45 research outputs found
International consensus guidelines for the diagnosis and management of food protein–induced enterocolitis syndrome: Executive summary—Workgroup Report of the Adverse Reactions to Foods Committee, American Academy of Allergy, Asthma & Immunology
- Author
- Allen Katrina
- Atkins Dan
- Bahna Sami
- Barad Ashis V.
- Berin Cecilia
- Brown Whitehorn Terri
- Burks A. Wesley
- Caubet Jean-Christoph
- Chehade Mirna
- Cianferoni Antonella
- Conte Marisa
- Davis Carla
- Fiocchi Alessandro
- Greenhawt Matthew
- Grimshaw Kate
- Groetch Marion E.
- Gupta Ruchi
- Hofmeister Brittany
- Hwang
- Katz Yitzhak
- Konstantinou George N.
- Leonard Stephanie A.
- Lightdale Jennifer
- McGhee Sean
- Mehr Sami
- Monti Giovanno
- Muraro Antonella
- Noel Stacey Katherine
- Nomura Ichiro
- Noone Sally
- Nowak-Węgrzyn Anna
- Sampson Hugh A.
- Schultz Fallon
- Sicherer Scott H.
- Sopo Stefano Miceli
- Spergel Jonathan M.
- Thompson Cecilia C.
- Turner Paul J.
- Venter Carina
- Westcott-Chavez A. Amity
- Wood Robert A.
- Publication venue
- Publication date
- 01/01/2017
- Field of study
Food protein-induced enterocolitis (FPIES) is a non-IgE cell- mediated food allergy that can be severe and lead to shock. Despite the potential seriousness of reactions, awareness of FPIES is low; high-quality studies providing insight into the pathophysiology, diagnosis, and management are lacking; and clinical outcomes are poorly established. This consensus document is the result of work done by an international workgroup convened through the Adverse Reactions to Foods Committee of the American Academy of Allergy, Asthma & Immunology and the International FPIES Association advocacy group. These are the first international evidence-based guidelines to improve the diagnosis and management of patients with FPIES. Research on prevalence, pathophysiology, diagnostic markers, and future treatments is necessary to improve the care of patients with FPIES. These guidelines will be updated periodically as more evidence becomes available
2018 Scholars at Work Conference Program
- Author
- Bakke Abigail
- Bergstrom Kelly
- Campana Kristie L.
- Cohen Rachel
- Dennis Jeffery
- Epplen Sarah
- Hanel Rachael
- Hardwick Jonathan
- Houlihan Daniel
- Judkins Jaxson
- Kasahara Grace Mariko
- Kerber Anne
- Lafata Carl
- Land Allison M.
- Lassonde Karla A.
- Mahowald Megan
- Maki Laura
- Martensen Brian
- Martin Justine
- Mosher Luke
- Pluskwik Elizabeth
- Pope-Ruark Rebecca
- Reding Noreen
- Schmachtenberger Ellsbeth
- Seth Kristel
- Sharlin David
- Smith Brittany
- Stark Emily
- Turner Jennifer M.
- Vaughan Tyler
- Wallace Teri
- Wang Yuezhou
- Wiley Diane
- Publication venue
- Cornerstone: A Collection of Scholarly and Creative Works for Minnesota State University, Mankato
- Publication date
- 30/03/2018
- Field of study
Program for the 2018 Scholars at Work Conference at Minnesota State University, Mankato on March 30, 2018
2020 American College of Rheumatology Guideline for the Management of Reproductive Health in Rheumatic and Musculoskeletal Diseases
- Author
- Barbhaiya Medha
- Bermas Bonnie L.
- Bettendorf Brittany
- Birru Talabi Mehret
- Branch D. Ware
- Buyon Jill
- Chakravarty Eliza E.
- Chambers Christina
- Christopher‐stine Lisa
- Clowse Megan E. B.
- Crow‐hercher Rachelle
- Cush John
- Druzin Maurice
- D’Anci Kristen E.
- Eudy Amanda
- Guyatt Gordon
- Jayatilleke Arundathi
- Kavanaugh Arthur
- Laskin Carl A.
- Lockshin Michael D.
- Marder Wendy
- Plante Lauren
- Salmon Jane
- Sammaritano Lisa R.
- Shah Amit Aakash
- Simard Julia
- Somers Emily C.
- Steen Virginia
- Sullivan Nancy
- Tarter Laura L.
- Tedeschi Sara K.
- Turgunbaev Marat
- Turner Amy
- Vinet Evelyne
- White C. Whitney
- Yazdany Jinoos
- Publication venue
- 'Wiley'
- Publication date
- 01/04/2020
- Field of study
Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/154675/1/art41191.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/154675/2/art41191_am.pd
Disruption of Mitochondrial DNA Replication in Drosophila Increases Mitochondrial Fast Axonal Transport In Vivo
- Author
- A Atlante
- A Ebneth
- A Hansson
- A Heddi
- A Mansouri
- AB Knott
- AD Pilling
- AE Senior
- AF Davis
- AL Gott
- AYN Goldstein
- B Iyengar
- B Iyengar
- BM Paschal
- Bradley D. Hammond
- Brittany A. Turner
- C Adan
- CD Gajewski
- D Liu
- DC Samuels
- DJ Klionsky
- DL Lewis
- DR Klopfenstein
- DTW Chang
- F Ferreirinha
- F Legros
- F Martinez-Azorin
- F Piccioni
- G Davidzon
- J Betts
- J Verburg
- JA Smeitink
- JM Goddard
- JM Shoffner
- KE Miller
- KE Miller
- KJ De Vos
- Kyle E. Miller
- Laurie S. Kaguni
- LS Goldstein
- LS Kaguni
- M Amiri
- M Escobar-Khondiker
- M Kundu
- M McKenzie
- Mary B. Rheuben
- ME Fisher
- Mel B. Feany
- MF Beal
- MJ Longley
- N Ashley
- N Hirokawa
- P Luoma
- PJ Hollenbeck
- PT Luoma
- RD Vale
- Rehan M. Baqri
- RH Baloh
- RK Naviaux
- RK Naviaux
- RL Friede
- S DiMauro
- S Ochs
- S Sanyal
- SL Mironov
- ST Brady
- ST Sweeney
- T Harrower
- W Lewis
- Y Wang
- Publication venue
- Public Library of Science
- Publication date
- 01/01/2009
- Field of study
Mutations in mitochondrial DNA polymerase (pol γ) cause several progressive human diseases including Parkinson's disease, Alper's syndrome, and progressive external ophthalmoplegia. At the cellular level, disruption of pol γ leads to depletion of mtDNA, disrupts the mitochondrial respiratory chain, and increases susceptibility to oxidative stress. Although recent studies have intensified focus on the role of mtDNA in neuronal diseases, the changes that take place in mitochondrial biogenesis and mitochondrial axonal transport when mtDNA replication is disrupted are unknown. Using high-speed confocal microscopy, electron microscopy and biochemical approaches, we report that mutations in pol γ deplete mtDNA levels and lead to an increase in mitochondrial density in Drosophila proximal nerves and muscles, without a noticeable increase in mitochondrial fragmentation. Furthermore, there is a rise in flux of bidirectional mitochondrial axonal transport, albeit with slower kinesin-based anterograde transport. In contrast, flux of synaptic vesicle precursors was modestly decreased in pol γ−α mutants. Our data indicate that disruption of mtDNA replication does not hinder mitochondrial biogenesis, increases mitochondrial axonal transport, and raises the question of whether high levels of circulating mtDNA-deficient mitochondria are beneficial or deleterious in mtDNA diseases
2019 Scholars at Work Conference Program
- Author
- Anton Alexander
- Arsznov Bradley
- Bakke Abigail
- Bates Rebecca
- Beschorner Beth
- Campana Kristie L.
- Cariveau Yvonne
- Cato A. Marie
- Chen Leon
- Chiou H Sheen
- Dennis Jeffery P.
- Elliott Kathryn S.
- Epplen Sarah
- Fuller Rachelle
- Gehling Jackie
- Gordillo Adriana
- Hanel Rachael
- Hoy Aaron
- Jacobi Laura
- Judkins Jaxson
- Kim Oksana
- Krumwiede Norma
- Kruse Sarah L. Klammer
- Lahlum Lori Ann
- Langley Moses M.
