Quasi-periodic oscillations in accreting magnetic white dwarfs: I. Observational constraints in X-ray and optical

International audienceQuasi-periodic oscillations (QPOs) are observed in the optical flux of some polars with typical periods of 1 to 3 s but none have been observed yet in X-rays where a significant part of the accreting energy is released. QPOs are expected and predicted from shock oscillations. Most of the polars have been observed by the XMM-Newton satellite. We made use of the homogeneous set of observations of the polars by XMM-Newton to search for the presence of QPOs in the (0.5–10 keV) energy range and to set significant upper limits for the brightest X-ray polars. We extracted high time-resolution X-ray light curves by taking advantage of the 0.07 s resolution of the EPIC-PN camera. Among the 65 polars observed with XMM-Newton from 1998 to 2012, a sample of 24 sources was selected on the basis of their counting rate in the PN instrument to secure significant limits. We searched for QPOs using Fast Fourier Transform (FFT) methods and defined limits of detection using statistical tools. Among the sample surveyed, none shows QPOs at a significant level. Upper limits to the fractional flux in QPOs range from 7% to 71%. These negative results are compared to the detailed theoretical predictions of numerical simulations based on a 2D hydrodynamical code presented in Paper II. Cooling instabilities in the accretion column are expected to produce shock quasi-oscillations with a maximum amplitude reaching ~40% in the bremsstrahlung (0.5–10 keV) X-ray emission and ~20% in the optical cyclotron emission. The absence of X-ray QPOs imposes an upper limit of ~(5–10) g cm-2 s-1 on the specific accretion rate but this condition is found inconsistent with the value required to account for the amplitudes and frequencies of the observed optical QPOs. This contradiction outlines probable shortcomings with the shock instability model

Pregnancy in the lab

No matter your career stage, pregnancy in the lab raises complex questions - and definitive answers are hard to come by. In conversation with members of , we share our experience, discuss research into the challenges and move the conversation to the support needed by people who are pregnant. We conclude that community is critical to improve experiences

Fast quasi-periodic oscillations in the eclipsing polar VV Puppis from VLT and XMM-Newton observations

International audienceWe present high time resolution optical photometric data of the polar VV Puppis obtained simultaneously in three filters (u′, HeII λ4686, r′) with the ULTRACAM camera mounted at the ESO-VLT telescope. An analysis of a long 50 ks XMM-Newton observation of the source, retrieved from the database, is also provided. Quasi-periodic oscillations (QPOs) are clearly detected in the optical during the source bright phase intervals when the accreting pole is visible, confirming the association of the QPOs with the basis of the accretion column. QPOs are detected in the three filters at a mean frequency of ∼0.7 Hz with a similar amplitude ∼1%. Mean orbitally-averaged power spectra during the bright phase show a rather broad excess with a quality factor Q = ν/Δν = 5−7 but smaller data segments commonly show a much higher coherency with Q up to 30. The X-ray Multi-mirror Mission XMM (0.5–10 keV) observation provides the first accurate estimation of the hard X-ray component with a high kT ∼ 40 keV temperature and confirms the high extreme ultraviolet (EUV)-soft/hard ratio in the range of 4−15 for VV Pup. The detailed X-ray orbital light curve displays a short Δϕ ≃ 0.05 ingress into self-eclipse of the active pole, indicative of an accretion shock height of ∼75 km. No significant X-ray QPOs are detected with an amplitude upper limit of ∼30% in the range 0.1–5 Hz. Detailed hydrodynamical numerical simulations of the post-shock accretion region with parameters consistent with VV Pup demonstrate that the expected frequencies from radiative instability are identical for X-rays and optical regime at values ν ∼ 40–70 Hz, more than one order magnitude higher than observed. This confirms previous statements suggesting that present instability models are unable to explain the full QPO characteristics within the parameters commonly known for polars

Quasi-periodic oscillations in accreting magnetic white dwarfs II. The asset of numerical modelling for interpreting observations

