Light bosons and photospheric solutions to the solar abundance problem

It is well known that current spectroscopic determinations of the chemical composition of the Sun are starkly at odds with the metallicity implied by helioseismology. We investigate whether the discrepancy may be due to conversion of photons to a new light boson in the solar photosphere. We examine the impact of particles with axion-like interactions with the photon on the inferred photospheric abundances, showing that resonant axion-photon conversion is not possible in the region of the solar atmosphere in which line-formation occurs. Although non-resonant conversion in the line-forming regions can in principle impact derived abundances, constraints from axion-photon conversion experiments rule out the couplings necessary for these effects to be detectable. We show that this extends to hidden photons and chameleons (which would exhibit similar phenomenological behaviour), ruling out known theories of new light bosons as photospheric solutions to the solar abundance problem.Comment: 11 pages, PDFLaTeX. v2: Major revision. Inclusion of refractive index effect on photon-ALP conversion strengthens our conclusion that such an effect cannot explain the solar abundance problem with a coupling allowed by experimental axion-like particle searches. We now include a discussion of chameleons and hidden photons, with similar conclusion

New Results on Standard Solar Models

We describe the current status of solar modelling and focus on the problems originated with the introduction of solar abundance determinations with low CNO abundance values. We use models computed with solar abundance compilations obtained during the last decade, including the newest published abundances by Asplund and collaborators. Results presented here make focus both on helioseismic properties and the models as well as in the neutrino fluxes predictions. We also discuss changes in radiative opacities to restore agreement between helioseismology, solar models, and solar abundances and show the effect of such modifications on solar neutrino fluxes.Comment: 9 pages. Review talk presented at "Synergies between solar and stellar modelling", Rome, June 2009. To be published by Astrophysics and Space Scienc

Mutation of pescadillo Disrupts Oligodendrocyte Formation in Zebrafish

Background: In vertebrates, the myelin sheath is essential for efficient propagation of action potentials along the axon shaft. Oligodendrocytes are the cells of the central nervous system that create myelin sheaths. During embryogenesis, ventral neural tube precursors give rise to oligodendrocyte progenitor cells, which divide and migrate throughout the central nervous system. This study aimed to investigate mechanisms that regulate oligodendrocyte progenitor cell formation. Methodology/Principal Findings: By conducting a mutagenesis screen in transgenic zebrafish, we identified a mutation, designated vu166, by an apparent reduction in the number of oligodendrocyte progenitor cells in the dorsal spinal cord. We subsequently determined that vu166 is an allele of pescadillo, a gene known to play a role in ribosome biogenesis and cell proliferation. We found that pescadillo function is required for both the proper number of oligodendrocyte progenitors to form, by regulating cell cycle progression, and for normal levels of myelin gene expression. Conclusions/Significance: Our data provide evidence that neural precursors require pes function to progress through th

The effect of membrane curvature on the conformation of antimicrobial peptides: implications for binding and the mechanism of action

Short cationic antimicrobial peptides (AMPs) are believed to act either by inducing transmembrane pores or disrupting membranes in a detergent-like manner. For example, the antimicrobial peptides aurein 1.2, citropin 1.1, maculatin 1.1 and caerin 1.1, despite being closely related, appear to act by fundamentally different mechanisms depending on their length. Using molecular dynamics simulations, the structural properties of these four peptides have been examined in solution as well as in a variety of membrane environments. It is shown that each of the peptides has a strong preference for binding to regions of high membrane curvature and that the structure of the peptides is dependent on the degree of local curvature. This suggests that the shorter peptides aurein 1.2 and citropin 1.1 act via a detergent-like mechanism because they can induce high local, but not long-range curvature, whereas the longer peptides maculatin 1.1 and caerin 1.1 require longer range curvature to fold and thus bind to and stabilize transmembrane pores

TESS and ESPRESSO discover a super-Earth and a mini-Neptune orbiting the K-dwarf TOI-238

