Methodology for determining foliar penetration of herbicides with reference to oil-based adjuvants

51 ref.International audienc

The ANTENATAL multicentre study to predict postnatal renal outcome in fetuses with posterior urethral valves: Objectives and design

Background. Posterior urethral valves (PUV) account for 17% of paediatric end-stage renal disease. A major issue in the management of PUV is prenatal prediction of postnatal renal function. Fetal ultrasound and fetal urine biochemistry are currently employed for this prediction, but clearly lack precision. We previously developed a fetal urine peptide signature that predicted in utero with high precision postnatal renal function in fetuses with PUV. We describe here the objectives and design of the prospective international multicentre ANTENATAL (multicentre validation of a fetal urine peptidome-based classifier to predict postnatal renal function in posterior urethral valves) study, set up to validate this fetal urine peptide signature.Methods. Participants will be PUV pregnancies enrolled from 2017 to 2021 and followed up until 2023 in >30 European centres endorsed and supported by European reference networks for rare urological disorders (ERN eUROGEN) and rare kidney diseases (ERN ERKNet). The endpoint will be renal/patient survival at 2 years postnatally. Assuming a = 0.05, 1-b = 0.8 and a mean prevalence of severe renal outcome in PUV individuals of 0.35, 400 patients need to be enrolled to validate the previously reported sensitivity and specificity of the peptide signature.Results. In this largest multicentre study of antenatally detected PUV, we anticipate bringing a novel tool to the clinic. Based on urinary peptides and potentially amended in the future with additional omics traits, this tool will be able to precisely quantify postnatal renal survival in PUV pregnancies. The main limitation of the employed approach is the need for specialized equipment.Conclusions. Accurate risk assessment in the prenatal period should strongly improve the management of fetuses with PUV

Toxicologie predictive: les voies du futur

National audienc

Toxicologie predictive: les voies du futur

National audienc

Christelijk onderwijs in ontwikkeling. Jaarboek 1996

Although technological and environmental benefits are important stimuli for nanotechnology development, these technologies have been contested from an environmental point of view. The steady growth of applications of engineered nanomaterials has heated up the debate on quantifying the environmental repercussions. The two main scientific methods to address these environmental repercussions are risk assessment and life-cycle assessment. The strengths and weaknesses of each of these methods, and the relation between them, have been a topic of debate in the world of traditional chemistry for over two decades. Here we review recent developments in this debate in general and for the emerging field of nanomaterials specifically. We discuss the pros and cons of four schools of thought for combining and integrating risk assessment and life-cycle assessment and conclude with a plea for action.Conservation BiologyIndustrial Ecolog