613 research outputs found
Patients Attitude to Technology: A Way to Improve Hydrocephalus Management and Follow up Using Smartphone Intelligent Application
Smartphone applications (”apps”) have become ubiquitous with the advent of smartphones and tablets in recent years.Increasingly the utility of these apps is being explored in healthcare delivery. Hydrocephalus is a condition that is usually followed by a neurosurgeon for the patient’s life. We explore patient acceptability of a mobile app as an adjunct to outpatient follow-up of patients with hydrocephalus. A questionnaire was circulated amongst patients with hydrocephalus (adults and children). Patients were asked questions about their hydrocephalus; expectations for outpatient follow up, whether they have smartphone/tablet/internet access and whether they would be interested in a mobile app for their long term hydrocephalus
follow up. 191 patients completed questionnaires, 98 respondents were adults (mean age 46.1) and 93 were children less than 18 years old (mean age 8). Overall 36.1% of patients did not know the cause of their hydrocephalus. 96.7% have a shunt. 76.5% of adults and 80.6% of children had 1-4 shunt surgeries, 14.3% of adults and 11.8% of children had 5-9 shunt surgeries, 3.1% of adults and 5.4% of children had 10-14 shunt surgeries. 71.7% of patients expect to be followedup routinely in clinic for life. All children had smartphones or tablets, compared to 86.7% of adults. Children were more interested in a hydrocephalus app, 84.9% saying yes, compared to 71.4% of adults. Adults who were not interested in the app did not have a smartphone or tablet. Hydrocephalus management is a lifelong task and innovations in technology for engaging patients in its management are vital. The majority of patients are interested in mobile apps for outpatient management of hydrocephalus. We will follow this up with a feasibility study of a custom designed hydrocephalus app
Extending scientific computing system with structural quantum programming capabilities
We present a basic high-level structures used for developing quantum
programming languages. The presented structures are commonly used in many
existing quantum programming languages and we use quantum pseudo-code based on
QCL quantum programming language to describe them. We also present the
implementation of introduced structures in GNU Octave language for scientific
computing. Procedures used in the implementation are available as a package
quantum-octave, providing a library of functions, which facilitates the
simulation of quantum computing. This package allows also to incorporate
high-level programming concepts into the simulation in GNU Octave and Matlab.
As such it connects features unique for high-level quantum programming
languages, with the full palette of efficient computational routines commonly
available in modern scientific computing systems. To present the major features
of the described package we provide the implementation of selected quantum
algorithms. We also show how quantum errors can be taken into account during
the simulation of quantum algorithms using quantum-octave package. This is
possible thanks to the ability to operate on density matrices
Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species
Antigenic variation enables pathogens to avoid the host immune response by continual switching of surface proteins. The protozoan blood parasite Trypanosoma brucei causes human African trypanosomiasis ("sleeping sickness") across sub-Saharan Africa and is a model system for antigenic variation, surviving by periodically replacing a monolayer of variant surface glycoproteins (VSG) that covers its cell surface. We compared the genome of Trypanosoma brucei with two closely related parasites Trypanosoma congolense and Trypanosoma vivax, to reveal how the variant antigen repertoire has evolved and how it might affect contemporary antigenic diversity. We reconstruct VSG diversification showing that Trypanosoma congolense uses variant antigens derived from multiple ancestral VSG lineages, whereas in Trypanosoma brucei VSG have recent origins, and ancestral gene lineages have been repeatedly co-opted to novel functions. These historical differences are reflected in fundamental differences between species in the scale and mechanism of recombination. Using phylogenetic incompatibility as a metric for genetic exchange, we show that the frequency of recombination is comparable between Trypanosoma congolense and Trypanosoma brucei but is much lower in Trypanosoma vivax. Furthermore, in showing that the C-terminal domain of Trypanosoma brucei VSG plays a crucial role in facilitating exchange, we reveal substantial species differences in the mechanism of VSG diversification. Our results demonstrate how past VSG evolution indirectly determines the ability of contemporary parasites to generate novel variant antigens through recombination and suggest that the current model for antigenic variation in Trypanosoma brucei is only one means by which these parasites maintain chronic infections
An Empirical Study of Bots in Software Development -- Characteristics and Challenges from a Practitioner's Perspective
Software engineering bots - automated tools that handle tedious tasks - are
increasingly used by industrial and open source projects to improve developer
productivity. Current research in this area is held back by a lack of consensus
of what software engineering bots (DevBots) actually are, what characteristics
distinguish them from other tools, and what benefits and challenges are
associated with DevBot usage. In this paper we report on a mixed-method
empirical study of DevBot usage in industrial practice. We report on findings
from interviewing 21 and surveying a total of 111 developers. We identify three
different personas among DevBot users (focusing on autonomy, chat interfaces,
and "smartness"), each with different definitions of what a DevBot is, why
developers use them, and what they struggle with. We conclude that future
