Evidence for exercise training in autonomic function modulation in patients with chronic obstructive pulmonary disease (COPD) : a systematic review

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WETWALL - an innovative design concept for the treatment of wastewater at an urban scale

Rising temperatures, increasing food demand and scarcity of water and land resources highlight the importance of promoting the sustainable expansion of agriculture to our urban environment, while preserving water resources. Treating urban wastewaters, such as greywater and hydroponic wastewater, may represent a strategic point for the implementation of urban farming, ensuring food security, reducing pressures on water resources and promoting climate change mitigation. The WETWALL design concept proposes a unique ecotechnology for secondary wastewater treatment at an urban scale, which brings the novelty of a modular living wall hybrid flow. This concept is based on the integration of two established nature-based solutions/ecomimetic designs: constructed wetlands and a modular living walls. First presented is an overview about the state of the art in the scope of living walls treating wastewater, in order to identify the main design aspects related to the performance of such systems, which mainly concerns the removal of nitrates and phosphates. Second, the WETWALL design concept is presented. A scheme regarding the selection of the main components, such as plants and substrate, is proposed, and potential structure developments and operation strategies are discussed. In addition, considering the scope of integrating the circular economy with the design process, potential interactions between this technology and the urban environment are discussed. The main goal of this article is to substantiate the potential of the WETWALL design concept as an innovative wastewater treatment at an urban scale.Biggest thanks to the National Council for Scientific and Technological Development – Brazil (CNPQ), for their financial support (doctoral fellowship). The authors also would like to thank the UNESCO Chair on Sustainability of the Polytechnic University of Catalonia (Spain), the Aarhus University (Denmark) and the research groups GREA (2014 SGR 123), DIOPMA (2014 SGR 1543) and GICITED (2014 SGR 1298)

La centralità delle risorse umane ed il ruolo della formazione: il caso Unicoop Firenze

L’elaborato si propone di analizzare la rilevanza strategica delle risorse umane come variabile economica critica per le aziende che a differenza delle risorse materiali e finanziarie, possedute nella stessa quantità e qualità dai concorrenti rappresenta una risorsa unica ed inimitabile. Viene evidenziato inoltre come il tradizionale processo di valutazione delle risorse umane possa essere anacronistico, poiché le aziende temporeggiano in attesa dei risultati prima di intervenire i quali però sono indicatori ritardati e registrano il passato. Si sostiene invece, che prendendo in considerazione la formazione come strumento di valutazione delle risorse umane si può riuscire a fronteggiare tale inconveniente passando così ad un controllo antecedente dei comportamenti. La centralità delle risorse umane ed il ruolo della formazione sono stati indagati in Unicoop Firenze

Desirable plant cell wall traits for higher-quality miscanthus lignocellulosic biomass

Additional file 7. Box and whisker plots showing the distribution of biomass compositional measurements, and the P-values of t tests used to discriminate between genotypes with high or low saccharification efficiency indices

A unified formulation for the computation of the six-degrees-of-freedom-motion-induced errors in floating Doppler wind LiDARs

This work presents an analytical formulation to assess the six-degrees-of-freedom-motion-induced error in floating Doppler wind LiDARs (FDWLs). The error products derive from the horizontal wind speed bias and apparent turbulence intensity. Departing from a geometrical formulation of the FDWL attitude and of the LiDAR retrieval algorithm, the contributions of the rotational and translational motion to the FDWL-measured total error are computed. Central to this process is the interpretation of the velocity–azimuth display retrieval algorithm in terms of a first-order Fourier series. The obtained 6 DoF formulation is validated numerically by means of a floating LiDAR motion simulator and experimentally in nearshore and open-sea scenarios in the framework of the Pont del Petroli and IJmuiden campaigns, respectively. Both measurement campaigns involved a fixed and a floating ZephIRTM 300 LiDAR. The proposed formulation proved capable of estimating the motion-induced FDWL horizontal wind speed bias and returned similar percentiles when comparing the FDWL with the fixed LiDAR. The estimations of the turbulence intensity increment statistically matched the FDWL measurements under all motional and wind scenarios when clustering the data as a function of the buoy’s mean tilt amplitude, mean translational-velocity amplitude, and mean horizontal wind speed.This research project was part of the project PID2021-126436OB-C21 funded by the Ministerio de Ciencia e Investigación (MCIN)/Agencia Estatal de Investigación (AEI)/10.13039/501100011033 y FEDER “Una manera de hacer Europa”. The work of A. Salcedo-Bosch was supported by grant 2020 FISDU 00455 funded by Generalitat de Catalunya—AGAUR. The work of M.P Araújo da Silva was supported under Grant PRE2018-086054 funded by MCIN/AEI/10.13039/501100011033 and FSE “El FSE invierte en tu futuro”. The European Commission collaborated under projects H2020 ATMO-ACCESS (GA-101008004) and H2020 ACTRIS-IMP (GA-871115).Peer ReviewedPostprint (published version

Stress as a determinant of saliva-mediated adherence and coadherence of oral and nonoral microorganisms

