Organizational structure and performance in Dutch SMEs

The relationship between organisational structure and performance has received little attention over the past few decades, especially in regards to firms with less than 100 employees. All too often, the stereotype of SMEs as unstructured, informal 'adhocracies' is heard. Based on the study of a stratified sample of more than 1400 Dutch SMEs (in three size classes and nine economic sectors) we show that this stereotype is false. We derive a set of typical organisational structures. We further investigated the circumstances under which these structures seem to perform well, and the circumstances under which they appear to perform poorly. Un update of this report is made on Januari 2005 (N200420).

An oxaloacetate decarboxylase homologue protein influences the intracellular survival of Legionella pneumophila

Legionella pneumophila is a facultative intracellular parasite which is able to survive in various eukaryotic cells. We characterised a Tn5-mutant of the L. pneumophila Corby strain and were able to identify the insertion site of the transposon. It is localised within an open reading frame which shows high homology to the α-subunit of the oxaloacetate decarboxylase (OadA) of Klebsiella pneumoniae. The OadA homologous protein of L. pneumophila was detected in the wild-type strain by Western blotting. Since the intracellular multiplication of the oadA− mutant strain is reduced in guinea pig alveolar macrophages and human monocytes, it is concluded that the oadA gene product has an effect on the intracellular survival of L. pneumophil

Undecidability of asynchronous session subtyping

Session types are used to describe communication protocols in distributed systems and, as usual in type theories, session subtyping characterizes substitutability of the communicating processes. We investigate the (un)decidability of subtyping for session types in asynchronously communicating systems. We first devise a core undecidable subtyping relation that is obtained by imposing limitations on the structure of types. Then, as a consequence of this initial undecidability result, we show that (differently from what stated or conjectured in the literature) the three notions of asynchronous subtyping defined so far for session types are all undecidable. Namely, we consider the asynchronous session subtyping by Mostrous and Yoshida for binary sessions, the relation by Chen et al. for binary sessions under the assumption that every message emitted is eventually consumed, and the one by Mostrous et al. for multiparty session types. Finally, by showing that two fragments of the core subtyping relation are decidable, we evince that further restrictions on the structure of types make our core subtyping relation decidable.Comment: 36 page

Hybrid integration on low-cost flex foils using photonic flash soldiering

Soldering of packaged electronic components using industry standard Sn-Ag-Cu (SAC) lead-free solders on low-cost foils, which are often the substrate of choice for flexible electronics, is challenging. This is mainly originating from the fact that the reflow temperatures of these solder alloys are normally higher than the maximum processing temperature of the low-cost flex foils. To enable component integration on the low-cost foils a novel method for soldering has been introduced by Holst Centre as an alternative to oven reflow, termed 'photonic soldering'. In this method high intensity photonic flashes are used to deliver the thermal energy required for soldering. By taking advantage of the selectivity of light absorption, the required energy for soldering is delivered to the components and circuit tracks while excessive heating of the foils is avoided. This paper presents successful photonic flash soldering of packaged LED components on low-cost polyethylene terephthalate (PET) foils using conventional SAC solders as a demonstration of the capabilities of this novel soldering technology

A SAMPLING STRATEGY FOR RECENT AND FOSSIL BRACHIOPODS: SELECTING THE OPTIMAL SHELL SEGMENT FOR GEOCHEMICAL ANALYSES

Recent and fossil brachiopod shells have a long record as biomineral archives for (palaeo)climatic and (palaeo)environmental reconstructions, as they lack or exhibit limited vital effects in their calcite shell and generally are quite resistant to diagenetic alteration. Despite this, only few studies address the issue of identifying the best or optimal part of the shell for geochemical analyses. We investigated the link between ontogeny and geochemical signatures recorded in different parts of the shell. To reach this aim, we analysed the elemental (Ca, Mg, Sr, Na) and stable isotope (δ18O, δ13C) compositions of five recent brachiopod species (Magellania venosa, Liothyrella uva, Aerothyris kerguelensis, Liothyrella neozelanica and Gyphus vitreus), spanning broad geographical and environmental ranges (Chile, Antarctica, Indian Ocean, New Zealand and Italy) and having different shell layer successions (two-layer and three-layer shells). We observed similar patterns in the ventral and dorsal valves of these two groups, but different ontogenetic trends by the two- and three-layer shells in their trace element and stable isotope records. Our investigation led us to conclude that the optimal region to sample for geochemical and isotope analyses is the middle part of the mid-section of the shell, avoiding the primary layer, posterior and anterior parts as well as the outermost part of the secondary layer in recent brachiopods. Also, the outermost and innermost rims of shells should be avoided due to diagenetic impacts on fossil brachiopods

