A Multi-centre Study to Evaluate the Long-Term Efficacy and Safety of Biosimilar Infliximab (Infimab™) in Ankylosing Spondylitis in Real-world Clinical Settings - A perspective from Eastern India

Introduction: Owing to dearth of data on infliximab biosimilars in Indian patients, a pan-India case database-based study with infliximab biosimilar BOW015 (Infimab™) was carried out to capture its efficacy and safety in real world clinical settings in India. Here, we assessed its efficacy and safety in ankylosing spondylitis (AS) among patients in the East India cohort. Materials and methods: Data were collected from multiple centers across the eastern region of India. Patients diagnosed with AS, within the preceding 4-6 months during the preceding one year were included in the study. Patients who were given BOW015 for other indications, prior innovator infliximab or other biologics were excluded from the study. Primary variable was Ankylosing Spondylitis Disease Activity Scale (ASDAS) response defined as change of > 2 in the ASDAS score from the baseline by 4-6 months of follow up. Results: The cohort consisted of 149 patients, predominantly male (69.8%), with mean (±SD) age of 36.75 (±11.11) years and mean (±SD) body weight of 58.26 (±15.4) kgs. Of the treated patients, 91 (61.1%) patients were administered four doses, 10 (6.7%) patients were administered three doses, 37 (24.8%) patients were administered two doses and 11 (7.4%) patients were administered only a single dose of BOW015. In the final analysis set, 81 patients had data at baseline and 4th visit. Among the 81 patients, 74 (91%) patients achieved major improvement, 5 (6%) patients achieved clinically important improvement and 2 (3%) were non-responders at 4th visit. Secondarily, cross categorization of the cohort into disease activity categories by number of infusions administered from baseline to 4th visit and assessment of trends in Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) scores were also carried out and these too confirmed the efficacy of BOW015. Conclusion: Infimab™ (BOW015) showed significant improvement in ASDAS and BASDAI in patients with AS at the end of 4-6 months of follow up with its clinical benefits being apparent as early as first dose of BOW015

Multiple novel prostate cancer susceptibility signals identified by fine-mapping of known risk loci among Europeans

Genome-wide association studies (GWAS) have identified numerous common prostate cancer (PrCa) susceptibility loci. We have fine-mapped 64 GWAS regions known at the conclusion of the iCOGS study using large-scale genotyping and imputation in 25 723 PrCa cases and 26 274 controls of European ancestry. We detected evidence for multiple independent signals at 16 regions, 12 of which contained additional newly identified significant associations. A single signal comprising a spectrum of correlated variation was observed at 39 regions; 35 of which are now described by a novel more significantly associated lead SNP, while the originally reported variant remained as the lead SNP only in 4 regions. We also confirmed two association signals in Europeans that had been previously reported only in East-Asian GWAS. Based on statistical evidence and linkage disequilibrium (LD) structure, we have curated and narrowed down the list of the most likely candidate causal variants for each region. Functional annotation using data from ENCODE filtered for PrCa cell lines and eQTL analysis demonstrated significant enrichment for overlap with bio-features within this set. By incorporating the novel risk variants identified here alongside the refined data for existing association signals, we estimate that these loci now explain ∼38.9% of the familial relative risk of PrCa, an 8.9% improvement over the previously reported GWAS tag SNPs. This suggests that a significant fraction of the heritability of PrCa may have been hidden during the discovery phase of GWAS, in particular due to the presence of multiple independent signals within the same regio

Ethics of Social Research

As society develops, it is important to keep ethical problems under continuing scrutiny and debate. It should also be recognized that a productive balance is between society’s need for knowledge and its member’s need for protection against intrusion, inconvenience, or discomfort. Freedom of enquiry must be balanced against the rights of privacy. While the issues are complex, accommodation and resolution are possible.ethics, rights of privacy, intrusion, invasion of privacy, Scoiology, Anthropology, Economics

2011), “Anthropometric assessment of nutritional status among college women of Midnapore

ABSTRACT A woman's nutritional status has important implications for her health as well as the health of her children. The present cross-sectional study was undertaken to determine the overall prevalence of undernutrition among young adult women of Raja N. L. Khan Women's College, Midnapore, West Bengal, India. Our study measured data on height and weight of adults aged 18-20 years. A total of 491 females were measured. One commonly used indicator i.e., body mass index (BMI; kg/m 2 ), was used to evaluate the nutritional status of the subjects. Based on BMI, chronic energy deficiency (CED) was used as a measure of undernutrition. The mean (SD) BMI of the subjects was 20.05 kg/m 2 (SD = 2.63). Results revealed that there was a significant (F = 4.085***, p < 0.001) increasing age trend in mean BMI. The overall age combined prevalence of CED was 28.3 %. Overall, only 4.5 % belonged to the overweight category. A significant (chi-square = 31.439; p < 0.001) age relationship existed in the prevalence of CED. According to the WHO classification of low BMI, it is clear that studied college girls of Midnapore, India are in serious situation for all ages and the youngest (18 years) among them are experiencing the most serious situation (32.7 %) with respect to their health and nutritional status. Overall prevalence of CED was (28.3 %). Conditions of the young women's were more severe and this severity decreases with increasing age of these women's. Results have been compared with recent reports from 18 states of India

Where Brain, Body and World Collide

The production cross section of electrons from semileptonic decays of beauty hadrons was measured at mid-rapidity (|y| < 0.8) in the transverse momentum range 1 < pt < 8 Gev/c with the ALICE experiment at the CERN LHC in pp collisions at a center of mass energy sqrt{s} = 7 TeV using an integrated luminosity of 2.2 nb^{-1}. Electrons from beauty hadron decays were selected based on the displacement of the decay vertex from the collision vertex. A perturbative QCD calculation agrees with the measurement within uncertainties. The data were extrapolated to the full phase space to determine the total cross section for the production of beauty quark-antiquark pairs