- Lassonde Karla A.
- Lopez Rivera Alma G.
- Lybeck Rick
- McAlarnen Michelle M.
- McCullough Mark
- McCutchen Chad
- Miller Carrie Lewis
- Miller Liz
- Mixon Daardi Sizemore
- Mollenkopf-Pigsley Christine
- Parks Sara
- Pluskwik Elizabeth
- Rickels Alyssa
- Royle Colleen
- Sauter Emily
- Schalge Susan
- Schomberg Jessica
- Smith Brittany
- Stark Emily
- Tiernan Jen
- Turner Jennifer M.
- Veltsos Christophe
- Veltsos Jennifer
- Whitney Dawn
- Winstead Vincent
- Zhu Ke
- Publication venue
- Cornerstone: A Collection of Scholarly and Creative Works for Minnesota State University, Mankato
- Publication date
- 29/03/2019
- Field of study
Program for the 2019 Scholars at Work Conference at Minnesota State University, Mankato on March 29, 2019
Black race as a predictor of poor health outcomes among a national cohort of HIV/AIDS patients admitted to US hospitals: a cohort study
- Author
- AJ Muir
- AK Nakashima
- AL Estrada
- AL Estrada
- BJ Turner
- Brittany R Makos
- BS Kennedy
- CA Benson
- Carolyn M Brown
- Centers for Disease Control and Prevention
- Centers for Disease Control and Prevention
- Centers for Disease Control and Prevention
- Centers for Disease Control and Prevention
- Centers for Disease Control and Prevention
- Christine U Oramasionwu
- Christopher R Frei
- CU Oramasionwu
- D Nash
- DC Lemly
- DT Fleming
- E Vittinghoff
- EG Bing
- FJ Hellinger
- FJ Hellinger
- FJ Palella Jr
- FJ Palella Jr
- GA Cabral
- GM Lucas
- GM McQuillan
- HI Hall
- HI Hall
- HK Monga
- I De Alba
- JA Cook
- JA Fleishman
- JC Keruly
- Jeff Skinner
- JJ Wu
- JM Blair
- JN Wasserheit
- Jonathan M Hunter
- K Buchacz
- KA Bonuck
- KA Fenton
- KA Gebo
- KA McGinnis
- Kenneth A Lawson
- Laurajo Ryan
- MA Fischl
- NA Merriman
- PD Stein
- R Palacios
- RS Gupta
- RS Levine
- S Jain
- TP Giordano
- W Alazawi
- W McFarland
- WE Cunningham
- WM Hlaing
- YW Chiu
- Publication venue
- BioMed Central
- Publication date
- 01/01/2009
- Field of study
BACKGROUND: In general, the Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome (HIV/AIDS) population has begun to experience the benefits of highly active antiretroviral therapy (HAART); unfortunately, these benefits have not extended equally to Blacks in the United States, possibly due to differences in patient comorbidities and demographics. These differences include rates of hepatitis B and C infection, substance use, and socioeconomic status. To investigate the impact of these factors, we compared hospital mortality and length of stay (LOS) between Blacks and Whites with HIV/AIDS while adjusting for differences in these key characteristics.
METHODS: The 1996-2006 National Hospital Discharge Surveys were used to identify HIV/AIDS patients admitted to US hospitals. Survey weights were incorporated to provide national estimates. Patients < 18 years of age, those who left against medical advice, those with an unknown discharge disposition and those with a LOS < 1 day were excluded. Patients were stratified into subgroups by race (Black or White). Two multivariable logistic regression models were constructed with race as the independent variable and outcomes (mortality and LOS > 10 days) as the dependent variables. Factors that were significantly different between Blacks and Whites at baseline via bivariable statistical tests were included as covariates.
RESULTS: In the general US population, there are approximately 5 times fewer Blacks than Whites. In the present study, 1.5 million HIV/AIDS hospital discharges were identified and Blacks were 6 times more likely to be hospitalized than Whites. Notably, Blacks had higher rates of substance use (30% vs. 24%; P < 0.001), opportunistic infections (27% vs. 26%; P < 0.001) and cocaine use (13% vs. 5%; P < 0.001). Conversely, fewer Blacks were co-infected with hepatitis C virus (8% vs. 12%; P < 0.001). Hepatitis B virus was relatively infrequent (3% for both groups). Crude mortality rates were similar for both cohorts (5%); however, a greater proportion of Blacks had a LOS > 10 days (21% vs. 19%; P < 0.001). Black race, in the presence of comorbidities, was correlated with a higher odds of LOS > 10 days (OR, 95% CI = 1.20 [1.10-1.30]), but was not significantly correlated with a higher odds of mortality (OR, 95% CI = 1.07 [0.93-1.25]).
CONCLUSION: Black race is a predictor of LOS > 10 days, but not mortality, among HIV/AIDS patients admitted to US hospitals. It is possible that racial disparities in hospital outcomes may be closing with time
Genome-wide Analyses Identify KIF5A as a Novel ALS Gene
- Author
- A. Nazli Basak
- A. Nazli Basak
- Aaron D. Gitler
- Aaron D. Gitler
- Aaron G. Day-Williams
- Adriano Chio
- Adriano Chiò
- Ahmad Al Kheifat
- Alan E. Renton
- Albert C. Ludolph
- Alberto Garcia Redondo
- Alberto García-Redondo
- Alberto M. Rivera
- Aleksey Shatunov
- Aleksey Shatunov
- Alessandra Chesi
- Alessandro Arosio
- Alex LeNail
- Alexander LeNail
- Alexander Sherman
- Alexis Brice
- Alfredo Iacoangeli
- Alya R. Raphael
- Amelia Conte
- Ammar Al-Chalabi
- Ammar Al-Chalabi
- Andrea Calvo
- Andrea Calvo
- Andrea Malaspina
- Andrea Malaspina
- Andrea Swenson
- Andrew B. Singleton
- Andrew King
- Andrew S. Allen
- Angela L. Jones
- Angelo Pirisi
- Anna Ticca
- Anne Cooley
- Anneloor L.M.A. ten Asbroek
- Annelot Dekker
- Antonia Ratti
- Antonia Ratti
- Antonino Cannas
- Antonio Canosa
- Antonio Fasano
- Antonio Ilardi
- Antonio Milia
- Antonio Petrucci
- Aoife Kenna
- Athina Soragia Gkazi
- Aude Nicolas
- Avinash Abhyankar
- Avindra Nath
- Barbara Castellotti
- Barbara Poletti
- Bas Middelkoop
- Bas Middelkoop
- Braden E. Boone
- Bradley N. Smith
- Brendan J. Kenna
- Brian J. Krueger
- Brittany N. Lasseigne
- Bryan J. Traynor
- Carla Caredda
- Carla Pani
- Carlayne Jackson
- Carlo Ferrarese
- Caroline Vance
- Chris Shaw
- Christian Lunetta
- Christian Lunetta
- Christine Clayman
- Christopher B. Brady
- Christopher E. Shaw
- Cinzia Bertolin
- Cinzia Femiano
- Cinzia Gellera
- Cinzia Gellera
- Cinzia Tiloca
- Cinzia Tiloca
- Claire Troakes
- Claudia Caponnetto
- Claudia Caponnetto
- Claudia Colombrita
- Claudia Ricci
- Clive N. Svendsen
- Clive N. Svendsen
- Corey McMillan
- Cristiane de Araujo Martins Moreno
- Cristina Cereda
- Cristina Cereda