DevBot research should situate their work within our framework, to clearly
identify what type of bot the work targets, and what advantages practitioners
can expect. Further, we find that there currently is a lack of general purpose
"smart" bots that go beyond simple automation tools or chat interfaces. This is
problematic, as we have seen that such bots, if available, can have a
transformative effect on the projects that use them.Comment: To be published at the ACM Joint European Software Engineering
Conference and Symposium on the Foundations of Software Engineering
(ESEC/FSE
Revival of the magnetar PSR J1622-4950: observations with MeerKAT, Parkes, XMM-Newton, Swift, Chandra, and NuSTAR
New radio (MeerKAT and Parkes) and X-ray (XMM-Newton, Swift, Chandra, and
NuSTAR) observations of PSR J1622-4950 indicate that the magnetar, in a
quiescent state since at least early 2015, reactivated between 2017 March 19
and April 5. The radio flux density, while variable, is approximately 100x
larger than during its dormant state. The X-ray flux one month after
reactivation was at least 800x larger than during quiescence, and has been
decaying exponentially on a 111+/-19 day timescale. This high-flux state,
together with a radio-derived rotational ephemeris, enabled for the first time
the detection of X-ray pulsations for this magnetar. At 5%, the 0.3-6 keV
pulsed fraction is comparable to the smallest observed for magnetars. The
overall pulsar geometry inferred from polarized radio emission appears to be
broadly consistent with that determined 6-8 years earlier. However, rotating
vector model fits suggest that we are now seeing radio emission from a
different location in the magnetosphere than previously. This indicates a novel
way in which radio emission from magnetars can differ from that of ordinary
pulsars. The torque on the neutron star is varying rapidly and unsteadily, as
is common for magnetars following outburst, having changed by a factor of 7
within six months of reactivation.Comment: Published in ApJ (2018 April 5); 13 pages, 4 figure
Physics, Topology, Logic and Computation: A Rosetta Stone
In physics, Feynman diagrams are used to reason about quantum processes. In
the 1980s, it became clear that underlying these diagrams is a powerful analogy
between quantum physics and topology: namely, a linear operator behaves very
much like a "cobordism". Similar diagrams can be used to reason about logic,
where they represent proofs, and computation, where they represent programs.
With the rise of interest in quantum cryptography and quantum computation, it
became clear that there is extensive network of analogies between physics,
topology, logic and computation. In this expository paper, we make some of
these analogies precise using the concept of "closed symmetric monoidal
category". We assume no prior knowledge of category theory, proof theory or
computer science.Comment: 73 pages, 8 encapsulated postscript figure
The MeerKAT telescope as a pulsar facility: System verification and early science results from MeerTime
We describe system verification tests and early science results from the pulsar processor (PTUSE) developed for the newly commissioned 64-dish SARAO MeerKAT radio telescope in South Africa. MeerKAT is a high-gain ( ) low-system temperature ( ) radio array that currently operates at 580–1 670 MHz and can produce tied-array beams suitable for pulsar observations. This paper presents results from the MeerTime Large Survey Project and commissioning tests with PTUSE. Highlights include observations of the double pulsar , pulse profiles from 34 millisecond pulsars (MSPs) from a single 2.5-h observation of the Globular cluster Terzan 5, the rotation measure of Ter5O, a 420-sigma giant pulse from the Large Magellanic Cloud pulsar PSR , and nulling identified in the slow pulsar PSR J0633–2015. One of the key design specifications for MeerKAT was absolute timing errors of less than 5 ns using their novel precise time system. Our timing of two bright MSPs confirm that MeerKAT delivers exceptional timing. PSR exhibits a jitter limit of whilst timing of PSR over almost 11 months yields an rms residual of 66 ns with only 4 min integrations. Our results confirm that the MeerKAT is an exceptional pulsar telescope. The array can be split into four separate sub-arrays to time over 1 000 pulsars per day and the future deployment of S-band (1 750–3 500 MHz) receivers will further enhance its capabilities
Evidence for a vector charmonium-like state in
We report the measurement of via
initial-state radiation using a data sample of an integrated luminosity of
921.9 fb collected with the Belle detector at the and
nearby. We find evidence for an enhancement with a 3.4 significance in
the invariant mass of The measured mass and width
are
and ,
respectively. The mass, width, and quantum numbers of this enhancement are
consistent with the charmonium-like state at 4626 MeV/ recently reported
by Belle in The product of the cross section and the branching fraction of
is measured from
threshold to 5.6 GeV.Comment: 9 pages, 4 figure
Measurement of the Branching Fraction of the Decay in Fully Reconstructed Events at Belle
We present an analysis of the exclusive
decay, where represents an
electron or a muon, with the assumption of charge-conjugation symmetry and
lepton universality. The analysis uses the full data sample
collected by the Belle detector, corresponding to 711 fb of integrated
luminosity. We select the events by fully reconstructing one meson in
hadronic decay modes, subsequently determining the properties of the other
meson. We extract the signal yields using a binned maximum-likelihood fit to
the missing-mass squared distribution in bins of the invariant mass of the two
pions or the momentum transfer squared. We measure a total branching fraction
of , where the
uncertainties are statistical and systematic, respectively. This result is the
first reported measurement of this decay.Comment: 23 pages, 19 figure
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