763 research outputs found
Finding the Silver Lining in a Pandemic: A Virtual International Interprofessional Education Course in Partnership with Older Adults Living in Baltimore, MD
Prevalence of Potentially Inappropriate Medication Use in Older Adults Using the 2012 Beers Criteria
The Beers list of potentially inappropriate medications (PIMs) provides a key indicator of medication prescribing quality. The criteria were updated in 2012, adding new drugs and assessing evidence strength
Ancient DNA from European Early Neolithic Farmers Reveals Their Near Eastern Affinities
The first farmers from Central Europe reveal a genetic affinity to modern-day populations from the Near East and Anatolia, which suggests a significant demographic input from this area during the early Neolithic
A 2.3-Day Periodic Variability in the Apparently Single Wolf-Rayet Star WR 134: Collapsed Companion or Rotational Modulation?
We present the results of an intensive campaign of spectroscopic and
photometric monitoring of the peculiar Wolf-Rayet star WR 134 from 1989 to
1997.
This unprecedentedly large data set allows us to confirm unambiguously the
existence of a coherent 2.25 +/- 0.05 day periodicity in the line-profile
changes of He II 4686, although the global pattern of variability is different
from one epoch to another. This period is only marginally detected in the
photometric data set. Assuming the 2.25 day periodic variability to be induced
by orbital motion of a collapsed companion, we develop a simple model aiming at
investigating (i) the effect of this strongly ionizing, accreting companion on
the Wolf-Rayet wind structure, and (ii) the expected emergent X-ray luminosity.
We argue that the predicted and observed X-ray fluxes can only be matched if
the accretion on the collapsed star is significantly inhibited. Additionally,
we performed simulations of line-profile variations caused by the orbital
revolution of a localized, strongly ionized wind cavity surrounding the X-ray
source. A reasonable fit is achieved between the observed and modeled
phase-dependent line profiles of He II 4686. However, the derived size of the
photoionized zone substantially exceeds our expectations, given the observed
low-level X-ray flux. Alternatively, we explore rotational modulation of a
persistent, largely anisotropic outflow as the origin of the observed cyclical
variability. Although qualitative, this hypothesis leads to greater consistency
with the observations.Comment: 34 pages, 16 figures. Accepted by the Astrophysical Journa
Micrometeoroid Events in LISA Pathfinder
The zodiacal dust complex, a population of dust and small particles that
pervades the Solar System, provides important insight into the formation and
dynamics of planets, comets, asteroids, and other bodies. Here we present a new
set of data obtained using a novel technique: direct measurements of momentum
transfer to a spacecraft from individual particle impacts. This technique is
made possible by the extreme precision of the instruments flown on the LISA
Pathfinder spacecraft, a technology demonstrator for a future space-based
gravitational wave observatory that operated near the first Sun-Earth Lagrange
point from early 2016 through Summer of 2017. Using a simple model of the
impacts and knowledge of the control system, we show that it is possible to
detect impacts and measure properties such as the transferred momentum (related
to the particle's mass and velocity), direction of travel, and location of
impact on the spacecraft. In this paper, we present the results of a systematic
search for impacts during 4348 hours of Pathfinder data. We report a total of
54 candidates with momenta ranging from 0.2 to
230. We furthermore make a comparison of these candidates
with models of micrometeoroid populations in the inner solar system including
those resulting from Jupiter-family comets, Oort-cloud comets, Hailey-type
comets, and Asteroids. We find that our measured population is consistent with
a population dominated by Jupiter-family comets with some evidence for a
smaller contribution from Hailey-type comets. This is in agreement with
consensus models of the zodiacal dust complex in the momentum range sampled by
LISA Pathfinder.Comment: 22 pages, 14 figures, accepted in Ap
Massive migration from the steppe is a source for Indo-European languages in Europe
We generated genome-wide data from 69 Europeans who lived between 8,000-3,000
years ago by enriching ancient DNA libraries for a target set of almost four
hundred thousand polymorphisms. Enrichment of these positions decreases the
sequencing required for genome-wide ancient DNA analysis by a median of around
250-fold, allowing us to study an order of magnitude more individuals than
previous studies and to obtain new insights about the past. We show that the
populations of western and far eastern Europe followed opposite trajectories
between 8,000-5,000 years ago. At the beginning of the Neolithic period in
Europe, ~8,000-7,000 years ago, closely related groups of early farmers
appeared in Germany, Hungary, and Spain, different from indigenous
hunter-gatherers, whereas Russia was inhabited by a distinctive population of
hunter-gatherers with high affinity to a ~24,000 year old Siberian6 . By
~6,000-5,000 years ago, a resurgence of hunter-gatherer ancestry had occurred
throughout much of Europe, but in Russia, the Yamnaya steppe herders of this
time were descended not only from the preceding eastern European
hunter-gatherers, but from a population of Near Eastern ancestry. Western and
Eastern Europe came into contact ~4,500 years ago, as the Late Neolithic Corded
Ware people from Germany traced ~3/4 of their ancestry to the Yamnaya,
documenting a massive migration into the heartland of Europe from its eastern
periphery. This steppe ancestry persisted in all sampled central Europeans
until at least ~3,000 years ago, and is ubiquitous in present-day Europeans.