Magnetic cataclysmic variables are close binary systems containing a strongly magnetized white dwarf that accretes matter coming from an M-dwarf companion. High-energy radiation coming from those objects is emitted from the accretion column close to the white dwarf photosphere at the impact region. Its properties depend on the characteristics of the white dwarf and an accurate accretion column model allows the properties of the binary system to be inferred, such as the white dwarf mass, its magnetic field, and the accretion rate. We study the temporal and spectral behaviour of the accretion region and use the tools we developed to accurately connect the simulation results to the X-ray and optical astronomical observations. The radiation hydrodynamics code Hades was adapted to simulate this specific accretion phenomena. Classical approaches were used to model the radiative losses of the two main radiative processes: bremsstrahlung and cyclotron. The oscillation frequencies and amplitudes in the X-ray and optical domains are studied to compare those numerical results to observational ones. Different dimensional formulae were developed to complete the numerical evaluations. The complete characterization of the emitting region is described for the two main radiative regimes: when only the bremsstrahlung losses and when both cyclotron and bremsstrahlung losses are considered. The effect of the non-linear cooling in- stability regime on the accretion column behaviour is analysed. Variation in luminosity on short timescales (~ 1 s quasi-periodic oscillations) is an expected consequence of this specific dynamic. The importance of secondary shock instability on the quasi-periodic oscillation phenomenon is discussed. The stabilization effect of the cyclotron process is confirmed by our numerical simulations, as well as the power distribution in the various modes of oscillation.Comment: 13 pages, 13 figures, 2 tables. Accepted for publication in A&

Reliability and validity of three questionnaires measuring context-specific sedentary behaviour and associated correlates in adolescents, adults and older adults

BACKGROUND: Reliable and valid measures of total sedentary time, context-specific sedentary behaviour (SB) and its potential correlates are useful for the development of future interventions. The purpose was to examine test-retest reliability and criterion validity of three newly developed questionnaires on total sedentary time, context-specific SB and its potential correlates in adolescents, adults and older adults. METHODS: Reliability and validity was tested in six different samples of Flemish (Belgium) residents. For the reliability study, 20 adolescents, 22 adults and 20 older adults filled out the age-specific SB questionnaire twice. Test-retest reliability was analysed using Kappa coefficients, Intraclass Correlation Coefficients and/or percentage agreement, separately for the three age groups. For the validity study, data were retrieved from 62 adolescents, 33 adults and 33 older adults, with activPAL as criterion measure. Spearman correlations and Bland-Altman plots (or non-parametric approach) were used to analyse criterion validity, separately for the three age groups and for weekday, weekend day and average day. RESULTS: The test-retest reliability for self-reported total sedentary time indicated following values: ICC = 0.37-0.67 in adolescents; ICC = 0.73-0.77 in adults; ICC = 0.68-0.80 in older adults. Item-specific reliability results (e.g. context-specific SB and its potential correlates) showed good-to-excellent reliability in 67.94%, 68.90% and 66.38% of the items in adolescents, adults and older adults respectively. All items belonging to sedentary-related equipment and simultaneous SB showed good reliability. The sections of the questionnaire with lowest reliability were: context-specific SB (adolescents), potential correlates of computer use (adults) and potential correlates of motorized transport (older adults). Spearman correlations between self-reported total sedentary time and the activPAL were different for each age group: rho = 0.02-0.42 (adolescents), rho = 0.06-0.52 (adults), rho = 0.38-0.50 (older adults). Participants over-reported total sedentary time (except for weekend day in older adults) compared to the activPAL, for weekday, weekend day and average day respectively by +57.05%, +46.29%, +53.34% in adolescents; +40.40%, +19.15%, +32.89% in adults; +10.10%, -6.24%, +4.11% in older adults. CONCLUSIONS: The questionnaires showed acceptable test-retest reliability and criterion validity. However, over-reporting of total SB was noticeable in adolescents and adults. Nevertheless, these questionnaires will be useful in getting context-specific information on SB

Systematic comparative validation of self-report measures of sedentary time against an objective measure of postural sitting (activPAL)

