The Grizzly, October 26, 2023

A Conversation With Dr. Gundolf Graml • Thinking Locally With UC Votes • Future Developments on Main • A Look Inside Art Club • Film Club Documentary • Opinions: A Divided Ursinus • Ursinus Women\u27s Rugby Team Prepares to Tackle the Season Ahead • UC Field Hockey Doesn\u27t Cut Corners in Victory Over Ranked Swarthmorehttps://digitalcommons.ursinus.edu/grizzlynews/2019/thumbnail.jp

The Grizzly, November 2, 2023

Homecoming Recap • Berman Receives Grant for Upcoming Exhibition • Midweek Meditation • Brave in Season: Jon Volkmer\u27s New Novel is a Damn Good Read • Victims of Duty: Absurdism and Ambiguity • Diving All in on Troubles End Brewing • Weekly Crossword Puzzle • From North Carolina to Southeast PA: The Future of Ursinus Basketball • UC Cross Country Chasing Historyhttps://digitalcommons.ursinus.edu/grizzlynews/2020/thumbnail.jp

Opposite-polarity motors activate one another to trigger cargo transport in live cells

Mechanical interactions between any two opposite-polarity motors are necessary and sufficient for bidirectional organelle transport in live cells

Left frontal hub connectivity delays cognitive impairment in autosomal-dominant and sporadic Alzheimer's disease

Patients with Alzheimer's disease vary in their ability to sustain cognitive abilities in the presence of brain pathology. A major open question is which brain mechanisms may support higher reserve capacity, i.e. relatively high cognitive performance at a given level of Alzheimer's pathology. Higher functional MRI-assessed functional connectivity of a hub in the left frontal cortex is a core candidate brain mechanism underlying reserve as it is associated with education (i.e. a protective factor often associated with higher reserve) and attenuated cognitive impairment in prodromal Alzheimer's disease. However, no study has yet assessed whether such hub connectivity of the left frontal cortex supports reserve throughout the evolution of pathological brain changes in Alzheimer's disease, including the presymptomatic stage when cognitive decline is subtle. To address this research gap, we obtained cross-sectional resting state functional MRI in 74 participants with autosomal dominant Alzheimer's disease, 55 controls from the Dominantly Inherited Alzheimer's Network and 75 amyloid-positive elderly participants, as well as 41 amyloid-negative cognitively normal elderly subjects from the German Center of Neurodegenerative Diseases multicentre study on biomarkers in sporadic Alzheimer's disease. For each participant, global left frontal cortex connectivity was computed as the average resting state functional connectivity between the left frontal cortex (seed) and each voxel in the grey matter. As a marker of disease stage, we applied estimated years from symptom onset in autosomal dominantly inherited Alzheimer's disease and cerebrospinal fluid tau levels in sporadic Alzheimer's disease cases. In both autosomal dominant and sporadic Alzheimer's disease patients, higher levels of left frontal cortex connectivity were correlated with greater education. For autosomal dominant Alzheimer's disease, a significant left frontal cortex connectivity × estimated years of onset interaction was found, indicating slower decline of memory and global cognition at higher levels of connectivity. Similarly, in sporadic amyloid-positive elderly subjects, the effect of tau on cognition was attenuated at higher levels of left frontal cortex connectivity. Polynomial regression analysis showed that the trajectory of cognitive decline was shifted towards a later stage of Alzheimer's disease in patients with higher levels of left frontal cortex connectivity. Together, our findings suggest that higher resilience against the development of cognitive impairment throughout the early stages of Alzheimer's disease is at least partially attributable to higher left frontal cortex-hub connectivity

One single large intramuscular dose of naloxone is effective and safe in suspected heroin poisoning

Objective: Naloxone is an established antidote for the treatment of heroin poisoning; however, dosing regimens vary widely, with a current trend towards small titrated intravenous dosing. This study aims to characterise naloxone use in the treatment of patients presenting with suspected heroin poisoning. Methods: This was a retrospective review of poisoned patients presenting to a clinical toxicology unit in Brisbane from January 2015 to December 2017. Patient demographics, clinical effects, naloxone dosing, observation periods and complications were extracted from the patient's medical records. Results: There were 117 presentations accounted for by 108 patients. Prehospital naloxone was provided to 57 (49%) patients, 46 of which received a standardised 1.6 mg i.m. dose. The remaining 60 (51%) patients received their first naloxone in hospital, with 58 (97%) receiving this by titrated i.v. doses. A subsequent naloxone infusion was required significantly more often in those treated with i.v. titrated naloxone compared to i.m. dose (27/69 [39%] vs 5/48 [10%], P = 0.0006). The need for parenteral sedation to manage acute behavioural disturbance following naloxone provision was rare (3/117 [3%]). Conclusions: In this retrospective observational study, a single large i.m. dose of naloxone reversed the toxicity of suspected heroin overdose in the majority of patients. In addition, patients were less likely to require repeated intermittent doses or naloxone infusion than those treated solely with i.v. naloxone. Further comparison in a prospective study is warranted to validate these observations in confirmed heroin overdose. Requirement for sedation secondary to acute behavioural disturbance was rare regardless of the route

Diurnal cycle of precipitation amount and frequency in Sweden : observation versus model simulation

This study investigated the diurnal cycle of precipitation in Sweden using hourly ground observations for 1996-2008. General characteristics of phase and amplitude for the diurnal cycle of precipitation, both in amount and frequency, were identified. In the warm season (April-September), the 'typical' afternoon (14-16 LST) peaks are dominant over inland Sweden, whereas late night to early morning (04-06 LST) peaks with relatively weak amplitude are discernable in the east coast along the Baltic Sea. The diurnal variation is almost negligible in the cold season (October-March), due to the weak solar radiation at high latitudes. The variations of convective activity forced by solar heating and modulated by geographical characteristics were suggested as primarily factors to invoke the cycles and spatial variation identified. The observed cycle was compared with the cycle simulated by a regional climate model. The model fairly well captures the spatial pattern of the phase of the diurnal cycle. However, the warm season afternoon peak is simulated too early and too uniformly across the stations, associated with too frequent occurrences of convective rainfall events with relatively light intensity. These discrepancies point to the need to improve the convection parametrization and geographic representation of the model