61 research outputs found

    Corporate governance in emerging markets and its impact on finance performance

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    This paper reviews the theoretical framework of Corporate Governance and multiple issues in which it is evaluated such as agency costs, asymmetric information, insider trading, manipulation of earnings, Board of Directors, etc. Finally, it is reviewed the impact of Corporate Governance over cost of equity, capital structure and financial performance

    Dise?o y construcci?n de la habilitaci?n urbano industrial del Complejo Maderero de Pucallpa

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    El proyecto denominado ?Dise?o y construcci?n de la habilitaci?n urbano industrial del Complejo Maderero de Pucallpa, responde a atender la necesidad de contar con infraestructura para el uso de lotes industriales que impulsen la cadena de valor de la transformaci?n de la madera en la Regi?n Ucayali. Para el desarrollo del presente Proyecto se ha aplicado las buenas pr?cticas del PMBOOK 6ta. Edici?n, siendo el alcance del Proyecto desde la elaboraci?n de estudios previos, el desarrollo del dise?o de Habilitaci?n Urbana, la elaboraci?n del expediente t?cnico, gesti?n y tramitaci?n de certificados y licencia, hasta la procura y ejecuci?n de las obras de habilitaci?n urbana industrial que albergue 134 lotes industriales en 17 manzanas, distribuidos en 04 sectores, con cerco perimetral y p?rtico de ingreso, as? como la construcci?n de un edificio administrativo de dos pisos. EL plazo de ejecuci?n es de veintiocho (28) meses, con un monto de inversi?n de US 25,148,000, desarroll?ndose dentro de un terreno con un ?rea de 51 has, activo de propiedad del principal stakeholder la Asociaci?n de Madereros de Pucallpa. Cuenta con un plan de acci?n de mitigaci?n y reserva de contingencia, basado en la identificaci?n de los riesgos principales del proyecto

    Mesenchymal Stem Cells Prevent the Rejection of Fully Allogenic Islet Grafts by the Immunosuppressive Activity of Matrix Metalloproteinase-2 and -9

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    OBJECTIVE Mesenchymal stem cells (MSCs) are known to be capable of suppressing immune responses, but the molecular mechanisms involved and the therapeutic potential of MSCs remain to be clarified. RESEARCH DESIGN AND METHODS We investigated the molecular mechanisms underlying the immunosuppressive effects of MSCs in vitro and in vivo. RESULTS Our results demonstrate that matrix metalloproteinases (MMPs) secreted by MSCs, in particular MMP-2 and MMP-9, play an important role in the suppressive activity of MSCs by reducing surface expression of CD25 on responding T-cells. Blocking the activity of MMP-2 and MMP-9 in vitro completely abolished the suppression of T-cell proliferation by MSCs and restored T-cell expression of CD25 as well as responsiveness to interleukin-2. In vivo, administration of MSCs significantly reduced delayed-type hypersensitivity responses to allogeneic antigen and profoundly prolonged the survival of fully allogeneic islet grafts in transplant recipients. Significantly, these MSC-mediated protective effects were completely reversed by in vivo inhibition of MMP-2 and MMP-9. CONCLUSIONS We demonstrate that MSCs can prevent islet allograft rejection leading to stable, long-term normoglycemia. In addition, we provide a novel insight into the mechanism underlying the suppressive effects of MSCs on T-cell responses to alloantigen.</p

    From Epigenetic Associations to Biological and Psychosocial Explanations in Mental Health

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    The development of mental disorders constitutes a complex phenomenon driven by unique social, psychological and biological factors such as genetics and epigenetics, throughout an individual's life course. Both environmental and genetic factors have an impact on mental health phenotypes and act simultaneously to induce changes in brain and behavior. Here, we describe and critically evaluate the current literature on gene-environment interactions and epigenetics on mental health by highlighting recent human and animal studies. We furthermore review some of the main ethical and social implications concerning gene-environment interactions and epigenetics and provide explanations and suggestions on how to move from statistical and epigenetic associations to biological and psychological explanations within a multi-disciplinary and integrative approach of understanding mental health

    Effects of CSR and CR on business confidence in an emerging country

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    Corporate social responsibility has been one of the main pillars of development for companies in developed countries and studies are being conducted for developed countries and the productive sector of the economy. Therefore, the main objective of this paper is to analyze the relationship between corporate social responsibility (CSR), corporate reputation (CR), and business confidence in the context of the banking sector in an emerging country (Peru). To test the hypotheses presented in this paper, we sent a survey to 1745 banking executive officers of the branch offices in Peru. These key individuals were selected as the target population of the study because the authors sought to study the management?s perception of CSR and business confidence. From the data obtained from the survey, it has been determined that the strategic consideration of CSR in Peruvian banks directly influences the perception of business confidence. Secondly, it has been demonstrated that the strategic consideration of CSR in Peruvian banks positively influences corporate reputation and, finally, the perception of the importance of the corporate reputation of Peruvian banks and significantly influences the perception of business confidence by the managers. The main contribution of this paper is that it analyzes empirically how business confidence is perceived by managers, who are the main agents involved in implementing CSR actions, based on their opinion of the strategic consideration of CSR and the perception of CR in a context barely investigated, an emerging country

    Instructivo para la organizaci?n y ejecuci?n de simulacros de evacuaci?n

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    Used technologies in current production and conservation systems in Jucuapa River sub watershed, Matagalpa, Nicaragua

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    Tesis (M. Sc) -- CATIE, Turrialba (Costa Rica),2005also to determine adoption levels of technologies that either adjust or not to watershed management, and to identify and analyze conditioning factors for their adoption. Se realiz? un estudio en la Subcuenca del R?o Jucuapa en Matagalpa, Nicaragua, con los objetivos de identificar las tecnolog?as que se est?n implementando en los sistemas de producci?n y conservaci?n, determinar los niveles de adopci?n de las tecnolog?as que se ajustan o no al enfoque de manejo de cuencas, e identificar factores condicionantes para su adopci?n. A study was made in Jucuapa River Sub watershed in Matagalpa, Nicaragua with the objective of identyfing technologies that are being implemented in production and conservation system
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