Background: Sedentary behaviour is a public health concern that requires surveillance and epidemiological research. For such large scale studies, self-report tools are a pragmatic measurement solution. A large number of self-report tools are currently in use, but few have been validated against an objective measure of sedentary time and there is no comparative information between tools to guide choice or to enable comparison between studies. The aim of this study was to provide a systematic comparison, generalisable to all tools, of the validity of self-report measures of sedentary time against a gold standard sedentary time objective monitor. Methods: Cross sectional data from three cohorts (N = 700) were used in this validation study. Eighteen self-report measures of sedentary time, based on the TAxonomy of Self-report SB Tools (TASST) framework, were compared against an objective measure of postural sitting (activPAL) to provide information, generalizable to all existing tools, on agreement and precision using Bland-Altman statistics, on criterion validity using Pearson correlation, and on data loss. Results: All self-report measures showed poor accuracy compared with the objective measure of sedentary time, with very wide limits of agreement and poor precision (random error > 2.5 h). Most tools under-reported total sedentary time and demonstrated low correlations with objective data. The type of assessment used by the tool, whether direct, proxy, or a composite measure, influenced the measurement characteristics. Proxy measures (TV time) and single item direct measures using a visual analogue scale to assess the proportion of the day spent sitting, showed the best combination of precision and data loss. The recall period (e.g. previous week) had little influence on measurement characteristics. Conclusion: Self-report measures of sedentary time result in large bias, poor precision and low correlation with an objective measure of sedentary time. Choice of tool depends on the research context, design and question. Choice can be guided by this systematic comparative validation and, in the case of population surveillance, it recommends to use a visual analog scale and a 7 day recall period. Comparison between studies and improving population estimates of average sedentary time, is possible with the comparative correction factors provided

Tripodal transmembrane transporters for bicarbonate

Easy-to-make tripodal tris-thiourea receptors based upon tris(2-aminoethyl)amine are capable of chloride/bicarbonate transport and as such represent a new class of bicarbonate transport agent.<br/

A synthetic ion transporter that disrupts autophagy and induces apoptosis by perturbing cellular chloride concentrations

Perturbations in cellular chloride concentrations can affect cellular pH, autophagy and lead to the onset of apoptosis. With this in mind synthetic ion transporters have been used to disturb cellular ion homeostasis and thereby induce cell death; however, it is not clear whether synthetic ion transporters can also be used to disrupt autophagy. Here we show that squaramide-based ion transporters enhance the transport of chloride anions in liposomal models and promote sodium chloride influx into the cytosol. Liposomal and cellular transport activity of the squaramides is shown to correlate with cell death activity, which is attributed to caspase-dependent apoptosis. One ion transporter was also shown to cause additional changes in the lysosomal pH which leads to impairment of lysosomal enzyme activity and disruption of autophagic processes. This disruption is independent of the initiation of apoptosis by the ion transporter. This study provides the first experimental evidence that synthetic ion transporters can disrupt both autophagy and induce apoptosis

Validity and reliability of subjective methods to assess sedentary behaviour in adults: a systematic review and meta-analysis.

BACKGROUND: Subjective measures of sedentary behaviour (SB) (i.e. questionnaires and diaries/logs) are widely implemented, and can be useful for capturing type and context of SBs. However, little is known about comparative validity and reliability. The aim of this systematic review and meta-analysis was to: 1) identify subjective methods to assess overall, domain- and behaviour-specific SB, and 2) examine the validity and reliability of these methods. METHODS: The databases MEDLINE, EMBASE and SPORTDiscus were searched up to March 2020. Inclusion criteria were: 1) assessment of SB, 2) evaluation of subjective measurement tools, 3) being performed in healthy adults, 4) manuscript written in English, and 5) paper was peer-reviewed. Data of validity and/or reliability measurements was extracted from included studies and a meta-analysis using random effects was performed to assess the pooled correlation coefficients of the validity. RESULTS: The systematic search resulted in 2423 hits. After excluding duplicates and screening on title and abstract, 82 studies were included with 75 self-reported measurement tools. There was wide variability in the measurement properties and quality of the studies. The criterion validity varied between poor-to-excellent (correlation coefficient [R] range - 0.01- 0.90) with logs/diaries (R = 0.63 [95%CI 0.48-0.78]) showing higher criterion validity compared to questionnaires (R = 0.35 [95%CI 0.32-0.39]). Furthermore, correlation coefficients of single- and multiple-item questionnaires were comparable (1-item R = 0.34; 2-to-9-items R = 0.35; ≥10-items R = 0.37). The reliability of SB measures was moderate-to-good, with the quality of these studies being mostly fair-to-good. CONCLUSION: Logs and diaries are recommended to validly and reliably assess self-reported SB. However, due to time and resources constraints, 1-item questionnaires may be preferred to subjectively assess SB in large-scale observations when showing similar validity and reliability compared to longer questionnaires. REGISTRATION NUMBER: CRD42018105994

POLAR project: Numerical modeling of the accretion column

International audienc