2,673 research outputs found
Corporate Law: Will Requiring a Breach of a Fiduciary Duty Under Rule 14e-3 of the Securities Exchange Act Encourage Market Efficiency By Protecting the Flow of Information Into the Market, Or Will It Undermine Investor Confidence in the Market? (United States v. Chestman, 903 F.2d 75 (2d Cir. 1990))
Educators\u27 and parents\u27 perceived attitudes towards and level of importance concerning home schooling
An exploratory qualitative study of values issues associated with training and practice in pluralistic counselling
Background: A pluralistic model of practice has become increasingly influential in recent years. A distinctive feature of this approach is its explicit grounding within a philosophical and moral perspective.Aim: The aim of this study was to investigate issues and challenges that pluralistic counsellors experience in relation to values dilemmas that arise in practice.Methodology: Twelve practitioners, of various experience levels, who identified as pluralistic counsellors, were invited to take part in semi-structured interviews. Transcripts were analysed using a method of thematic analysis.Findings: Participants viewed their personal values to be compatible with the values that they perceived pluralistic counselling to hold, and reported that they chose pluralism as a modality because they found a similarity between their personal values and the values of pluralistic counselling. Core values associated with pluralistic practice included the following: the importance of connection, ‘there is no one right way to be’, equality (not taking an expert role), honesty, and willingness to make use of research evidence. Participants also described value dilemmas, and their use of supervision in dealing with value issues.Implications: The implications of these findings for training, research and practice are discussed
Estimation of flattening coefficient for absorption and circular dichroism using simulation
The absorbance and circular dichroism (CD) of suspensions is lower than if the same amount of chromophore were uniformly distributed throughout the medium. Several mathematical treatments of this absorption flattening phenomenon have been presented using various assumptions and approximations. This article demonstrates an alternative simulation approach that allows relaxation of assumptions. On current desktop computers, the algorithm runs quickly with enough particles and light paths considered to get answers that are usually accurate to better than 3%. Results from the simulation agree with the most popular analytical model for 0.01 volume fraction of particles, showing that the extent of flattening depends mainly on the absorbance through a particle diameter. Unlike previous models, the simulation can show that flattening is significantly lower when volume fraction increases to 0.1 but is higher when the particles have a size distribution. The simulation can predict the slope of the nearly linear relationship between flattening of CD and the absorbance of the suspension. This provides a method to correct experimental CD data where volume fraction and particle size are known
Web Site Media Relations: A New Direction for Agricultural Public Relations Professionals
Agricultural public relations practitioners and communicators face a challenge in following the current trend in Web-based media information dissemination. Most agricultural organizations serve a traditional clientele that prefer conventional media as a source of news and information. This may result in many agricultural communicators overlooking the information needs of the media, which in turn could be a reason for the media to neglect agricultural news. A content analysis was conducted of Web sites created and maintained by all major Florida agricultural commodity organizations to determine the percentage of Florida Agricultural Web sites that provide media information, the location of media information within the Web sites, and the type of media information provided. Results indicated that the primary objective of these agricultural commodity Web sites appears to be to provide an internal communication mechanism for members. It was evident that the agricultural sites are not created with the needs of journalists or members of the media as a priority. Certainly, it is positive that there are press releases, feature stories, and logo graphics available on numerous Web sites; however, many releases were outdated and many elements of a good pressroom were absent
Construing the cultural other and the self: A Personal Construct analysis of English and Italian perceptions of national character
How we perceive other cultures is arguably of increasing importance in contemporary society, impacting on realms such as international relations, business and tourism. The qualitative research reported in this paper was carried out in the UK and in Italy and adopted a Personal Construct Psychology approach. It aimed to explore intercultural perceptions in a sample of people who had some degree of experience with the ‘other’ culture, and a unique feature of the research is that it asked how those perceptions might be affected if people from both cultures are given access to each other’s perceptions. There was considerable commonality in the perceptions of the English and Italian participants, and each culture envied some of the qualities of the other. However, they initially struggled to accommodate how they were seen by the other and endeavoured to resolve difference by construing at a more superordinate level. The findings also suggest that national identity is rooted in the construing of others’ constructions, achieved through relationship and comparison
ADAD1 and ADAD2, testis-specific adenosine deaminase domain-containing proteins, are required for male fertility.
