Rumor, gender, and authority in English Renaissance drama

The dramatic works of Christopher Marlowe, William Shakespeare, and Ben Jonson register a certain type of male character who is capable of discerning listening, an action that becomes an agent of specific masculine authority and identity. However, rumor\u27s inherent ambiguity and indeterminacy poses the greatest threat to discerning listening. The paradox that emerges is that while the drama posits men as superior authors of information, it is men---and not women---who are responsible for the circulation of unauthorized information and rumor on the stage. Early modern literary and cultural discourses repeatedly pointed to the dangers of loose tongues and transgressive speech, and such idle chatter was consistently gendered female. Male characters continually attempt to disown their own loose speech by placing women and their gossip as the true threat to informational authority. As early modern drama exposes transgressive male talk and a male anxiety of informational access, men must seek to maintain their informational authority from male unauthorized speech. This dissertation traces a shift in concerns about the female tongue to the male tongue and how discerning listening became a necessary component in the establishment and maintenance of authorial identity on the early modern stage. I claim that rumor is an omnipresent and diffuse cultural, social, political, and theatrical issue with extreme consequences for male sovereignty. As certainty and truth break down through the workings of rumor, so too do the received notions of masculine identity. Furthermore, female characters with their authorizing ears are often seen exercising agency on the early modern stage in what I call female aural environments, where careful listening, rather than excessive speech and gossip, becomes a vehicle for uncovering truth. I contend that the early modern theater is a theater of rumor and early modern drama exposes the cultural reality of male speech gone astray, making the case for the necessity of becoming a discerning earwitness amid the buzz of the realm

Manly Mechanicals on the Early Modern English Stage

A review of the book Manly Mechanicals on the Early Modern English Stage, by Ronda Arab is presented

Why Are Outcomes Different for Registry Patients Enrolled Prospectively and Retrospectively? Insights from the Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF).

Background: Retrospective and prospective observational studies are designed to reflect real-world evidence on clinical practice, but can yield conflicting results. The GARFIELD-AF Registry includes both methods of enrolment and allows analysis of differences in patient characteristics and outcomes that may result. Methods and Results: Patients with atrial fibrillation (AF) and ≥1 risk factor for stroke at diagnosis of AF were recruited either retrospectively (n = 5069) or prospectively (n = 5501) from 19 countries and then followed prospectively. The retrospectively enrolled cohort comprised patients with established AF (for a least 6, and up to 24 months before enrolment), who were identified retrospectively (and baseline and partial follow-up data were collected from the emedical records) and then followed prospectively between 0-18 months (such that the total time of follow-up was 24 months; data collection Dec-2009 and Oct-2010). In the prospectively enrolled cohort, patients with newly diagnosed AF (≤6 weeks after diagnosis) were recruited between Mar-2010 and Oct-2011 and were followed for 24 months after enrolment. Differences between the cohorts were observed in clinical characteristics, including type of AF, stroke prevention strategies, and event rates. More patients in the retrospectively identified cohort received vitamin K antagonists (62.1% vs. 53.2%) and fewer received non-vitamin K oral anticoagulants (1.8% vs . 4.2%). All-cause mortality rates per 100 person-years during the prospective follow-up (starting the first study visit up to 1 year) were significantly lower in the retrospective than prospectively identified cohort (3.04 [95% CI 2.51 to 3.67] vs . 4.05 [95% CI 3.53 to 4.63]; p = 0.016). Conclusions: Interpretations of data from registries that aim to evaluate the characteristics and outcomes of patients with AF must take account of differences in registry design and the impact of recall bias and survivorship bias that is incurred with retrospective enrolment. Clinical Trial Registration: - URL: http://www.clinicaltrials.gov . Unique identifier for GARFIELD-AF (NCT01090362)

Risk profiles and one-year outcomes of patients with newly diagnosed atrial fibrillation in India: Insights from the GARFIELD-AF Registry.

BACKGROUND: The Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF) is an ongoing prospective noninterventional registry, which is providing important information on the baseline characteristics, treatment patterns, and 1-year outcomes in patients with newly diagnosed non-valvular atrial fibrillation (NVAF). This report describes data from Indian patients recruited in this registry. METHODS AND RESULTS: A total of 52,014 patients with newly diagnosed AF were enrolled globally; of these, 1388 patients were recruited from 26 sites within India (2012-2016). In India, the mean age was 65.8 years at diagnosis of NVAF. Hypertension was the most prevalent risk factor for AF, present in 68.5% of patients from India and in 76.3% of patients globally (P < 0.001). Diabetes and coronary artery disease (CAD) were prevalent in 36.2% and 28.1% of patients as compared with global prevalence of 22.2% and 21.6%, respectively (P < 0.001 for both). Antiplatelet therapy was the most common antithrombotic treatment in India. With increasing stroke risk, however, patients were more likely to receive oral anticoagulant therapy [mainly vitamin K antagonist (VKA)], but average international normalized ratio (INR) was lower among Indian patients [median INR value 1.6 (interquartile range {IQR}: 1.3-2.3) versus 2.3 (IQR 1.8-2.8) (P < 0.001)]. Compared with other countries, patients from India had markedly higher rates of all-cause mortality [7.68 per 100 person-years (95% confidence interval 6.32-9.35) vs 4.34 (4.16-4.53), P < 0.0001], while rates of stroke/systemic embolism and major bleeding were lower after 1 year of follow-up. CONCLUSION: Compared to previously published registries from India, the GARFIELD-AF registry describes clinical profiles and outcomes in Indian patients with AF of a different etiology. The registry data show that compared to the rest of the world, Indian AF patients are younger in age and have more diabetes and CAD. Patients with a higher stroke risk are more likely to receive anticoagulation therapy with VKA but are underdosed compared with the global average in the GARFIELD-AF. CLINICAL TRIAL REGISTRATION-URL: http://www.clinicaltrials.gov. Unique identifier: NCT01090362

