superwinds, mechanisms yet to be explored in more detail. SFDGs is the initial state of all dwarf galaxies and the relation to the environment provides us with a key to how different types of dwarf galaxies are emerging. In this review we will put the emphasis on the exotic starburst phase, as it seems less important for present day galaxy evolution but perhaps fundamental in the initial phase of galaxy formation.Comment: To appear in JENAM Symposium "Dwarf Galaxies: Keys to Galaxy Formation and Evolution", P. Papaderos, G. Hensler, S. Recchi (eds.). Lisbon, September 2010, Springer Verlag, in pres

Top-heavy integrated galactic stellar initial mass functions (IGIMFs) in starbursts

Star formation rates (SFR) larger than 1000 Msun/ yr are observed in extreme star bursts. This leads to the formation of star clusters with masses > 10^6 Msun in which crowding of the pre-stellar cores may lead to a change of the stellar initial mass function (IMF). Indeed, the large mass-to-light ratios of ultra-compact dwarf galaxies and recent results on globular clusters suggest the IMF to become top-heavy with increasing star-forming density. We explore the implications of top-heavy IMFs in these very massive and compact systems for the integrated galactic initial mass function (IGIMF), which is the galaxy-wide IMF, in dependence of the star-formation rate of galaxies. The resulting IGIMFs can have slopes, alpha_3, for stars more massive than about 1 Msun between 1.5 and the Salpeter slope of 2.3 for an embedded cluster mass function (ECMF) slope (beta) of 2.0, but only if the ECMF has no low-mass clusters in galaxies with major starbursts. Alternatively, beta would have to decrease with increasing SFR >10 Msun/ yr such that galaxies with major starbursts have a top-heavy ECMF. The resulting IGIMFs are within the range of observationally deduced IMF variations with redshift.Comment: Accepted for publication in MNRAS, reference adde