- Cristina Moglia
- Daniel J. MacGowan
- Daniel J.L. MacGowan
- Daniela Corongiu
- Daniela Loi
- David B. Goldstein
- David B. Goldstein
- David B. Goldstein
- David J. Stone
- David Lacomis
- David Walk
- Dena G. Hernandez
- Denis C. Bauer
- Dhruv Sareen
- Dhruv Sareen
- Diane McKenna-Yasek
- Diane McKenna-Yasek
- Edward B. Lee
- Efthimios Dardiotis
- Ekaterina Rogaeva
- Elizabeth T. Cirulli
- Emanuela Costantino
- Emilien Bernard
- Emily Baxi
- Emily Baxi
- Emmeline Lagrange
- Enzo Ortu
- Eran Hornstein
- Ericka Simpson
- Ericka Simpson
- Erik P. Pioro
- Erik Pioro
- Ernest Fraenkel
- Ernest Fraenkel
- Ernest Fraenkel
- Eva L. Feldman
- Evadnie Rampersaud
- Evadnie Rampersaud
- Fabio Giannini
- Fabiola De Marchi
- Fabrizio Pisano
- Fabrizio Salvi
- Fabrizio Salvi
- Faraz Faghri
- Federico Casale
- Federico Verde
- Federico Verde
- Francesca L. Conforti
- Francesca L. Conforti
- Francesca Trojsi
- Francesca Trojsi
- Francesco Landi
- Francesco Marrosu
- Francesco O. Logullo
- Francesco O. Logullo
- Franco Taroni
- Franco Taroni
- Frank Baas
- Frank Baas
- Freya Kamel
- Gabriele Mora
- Gabriele Mora
- Gabriele Siciliano
- Gabriella Restagno
- Gang Wu
- Gang Wu
- Garth A. Nicholson
- George Manousakis
- Giacomo P. Comi
- Giacomo P. Comi
- Giancarlo Logroscino
- Gianluca Floris
- Gianluigi Mancardi
- Gianni Sorarù
- Gianni Sorarù
- Gijs Tazelaar
- Gioacchino Tedeschi
- Giorgia Querin
- Giovanni Piccirillo
- Giuseppe Borghero
- Giuseppe Borghero
- Giuseppe Fuda
- Giuseppe Lauria
- Giuseppe Lauria
- Giuseppe Lauria Pinter
- Giuseppe Marangi
- Giuseppe Marangi
- Giuseppe Marrali
- Glenn Gerhard
- Gregory A. Cox
- Gregory M. Cooper
- Guy A. Rouleau
- Guy A. Rouleau
- Gwendal Lemasson
- Gérard Besson
- Hannah A. Pliner
- Hannu Laaksovirta
- Hemali Phatnani
- Hemali Phatnani
- Hisham Hamdalla
- Ian P. Blair
- Ian P. Blair
- Ilaria Bartolomei
- Irene Ossola
- Isabella Fogh
- Isabella Fogh
- Isabella L. Simone
- Isabella Simone
- Isabelle Le Ber
- J. Paul Taylor
- J. Paul Taylor
- J. Raphael Gibbs
- Jack R. Wimbish
- Jacob McCauley
- Jacqueline de Belleroche
- James Broach
- James Caress
- James D. Berry
- James D. Berry
- James D. Berry
- James R. Broach
- Jan H. Veldink
- Jan Veldink
- Janel O. Johnson
- Janice A. Dominov
- Janine Kirby
- Jaya Trivedi
- Jeannine Heckmann
- Jeffrey D. Rothstein
- Jeffrey D. Rothstein
- Jeffrey Statland
- Jennifer A. Fifita
- Jennifer E. Van Eyk
- Jenny Van Eyk
- Jessica Mandrioli
- Jessica Mandrioli
- Jesus Mora Pardina
- Jesús Esteban-Pérez
- Jesús S. Mora
- Jinghui Zhang
- Jinhui Ding
- Joanne Wuu
- Joanne Wuu
- Jochen H. Weishaupt
- John D. Eicher
- John E. Landers
- John Ealing
- John F. Staropoli
- John Hardy
- John Landers
- John M. Ravits
- John M. Ravits
- John P. Carulli
- John Q. Trojanowski
- John Ravits
- Johnathan Cooper-Knock
- Joke J.F.A. van Vugt
- Joke van Vugt
- Jonathan Cooper-Knock
- Jonathan D. Glass
- Jonathan D. Glass
- Jonathan D. Glass
- Jonathan Glass
- Jonathan Katz
- Jonathan Keebler
- Jonathan Mill
- Joshua Dubnau
- Joshua T. Geiger
- José Luis Muñoz-Blanco
- Juan C. Troncoso
- Julia Kaye
- Julia Kaye
- Julien Couthouis
- Justin Kwan
- Kalliopi Marinou
- Karen E. Morrison
- Karen Morrison
- Katherine B. Sims
- Katie C. Sidle
- Kelly Gwathmey
- Kelly L. Williams
- Kelly L. Williams
- Kevin B. Boylan
- Kevin Kenna
- Kevin Mouzat
- Kevin Mouzat
- Kevin P. Kenna
- Kevin Talbot
- Kristel R. Van Eijk
- Kristel van Eijk
- Lauren Elman
- Leandro Lima
- Leandro Lima
- Leo Wang
- Leonard H. van den Berg
- Leonard van den Berg
- Leslie D. Parish
- Leslie M. Thompson
- Leslie M. Thompson
- Leslie M. Thompson
- Letizia Mazzini
- Letizia Mazzini
- Liberty Jenkins
- Liisa Myllykangas
- Lilja Jansson
- Lindsay L. Waite
- Lorena Mosca
- Lorne Zinman
- Luca Maderna
- Lucia Corrado
- Lucia Corrado
- Lucie Bruijn
- Lucio Tremolizzo
- Ludo Van Den Bosch
- Luigi Ferrucci
- Lyle W. Ostrow
- Lyle W. Ostrow
- Maarten Kooyman
- Maarten Kooyman
- Mamede de Carvalho
- Mamede de Carvalho
- Marc Gotkine
- Marcella Zollino
- Marco Barberis
- Marco Luigetti
- Margherita Capasso
- Margherita Capasso
- Maria Giovanna Marrosu
- Maria Rita Murru
- Maria Rosaria Monsurrò
- Marialuisa Santarelli
- Marielle Wallace
- Mario Sabatelli
- Mario Sabatelli
- Marka Van Blitterswijk
- Markus Weber
- Markus Weber
- Martin R. Turner
- Mary Kay Floeter
- Massimiliano Filosto
- Massimo Corbo
- Matthew B. Harms
- Matthew B. Harms
- Matthew B. Harms
- Matthew Kiernan
- Matthieu Moisse
- Mattieu Moisse
- Maura Brunetti
- Maura Pugliatti
- Maurizio Grassano
- Maurizio Inghilleri
- Maurizio Melis
- Mauro Ceroni
- Mayana Zatz
- Meraida Polak
- Merit Cudkowicz
- Merit Cudkowicz
- Michael A. Van Es
- Michael Benatar
- Michael Benatar
- Michael C. Zody
- Michael van Es
- Michele Benigni
- Michelle Penny
- Miguel Mitne Neto
- Mike A. Nalls
- Miko Valori
- Molly G. Hammell
- Natalie A. Murphy
- Natalie A. Twine
- Nathalie Guy
- Neil A. Shneider
- Neil A. Shneider
- Neil A. Shneider
- Neil W. Kowall
- Nicholas J. Maragakis
- Nicholas J. Maragakis
- Nicola Fini
- Nicola Ticozzi
- Nicola Ticozzi
- Nicola Ticozzi
- Nikolaos A. Patsopoulos
- Nilo Riva
- Nilo Riva
- Noah Zaitlen
- null Shankaracharya
- Orla Hardiman
- Orla Hardiman
- Pamela J. Shaw
- Pamela Keagle
- Pamela Shaw
- Paola Carrera
- Paola Mandich
- Paola Origone
- Paolo Volanti
- Paolo Volanti
- Patrick A. Dion
- Patrick Vourch
- Patrizia Occhineri
- Pentti Tienari
- Peter Andersen
- Peter C. Sapp
- Peter C. Sapp
- Peter M. Andersen
- Philip Van Damme
- Philip van Damme
- Philippe Corcia
- Philippe Corcia
- Philippe Corcia
- Philippe Couratier
- Philippe Couratier
- Pierre Clavelou
- Pietro Fratta
- Pietro Fratta
- Quanli Wang
- Raffaella Tanel
- Rajeeva Lochan Musunuri
- Rebecca Schule
- Riccardo Sideri
- Richard Barohn
- Richard Bedlack
- Richard M. Myers
- Richard M. Myers
- Richard S. Bedlack
- Richard W. Orrell
- Rick A. Van der Spek
- Rick van der Spek
- Robert Bowser
- Robert Brown
- Robert H. Baloh
- Robert H. Baloh
- Robert H. Baloh
- Robert H. Baloh
- Robert H. Brown
- Roberta Puddu
- Roberto Del Bo
- Roger Pamphlett
- Rosa Rademakers
- Rosa Rademakers
- Rossella Spataro
- Roy H. Campbell
- Russell L. McLaughlin
- Russell McLaughlin
- Ruth Chia
- Safa Al-Sarraj
