Scholarships to be Established at Oxford under the Will of the Late Right Honorable Cecil John Rhodes

Booklet concerning the scholarships to be established at Oxford under the will of the late Cecil John Rhodes. Includes an extract from his testamentary dispositions

Mental health of Indigenous Australians: a review of findings from community surveys

Objective: To assemble what is known about the mental health of Indigenous Australians from community surveys. Data sources: A systematic search was carried out of publications and data sources since 2000 using PubMed, PsycINFO, Australian Medical Index, the National Library of Australia and datasets known to the authors. Study selection: Surveys had to involve representative sampling of a population, identify Aboriginal and Torres Strait Islander people and include a measure of mental health. Data extraction: 11 surveys were found. Data were extracted on prevalence rates for Indigenous people by age and sex, along with comparison data from the general population, where available. Data synthesis: Across seven studies, Indigenous adults were consistently found to have a higher prevalence of self-reported psychological distress than the general community. However, two studies of Indigenous adolescents did not find a higher prevalence of psychological distress. Two surveys of parents and carers of Indigenous children and adolescents found a higher prevalence of behaviour problems. Conclusions: There is an inequality in mental health between Indigenous and non-Indigenous Australians that starts from an early age. This needs to be a priority for research, preventive action and health services

The Ethics of Traditional Chinese and Western Herbal Medicine Research: Views of Researchers and Human Ethics Committees in Australia

Despite the growth of traditional Chinese medicine (TCM) and western herbal medicine (WHM) research in Australia, little is known about how ethics committees (HRECs) assess the ethics of TCM or WHM research. The objectives of this study were to examine the experiences of TCM and WHM researchers and HRECs with the evaluation of ethics applications. Two cross-sectional surveys were undertaken of HRECs and TCM and WHM researchers in Australia. Anonymous self-completion questionnaires were administered to 224 HRECs and 117 researchers. A response confirming involvement in TCM or WHM research applications was received from 20 HRECs and 42 researchers. The most frequent ethical issues identified by HRECs related to herbal products including information gaps relating to mode of action of herbal medicines and safety when combining herbal ingredients. Researchers concurred that they were frequently requested to provide additional information on multiple aspects including safety relating to the side effects of herbs and herb-drug interactions. Overall adherence with the principles of ethical conduct was high among TCM and WHM researchers although our study did identify the need for additional information regarding assessment of risk and risk management

Plasmodium falciparum parasite population structure and gene flow associated to anti-malarial drugs resistance in Cambodia

Background: Western Cambodia is recognized as the epicentre of emergence of Plasmodium falciparum multi-drug resistance. The emergence of artemisinin resistance has been observed in this area since 2008–2009 and molecular signatures associated to artemisinin resistance have been characterized in k13 gene. At present, one of the major threats faced, is the possible spread of Asian artemisinin resistant parasites over the world threatening millions of people and jeopardizing malaria elimination programme efforts. To anticipate the diffusion of artemisinin resistance, the identification of the P. falciparum population structure and the gene flow among the parasite population in Cambodia are essential. Methods: To this end, a mid-throughput PCR-LDR-FMA approach based on LUMINEX technology was developed to screen for genetic barcode in 533 blood samples collected in 2010–2011 from 16 health centres in malaria endemics areas in Cambodia. Results: Based on successful typing of 282 samples, subpopulations were characterized along the borders of the country. Each 11-loci barcode provides evidence supporting allele distribution gradient related to subpopulations and gene flow. The 11-loci barcode successfully identifies recently emerging parasite subpopulations in western Cambodia that are associated with the C580Y dominant allele for artemisinin resistance in k13 gene. A subpopulation was identified in northern Cambodia that was associated to artemisinin (R539T resistant allele of k13 gene) and mefloquine resistance. Conclusions: The gene flow between these subpopulations might have driven the spread of artemisinin resistance over Cambodia

When misconceptions impede best practices: evidence supports biological control of invasive Phragmites