These results provide support for the theory of a steppe origin of at least
some of the Indo-European languages of Europe
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Compression of morbidity in a progeroid mouse model through the attenuation of myostatin/activin signalling
Background One of the principles underpinning our understanding of ageing is that DNA damage induces a stress response that shifts cellular resources from growth towards maintenance. A contrasting and seemingly irreconcilable view is that prompting growth of, for example, skeletal muscle confers systemic benefit. Methods To investigate the robustness of these axioms, we induced muscle growth in a murine progeroid model through the use of activin receptor IIB ligand trap that dampens myostatin/activin signalling. Progeric mice were then investigated for neurological and muscle function as well as cellular profiling of the muscle, kidney, liver, and bone. Results We show that muscle of Ercc1(Delta/-) progeroid mice undergoes severe wasting (decreases in hind limb muscle mass of 40-60% compared with normal mass), which is largely protected by attenuating myostatin/activin signalling using soluble activin receptor type IIB (sActRIIB) (increase of 30-62% compared with untreated progeric). sActRIIB-treated progeroid mice maintained muscle activity (distance travel per hour: 5.6 m in untreated mice vs. 13.7 m in treated) and increased specific force (19.3 mN/mg in untreated vs. 24.0 mN/mg in treated). sActRIIb treatment of progeroid mice also improved satellite cell function especially their ability to proliferate on their native substrate (2.5 cells per fibre in untreated progeroids vs. 5.4 in sActRIIB-treated progeroids after 72 h in culture). Besides direct protective effects on muscle, we show systemic improvements to other organs including the structure and function of the kidneys; there was a major decrease in the protein content in urine (albumin/creatinine of 4.9 sActRIIB treated vs. 15.7 in untreated), which is likely to be a result in the normalization of podocyte foot processes, which constitute the filtration apparatus (glomerular basement membrane thickness reduced from 224 to 177 nm following sActRIIB treatment). Treatment of the progeric mice with the activin ligand trap protected against the development of liver abnormalities including polyploidy (18.3% untreated vs. 8.1% treated) and osteoporosis (trabecular bone volume; 0.30 mm(3) in treated progeroid mice vs. 0.14 mm(3) in untreated mice, cortical bone volume; 0.30 mm(3) in treated progeroid mice vs. 0.22 mm(3) in untreated mice). The onset of neurological abnormalities was delayed (by similar to 5 weeks) and their severity reduced, overall sustaining health without affecting lifespan. Conclusions This study questions the notion that tissue growth and maintaining tissue function during ageing are incompatible mechanisms. It highlights the need for future investigations to assess the potential of therapies based on myostatin/activin blockade to compress morbidity and promote healthy ageing.Peer reviewe
The Eighth Data Release of the Sloan Digital Sky Survey: First Data from SDSS-III
The Sloan Digital Sky Survey (SDSS) started a new phase in August 2008, with
new instrumentation and new surveys focused on Galactic structure and chemical
evolution, measurements of the baryon oscillation feature in the clustering of
galaxies and the quasar Ly alpha forest, and a radial velocity search for
planets around ~8000 stars. This paper describes the first data release of
SDSS-III (and the eighth counting from the beginning of the SDSS). The release
includes five-band imaging of roughly 5200 deg^2 in the Southern Galactic Cap,
bringing the total footprint of the SDSS imaging to 14,555 deg^2, or over a
third of the Celestial Sphere. All the imaging data have been reprocessed with
an improved sky-subtraction algorithm and a final, self-consistent photometric
recalibration and flat-field determination. This release also includes all data
from the second phase of the Sloan Extension for Galactic Understanding and
Evolution (SEGUE-2), consisting of spectroscopy of approximately 118,000 stars
at both high and low Galactic latitudes. All the more than half a million
stellar spectra obtained with the SDSS spectrograph have been reprocessed
through an improved stellar parameters pipeline, which has better determination
of metallicity for high metallicity stars.Comment: Astrophysical Journal Supplements, in press (minor updates from
submitted version
The Ninth Data Release of the Sloan Digital Sky Survey: First Spectroscopic Data from the SDSS-III Baryon Oscillation Spectroscopic Survey
The Sloan Digital Sky Survey III (SDSS-III) presents the first spectroscopic
data from the Baryon Oscillation Spectroscopic Survey (BOSS). This ninth data
release (DR9) of the SDSS project includes 535,995 new galaxy spectra (median
z=0.52), 102,100 new quasar spectra (median z=2.32), and 90,897 new stellar
spectra, along with the data presented in previous data releases. These spectra
were obtained with the new BOSS spectrograph and were taken between 2009
December and 2011 July. In addition, the stellar parameters pipeline, which
determines radial velocities, surface temperatures, surface gravities, and
metallicities of stars, has been updated and refined with improvements in
temperature estimates for stars with T_eff<5000 K and in metallicity estimates
for stars with [Fe/H]>-0.5. DR9 includes new stellar parameters for all stars
presented in DR8, including stars from SDSS-I and II, as well as those observed
as part of the SDSS-III Sloan Extension for Galactic Understanding and
Exploration-2 (SEGUE-2).
The astrometry error introduced in the DR8 imaging catalogs has been
corrected in the DR9 data products. The next data release for SDSS-III will be
in Summer 2013, which will present the first data from the Apache Point
Observatory Galactic Evolution Experiment (APOGEE) along with another year of
data from BOSS, followed by the final SDSS-III data release in December 2014.Comment: 9 figures; 2 tables. Submitted to ApJS. DR9 is available at
http://www.sdss3.org/dr
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