- Sampath Arepalli
- Samuel Maiser
- Sandra D’Alfonso
- Sandra D’Alfonso
- Sara Pulit
- Sara Rollinson
- Sebastian D. Hayes
- Sebastiano Cavallaro
- Seneshaw Asress
- Serena Lattante
- Serge Lumbroso
- Serge Lumbroso
- Shaida Khan
- Shawn E. Levy
- Siddharthan Chandran
- Siddharthan Chandran
- Silvana Penco
- Silvia Peverelli
- Simon D. Topp
- Sitharthan Kamalakaran
- Slavé Petrovski
- Sonia Messina
- Sonja W. Scholz
- Stacia K. Wyman
- Stacia Wyman
- Stanley Appel
- Stanley H. Appel
- Stefan M. Pulst
- Stefan M. Pulst
- Stefania Battistini
- Stefania Battistini
- Stefania Cammarosano
- Stefania Corti
- Stefania Cuccu
- Stefania Tranquilli
- Stefania Tranquilli
- Stella Gagliardi
- Stephan Züchner
- Stephen A. Goutman
- Stephen Goutman
- Stephen J. Kolb
- Stephen J. Kolb
- Stephen Newhouse
- Steve Finkbeiner
- Steven Finkbeiner
- Steven Finkbeiner
- Stuart Pickering-Brown
- Sumaira Hussain
- Summer B. Gibson
- Summer Gibson
- Summer Gibson
- Susana Pinto
- Suvankar Pal
- Suvankar Pal
- Tea B. Cau
- Ted Burns
- Terry D. Heiman-Patterson
- Terry Heiman-Patterson
- Thomas Meitinger
- Tim Harris
- Tim Harris
- Tim M. Strom
- Timothy M. Miller
- Timothy M. Miller
- Timothy M. Miller
- Timothy M. Miller
- Timothy M. Miller
- Tiziana Colletti
- Tom Maniatis
- Travis L. Dunckley
- Uday Shankar Evani
- Umberto Manera
- Valeria Piras
- Vincent Meininger
- Vincenzo La Bella
- Vincenzo La Bella
- Vincenzo Silani
- Vincenzo Silani
- Vincenzo Silani
- Vivian Drory
- Vivian E. Drory
- Viviana Pensato
- Vivianna M. Van Deerlin
- Vivianna M. Van Deerlin
- Véronique Danel
- Wendy K. Chung
- William Camu
- William Camu
- William Sproviero
- Wim Robberecht
- Wim Robberecht
- Winnie W. Xin
- Winston Hide
- Wouter van Rheenen
- Wouter van Rheenen
- Ximena Arcila-Londono
- Yevgeniya Abramzon
- Yi-Fan Lu
- Yuen So
- Yujun Han
- Zachary Simmons
- Zachary Simmons
- Zachary Simmons
- Zhong Ren
- Publication venue
- Publication date
- 01/01/2018
- Field of study
To identify novel genes associated with ALS, we undertook two lines of investigation. We carried out a genome-wide association study comparing 20,806 ALS cases and 59,804 controls. Independently, we performed a rare variant burden analysis comparing 1,138 index familial ALS cases and 19,494 controls. Through both approaches, we identified kinesin family member 5A (KIF5A) as a novel gene associated with ALS. Interestingly, mutations predominantly in the N-terminal motor domain of KIF5A are causative for two neurodegenerative diseases: hereditary spastic paraplegia (SPG10) and Charcot-Marie-Tooth type 2 (CMT2). In contrast, ALS-associated mutations are primarily located at the C-terminal cargo-binding tail domain and patients harboring loss-of-function mutations displayed an extended survival relative to typical ALS cases. Taken together, these results broaden the phenotype spectrum resulting from mutations in KIF5A and strengthen the role of cytoskeletal defects in the pathogenesis of ALS.Peer reviewe
AI is a viable alternative to high throughput screening: a 318-target study
- Author
- Abaffy Tatjana
- Abraham Elena Theres
- Abrahão Jônatas Santos
- Abramyan Tigran M.
- Agianian Bogos
- Agogo-Mawuli Percy
- Agoulnik Alexander I.
- Agrawal Rajendra K.
- Aguilera Elena
- Ahmed Mostafa
- Akk Gustav
- Akopian Tatos
- Al-Yozbaki Minnatallah
- Aldhamen Yasser Ali
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- Wu Pengpeng
- Wu Xiaoyang
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- Xiang Fei
- Xu Hongyang
- Xu Jiake
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- Xu Xin
- Yan Riqiang
- Yang Chao-Yie
- Yen Yun
- Young Matthew A.
- Yu Fang
- Yu Xinfang
- Yuan Haynes
- Yuan Xinrui
- Zahler Stefan
- Zeina Christina M.
- Zelinskaya Natalia
- Zhang Dingqiang
- Zhang Gang
- Zhang Wenjun
- Zhang Xu
- Zhang Yan Jessie
- Zhang Zhiguo
- Zhao Jinshi
- Zhou Han
- Zhou Hui
- Zhou Jia
- Zhou Pei
- Zhou Shan
- Zhu Jiaqi
- Zhu Siran
- Zhu Yini
- Zhuo Ling
- Zochodne Douglas William
- Publication venue
- Publication date
- 01/01/2024
- Field of study
: High throughput screening (HTS) is routinely used to identify bioactive small molecules. This requires physical compounds, which limits coverage of accessible chemical space. Computational approaches combined with vast on-demand chemical libraries can access far greater chemical space, provided that the predictive accuracy is sufficient to identify useful molecules. Through the largest and most diverse virtual HTS campaign reported to date, comprising 318 individual projects, we demonstrate that our AtomNet® convolutional neural network successfully finds novel hits across every major therapeutic area and protein class. We address historical limitations of computational screening by demonstrating success for target proteins without known binders, high-quality X-ray crystal structures, or manual cherry-picking of compounds. We show that the molecules selected by the AtomNet® model are novel drug-like scaffolds rather than minor modifications to known bioactive compounds. Our empirical results suggest that computational methods can substantially replace HTS as the first step of small-molecule drug discovery
Finishing the euchromatic sequence of the human genome
- Author
- . Haifeng
- . Magner
- . Yin
- Abbott Scott
- Abbott-Ozersky Amanda
- Abdellah Zahra
- Abouelleil Amr
- Abrajano Anne
- Adachi Tamami
- Adam Catherine
- Adams Charles Q.
- Adamson Aaron
- Adekoya Emmanuel
- Adio-Oduola Babajide
- Aerts Andrea
- Aggarwal Arun
- Ahmadi Alireza
- Ahmed Shahana
- Aimable Matthew
- Ainscough Rachael
- Ait-Zahra Mostafa
- Aizu Tomoyuki
- Alcivare Dana
- Alegria Michelle
- Ali Alla
- Ali Johar
- Allegria-hartmann Michelle
- Alleman Jennifer
- Allen Carlana C.
- Allen Heather
- Allen Nicole R.
- Allen Susan
- Allen Thaddeus
- Almeida Jeff
- Almond Claire
- Alsbrooks Stephen L.
- Altherr Michael R.
- Amaratunge Harshinie C.
- Ambler Andrew
- Ambrose Karen
- Ambrose Kerrie
- Amemiya Chris
- Amico-Keller Gina
- Amin Amita G.
- Anderson Mechele
- Anderson Scott
- Anderson Scott
- Andora Janice
- Andredesz Carol
- Andrew Robert
- Andrews Dan
- Andrews Daniel
- Andrews Neil
- Andrews Stephanie
- Andriese Tim
- Anthouard Véronique
- Antonarakis Stylianos E.