Development of a biological control program for invasive Phagmites australis australis in North America required 20 years of careful research, and consideration of management alternatives. A recent paper by Kiviat et al. (Biol Invasions 21:2529–2541, 2019. https://doi.org/10.1007/s10530-019-02014-9) articulates opposition to this biocontrol program and questions the ethics and thoroughness of the researchers. Here we address inaccuracies and misleading statements presented in Kiviat et al. (2019), followed by a brief overview of why biological control targeting Phragmites in North America can be implemented safely with little risk to native species. Similar to our colleagues, we are very concerned about the risks invasive Phragmites represent to North American habitats. But to protect those habitats and the species, including P. australis americanus, we come to a different decision regarding biological control. Current management techniques have not been able to reverse the invasiveness of P. australis australis, threats to native rare and endangered species continue, and large-scale herbicide campaigns are not only costly, but also represent threats to non-target species. We see implementation of biocontrol as the best hope for managing one of the most problematic invasive plants in North America. After extensive review, our petition to release two host specific stem miners was approved by The Technical Advisory Group for the Release of Biological Control Agents in the US and Canadian federal authorities

Effect of humidity and temperature on the performance of three strains of Aphalara itadori, a biocontrol agent for Japanese knotweed

Japanese knotweed (Fallopia japonica) is a highly damaging invasive species affecting UK infrastructure and biodiversity. Under laboratory conditions, the psyllid Aphalara itadori has demonstrated its potential to be a successful biocontrol agent for F. japonica. However, this potential has not materialised in the field where long-term establishment of A. itadori has been unsuccessful and faces the added challenge of climate change. Intraspecific variation (variation among individuals of a species) has been shown to support establishment in alien species and improve resilience to changing environmental conditions, here we propose it could improve the performance of biocontrols. To test this possibility we compared the performance and impact on F. japonica of three strains of A. itadori with different genetic backgrounds, including a newly created hybrid. We hypothesize that genetic variability would be increased in hybrids resulting in greater biocontrol effectiveness (greater impact on plant growth). We also explored the potential influence of changing climate in performance, testing all strains under two humidity conditions (with the same temperature). Contrary to our expectation, the hybrid strain had the worst performance (slowest development rate and lower survival from egg to adult emergence) under both environmental conditions. Exposure to different strains of A. itadori did not result in consistent differences in plant growth, suggesting similar biocontrol effectiveness among strains. Under the drier, more stressful, conditions plants exposed to A. itadori had fewer leaves and accumulated less above-ground biomass. Overall, our results suggest that genetic variability may not be the key to improve A. itadori biocontrol effectiveness, but that predicted climate change, which anticipates drier and hotter summers in the UK, could reduce the growth potential of F. japonica when exposed to A. itadori

Pest risk assessment of Atropellis spp. for the EU territory

Following a request from the European Commission, the EFSA Plant Health (PLH) Panel performed a risk assessment for Atropellis spp. in the EU focusing on the risk of entry, the host range and the potential impacts. Atropellis is a fungal pathogen of several Pinus spp. in North America. The pathogen has not been reported from Europe and is a quarantine pest regulated in Annex IIAI of Council Directive 2000/29/EC on plants (other than fruit and seeds), isolated bark and wood of Pinus. The main pathways of entry considered were Pinus plants, wood and isolated bark. Given the ban of importing Pinus plants from outside Europe into the EU and the lack of information on EU imports of isolated Pinus bark, only the wood pathway was assessed quantitatively. The conclusion of the assessment of entry for scenario A0 (current regulatory situation) is that the risk of entry of Atropellis spp. is close to zero. This conclusion is expected to apply also in the case of removing the specific Atropellis regulations, because of the remaining generic Pinus requirements, as well as in a scenario with additional risk reduction options. The uncertainty associated with this assessment is relatively limited, given that all the quartiles of the estimated distribution of the number of potential founder populations are close to zero. For the North American Pinus spp. known to be susceptible and widely planted in the EU (mainly P. contorta and P. strobus), the damage observed in North America (loss of wood quality, stem deformations, mortality in young stands, environmental consequences) is expected in the EU to a similar (or higher) degree, should the pathogen be introduced. Similar impacts are expected on the European Pinus spp. known to be host of Atropellis spp. These include widespread and locally abundant species such as P. nigra, P. sylvestris and P. pinaster. There are, however, large uncertainties associated with this impact assessment due to the unknown susceptibility of several other Pinus spp. present in Europe. There is a need for research on the susceptibility to Atropellis spp. of those European Pinus spp