Iron Behaving Badly: Inappropriate Iron Chelation as a Major Contributor to the Aetiology of Vascular and Other Progressive Inflammatory and Degenerative Diseases

The production of peroxide and superoxide is an inevitable consequence of aerobic metabolism, and while these particular "reactive oxygen species" (ROSs) can exhibit a number of biological effects, they are not of themselves excessively reactive and thus they are not especially damaging at physiological concentrations. However, their reactions with poorly liganded iron species can lead to the catalytic production of the very reactive and dangerous hydroxyl radical, which is exceptionally damaging, and a major cause of chronic inflammation. We review the considerable and wide-ranging evidence for the involvement of this combination of (su)peroxide and poorly liganded iron in a large number of physiological and indeed pathological processes and inflammatory disorders, especially those involving the progressive degradation of cellular and organismal performance. These diseases share a great many similarities and thus might be considered to have a common cause (i.e. iron-catalysed free radical and especially hydroxyl radical generation). The studies reviewed include those focused on a series of cardiovascular, metabolic and neurological diseases, where iron can be found at the sites of plaques and lesions, as well as studies showing the significance of iron to aging and longevity. The effective chelation of iron by natural or synthetic ligands is thus of major physiological (and potentially therapeutic) importance. As systems properties, we need to recognise that physiological observables have multiple molecular causes, and studying them in isolation leads to inconsistent patterns of apparent causality when it is the simultaneous combination of multiple factors that is responsible. This explains, for instance, the decidedly mixed effects of antioxidants that have been observed, etc...Comment: 159 pages, including 9 Figs and 2184 reference

COVID-19 symptoms at hospital admission vary with age and sex: results from the ISARIC prospective multinational observational study

Background: The ISARIC prospective multinational observational study is the largest cohort of hospitalized patients with COVID-19. We present relationships of age, sex, and nationality to presenting symptoms. Methods: International, prospective observational study of 60 109 hospitalized symptomatic patients with laboratory-confirmed COVID-19 recruited from 43 countries between 30 January and 3 August 2020. Logistic regression was performed to evaluate relationships of age and sex to published COVID-19 case definitions and the most commonly reported symptoms. Results: ‘Typical’ symptoms of fever (69%), cough (68%) and shortness of breath (66%) were the most commonly reported. 92% of patients experienced at least one of these. Prevalence of typical symptoms was greatest in 30- to 60-year-olds (respectively 80, 79, 69%; at least one 95%). They were reported less frequently in children (≤ 18 years: 69, 48, 23; 85%), older adults (≥ 70 years: 61, 62, 65; 90%), and women (66, 66, 64; 90%; vs. men 71, 70, 67; 93%, each P &lt; 0.001). The most common atypical presentations under 60 years of age were nausea and vomiting and abdominal pain, and over 60 years was confusion. Regression models showed significant differences in symptoms with sex, age and country. Interpretation: This international collaboration has allowed us to report reliable symptom data from the largest cohort of patients admitted to hospital with COVID-19. Adults over 60 and children admitted to hospital with COVID-19 are less likely to present with typical symptoms. Nausea and vomiting are common atypical presentations under 30 years. Confusion is a frequent atypical presentation of COVID-19 in adults over 60 years. Women are less likely to experience typical symptoms than men

Look on this picture, and on this : Framing Shakespeare in William Wells Brown\u27s The \u27Escape\u27

In 1856, Brown began to read his first drama to New England audiences, entitled Experience; or, How to Give a Northern Man a Backbone, and in 1857, he began to read to various antislavery audiences what would become the first published drama by an African American, The Escape; or A Leap for Freedom. Not coincidently, after returning from five years in Europe, where, according to William Edward Farrison, Brown had read and seen a considerable amount of drama, including many Shakespearean plays, and with the vision of the theater and performers he witnessed at the Crystal Palace firmly in his mind, Brown came to write, perform, and publish a dramatic work. Furthermore, William Wells Brown\u27s performance and publication of The Escape emerged from a moment when blackface minstrelsy had just reached the peak of its popularity, the years 1846 to 1854. In Highbrow/Lowbrow, Lawrence Levine writes that Shakespeare and Shakespeare\u27s plays were an integral part of American culture that dominated the theater as popular entertainment for the majority of the nineteenth century. Oratory was a prominent feature in the national lifestyle, and it followed that Shakespeare\u27s word play, dialogues, and soliloquies would attract Americans who already were drawn to the parallels between Shakespeare\u27s characters and situations and their own society. Burlesque and parody were highly popular on the American stage, and because of Shakespeare\u27s cultural currency, his plays were a prime target

Renaissance Earwitnesses: Rumor and Early Modern Masculinity

Renaissance Earwitnesses examines masculinity on the early modern stage through sensory culture. In his reading of plays by Marlowe, Shakespeare, Cary, and Jonson, Keith M. Botelho argues that earwitnessing, or judicious listening, is a vehicle early modern dramatists used to rethink constructions of male informational authority. Drawing on sound and gender studies and providing close analysis of the circulation of rumor both on and off the stage, Botelho reveals male anxieties to be self-generated, emerging not from female gossip, but from male rumormongering. By rethinking the gendered dimensions to the flow of information, Botelho makes an important contribution to early modern scholarship