- Anyalebechi Vivian
- Aoki Norie
- Apostolou Sinoula
- Apweiler Eva
- Arachchi Harindra
- Arai Rie
- Arbery Hazel
- Arcaina Marlon
- Arcaina Terisita
- Archer Beth
- Arellano Andre
- Arellano-Jones Perry
- Armbruster Jeff
- Armstrong Jon
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- Arredondo Heather Hope
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- Asakawa Teruyo
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- Cinkowsky Michael J.
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- DeArellano Kurt
- Deaven Larry I.
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- Förste Silke
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- Harbes Brandy A.
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- Krawczyk Marie-Claude
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- Kremmidiotis Gabriel
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- Kruchowski Scott S.
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- Mercado Iracema C.
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- Mistry Dippica
- Mistry Shailesh
- Mitchell Jake
- Mitchell Jeff
- Mitchell Teresa
- Mitina Sophia
- Mitsui Aki
- Mitsuyama Susumu
- Miyazawa Akemi
- Mlenga Val
- Mohabbat Farida
- Mohabbat Khatera
- Mohammadi Maryam
- Mohrenweiser Harvey
- Molina Christophe
- Monforte Joseph
- Montemayor Julie
- Montgomery Baize
- Montgomery Mishelle
- Mooney Paul
- Moore Madeline
- Moore Niki
- Moreland Andrea
- Morgan Jenna
- Morgan Margaret B.
- Morita Hiroko
- Morris Sidney
- Mortimore Beverly
- Morton Jerry
- Motoyama Ayuko
- Mott Richard
- Moyzis Robert K.
- Mu Feng
- Mukherjee Shibani
- Mullenger Ian
- Mullikin Jim
- Mulrain Leon
- Munday Brian
- Munday Elaine
- Mundt Mark O.
- Mungall Andy
- Munidasa Mala
- Munk A. Christine
- Munk Christie A.
- Munson Glen
- Murakami Katsuhiko
- Murayama Yuji
- Murnane Clare
- Murphy Matthew B.
- Murphy Michael
- Murray Christine
- Murray Debra Dianne
- Murray Jennifer
- Murrell Kerry
- Muzny Donna Marie
- Myers Alison
- Myers Richard
- Müller Ines
- Nagamine Kentaro
- Nagao Syunsuke
- Nagaraja R.
- Nair Latha
- Nair Seema R.
- Naka Maho
- Nakagawa Masayo
- Nakagawa Saori
- Nakamura Etsuko
- Nakato Eriko
- Nanavati Amit N.
- Nandkeshwar Richard
- Nankervis Colin E.
- Naranjo Cleo M.
- Nash William
- Naylor Jerome
- Nazareth Lynne V.
- Neal Dearl D.
- Negus David
- Nelson Catherine
- Nelson David O.
- Nelson Deborah A.
- Nelson Joanne
- Nelson Kathryn
- Nelson Ward
- Nesbitt Ryan
- Neunkirch Jennifer
- Newes Christian
- Newman April
- Ng Bee
- Ng Terrance
- Ngo Robin Ngoc
- Nguyen Bao-Viet
- Nguyen Christine
- Nguyen Cindy
- Nguyen Hoa
- Nguyen Le-Thu Dinh
- Nguyen Lisa
- Nguyen Minh
- Nguyen Na
- Nguyen Natalie M.
- Nguyen Ngoc Bich
- Nguyen Thu
- Nhan Mike
- Ni Lin
- Niblett David
- Nicholson Jonathan
- Nickerson Elizabeth
- Nickerson Tim
- Nicol Robert
- Nijjar Sukhjit
- Ning Zemin
- Nisbet James
- Nishida Aki
- Niu Yuxin
- Niu Yuxin
- Nivens Amber
- Noguchi Hideki
- Nolan Matt
- Norbu Chou Dolma
- Norbu Nyima
- Nordsiek Gabriele
- Norris Sarah Louise
- Novik Karen
- Nowlin Larry
- Nusbaum Chad
- Nwaokelemeh Ogechi O.
- Nwokenkwo Stanley
- O\u27Donnell Paula
- O\u27Donovan Daniel
- O\u27Leary Sinead
- O\u27Loughlin Jennifer
- O\u27Neill Keith
- Obayashi Izumi
- Obregon Melissa
- Oddone Paola
- Oddone Pierre
- Oddy Lachlan
- Odell Christopher
- Ogawara Etsuko
- Ogbighele Francess
- Oguh Maryann
- Ohmori Kyoko
- Ohno Saho
- Ohta Nao
- Ohtsubo Masafumi
- Oinn Tom
- Okoawo Ose
- Okui Michiyo
- Okumura Reina
- Okwuonu Geoffrey O.
- Okwuonu Kenneth C.
- Olarnpunsagoon Alisa
- Olivas Jason
- Oliver Hayley
- Oliver Karen
- Olsen Anne S.
- Olson Maynard V.
- Omotosho Bamidele
- Onoda Junko
- Oomori Nobuhiro
- Ooshima Kenshiro
- Oragunye Njideka
- Orantes Jerry
- Orbell Helena
- Osada Misuzu
- Osborn Anthony
- Osborne Joan
- Osman Sahal
- Ovcharenko Ivan
- Overton-Larty Emma
- Oviedo Rodolfo J.
- Ow David
- Ozawa Ritsuko
- Ozersky Philip
- Pace Araceli C.
- Pack Elizabeth
- Padki Anuradha
- Pahlavan Shane
- Palaniappan Krishnaveni
- Palazzolo Michael
- Palmeiri Anthony
- Palmer Sophie
- Pan Jiaofeng
- Pan Sisu
- Panasenko Vladimir
- Pandian Richard
- Parker Adrian
- Parker David Neil
- Parker Stephen
- Parkin Christopher
- Parkin Kim
- Parks Kenya L.
- Parry-Brown Ginny
- Parson-Quintana Beverly
- Pasternak Shiran
- Patel Bella Mayurkumar
- Patel Dina
- Patel Jalpa N.
- Patel Ritesh
- Patel Shripa
- Patel Vishal V.
- Patrick James
- Paul Heidie A.
- Paul Shelia
- Paulson Edward
- Payton Brett A.
- Pearce Alexandra
- Pearman Charlene
- Pearson Danita
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- Peck Anna
- Peck Richard
- Pedan John
- Pelan Sarah
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- Peng Vivian
- Peng Vivian
- Peng Yi
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- Pennacchio Len A.
- Pennacchio Len A.
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- Perez Agapito
- Perez Lesette M.
- Perito Andrew
- Perrault Isabelle
- Perrier Rene
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- Perrin William
- Pesavento Brad
- Peters Anna
- Peters Leonard G.
- Peterson Jane
- Peterson Karl
- Petit Jean-Louis
- Pettett Roger
- Petz Uta
- Pfeiffer Joyce
- Phan Hoan
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- Phillimore Ben
- Phillips Kim
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- Phulchung Tenzin
- Phunkang Pema
- Pickens Adam
- Pieper Natasha
- Pierre Nadia
- Piqani Bruno
- Piscia C.
- Pitesky Maurice
- Pitluck Sam
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- Playford Emma
- Plopper Farah Jo Homsi
- Plumb Bob
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- Pohl Craig
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- Poliakov Alex
- Pollard Martin
- Polman Jos
- Ponting Chris P.
- Porter Aaron
- Porter Keith
- Porter Tarryn
- Posada Martha
- Potter Christopher
- Potter Simon
- Poundstone Pat
- Pourrajabi Nima M.
- Powell Don
- Powell Jason
- Prado Daisy
- Prange Christa
- Prathalingham Radhika
- Predki Paul
- Prigmore Elena
- Primus Eltrick L.
- Primus Jennifer
- Probst Lyle
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- Pruitt Kim
- Pu Ling-Ling
- Puazo Maria
- Putnam Nicholas
- Qasem Osama
- Qi Qiuhui
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- Qi Xiaohua
- Qian Xufang
- Qian Zengmin
- Qiang Boqin
- Qiang Boqin
- Qiao Zhenyong
- Qin Xiang
- Quail Michael
- Quan Glenda
- Quarrie Hannah
- Quiles Miyo M.
- Quince Chris
- Quiroz Juana B.
- Qureshi Matloob
- Rabata Dina
- Rachlin Eric K.