An expert consensus on the recommendations for the use of biomarkers in Fabry disease

Fabry disease is an X-linked lysosomal storage disorder caused by the accumulation of glycosphingolipids in various tissues and body fluids, leading to progressive organ damage and life-threatening complications. Phenotypic classification is based on disease progression and severity and can be used to predict outcomes. Patients with a classic Fabry phenotype have little to no residual α-Gal A activity and have widespread organ involvement, whereas patients with a later-onset phenotype have residual α-Gal A activity and disease progression can be limited to a single organ, often the heart. Diagnosis and monitoring of patients with Fabry disease should therefore be individualized, and biomarkers are available to support with this. Disease-specific biomarkers are useful in the diagnosis of Fabry disease; non-disease-specific biomarkers may be useful to assess organ damage. For most biomarkers it can be challenging to prove they translate to differences in the risk of clinical events associated with Fabry disease. Therefore, careful monitoring of treatment outcomes and collection of prospective data in patients are needed. As we deepen our understanding of Fabry disease, it is important to regularly re-evaluate and appraise published evidence relating to biomarkers. In this article, we present the results of a literature review of evidence published between February 2017 and July 2020 on the impact of disease-specific treatment on biomarkers and provide an expert consensus on clinical recommendations for the use of those biomarkers.publishedVersio

West Nile virus and Usutu virus: a post-mortem monitoring study in wild birds from rescue centers, central Italy

West Nile virus (WNV) and Usutu virus (USUV) are mosquito-borne flaviviruses that have been associated with neurological diseases in humans and wild birds. Wild bird rescue centers are potential significant hot spots for avian infection surveillance, as recognized in the Italian Integrate National Surveillance Plan for Arboviruses. Here we report the results of a post-mortem active monitoring study conducted from November 2017 to October 2020 on animals hosted in five wild bird rescue centers of Central Italy. Five hundred seventy-six (n = 576) wild birds were tested by real-time polymerase chain reaction (RT-PCR) for the presence of WNV or USUV RNA fragments. No birds tested positive for USUV RNA (n = 0; 0.00%). Evidence of WNV RNA (Ct value = 34.36) was found in one bird (n = 1; 0.17%), an adult little grebe (Tachybaptus ruficollis subsp. ruficollis), that tested WNV positive in December 2019. This study highlights the strategic role of wildlife rescue centers in monitoring both the introduction and circulation of avian emerging zoonotic diseases. In addition, the presence of WNV during the cold season evidences the possible role of birds in overwintering mechanisms in the Italian territory and requires further investigation

Experimental Pandemic (H1N1) 2009 Virus Infection of Cats

To demonstrate that pandemic (H1N1) 2009 virus may cause respiratory disease in cats, we intratracheally infected cats. Diffuse alveolar damage developed. Seroconversion of sentinel cats indicated cat-to-cat virus transmission. Unlike in cats infected with highly pathogenic avian influenza virus (H5N1), extrarespiratory lesions did not develop in cats infected with pandemic (H1N1) 2009 virus

VdBH 222: a starburst cluster in the inner Milky Way

Context. It has been suggested that the compact open cluster VdBH 222 is a young massive distant object.Aims. We set out to characterise VdBH 222 using a comprehensive set of multi-wavelength observations.Methods.We obtained multi-band optical (UBVR) and near-infrared (JHKS) photometry of the cluster field, as well as multi-object and long-slit optical spectroscopy for a large sample of stars in the field. We applied classical photometric analysis, as well as more sophisticated methods using the CHORIZOS code, to determine the reddening to the cluster. We then plotted dereddened HR diagrams and determined cluster parameters via isochrone fitting.Results. We have identified a large population of luminous supergiants confirmed as cluster members via radial velocity measurements. We find nine red supergiants (plus one other candidate) and two yellow supergiants. We also identify a large population of OB stars. Ten of them are bright enough to be blue supergiants. The cluster lies behind ≈7.5 mag of extinction for the preferred value of RV = 2.9. Isochrone fitting allows for a narrow range of ages between 12 and 16 Ma. The cluster radial velocity is compatible with distances of ~6 and ~10 kpc. The shorter distance is inconsistent with the age range and Galactic structure. The longer distance implies an age ≈ 12 Ma and a location not far from the position where some Galactic models place the far end of the Galactic bar.Conclusions. VdBH 222 is a young massive cluster with a likely mass >20 000 M⊙. Its population of massive evolved stars is comparable to that of large associations, such as Per OB1. Its location in the inner Galaxy, presumably close to the end of the Galactic bar, adds to the increasing evidence for vigorous star formation in the inner regions of the Milky Way