Adenosine-to-inosine RNA editing, a fundamental RNA modification, is regulated by adenosine deaminase (AD) domain containing proteins. Within the testis, RNA editing is catalyzed by ADARB1 and is regulated in a cell-type dependent manner. This study examined the role of two testis-specific AD domain proteins, ADAD1 and ADAD2, on testis RNA editing and male germ cell differentiation. ADAD1, previously shown to localize to round spermatids, and ADAD2 had distinct localization patterns with ADAD2 expressed predominantly in mid- to late-pachytene spermatocytes suggesting a role for both in meiotic and post-meiotic germ cell RNA editing. AD domain analysis showed the AD domain of both ADADs was likely catalytically inactive, similar to known negative regulators of RNA editing. To assess the impact of Adad mutation on male germ cell RNA editing, CRISPR-induced alleles of each were generated in mouse. Mutation of either Adad resulted in complete male sterility with Adad1 mutants displaying severe teratospermia and Adad2 mutant germ cells unable to progress beyond round spermatid. However, mutation of neither Adad1 nor Adad2 impacted RNA editing efficiency or site selection. Taken together, these results demonstrate ADAD1 and ADAD2 are essential regulators of male germ cell differentiation with molecular functions unrelated to A-to-I RNA editing
The citation triad: an overview of a scientist's publication output based on Ferrers diagrams
In a recent work by Anderson, Hankin, and Killworth (2008), Ferrers diagrams and Durfee squares are used to represent the scientific output of a scientist and construct a new h-based bibliometric indicator, the tapered h-index (hT). In the first part of this paper we examine hT, identifying its main drawbacks and weaknesses: an arbitrary scoring system and an illusory increase in discrimination power compared to h. Subsequently,wepropose a new bibliometric tool, the citation triad (CT), that better exploits the information contained in a Ferrers diagram, giving a synthetic overview of a scientist's publication output. The advantages of this new approach are discussed in detail. Argument is supported by several examples based on empirical dat
Optimization and Validation of a Modified Radial-Arm Water Maze Protocol Using a Murine Model of Mild Closed Head Traumatic Brain Injury
Cognitive impairments can be a significant problem after a traumatic brain injury (TBI), which affects millions worldwide each year. There is a need for establish reproducible cognitive assays in rodents to better understand disease mechanisms and to develop therapeutic interventions towards treating TBI-induced impairments. Our goal was to validate and standardize the radial arm water maze (RAWM) test as an assay to screen for cognitive impairments caused by TBI. RAWM is a visuo-spatial learning test, originally designed for use with rats, and later adapted for mice. The present study investigates whether test procedures, such us the presence of extra-maze cues influences learning and memory performance. C57BL/6 mice were tested in an 8-arm RAWM using a four-day protocol. We demonstrated that two days of training, exposing the mice to extra-maze cues and a visible platform, influenced learning and memory performance. Mice that did not receive training performed poorer compared to mice trained. To further validate our RAWM protocol, we used scopolamine. We, also, demonstrated that a single mild closed head injury (CHI) caused deficits in this task at two weeks post-CHI. Our data supported the use of 7 trials per day and a spaced training protocol as key factor to unmask memory impairment following CHI. Here, we provide a detailed standard operating procedure for RAWM test, which can be applied to a variety of mouse models including neurodegenerative diseases and pathology, as well as when pharmacological approaches are used
The Structure of Addictions: A Confirmatory Factor Analysis Approach Using Structural Equations Modeling
Addiction is one of the most important mental health problems in contemporary society, but relatively little is known about how various kinds of addictive behaviors relate to each other. In this study, we take a complex structural model of addictions developed from Christian theological sources and our own previous research and test it against a large (N = 300) dataset of individuals who have rated their relationship to various objects of addiction. The analysis largely confirmed our theoretical model with some interesting modifications. We discuss implications of this research for addictions assessment and treatment
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