- Rachupka Anthony
- Radionenko Maxim
- Rajagopal Mohan
- Ramasami Umadevi
- Rameau Rayale
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- Ramirez Melissa
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- Ramsay Helen
- Ramsey Yvonne
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- Rand Vikki
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- Randolph David
- Randolph James
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- Rappaport Barry
- Rash Sam
- Ratford Joanne
- Ratford Lewis
- Ratliff Robert I.
- Ray Aditya
- Ray Vernada
- Raymond Chris
- Raymond Christina
- Read Daniel
- Redhead Donald
- Redon Richard
- Rees Christine
- Reeves Kacy
- Regala Warren
- Reichwald Kathrin
- Reid Mary
- Reigh Richard A.
- Reily Amy D.
- Reinhardt Astrid
- Reinhardt Richard
- Reiter Charlie
- Ren Shuangxi
- Ren Shuangxi
- Ren Yanru
- Retterer James
- Rice Alex
- Rice Catherine
- Rice Peter
- Rice Stephen
- Richard Suzzanne
- Richards Stephen
- Richardson Kristi
- Richardson Paul
- Richardson Paul
- Richardson Susan
- Ricke Darryl O.
- Ridler Kerry
- Riethman Harold
- Riethoven Lyn
- Rigby Rachel
- Riley B.E
- Rise Cecil
- Rivera Angel
- Rives Catharine M.
- Road JungShing
- Robert Catherine
- Roberts Simon
- Robinson Chris
- Robinson Dezere
- Robinson Donna I.
- Robinson Donna L.
- Robinson Melanie
- Rochford Rebecca
- Rock Susan M.
- Rodkey Travis L.
- Rodriguez Alex
- Rodriguez Joseph
- Rodriguez Juan
- Rogers Jane
- Rogers Lisa
- Rogers Stephanine
- Rogosin Andrea
- Rogov Peter
- Rohlfing Theresa
- Rojas Alberto
- Rokhsar Daniel
- Rong Li
- Rong Li
- Rosenbloom Kate R.
- Roskin Krishna M.
- Ross Hugh
- Ross Mark
- Ross Stephanie
- Rowen Lee
- Rubenfield Marc
- Rubin Edward M.
- Ruef Barbara
- Ruiz Erica M.
- Ruiz San Juana
- Rule Angela
- Rule James
- Rule Jeffrey
- Russell Ben
- Russell Jayne
- Ryan Andrea
- Sabo Aniko
- Saenphimmachak Channakhone
- Safdar Kamal
- Sakai Ryoko
- Sakaki Yoshiyuki
- Sakaldasis George
- Salamov Azaf
- Salazar Angelica
- Salter Natalie
- Samain Sylvie
- Sana Moazzam Mohammad
- Sanders Brent
- Sanders Christina
- Sanders Wendi
- Santibanez Jireh
- Santoyo-Lopez Javier
- Sanuki Naoko
- Sarmiento R.
- Sasaki Takashi
- Satpathy Suraj
- Saunders David
- Saunders Elizabeth H.
- Saurin William
- Savery Glenford G.
- Sawada Nori
- Sawhill William W.
- Saxman Eric
- Scarpelli Claude
- Scharfe Maren
- Schatzkamer Kyriena L.
- Scherer Steven Edward
- Schilhabel Markus
- Schlessinger David
- Schmeits James
- Schmidt Esther
- Schmoger Siliva
- Schmutz Jeremy
- Schnabl Matthew
- Schuler Gregory
- Schupbach Rebecca
- Schuster Michael
- Schön Oliver
- Scott Carol
- Scott Damian
- Scott Deborah
- Scott Duncan
- Scott Graham
- Scott Ian
- Scott Kelsi
- Scott Paul
- Seager Fiona
- Seaman Christopher
- Seaman Steven
- Searle Margaret
- Searle Paul
- Searle Stephen
- Sehra Harminder
- Seitz Kathleen
- Sekhon Mundeep
- Severin Jessica
- Seymour Burt
- Shah Neha
- Shakespeare Joe
- Shams Saima
- Shao Chunyan
- Shao Yufen
- Shapiro Harris
- Shardelow Jason
- Sharp Greg
- Sharpe Ted
- Shaw Teresa
- Shaw-Smith Charles
- She Xinwei
- Shearing Jennifer
- Shen Fengye
- Shen Hua
- Shen Meishan
- Shen Yan
- Shen Yan
- Shen Yan
- Sheng Haihui
- Sheppard Karen
- Sheridan Andrew
- Sheridan Elizabeth
- Sherpa Ngawang
- Shi Guibin
- Shi Hongfang
- Shibuya Kazunori
- Shiino Noriko
- Shimizu Atsushi
- Shimizu Hidetsugu
- Shimizu Nobuyoshi
- Shimizu Yoshiko
- Shin Maria
- Shindoh Nobuaki
- Shintani Ai
- Shiohama Aiko
- Shoji Minami
- Shotland Yoram
- Shought Timothy
- Shownkeen Ratna
- Shreve Jeff
- Siddiqui Roman
- Siepel Adam C.
- Silk Richard
- Silk Richard
- Sims Matthew
- Sims Matthew
- Sims Sarah
- Sims Sarah
- Sindelar Linda
- Sinha Prashant
- Sisson Ida
- Sivadasan Shanthi
- Sivadasan Shanthi
- Skowronski Evan
- Skuce Carl
- Skuce Carl
- Slater Nathaniel
- Slezak Tom
- Smedley Damian
- Smink Luc
- Smink Luc
- Smith Andrew
- Smith Andrew
- Smith Cherylyn
- Smith Doug
- Smith Douglas R.
- Smith James
- Smith James
- Smith Joel
- Smith Karen
- Smith Laura
- Smith Laura
- Smith Lorraine
- Smith Lorraine
- Smith Michael
- Smith Michelle
- Smith Michelle
- Smith Russell
- Smith Russell
- Smith Stephanie
- Smith Stephanie
- Smith Troy
- Sneath Hannah
- Sneath Hannah
- Sodergren Erica
- Soderlund Cari
- Soderlund Cari
- Soderlund Cari
- Solovyev Victor
- Solovyez Victor
- Sonaike Titilola
- Song Liping
- Song Liping
- Song Shuping
- Song Xing-Zhi
- Sonnhammer Erik
- Sonnhammer Erik
- Sorelle Richard P.
- Sotheran Elizabeth
- Sougnez Carrie
- Spainhower Corey
- Sparks Anastasia L.
- Spencer Brian
- Spieth John
- Spooner William
- Spraggon Lee
- Sqaures Suzanna
- Squares Janet
- Stabenau Arne
- Stables Michael
- Stalker James
- Stalker John
- Stallings Raymond I.
- Stalvey Malinda
- Stamford Steve
- Stammers Melanie
- Standring Lisa
- Stange-Thomann Nicole
- Stavropoulos Sharon
- Steffen David
- Stege Justin T.
- Steingruber Helen
- Stephens Yvonne
- Stephens-Bolds Shaela
- Stetson Kevin
- Stevko Victor
- Steward Charles
- Stewart Aengus
- Stewart Michael
- Still Ian
- Stock Mo
- Stone Casey
- Stone Evan
- Stone Sabrina
- Stoppard Lisa
- Storey Philip
- Storey Roy
- Stowe Sarah
- Strachan Carol
- Strachan Greg
- Strasser Jonathan
- Stribling Claire
- Strong Cynthia
- Stubbs Lisa
- Stubbs Matthew
- Stultz Janet
- Sturdy John
- Su Xiaohu
- Subramanian Sandhya
- Subramanian Sandhya
- Sudbrak Ralf
- Sugnet Charles W.
- Sulston John
- Summers Leslie J.
- Sun Hui
- Sun Jiajia
- Sun Jiandong
- Sun Jiu Qin
- Sun Min
- Sun Tao
- Sun Wei
- Sun Yongqiao
- Sun Yu
- Sun Yue
- Sutherland Grant R.
- Sutherland Robert D.
- Sutton Angelica E.
- Svatek Amanda F.
- Svetz Jessica
- Svetz Leah Anne
- Swainson Chris
- Swann Mark
- Swarbreck David
- Swearengen-Shahid Sharhonda
- Sycamore Neil
- Ségurens Béatrice
- Tabor Paul E.
