Therapeutic impact and diagnostic performance of multiplex PCR in patients with malignancies and suspected sepsis.

International audienceOBJECTIVES: New molecular methods allow rapid pathogen detection in patients with sepsis, but their impact on treatment decisions remains to be established. We evaluated the therapeutic usefulness of multiplex PCR testing in patients with cancer and sepsis. METHODS: 110 patients with cancer and sepsis were included prospectively and underwent LightCycler((R)) SeptiFast (LC-SF) multiplex PCR testing in addition to standard tests. Two independent panels of experts assessed the diagnosis in each patient based on medical record data; only one panel had the LC-SF results. The final diagnosis established by a third panel was the reference standard. RESULTS: The final diagnosis was documented sepsis in 50 patients (55 microorganisms), undocumented sepsis in 54, and non-infectious disease in 6. LC-SF detected 17/32 pathogens recovered from blood cultures (BC) and 11/23 pathogens not recovered from BC; 12 microorganisms were detected neither by BC nor by LC-SF. LC-SF produced false-positive results in 10 cases. The LC-SF results would have significantly improved treatment in 11 (10%) patients and prompted immediate antimicrobial therapy not given initially in 3 patients. CONCLUSIONS: In cancer patients with suspected sepsis, LC-SF detected 11/55 (20%) true pathogens not recovered from BCs and would have improved the initial management in 11/110 (10%) patients

Innenrücktitelbild: Small Molecule Inhibitors of Interferon‐Induced JAK‐STAT Signalling (Angew. Chem. 32/2022)

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La logistisation du monde

Moins médiatisée que la révolution digitale, une autre révolution, plus discrète et pourtant tout aussi bouleversante pour notre monde, s’est opérée au cours des dernières décennies : celle de la logistique. L’ouvrage revient sur cette « logistisation » du monde, à travers 56 chroniques. Destinées à un grand public, elles ont été écrites par des chercheurs du CRET-LOG, qui constitue le principal centre de recherche en logistique en France. Rédigées dans un langage clair, ces courtes chroniques donnent au lecteur les clefs pour comprendre de manière globale et systémique la révolution logistique. Les chroniques sont réunies en huit parties, qui couvrent tout le spectre de la logistique contemporaine : son omniprésence et son universalité son rôle stratégique pour les entreprises sa place de support à la consommation l’industrie logistique qui la sous-tend la façon dont elle crée de la valeur son rôle de levier vers un développement plus durable les enjeux politiques de la logistique les liens industrie-recherche en logistique. L’ouvrage a l’ambition de médiatiser et diffuser largement la pensée logistique auprès du grand public et intéressera tous ceux qui veulent comprendre les évolutions de notre monde

Genetic diagnosis of primary immunodeficiencies: A survey of the French national registry

International audienceTo the Editor:Since the mid-1980s, continuous progress in genetics and genomics has accelerated the rapid identification of causative genetic variants leading to primary immunodeficiencies (PIDs; >300 genes),1 with the noticeable exception of B-cell disorders, such as common variable immunodeficiency (CVID). The identification of these mutations not only validates a clinical diagnosis but also is useful in several other respects (more accurate prognosis on phenotype/genotype correlation, targeted therapy, and genetic counseling). [...