The number of super-Earth and mini-Neptune planet discoveries has increased significantly in the last two decades thanks to transit and radial velocity surveys. When it is possible to apply both techniques, we can characterise the internal composition of exoplanets, which in turn provides unique insights on their architecture, formation and evolution. We performed a combined photometric and radial velocity analysis of TOI-238 (TYC 6398-132-1), which has one short-orbit super-Earth planet candidate announced by NASA's TESS team. We aim to confirm its planetary nature using radial velocities taken with the ESPRESSO and HARPS spectrographs, to measure its mass and to detect the presence of other possible planetary companions. We carried out a joint analysis by including Gaussian processes and Keplerian orbits to account for the stellar activity and planetary signals simultaneously. We detected the signal induced by TOI-238 b in the radial velocity time-series, and the presence of a second transiting planet, TOI-238 c, whose signal appears in RV and TESS data. TOI-238 b is a planet with a radius of 1.402$^{+0.084}_{-0.086}$ R$_{\oplus}$ and a mass of 3.40$^{+0.46}_{-0.45}$ M$_{\oplus}$. It orbits at a separation of 0.02118 $\pm$ 0.00038 AU of its host star, with an orbital period of 1.2730988 $\pm$ 0.0000029 days, and has an equilibrium temperature of 1311 $\pm$ 28 K. TOI-238 c has a radius of 2.18$\pm$ 0.18 R$_{\oplus}$ and a mass of 6.7 $\pm$ 1.1 M$_{\oplus}$. It orbits at a separation of 0.0749 $\pm$ 0.0013 AU of its host star, with an orbital period of 8.465652 $\pm$ 0.000031 days, and has an equilibrium temperature of 696 $\pm$ 15 K. The mass and radius of planet b are fully consistent with an Earth-like composition, making it likely a rocky super-Earth. Planet c could be a water-rich planet or a rocky planet with a small H-He atmosphere.Comment: 33 pages, 31 figures, 5 tables. Accepted for publication at A&

Computational Identification of Uncharacterized Cruzain Binding Sites

Chagas disease, caused by the unicellular parasite Trypanosoma cruzi, claims 50,000 lives annually and is the leading cause of infectious myocarditis in the world. As current antichagastic therapies like nifurtimox and benznidazole are highly toxic, ineffective at parasite eradication, and subject to increasing resistance, novel therapeutics are urgently needed. Cruzain, the major cysteine protease of Trypanosoma cruzi, is one attractive drug target. In the current work, molecular dynamics simulations and a sequence alignment of a non-redundant, unbiased set of peptidase C1 family members are used to identify uncharacterized cruzain binding sites. The two sites identified may serve as targets for future pharmacological intervention

Perspectives in Global Helioseismology, and the Road Ahead

We review the impact of global helioseismology on key questions concerning the internal structure and dynamics of the Sun, and consider the exciting challenges the field faces as it enters a fourth decade of science exploitation. We do so with an eye on the past, looking at the perspectives global helioseismology offered in its earlier phases, in particular the mid-to-late 1970s and the 1980s. We look at how modern, higher-quality, longer datasets coupled with new developments in analysis, have altered, refined, and changed some of those perspectives, and opened others that were not previously available for study. We finish by discussing outstanding challenges and questions for the field.Comment: Invited review; to appear in Solar Physics (24 pages, 6 figures

Autoantibodies against type I IFNs in patients with life-threatening COVID-19

Interindividual clinical variability in the course of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is vast. We report that at least 101 of 987 patients with life-threatening coronavirus disease 2019 (COVID-19) pneumonia had neutralizing immunoglobulin G (IgG) autoantibodies (auto-Abs) against interferon-w (IFN-w) (13 patients), against the 13 types of IFN-a (36), or against both (52) at the onset of critical disease; a few also had auto-Abs against the other three type I IFNs. The auto-Abs neutralize the ability of the corresponding type I IFNs to block SARS-CoV-2 infection in vitro. These auto-Abs were not found in 663 individuals with asymptomatic or mild SARS-CoV-2 infection and were present in only 4 of 1227 healthy individuals. Patients with auto-Abs were aged 25 to 87 years and 95 of the 101 were men. A B cell autoimmune phenocopy of inborn errors of type I IFN immunity accounts for life-threatening COVID-19 pneumonia in at least 2.6% of women and 12.5% of men