- Tacey Kristina
- Tagett Beckie
- Tagney Matthew
- Tahara Takashi
- Takahashi Keiko
- Takano Nobuhiro
- Takaoka Tori
- Takayanagi Atsushi
- Takenaka Tracy
- Talamas Jessica
- Tam Serena
- Tamerisa Kavitha S.
- Tamirisa Aparna
- Tan Olivia
- Tan Steven
- Tan Xinyu
- Tan Xinyu
- Tang Hongli
- Tang Xiangjun
- Tansey Jennifer
- Tao Ran
- Tapia Roxanne
- Taring Elizabeth
- Tatsuyama Miho
- Tatum Owatha I.
- Taudien Stefan
- Taylor Amy
- Taylor Christina C.
- Taylor Gillian
- Taylor Kate
- Taylor Ruth
- Taylor Sam
- Taylor Susan
- Taylor Tineace R.
- Taylor Todd Duane
- Tchuinga Pierre
- Tee Louise
- Telford Ethan Brett
- Tenzin Pema
- Terada Yoriko
- Terry Astrid
- Tesfaye Senait
- Tesmer Judith G.
- Tester Julieanne
- Thayer Nina
- Theaker Andrew
- Theil James
- Theodore Joumathe
- Thexton David
- Thies Stephanie
- Thomas Craig
- Thomas Daniel
- Thomas Daryl J.
- Thomas Karen
- Thomas Nicole
- Thomas Paulette
- Thomas Ruth
- Thomas Shereen
- Thommai Roselin
- Thompson Linda S.
- Thorne Rachel Diane
- Thorpe Andrea
- Thorpe Karen
- Thoulutsang Yama
- Threadgold Glen
- Thurston Scott
- Tian Chaoguang
- Tian Chaoguang
- Tian Wei
- Tian Yan
- Tian Yong
- Tian Yuqing
- Tice Hope
- Tighe Damon
- Tin-Wollam Aye M.
- Tinsley Emma
- Tochigi Miwako
- Togashi Naoko
- Tomizawa Iori
- Tomlinson Chad
- Tong Jingli
- Topham Kerri
- Torcaso Bill
- Torney David C.
- Totoki Yasushi
- Towey Sarah
- Toyoda Atsushi
- Tracey Alan
- Tran Ly Thanh
- Tran-Gyamfi Mary
- Trani Lee
- Trankiem Margie
- Trask Barbara J.
- Travers Johnathan
- Trejos Zulma Y.
- Treuhaft Marianne
- Trevino Brenda Kaye
- Tromans Anthony
- Trong Stephan
- Trumbower Heather
- Tsai Ming
- Tsamla Tsamla
- Tsolas Jason
- Tsomo Nawang
- Tsujimoto Susan
- Tsukamoto Yumi
- Tsuruoka Hiromi
- Tsuzuki Rina
- Tu Yuefeng
- Tu Yuefeng
- Tubby Ben
- Tufarelli Cristina
- Turner Heidi
- Turney Kathryn
- Tynan Katherine
- Ueland Stephanie
- Ueng Samantha
- Ukegbu Ogechi Nkemdirim
- Ulanovsky Levy E.
- Un Chun
- Ung Quyen
- Upson Darren
- Urban Jeremy B.
- Ureta-Vidal Abel
- Ureta-Vidal Abel
- Usmani Kamran
- Ustaszewska Anna
- Uyama Nozomi
- Valas Ruben E.
- Valdez Michelle
- Valle Duane
- Valles Yvonne
- Van Brunt Andrew
- Van Dilla Marvin
- Van Helmond Zoe
- Van Luchene Ryan
- Vardanian Zachary
- Vargas Michelle
- Vargo Charles E.
- Vartanian Steffan
- Vasquez Lydia I.
- Vassiliev Helen
- Vastrik Imre
- Vaudin Mark
- Veil Rose
- Veklerov Eugene
- Velasco Nelson
- Velasquez Lisa
- Venkataranan Vijay
- Vera Virginia A.
- Verduzco Daniel
- Vergez Lisa
- Vico Virginie
- Viknaraja Ramya
- Villasana Donna M.
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- Viswanathan Vijay
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- Vo Nu
- Voak Paul
- Vollenhoven David
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- Wagner-McPherson Caryn
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- Walker Keya
- Walker Sarah
- Wall Melanie
- Wall Randy E.
- Wallace John
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- Wallis Michelle
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- Walsham Natalie
- Wan Ma
- Wang Chunyan
- Wang Dong
- Wang Feng
- Wang Guangxin
- Wang Guihai
- Wang Guihai
- Wang Hongjuan
- Wang Hongwei
- Wang Huanjie
- Wang Huifeng
- Wang Huifeng
- Wang Jian
- Wang Jian
- Wang Jian
- Wang Jie
- Wang Jing
- Wang Jingqiang
- Wang Jingqiang
- Wang Jinhua
- Wang Joann
- Wang Juan
- Wang Jun
- Wang Jun
- Wang Jun
- Wang Li
- Wang Lijie
- Wang Lijuan
- Wang Lijun
- Wang Ling
- Wang Liqun
- Wang Mei
- Wang Qiaoyan
- Wang Shifen
- Wang Shu
- Wang Suzhen
- Wang Wenjun
- Wang Xiaoling
- Wang Xiaoning
- Wang Xuefei
- Wang Xuegang
- Wang Yan
- Wang Yimin
- Wang Ying
- Wang Ying
- Wang Yuanyuan
- Wangchuck Tsering
- Wangdi Tsering
- Ward-Moore Stephanie
- Warren Graham
- Warren James T.
- Warry Georgina
- Watanabe Hidemi
- Watanabe Saki
- Waterston Robert H.
- Watson Andy
- Watt Nicola
- Webb Anthony
- Webb Jeannette
- Webber Caleb
- Weber Ryan J.
- Wehri Edward
- Wei Shulin
- Wei Xuehong
- Weidenbach Richard
- Weinstock George
- Weinstock Keith
- Weir John
- Weissenbach Jean
- Wells Alan
- Wells Sarah
- Welton Robert
- Wen Gaiping
- Wendi Mike
- Weng Li
- Wenning Sarah
- Wentz Sara
- Werler Daniela
- Wesley Mary Melissa
- West Paul
- West Tony
- Wetterstrand Kris
- Wheatley Angela
- Wheatley Carl
- Wheeler David A.
- Wheeler Gideon
- Wheeler Jeremy
- Whitaker Hayley
- White Adam
- White Amelia
- White Brian
- White Catherine
- White Flower
- White Jennifer
- White Johnathon
- White P. Scott
- White Scott P.
- White Simon
- Whitehead Sally
- Whiteley Matthew
- Whitmore Scott
- Whittaker Adam
- Whittaker Charles
- Whittaker Pamela
- Wickremasinghe Manosha I.
- Widaa Sara
- Wiegel Sarah
- Wild Anna
- Wilkinson Jane
- Wilkinson Jane
- Wilkinson Paul
- Willey David
- Williams Albert L.
- Williams Andy
- Williams Bill
- Williams Gabrielle A.
- Williams Leanne
- Williamson Angela L.
- Williamson Helen
- Wills Patricia L.
- Wills Richard
- Wilmer Tamsin
- Wilming Laurens
- Wilson Brian
- Wilson Gareth
- Wilson Margaret
- Wilson Nyree
- Wilson Piers
- Wilson Richard K.
- Wilson Siobhan
- Wilson Steve
- Wilson Wendy
- Wincker Patrick
- Window Philip
- Winster Jenny
- Winzar Claire
- Witt James
- Wleczyk Regina
- Wobus Fred
- Woessner Jeffrey
- Wohldmann Patty
- Wollard Jessica
- Womack Andrew W.
- Wong Benjamin
- Wong Gane K-S
- Wood Diane
- Wood Emma
- Wood Joe
- Wooden Hailey S.
- Wooden Steven H.
- Woodeson Sharon
- Woodfine Kathryn
- Woodmansey Rebecca
- Woods Eric
- Woodwark Cara
- Wooster Richard
- Worley Kim Carlyle
- Woyke Tanja
- Wray Matthew
- Wray Paul
- Wright Charmain
- Wright Debbie
- Wright Kathrine
- Wright Kristin
- Wright Rita A.