Objective:: The mucosal secretory proteins, such as the salivary proteins, play a key role in the acquisition and regulation of the mucosal microflora. Most notably, some microorganisms utilize the host's secretory proteins to adhere to the mucosa; a first step in colonization and infection. The secretory proteins also influence colonization by affecting the binding among microorganisms, a process denoted as coadherence. Previously we reported that acute stressors cause specific changes in saliva composition. The present study investigated to what extent these changes influence saliva-mediated microbial adherence and coadherence (ex vivo). Methods:: Thirty-two male undergraduates provided unstimulated saliva before and during a control condition and two stressors: A memory test and a surgery video presentation. We used saliva-coated microplates to test the adherence of bacteria for which the oral cavity is either a natural reservoir (eg, viridans streptococci) or a portal of entry (eg, Helicobacter pylori). We also tested the saliva-mediated co-adherence between Streptococcus gordonii and the yeast Candida albicans. Correlation analyses were performed to determine the relationships between changes in microbial adherence and the concentrations of potential salivary ligands, viz. cystatin S, the mucins MUC5B and MUC7, S-IgA, lactoferrin, [alpha]-amylase, and total salivary protein. Results:: During the memory test, saliva-mediated adhesion of Streptococcus sanguis, Streptococcus gordonii, and H. pylori increased, whereas the coadherence of C. albicans with S. gordonii decreased. During the surgical video presentation the saliva-mediated adherence of H. pylori, S. sanguis, and Streptococcus mitis increased. These changes were independent of salivary flow rate, but correlated with specific changes in salivary protein composition. Conclusion:: The results show that even moderate stressors, by altering the activity of the mucosal secretory glands, may affect microbial colonization processes such as adherence and coadherence. This study hereby presents a mechanism by which stress may affect the mucosal microflora and susceptibility to infectious disease

Genotype, development and tissue-derived variation of cell-wall properties in the lignocellulosic energy crop Miscanthus

BACKGROUND AND AIMS: Species and hybrids of the genus Miscanthus contain attributes that make them front-runners among current selections of dedicated bioenergy crops. A key trait for plant biomass conversion to biofuels and biomaterials is cell-wall quality; however, knowledge of cell-wall composition and biology in Miscanthus species is limited. This study presents data on cell-wall compositional changes as a function of development and tissue type across selected genotypes, and considers implications for the development of miscanthus as a sustainable and renewable bioenergy feedstock. METHODS: Cell-wall biomass was analysed for 25 genotypes, considering different developmental stages and stem vs. leaf compositional variability, by Fourier transform mid-infrared spectroscopy and lignin determination. In addition, a Clostridium phytofermentans bioassay was used to assess cell-wall digestibility and conversion to ethanol. KEY RESULTS: Important cell-wall compositional differences between miscanthus stem and leaf samples were found to be predominantly associated with structural carbohydrates. Lignin content increased as plants matured and was higher in stem tissues. Although stem lignin concentration correlated inversely with ethanol production, no such correlation was observed for leaves. Leaf tissue contributed significantly to total above-ground biomass at all stages, although the extent of this contribution was genotype-dependent. CONCLUSIONS: It is hypothesized that divergent carbohydrate compositions and modifications in stem and leaf tissues are major determinants for observed differences in cell-wall quality. The findings indicate that improvement of lignocellulosic feedstocks should encompass tissue-dependent variation as it affects amenability to biological conversion. For gene–trait associations relating to cell-wall quality, the data support the separate examination of leaf and stem composition, as tissue-specific traits may be masked by considering only total above-ground biomass samples, and sample variability could be mostly due to varying tissue contributions to total biomass

A cell wall reference profile for Miscanthus bioenergy crops highlights compositional and structural variations associated with development and organ origin

Miscanthus spp. are promising lignocellulosic energy crops, but cell wall recalcitrance to deconstruction still hinders their widespread use as bioenergy and biomaterial feedstocks. Identification of cell wall characteristics desirable for biorefining applications is crucial for lignocellulosic biomass improvement. However, the task of scoring biomass quality is often complicated by the lack of a reference for a given feedstock. A multidimensional cell wall analysis was performed to generate a reference profile for leaf and stem biomass from several miscanthus genotypes harvested at three developmentally distinct time points. A comprehensive suite of 155 monoclonal antibodies was used to monitor changes in distribution, structure and extractability of noncellulosic cell wall matrix glycans. Glycan microarrays complemented with immunohistochemistry elucidated the nature of compositional variation, and in situ distribution of carbohydrate epitopes. Key observations demonstrated that there are crucial differences in miscanthus cell wall glycomes, which may impact biomass amenability to deconstruction. For the first time, variations in miscanthus cell wall glycan components were comprehensively characterized across different harvests, organs and genotypes, to generate a representative reference profile for miscanthus cell wall biomass. Ultimately, this portrait of the miscanthus cell wall will help to steer breeding and genetic engineering strategies for the development of superior energy crops

Autonomic function in subjects with severe COPD

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