- Wu Chungen
- Wu Dongying
- Wu Jiaqian
- Wu Jung-Rung
- Wu Kevin
- Wu Qingfa
- Wu Qingfa
- Wu Ruiming
- Wu Xiao
- Wu Xiaojing
- Wu Zaining
- Wyatt Julia
- Wycoff-Montenegro Melissa
- Wylie Kris
- Wyman Dudley
- Wyman Stacia
- Xi Yan
- Xi Yingying
- Xie Fei
- Xie Gary
- Xie Jane
- Xiong Hui
- Xiong Yuqing
- Xu Alex
- Xu Jing
- Xu Jing
- Xu Ruqin
- Xu Shuhua
- Xu Wei
- Xu Xinlai
- Xu Yan
- Xu Yuning
- Xu Zhihong
- Xu Zuyuan
- Xuan Yali
- Xuan Zhenyu
- Xue Rui
- Yada Tetsushi
- Yadav Shailendra
- Yakub Syed
- Yamamoto Lynn
- Yamamoto Noriko
- Yamamoto Yuko
- Yamashita Yasue
- Yamazaki Satoru
- Yang Hao
- Yang Huanming
- Yang Huanming
- Yang Joan
- Yang Shiaw-Pyng
- Yang Shudong
- Yang Xiaonan
- Yang Xiaonan
- Yang Xiaoping
- Yang Yongkui
- Yano Candance
- Yao Zhijian
- Yao Zhijian
- Yaspo Marie-Laure
- Ye Chen
- Yeager Shane
- Yeh Mimi
- Yen Jennifer
- Yeshitela Rahel Retta
- Yoakum Martin
- Yokobata Kathy
- Yokoyama Jennifer
- Yonezawa Miho
- Yoon Lillienne
- Yoon Vivienne
- Yoshida Satoru
- You Bo
- Young Geneva
- Young Louise
- Young Shelia
- Younger Ruth
- Yu Bing
- Yu Charles
- Yu Fuli
- Yu Jun
- Yu Jun
- Yu Jun
- Yuan Kaiwen
- Yuan Ye
- Yuan Yida
- Yue Shujie
- Yumae Brian
- Yun Rui
- Zainoun Joanne
- Zembeck Lisa
- Zeng Yixin
- Zhai Dong
- Zhan Guoping
- Zhang Bo
- Zhang Caimin
- Zhang Fengmei
- Zhang Guangyu
- Zhang Guohua
- Zhang Guohua
- Zhang Haiqing
- Zhang Haiqing
- Zhang Haiqing
- Zhang Hongbo
- Zhang Hongbo
- Zhang Jingjing
- Zhang Jingjing
- Zhang Jingkun
- Zhang Jiuchun
- Zhang Jiuchun
- Zhang Lanzhi
- Zhang Li
- Zhang Li
- Zhang Meihua
- Zhang Meng
- Zhang Ming
- Zhang Qing
- Zhang Ruhua
- Zhang Shaojie
- Zhang Tiezhen
- Zhang Wei
- Zhang Wei
- Zhang Xianglin
- Zhang Xianglin
- Zhang Xiaoliang
- Zhang Xiuqing
- Zhang Yan
- Zhang Yi
- Zhang Yilin
- Zhang Yilin
- Zhang Ying
- Zhang Yuansen
- Zhang Yuzhi
- Zhang Zhengdong
- Zhao Hongmei
- Zhao Lijian
- Zhao Shenru
- Zhao Zhijing
- Zhen Zhicheng
- Zheng Haibo
- Zhong Ming
- Zhou Carol
- Zhou Haixia
- Zhou Jianling
- Zhou Nannan
- Zhou Xinfeng
- Zhou Yan
- Zhou Yang
- Zhou Yi
- Zhu Bingying
- Zhu Bofeng
- Zhu Fenghua
- Zhu Genfeng
- Zhu Genfeng
- Zhu Miao
- Zhu Ning
- Zhu Yongge
- Zhu Zhen
- Zhuang Shitao
- Zierten Deborah
- Zimmer Andrew
- Zody Michael C.
- Zollo Massimo
- Zorrilla Sara E.
- Zuo Lin
- Publication venue
- LSU Digital Commons
- Publication date
- 21/10/2004
- Field of study
The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead
Robust estimation of bacterial cell count from optical density
- Author
- Aarnio Tiu
- Aaron Leow Chung Yong
- Abbas Anser
- Abduraimova Aiganym
- Abraham Doris
- Acar Beliz Leyla
- Acosta Joaquin
- Adler Nina
- Adulyanukosol Natthawut
- Agena Ejouan
- Agena Ethan
- Aggarwal Priya
- Aguirre Adriana Lizeth Rubio
- Ahlgren Christopher
- Ahuja Janvi
- Aizik Dror
- Akbary Mina
- Akinfenwa Akinwumi
- Akingbesote Ngozi D.
- Akova Umut
- Aldo Ferdinan
- Alexopoulos Ioannis
- Allen Lucy
- Alonso Alejandro
- Altarawneh Dina
- Alvarado Andres Benjamin Sanchez
- Ambre Sanika
- Ameziane Annissa
- Amheine Khadija
- Amin Ihya Fakhrurizal
- Amir Sayeda Sakina
- Amstel Chiel van
- An Yongyan
- Anand Nithishwer Mouroug
- Ananthakrishnan Sathvik
- Anderson Karl
- Angel Sagi
- Annem Vidhya
- Anson Chung Tsun Ho
- Anwar Mariam
- Appel Alana
- Araya Lucas
- Armstrong Alexander
- Arora Neha
- Arora Vasu
- Arruda Beck
- Ashwin F Amal Jude
- Astapenka Artur
- Astles Ben
- Astorino Gabe
- Aubry Celine
- Avileli Rebecca
- Azad Mahnaz Sabeta
- Babar Rehmat
- Babu Priyanka
- Badalli Turan
- Badash Lior
- Baichman-Kass Amichai
- Baldwin Geoff S.
- Baltensperger Oliver Andreas
- Bao Guanke
- Bao Minyue
- Baronaite Ugne
- Barrat Leon Michael
- Barrington Seth
- Barshap Alon
- Bartzoka Natalia
- Basu Anubhav
- Basulto Cynthia
- Bath Scott
- Battina Rohith
- Bauersachs Daniel
- Beal Jacob
- Beale Renee
- Beard Eleanor
- Beck Selina
- Becker Evan
- Benavides Samantha Ayde Pena
- Bennis Nicole
- Bete Anna
- Bhatt Darshak
- Bhowmick Shilpa
- Bian Weixin
- Bijman Eline Yafele
- Bindt Felix
- Blas Karla Soto
- Bo Tang
- Boada Yadira
- Boer Meine
- Bohner Ariel
- Borovko Irina
- Bott Amie
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- Byun Sumin
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- Chen Ching-Wei
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- Chen Ryan
- Chen Weixuan
- Chen Yan
- Chen Yi-Cian
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- Chen Zhuoyang
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- Cheng Hsuan
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- Cheng Yu-Hsuan
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- Deepak Kumar S.
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- Shuan Yun
- Shulun [NO FIRST NAME IN SCOPUS]
- Shuyu Shi
- Sia Nympha Elisa M.
- Siemer Jessica
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- Publication venue
- Publication date
- 01/01/2020
- Field of study
Optical density (OD) is widely used to estimate the density of cells in liquid culture, but cannot be compared between instruments without a standardized calibration protocol and is challenging to relate to actual cell count. We address this with an interlaboratory study comparing three simple, low-cost, and highly accessible OD calibration protocols across 244 laboratories, applied to eight strains of constitutive GFP-expressing E. coli. Based on our results, we recommend calibrating OD to estimated cell count using serial dilution of silica microspheres, which produces highly precise calibration (95.5% of residuals <1.2-fold), is easily assessed for quality control, also assesses instrument effective linear range, and can be combined with fluorescence calibration to obtain units of Molecules of Equivalent Fluorescein (MEFL) per cell, allowing direct comparison and data fusion with flow cytometry measurements: in our study, fluorescence per cell measurements showed only a 1.07-fold mean difference between plate reader and flow cytometry data